KR101663376B1 - Method and apparatus for mapping retinal vessels - Google Patents
Method and apparatus for mapping retinal vessels Download PDFInfo
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- KR101663376B1 KR101663376B1 KR1020140143892A KR20140143892A KR101663376B1 KR 101663376 B1 KR101663376 B1 KR 101663376B1 KR 1020140143892 A KR1020140143892 A KR 1020140143892A KR 20140143892 A KR20140143892 A KR 20140143892A KR 101663376 B1 KR101663376 B1 KR 101663376B1
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- 238000000034 method Methods 0.000 title claims abstract description 23
- 238000013507 mapping Methods 0.000 title claims abstract description 8
- 210000001210 retinal vessel Anatomy 0.000 title claims abstract description 6
- 238000003384 imaging method Methods 0.000 claims abstract description 19
- 230000002792 vascular Effects 0.000 claims abstract description 8
- 102000001554 Hemoglobins Human genes 0.000 claims description 33
- 108010054147 Hemoglobins Proteins 0.000 claims description 33
- 238000002835 absorbance Methods 0.000 claims description 31
- 210000001525 retina Anatomy 0.000 claims description 23
- 230000001678 irradiating effect Effects 0.000 claims description 14
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 238000013500 data storage Methods 0.000 claims description 6
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- 239000002041 carbon nanotube Substances 0.000 claims description 3
- 229910021393 carbon nanotube Inorganic materials 0.000 claims description 3
- 210000004220 fundus oculi Anatomy 0.000 claims description 3
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- 208000032253 retinal ischemia Diseases 0.000 abstract description 10
- 230000002207 retinal effect Effects 0.000 abstract description 9
- 230000003287 optical effect Effects 0.000 abstract description 6
- 210000001519 tissue Anatomy 0.000 description 5
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- 206010012689 Diabetic retinopathy Diseases 0.000 description 3
- 238000011481 absorbance measurement Methods 0.000 description 3
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- 238000003745 diagnosis Methods 0.000 description 3
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- 201000004569 Blindness Diseases 0.000 description 2
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- 206010038886 Retinal oedema Diseases 0.000 description 1
- 208000014139 Retinal vascular disease Diseases 0.000 description 1
- 206010038923 Retinopathy Diseases 0.000 description 1
- 206010038933 Retinopathy of prematurity Diseases 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
The present invention relates to an optical retinal vascular imaging apparatus and a retinal vascular mapping method using the same. The method and apparatus for retinal vessel mapping of the present invention are non-invasive and can accurately measure the extent of retinal ischemia in a short time, and can be applied to patients having medium opacity.
Description
The present invention relates to an optical retinal vascular imaging apparatus and a retinal vascular mapping method using the same.
Retinal vascular disease, including diabetic retinopathy, exudative age related macular degeneration, premature retinopathy and vascular occlusion, is a major cause of visual impairment and blindness. These disease groups are the focus of intensive research to identify new therapeutic modalities to prevent or mitigate pathological ocular angiogenesis. For example, in diabetic retinopathy, diabetic retinopathy leads to deformation of the capillary vessels of the retina, eventually resulting in the withdrawal of the capillary vessels and the progression of ischemia resulting therefrom, the development of new blood vessels as a response thereto, , And fibrosis, resulting in blindness.
Fluorescein angiography using fluorescein is the imaging method that is mainly used in clinical practice as an evaluation of retinal ischemia. This is a method of intravenous injection of a fluorescent contrast agent called fluorescein and then observing the process of circulation of the fluorescent contrast agent in the blood vessels of the retina / choroid. In case of blood vessel leakage such as neovascularization due to fluorescein, Which is widely used. However, since this method is an angiography, it is easy to observe capillary loss, but it is difficult to evaluate ischemia itself, it takes a considerable time to test, injection of contrast agent is required, There is a disadvantage in that it can even cause death.
In order to overcome these disadvantages, adaptive optics, which can enhance the resolution of images and allow observation of fine blood circulation, has been considered. However, the time required for the examination per subject is considerable, However, it is not possible to observe changes of the arterioles / vein below the ischemia itself, and it is difficult to observe ischemia itself when there is media opacity (cataract, etc.).
Therefore, there is a need to develop a new method for measuring retinal ischemia, which is capable of functional assessment, is non-invasive, and complements safety issues.
One aspect of the present invention is to provide an optical retinal vascular imaging device.
Another aspect of the present invention is to provide a method of mapping retinal vessels to provide information necessary for ischemic diagnosis of the retina.
According to an aspect of the present invention, there is provided a light emitting device including: a light irradiating unit for generating a light source; A light receiving unit for receiving a light source reflected from a fundus oculi; A light absorbance measuring unit for measuring an absorbance of the light source received by the light receiving unit; A calculator for calculating the presence or absence of hemoglobin from the measured absorbance data; A conversion unit for converting the calculated result into fundus capillary blood vessel distribution data; And an image acquiring unit acquiring the capillary blood vessel distribution data image.
