KR101634911B1

KR101634911B1 - Method of manufacturing a micro-sized needle

Info

Publication number: KR101634911B1
Application number: KR1020150166974A
Authority: KR
Inventors: 강문식
Original assignee: 주식회사 이너센서
Priority date: 2015-11-27
Filing date: 2015-11-27
Publication date: 2016-06-30

Abstract

In the method of manufacturing a microneedle, a first mold having a first concave pattern having a horizontal area that becomes smaller as it goes down is prepared, and then a first needle pattern is formed in the first concave pattern. Meanwhile, a second mold having a second concave pattern corresponding to the first concave pattern and having a horizontal area that becomes smaller as it goes down is prepared, and then a second needle pattern is formed in the second concave pattern. Then, the first needle pattern is released from the first concave pattern, and the deformed first needle pattern is engaged with the second needle pattern.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a micro-

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method of manufacturing a micro needle, and more particularly, to a method of manufacturing a micro needle having a three-dimensional structure.

In order to seal the damage of the human body, a sealing patch of the type which uses a sealing needle or an organic adhesive is developed and used.

When organic adhesives are used, the adhesion is excellent but the discussion about chemical stability is continuing. Therefore, in order to replace organic adhesives, researches on needles for suturing are underway.

Particularly, a needle having a three-dimensional shape, for example, a horn shape, is required for stably sealing a human body.

As the suturing needle has a three-dimensional shape, the manufacturing process is complicated. For example, CNC or semiconductor MEMS process technology is used as a conventional technique in the manufacturing process of the sewing needle. However, in the case of the above-mentioned conventional techniques, a relatively long process time or complicated detailed process is required.

The present invention provides a method of manufacturing a microneedle having a three-dimensional structure that can be easily manufactured through a simplified process.

In a method of manufacturing a microneedle according to an embodiment of the present invention, a first mold having a first concave pattern having a horizontal area that becomes smaller as it goes down is prepared, and a first needle pattern is formed in the first concave pattern do. Meanwhile, a second mold having a second concave pattern corresponding to the first concave pattern and having a horizontal area that becomes smaller as it goes down is prepared, and then a second needle pattern is formed in the second concave pattern. Then, the first needle pattern is released from the first concave pattern, and the deformed first needle pattern is engaged with the second needle pattern.

In one embodiment of the present invention, in order to form the first needle pattern in the first concave pattern, after the first chemical liquid is applied on the first mold, the first chemical liquid is squeezed from the first mold Thereby selectively forming the first chemical liquid pattern in the first concave pattern. Thereafter, the first chemical liquid pattern can be cured.

Here, the first chemical liquid may include a biocompatible absorbent polymer material such as poly (glycerol sebacate acrylate) or PEG- (NH2) 6.

Further, in order to cure the first chemical liquid, a thermal curing process or an ultraviolet curing process may be performed.

In one embodiment of the present invention, to mold the first needle pattern, a first needle pattern may be dispensed onto the template from the first moles by pressing it against a template toward the first needle pattern.

In one embodiment of the present invention, each of the first and second needle patterns has a horn shape, so that the microneedles can be fabricated in a multilayered lobe shape.

According to the method of manufacturing a microneedle according to the present invention, microneedles having a three-dimensional structure such as a multi-layer horn shape can be easily manufactured through a molding process and a transfer process using a plurality of molds.

1 is a process sectional view illustrating a method of manufacturing a micro needle according to an embodiment of the present invention.
FIG. 2 is a cross-sectional view illustrating the microneedles manufactured according to the manufacturing method of FIG. 1. FIG.

Hereinafter, a method of a micro needle according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings. The present invention is capable of various modifications and various forms, and specific embodiments are illustrated in the drawings and described in detail in the text. It should be understood, however, that the invention is not intended to be limited to the particular forms disclosed, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. Like reference numerals are used for like elements in describing each drawing. In the accompanying drawings, the dimensions of the structures are enlarged to illustrate the present invention in order to clarify the present invention.

