KR101537055B1 - Multi channel absorbrance analysis system - Google Patents

Multi channel absorbrance analysis system Download PDF

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Publication number
KR101537055B1
KR101537055B1 KR1020140149728A KR20140149728A KR101537055B1 KR 101537055 B1 KR101537055 B1 KR 101537055B1 KR 1020140149728 A KR1020140149728 A KR 1020140149728A KR 20140149728 A KR20140149728 A KR 20140149728A KR 101537055 B1 KR101537055 B1 KR 101537055B1
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light
optical fiber
light beam
fiber mounting
optical
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KR1020140149728A
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Korean (ko)
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안상균
박기민
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주식회사 로탬
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59—Transmissivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

The present invention relates to a multi-channel absorbance analysis system. The multi-channel absorbance analysis system branches a light beam into each channel of a specimen cartridge to illuminate the channels, and then gathers light beams condensed by a condensing lens on an output side in a single bundle to measure the absorbance of each channel. Therefore, numerous specimens can be analyzed in a short period of time.

Description

[0001] MULTI CHANNEL ABSORBRANCE ANALYSIS SYSTEM [0002]

The present invention relates to a multichannel absorbance analyzing system using a biomaterial to be measured and a light transmitting biosensor responsive thereto, and more particularly, to a multichannel absorbance analyzing system using a biomaterial to be measured, And then collecting the light beams condensed by the output side condenser lens into one bundle and simultaneously measuring the absorbance of the sample for each channel, so that a large amount of sample can be analyzed in a short time.

In recent years, the development of new diagnostic methods and diagnostic instruments, which are performed by qualitative or quantitative measurement of trace amounts of substances contained in biological samples such as blood or urine, has been rapidly progressing for 30 years and is still developing at a rapid pace.

Enzyme immunoassay (ELISA) has been developed and developed in the 70s and 80s since the first introduction of Radioimmunoassay (RIA) using radioactive isotopes in the 1950s.

Enzyme immunoassay is one of the most widely used methods and has become an indispensable tool in the study of medicine and life sciences. In recent years, a modified ELISA assay has been developed. One of these methods is to immobilize a large number of antibodies in a 96-well and to analyze a large number of samples at once.

In a typical immunoassay, including RIA or ELISA, one type of analyte per sample can usually be quantified using a complex multistage process using expensive analytical instruments available only in the laboratory. Therefore, it is not easy to use in small hospitals, emergency rooms, homes, etc. where these facilities or facilities are not equipped. The diagnostic products designed to complement these weak points are simple diagnostic kits using immunochromatographic methods. Using such a diagnostic kit, quantitative and / or qualitative analysis of specific components contained in biological samples such as whole blood, serum, and urine can be performed quickly.

However, the immunochromatographic method is based on a specific reaction between two substances, for example, an antigen-antibody reaction. In order to compensate and / or supplement this test, or to obtain additional information, a biological The concentration of other substances such as hemoglobin contained in the sample had to be measured separately using a separate absorbance measurement apparatus / apparatus.

Conventional absorbance measuring apparatuses use a single channel cartridge and analyze the sample by measuring light passing through the sample by introducing light of a specific wavelength into the sample, which is disadvantageous in that it is not suitable for analysis of large capacity.

Further, even when a conventional multi-channel cartridge is used, there is a disadvantage in that the entire configuration and arrangement are complicated and it is difficult to analyze the sample accurately.

Korean Patent Registration No. 1149357

In order to solve the above-described problems, the present invention is able to measure the absorbance of a sample for each channel by collecting light beams condensed by the output-side condensing lens in one bundle after branching and irradiating the light beam for each channel of the sample cartridge, Channel absorbance analysis system capable of precisely analyzing a large amount of sample.