According to one embodiment, the apparatus may further include a display unit that displays the capillary blood vessel distribution data in real time.
According to an embodiment of the present invention, the light irradiating unit may further include a light source adjusting unit for adjusting the intensity of the light source, and the apparatus may further include a first filter for converting the light source into a red light or a wavelength range of infrared light .
According to one embodiment, the light source may be selected from the group consisting of red light, infrared light, and combinations thereof, wherein the red light has a wavelength of 630 nm to 780 nm and the infrared light has a wavelength of 850 nm to 1000 nm Lt; / RTI >
According to one embodiment, the light irradiating unit may be selected from the group consisting of light emitting diodes, organic light emitting diodes, laser diodes, and carbon nanotube lamps.
According to one embodiment, the conversion to capillary blood vessel distribution data may be to quantify the presence of hemoglobin and to image the capillary distribution of the retina from the values.
According to one embodiment, the apparatus may further comprise data storage means for storing capillary blood vessel distribution data.
According to one embodiment, the light receiving unit may further include a second filter for reducing noise generated from the light source.
Another aspect of the present invention relates to a method for obtaining absorbance data of a capillary blood vessel through fundus photography of a subject; And quantifying the presence or absence of hemoglobin from the obtained absorbance data and imaging the capillary distribution of the retina from the numerical value to provide information necessary for diagnosis of retinal ischemia .
According to one embodiment, the fundus photography may be performed by a light source selected from the group consisting of red light, infrared light, and combinations thereof, the red light having a wavelength of 630 nm to 780 nm, the infrared light having a wavelength of 850 nm It may have a wavelength of 1000 nm.
According to one embodiment, the imaging may be imaging of the capillary through color differences with surrounding tissue when hemoglobin is present.
The method and apparatus for retinal vessel mapping of the present invention are non-invasive and can accurately measure the extent of retinal ischemia in a short time, and can be applied to patients having medium opacity.
FIG. 1 illustrates an apparatus for measuring retinal ischemia according to an embodiment of the retina of an optical retinal vascular imaging apparatus according to an embodiment of the present invention.
FIG. 2 is an image photograph in which capillaries of the retina are mapped using an apparatus and a method according to an embodiment of the present invention.
The terms used in this specification will be briefly described and the present invention will be described in detail.
While the present invention has been described in connection with what is presently considered to be the most practical and preferred embodiment, it is to be understood that the invention is not limited to the disclosed embodiments. Also, in certain cases, there may be a term selected arbitrarily by the applicant, in which case the meaning thereof will be described in detail in the description of the corresponding invention. Therefore, the term used in the present invention should be defined based on the meaning of the term, not on the name of a simple term, but on the entire contents of the present invention.
When an element is referred to as "including" an element throughout the specification, it is to be understood that the element may include other elements as well, without departing from the spirit or scope of the present invention.
Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. In order to clearly illustrate the present invention, parts not related to the description are omitted, and like parts are denoted by similar reference numerals throughout the specification.
FIG. 1 illustrates an apparatus for measuring retinal ischemia according to an embodiment of the retina of an optical retinal vascular imaging apparatus according to an embodiment of the present invention.
According to one aspect of the present invention, there is provided a light emitting device comprising: a light irradiation part (10) for generating a light source; A
The apparatus according to one embodiment of the present invention may include a
According to one embodiment, the
According to one embodiment, the red light may have a wavelength of 630 nm to 780 nm, and most preferably a wavelength of 650 nm to 670 nm. According to one embodiment, the infrared light may have a wavelength of 850 nm to 1000 nm, and most preferably a wavelength of 900 nm to 940 nm.
According to one embodiment, the
The apparatus according to the embodiment of the present invention can obtain the capillary blood vessel distribution image with the desired brightness by adjusting the intensity of the light source irradiated to the eye fundus of the subject through the light
According to one embodiment, the
The apparatus according to one embodiment of the present invention may include a
The light source irradiated from the
The apparatus according to one embodiment of the present invention may include an
The
The apparatus according to one embodiment of the present invention may include a
In the calculating
The apparatus according to one embodiment of the present invention may include a
In the
According to one embodiment, the conversion to capillary blood vessel distribution data may be to quantify the presence of hemoglobin and to image the capillary distribution of the retina from the values. The imaging of the retinal capillary distribution can be, for example, indicated by a difference in color or brightness from surrounding tissue, but not limited thereto, in order to distinguish the capillaries from other parts.
The apparatus according to one embodiment of the present invention may include an
The
The apparatus according to an embodiment of the present invention may further include a
The
According to one embodiment, the apparatus may further comprise data storage means (70) for storing capillary blood vessel distribution data.
The data storage means 70 according to one embodiment may store the absorbance data, the capillary blood vessel distribution data of the fundus, the images of the capillary blood vessel distribution data, and the like directly or in the form of digital data. The data storing means 70 is a concept including various kinds of devices and systems capable of performing the above-mentioned functions. For example, the data storing means 70 includes an Internet server, a cellular phone, a personal computer, Can be interpreted as a broad concept.