The terms first, second, etc. may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another. For example, without departing from the scope of the present invention, the first component may be referred to as a second component, and similarly, the second component may also be referred to as a first component.

The terminology used in this application is used only to describe a specific embodiment and is not intended to limit the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In this application, the terms "comprises", "having", and the like are used to specify that a feature, a number, a step, an operation, an element, a part or a combination thereof is described in the specification, But do not preclude the presence or addition of one or more other features, integers, steps, operations, components, parts, or combinations thereof.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries are to be interpreted as having a meaning consistent with the contextual meaning of the related art and are to be interpreted as either ideal or overly formal in the sense of the present application Do not.

Referring to FIGS. 1 and 2, a method of manufacturing a microneedle according to an exemplary embodiment of the present invention includes forming a first mold 110 having a first concave pattern 115 having a horizontal area that becomes smaller as it goes down, Prepare.

The first mold 110 partially utilizes the soft polymeric material of the silicone elastomer series so that the first nano pattern formed in the first concave pattern 115 can be easily released from the first mold 110, .

The first concave pattern 115 may be formed on the upper surface of the first mold 110 through a photolithography process or a nano imprinting process.

According to the photolithography process, an etching mask is formed on the first mold 110, and the first concave pattern 115 is formed through an etching process using the etching mask. Further, a hard mask film (not shown) may be additionally formed on the first mold 110 before forming the etch mask.

According to the nanoimprinting process, a depression is formed on the flexible base by pressing the stamp toward the flexible base made of a flexible material such as a polymer resin. Thereafter, the first mold 110 having the first concave pattern 115 may be formed by curing the flexible base.

The first concave pattern 115 corresponds to a concave portion having a horizontal cross-sectional area that becomes narrower from the upper portion to the lower portion. Accordingly, when the first concave pattern 110 is buried, a pattern having a smaller horizontal cross-sectional area can be formed as it goes down. That is, a pattern having a reversed conical shape can be formed.

Thereafter, the first needle pattern 130 is formed in the first concave pattern 115. Thus, a first needle pawl 130 turn having an inverted horn shape can be formed.

In one embodiment of the present invention, the first chemical liquid 10 is applied on the first mold 110.

Here, the first chemical solution 10 is made of a biocompatible material. For example, the first drug solution 10 may include a biocompatible absorbent polymer material such as poly (glycerol sebacate acrylate) or PEG- (NH2) 6. Alternatively, the first drug solution 10 may be selected from the group consisting of glucose, lactose, fructose, galactose, mannose, maltose, lactulose, maltose, sucrose, trehalose, raffinose, melitose, melibiose, xylobiose, Cellobiose, stachyose, sorbitol, mannitol, erythritol, xylitol, lacitol, maltitol; Aldonic acid and its lactone derivatives such as gluconic acid and gluconic acid gamma -lactone, aldaric acid such as ribaraic acid, arabinaric acid and galactaric acid, ) And lactone derivatives thereof; Uronic acid such as glucuronic acid, galaccuronic acid and mannuronic acid; Starch, vegetable gums, substituted cellulose (e.g., carboxymethylcellulose, hydroxyethylcellulose and alkylcellulose), crystalline cellulose, heparin, hyaluronic acid, chitosan, dextran, alginate, tragacantha, agar and carrageenan do.

Thereafter, the first chemical solution 10 is squeezed from the first mold 110 to form a first chemical solution pattern selectively in the first concave pattern 115. At this time, the remaining first chemical liquid 10 on the upper surface of the first mold 110 except for the first concave pattern 115 can be removed.

Thereafter, the first chemical liquid pattern can be cured. The first chemical liquid pattern may be cured through a thermal curing process or an ultraviolet curing process.

Furthermore, in order to cure the first chemical liquid pattern, a natural hardening, dry hardening or blow hardening method may be performed.

A second mold 120 having a second concave pattern 125 corresponding to the first concave pattern 115 and having a horizontal area that becomes smaller as it goes down is prepared.