In order to achieve the above object, the present invention provides an absorbance analyzing system for analyzing the absorbance of a sample by irradiating a light beam onto a sample cartridge having a plurality of channels containing a sample, wherein the light beam responsive to the sample of the sample cartridge is provided ; An input side condenser lens for condensing the light beam of the light source unit; An optical filter for filtering the light beam condensed by the input side condenser lens; A light pipe for uniformizing a light beam passed through the optical filter; An input side optical module for branching and guiding the light beam provided by the light pipe to each channel of the sample cartridge; An input-side cylinder lens for collecting the light beams diffused through the input-side optical module and irradiating the light beams onto the respective channels of the sample cartridge; A plurality of output side condenser lenses for condensing a light beam passing through each channel of the sample cartridge; An output-side optical module for collecting the light beams condensed by the plurality of output-side condensing lenses into one bundle; And a light quantity variation measuring unit for receiving a light beam passed through the output side optical module and measuring a light quantity change (absorbance).

A light source control unit for controlling the intensity of the light source is connected to the light source unit, a processing unit is provided between the light source control unit and the light amount change measurement unit, and an optical attenuator is installed at a position adjacent to the sample cartridge, .

Wherein the optical attenuator outputs the light beam irradiated through the input side cylinder lens to the center of the output side optical module so as to receive the light beam directly from the light quantity variation measuring unit without passing through the sample cartridge, The processing unit controls the light source control unit so that the light beam intensity of the light source unit is maintained in a constant state in a fine real time manner .

The optical attenuator may be provided with a light attenuation filter for attenuating or attenuating the light beam in a state similar to the amount of light passing through the sample cartridge so that the light beam is not so saturated as to be too bright, have.

Wherein the input side optical module includes: a first optical fiber mounting portion disposed adjacent to the light pipe; And a second optical fiber mounting part formed in a shape diffused from the first optical fiber mounting part and provided adjacent to the input side cylinder lens.

Wherein the input side optical module includes: a first optical fiber mounting portion provided adjacent to the light pipe; A second optical fiber mounting portion formed in a shape diffused from the first optical fiber mounting portion and disposed adjacent to the input side cylinder lens; And an optical fiber cable connecting the first optical fiber mounting portion and the second optical fiber mounting portion.

Wherein the output-side optical module includes: a first optical fiber mounting portion divided for each channel; And a second fiber optic mount that assembles into one bundle.

Wherein the light beam passing through the optical attenuator is input to the side of the first optical fiber mounting portion of the output side optical module and then outputted to the center of the second optical fiber mounting portion of the output side optical module, And output in a circular arrangement on the second optical fiber mount of the optical module.

The second optical fiber mounting part may be formed in a circular shape so that light beams entering the lens of the light quantity variation measuring unit are introduced under the same condition for each channel.

The light amount variation measurement unit may be an image sensor.

As described above, according to the present invention, a multi-channel cartridge is used, in which a light beam is divided into individual channels of a sample cartridge, and the light beams condensed by the output-side condensing lens are collected into a bundle, Since the absorbance can be measured, it is possible to precisely analyze a large amount of samples in a short time, and it is possible to secure the reliability of the product by improving the analytical precision while simplifying the entire configuration and arrangement.

1 is a perspective view of a multi-channel cartridge according to the present invention;
2 is a plan view for explaining a configuration of a multi-channel absorbance analyzing system according to a first embodiment of the present invention;
3 is a side view for explaining a configuration of a multi-channel absorbance analyzing system according to the first embodiment of the present invention
4 and 5 are perspective views showing an output side optical module in the multi-channel absorbance analyzing system according to the first embodiment of the present invention.
6 is a side view for explaining a configuration of a multi-channel absorbance analyzing system according to a second embodiment of the present invention
7 is a perspective view showing the input side optical module in the multi-channel absorbance analyzing system according to the second embodiment of the present invention.
8 is a perspective view showing the appearance of the multi-channel absorbance analyzing system of the present invention
9 is a perspective view showing the internal structure of the multi-channel absorbance analyzing system according to the third embodiment of the present invention.
10 is a bottom view of Fig. 9

Hereinafter, a multi-channel absorbance analysis system according to a preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings.

FIG. 1 is a perspective view showing a multi-channel cartridge according to the present invention. FIG. 2 is a plan view for explaining a configuration of a multi-channel absorbance analyzing system according to a first embodiment of the present invention. FIGS. 4 and 5 are perspective views showing an output-side optical module in the multi-channel absorbance analyzing system according to the first embodiment of the present invention.