The apparatus of the present invention further includes a flash light
Another aspect of the present invention relates to a method for obtaining absorbance data of a capillary blood vessel through fundus photography of a subject; And quantifying the presence or absence of hemoglobin from the obtained absorbance data and imaging the capillary distribution of the retina from the numerical value to provide information necessary for diagnosis of retinal ischemia .
The retinal vessel mapping method according to one embodiment of the present invention will be described in detail as follows.
According to one embodiment, the method comprises obtaining absorbance data of capillary blood vessels through fundus photography of the subject.
The fundus photographing of the subject is performed by irradiating a light source to the fundus of the subject from the
According to one embodiment, the fundus photography may be performed by a light source selected from the group consisting of red light, infrared light, and combinations thereof, and the red light preferably has a wavelength of 630 nm to 780 nm, And preferably from 650 nm to 670 nm. In addition, the infrared light may preferably have a wavelength of 850 nm to 1000 nm, and most preferably have a wavelength of 900 nm to 940 nm.
The absorbance of all parts of the fundus is measured by the
According to one embodiment, the method may include quantifying the presence of hemoglobin from the absorbance data obtained, and imaging the capillary distribution of the retina from the numerical value.
Quantification of the presence of hemoglobin and imaging of the capillary distribution of the retina may be performed in a
The imaging may be performed through the
In general, the ischemic retina is the first to change capillary vessels such as capillary dislocation and capillary vasculature. Therefore, if capillaries are not distributed or an abnormality is found, it indicates that there is retinal ischemia. Thus, capillary blood vessels of the retina can be mapped by the above method to confirm whether the retina is ischemic.
FIG. 2 is an image photograph in which capillaries of the retina are mapped using an artificial eye according to an apparatus and method according to an embodiment of the present invention. As shown in FIG. 2, it is possible to directly and easily confirm the ischemic state of the retina from the image through the apparatus and the method of the present invention. Thus, it is possible to provide a retinal ischemia, retinal inflammation, retinal edema, traction retinal detachment, traction retinopathy, It can be effectively used to prevent or treat traumatic maculopathy.
The present invention has been described with reference to the preferred embodiments. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the disclosed embodiments should be considered in an illustrative rather than a restrictive sense. The scope of the present invention is defined by the appended claims rather than by the foregoing description, and all differences within the scope of equivalents thereof should be construed as being included in the present invention.
10:
11: Light source control unit
12: first filter
20:
21: second filter
30: Absorbance measurement part
40:
50:
60:
61:
70: Data storage means
80: a flash light source delivery portion
90: reflector
Claims (17)
And a second filter for reducing noise generated from the light source, the light receiving unit including a light source reflected from a fundus oculi;
A light absorbance measuring unit for measuring an absorbance of the light source received by the light receiving unit;
A calculator for calculating the presence or absence of hemoglobin from the measured absorbance data;
A conversion unit for digitizing the presence or absence of hemoglobin and imaging the capillary blood distribution data of the retina from the above values and converting the data into capillary blood vessel distribution data of the fundus by making a difference in color or brightness from surrounding tissue; And
And a digital camera or a smartphone built-in camera that acquires the capillary blood vessel distribution data image.
Quantifying the presence or absence of hemoglobin from the obtained absorbance data and imaging the capillary distribution of the retina from the above value through color difference with surrounding tissues in the presence of hemoglobin, A method of mapping retinal vessels to provide the necessary information.
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KR1020140143892A KR101663376B1 (en) | 2014-10-23 | 2014-10-23 | Method and apparatus for mapping retinal vessels |
PCT/KR2015/009500 WO2016064089A1 (en) | 2014-10-23 | 2015-09-09 | Method and apparatus for mapping retinal vessels |
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KR1020140143892A KR101663376B1 (en) | 2014-10-23 | 2014-10-23 | Method and apparatus for mapping retinal vessels |
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US11080850B2 (en) * | 2018-01-16 | 2021-08-03 | Electronics And Telecommunications Research Institute | Glaucoma diagnosis method using fundus image and apparatus for the same |
KR102305828B1 (en) * | 2019-09-27 | 2021-09-30 | 주식회사 엔서 | Apparatus and System for Diagnosing Dementia |
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JPH08154924A (en) * | 1994-12-05 | 1996-06-18 | Konan:Kk | Retinal camera having measuring function |
JP4817509B2 (en) * | 2001-02-19 | 2011-11-16 | キヤノン株式会社 | Optometry equipment |
JP4872082B2 (en) * | 2006-06-07 | 2012-02-08 | 国立大学法人九州工業大学 | Personal authentication method and personal authentication device using fundus blood flow measurement by laser light |
WO2009148067A1 (en) * | 2008-06-04 | 2009-12-10 | 株式会社 網膜情報診断研究所 | Retinal information diagnosis system |
KR101476906B1 (en) * | 2013-03-21 | 2014-12-26 | 이화여자대학교 산학협력단 | Method and apparatus for measuring ischemia measuring |
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