The second mold 120 may be prepared through a process substantially similar to the first mold 110. However, the second concave pattern 125 is formed at a position corresponding to the first concave pattern 115 formed on the first mold 110.

Also, the second concave pattern 125 may have a horizontal cross-sectional area that is substantially smaller than the first concave trough 125 turn. When the second needle pattern 140 formed in the second concave pattern 125 is coupled to the first needle pattern 130 to produce the microneedles, the microneedles may have a stable structure as a whole.

Next, a second needle pattern 140 is formed in the second concave pattern 125. At this time, the second needle pattern 140 may be formed through substantially the same process as the first needle pattern 130.

Next, the first needle pattern 130 is released from the first concave pattern 115, and the deformed first needle pattern 130 is coupled to the second needle pattern 140.

In one embodiment of the present invention, in order to release the first needle pattern 130, the first needle pattern 130 is pressed toward the template 30, The first needle pattern 130 can be released on the first needle pattern 30.

The template 30 may have a plate shape. The surface of the template 30 may be coated with an adhesive. Thus, the first needle pattern 130 can be firmly attached to the template 30.

Further, before the first needle pattern 130 is cured, the template 30 is pressed toward the first mold 110 so that the first needle pattern 130 is separated from the first mold 110 The template 30 can easily be released and easily attached to the template 30.

The first needle pattern 130 is aligned to face the second needle pattern 140 to engage the deformed first needle pattern 130 with the second needle pattern 140. Then, the first and second needle patterns 130 and 140 may be coupled to each other through a thermocompression bonding process. In this case, in the thermocompression bonding process, the first and second needle patterns 130 and 140 may be coupled to each other through heating and pressing of the first and second needle patterns 130 and 140 have.

Alternatively, the first and second needle patterns 130 and 140 may be coupled to each other through a laser bonding process for applying a laser to the contact portions.

In one embodiment of the present invention, each of the first and second needle patterns 130 and 140 may have a horn shape so that the microneedles can be fabricated in the shape of a lobe of a multilayer. Thus, the damaged area of the human body can be easily sealed using the micro needle. Also, since the micro needle 100 is composed of the first needle pattern 130 and the second needle pattern 140, which are made of a bio-bonding material, it is possible to suppress the generation of a harmful effect on the human body.

As described above, according to the method of manufacturing a microneedle according to the present invention, it is possible to easily manufacture a microneedle having a three-dimensional structure such as a multi-layer horn shape through a molding process and a transfer process using a plurality of molds. By adjusting the shape and size of the micro needle having the three-dimensional structure, it can be applied to various applications.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the present invention as defined by the following claims. It can be understood that it is possible.

Claims

Preparing a first mold having a first concave pattern having a horizontal area that becomes smaller as it goes down;
Forming a first needle pattern in the first concave pattern;
Preparing a second mold having a second concave pattern corresponding to the first concave pattern and having a horizontal area that becomes smaller as it goes down;
Forming a second needle pattern in the second concave pattern; And
Releasing the first needle pattern from the first concave pattern and bonding the deformed first needle pattern to the second needle pattern in a cured state,
Wherein forming the first needle pattern in the first concave pattern comprises:
Applying a first chemical liquid on the first mold;
Selectively etching the first chemical liquid from the first mold to form a first chemical liquid pattern in the first concave pattern; and
And curing the first chemical liquid pattern,
Wherein the first and second needle patterns are coupled through a laser bonding process.

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The method of claim 1, wherein the first drug solution comprises poly (glycerol sebacate acrylate) or PEG- (NH2) 6.

The method of manufacturing a micro needle according to claim 1, wherein the step of curing the first chemical liquid comprises performing a thermal curing process or an ultraviolet curing process.

2. The method of claim 1 wherein the step of releasing the first needle pattern comprises pressing a template against the first needle pattern to release a first needle pattern on the template from the first moles Characterized in that the micro needle is manufactured by a method comprising the steps of:

The method according to claim 1, wherein each of the first and second needle patterns has a horn shape and is fabricated in a multilayered lobe shape.

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