Referring to the drawings, the present invention is a absorbance analysis system for analyzing the absorbance of each sample by irradiating a light beam to each channel in the state where each sample is contained in the multi-channel of the sample cartridge 10.

A sample refers to a substance containing an analyte and is a liquid or liquid-like fluid material such as various solid tissues / cells, blood, serum, plasma, saliva, urine, sweat, hair, epilepsy or intracellular fluids, Materials extracted therefrom, and the like, or materials collected from the surrounding environment (e.g., air, soil, water, etc.). Examples include, but are not limited to, blood, urine, saliva, etc., and the blood may be whole blood, plasma, serum or blood, plasma, serum, or the like for which predetermined treatment .

The multi-channel absorbance analyzing system according to the first embodiment of the present invention can be constituted by an input side constituent section and an output side constituent section with reference to the sample cartridge 10.

The input side constituent unit includes a light source unit 110 for providing a light beam responsive to the sample of the sample cartridge 10, an input side condenser lens 120, an optical filter 130, a light pipe 140, Side optical module 150, and an input-side cylinder lens 160. As shown in Fig.

The optical filter 130 allows only a light beam of a wavelength sensitive to the measurement object and the sensor to pass therethrough, and the light pipe 140 serves to uniformize the light beam.

The light source unit 110 is connected to a light source control unit C for controlling the intensity of the light source and the light amount change.

A light source control unit C is required to irradiate an appropriate light source intensity and a uniform light beam according to the sample.

The light source control unit C may be connected to a processing unit P to be described later to control the light source intensity according to a signal of the processing unit P. [

A processing unit P is provided between the light source control unit C and the light amount variation measurement unit 190. The processing unit P is disposed between the sample cartridge 10 and the sample cartridge 10, An optical attenuator 20 is provided.

The optical attenuator 20 outputs the light beam irradiated through the input-side cylinder lens 160 to the center of the output-side optical module 180 so as to receive the light beam directly from the light quantity variation measuring unit without passing through the sample cartridge, The light amount change measuring unit 190 is configured to directly measure a change in the light beam irradiated from the light source unit 110. [

When the light amount change measuring unit 190 detects a light amount change due to heat generation and cooling of the light source unit 110 through a light beam passed through the optical attenuator 20 during the absorbance analysis, The light source controller 110 controls the light source control unit C so that the light beam intensity of the light source unit 110 is maintained in a constant state. Thus, the light source control can be checked independently of the sample measurement and analysis, and the light source can be precisely controlled.

The optical attenuator 20 removes or removes the optical attenuation filter 21 for attenuating the optical beam by maintaining a state similar to the amount of light passing through the sample cartridge so that the optical attenuator 20 is not too bright, saturated, or excessively low And is replaceable.

The input side condenser lens 120 condenses the light beam of the light source unit 110 and the optical filter 130 filters the light beam condensed by the input side condenser lens 120.

The input-side optical module 150 demultiplexes the light beam provided by the light pipe 140 to each channel of the sample cartridge 10 and guides it.

The input side optical module 150 includes a first optical fiber mounting portion 151 disposed adjacent to the light pipe 140 and a second optical fiber mounting portion 151 formed in a shape diffusing from the first optical fiber mounting portion 151, And a second optical fiber mounting portion 152 provided adjacent to the lens 160.

The input-side cylinder lens 160 collects the light beams diffused through the input-side optical module 150 and irradiates the light beams to the respective channels of the sample cartridge 10.

The output-side constituent section includes an output-side condenser lens 170, an output-side optical module 180, and a light quantity variation measurement unit (absorbance measurement unit) 190.

The output-side condenser lens 170 condenses a light beam that has passed through each channel of the sample cartridge 10.

The output-side optical module 180 serves to collect the light beams condensed by the plurality of output-side condenser lenses 170 in a light quantity change measuring unit 190 described later. To this end, a plurality of optical fibers, for example, eight optical fibers are circularly arranged in a circular bundle in the output-side optical module 180, and a light beam passing through the optical attenuator 20 is output .

The light amount change measuring unit 190 receives the light beam passed through the output side optical module 180 and measures a light amount change (absorbance). The light amount change measuring unit 190 may use an image sensor such as a CMOS or a CCD.

The absorbance of each sample is analyzed for each channel of the sample cartridge 10 from the light amount change measuring unit 190.

The processing unit P may display the analysis result through the monitor M so that the driver can visually confirm the analysis result.

The operation of the multi-channel absorbance analyzing system according to the first embodiment of the present invention will now be described.

A light beam irradiated on the light source unit 110 is condensed by the input side condenser lens 120 and the optical filter 130 is condensed by the condenser lens 120, Collects the light beam condensed by the input-side condenser lens 120. The light pipe 140 uniformizes the light beam passed through the optical filter 130 and the input side optical module 150 transmits the light beam provided by the light pipe 140 to each channel .

The light beams incident on the input side optical module 150 pass through the first optical fiber mounting part 151 and are branched into the second optical fiber mounting part 152 and guided for each channel.

The input-side cylinder lens 160 collects the light beams diffused through the input-side optical module 150 and irradiates each channel of the sample cartridge 10.

The light beams passing through the respective channels are condensed by the output-side condenser lens 170, and are then incident into the output-side optical module 180.

The output-side optical module 180 is composed of a first optical fiber mounting portion 181 branched for each channel and a second optical fiber mounting portion 182 for collecting in one bundle.

The output-side optical module 180 collects the light beams collected by the plurality of output-side collecting lenses 170 in one bundle, and irradiates the eight bundles of optical fibers into one circular bundle (circular rod). The light beams passing through the respective channels are outputted in a circular arrangement on the second optical fiber mounting portion 182 of the output side optical module 180.

The reason why the light beams passing through each of the channels are output in a circular arrangement is that the light beam entering the lens of the light quantity variation measuring unit 190 has a circular shape because the lens shape of the light quantity variation measuring unit 190 is circular So that they can be introduced under the same conditions for each channel.

The light amount change measuring unit 180 receives a light beam passed through the output side optical module 180, and measures a light amount change.

A processing unit P is installed between the light quantity variation measuring unit 180 and the light source control unit C and the processing unit P is provided for each channel of the sample cartridge 10 from the light quantity variation measuring unit 180 Analyze the absorbance of each sample.

FIG. 6 is a side view for explaining a configuration of a multi-channel absorbance analyzing system according to a second embodiment of the present invention. FIG. FIG. Since the remaining components except for the input side optical module 250 are the same as those of the first embodiment described above, the same reference numerals are assigned to the same components, and a description thereof will be omitted.

6 and 7, a multi-channel absorbance analysis system according to a second embodiment of the present invention will be described in detail.

The multichannel absorbance analyzing system according to the second embodiment of the present invention includes a light source unit 110 for providing a light beam responsive to a sample of a sample cartridge and an input side condenser lens 120 for condensing a light beam of the light source unit 110 An optical filter 130 for filtering the light beam condensed by the input side condenser lens 120, a light pipe 140 for uniformizing the light beam passed through the optical filter 130, An input side optical module 250 for branching and guiding the light beams provided from the input side optical module 140 to the respective channels of the sample cartridge 10 and a light source unit 250 for collecting the light beams diffused through the input side optical module 250, An output side optical module 180 for collecting the light beams condensed by the plurality of output side condenser lenses 170 into one bundle, (180) and receives the light It comprises a light quantity change measurement unit 190 to measure the change.

The input side optical module 250 includes a first optical fiber mounting portion 251 disposed adjacent to the light pipe 140 and a second optical fiber mounting portion 251 formed in a shape diffusing from the first optical fiber mounting portion 251, A second optical fiber mounting portion 252 provided adjacent to the first optical fiber mounting portion 260 and an optical fiber cable 253 connecting the first optical fiber mounting portion 251 and the second optical fiber mounting portion 252.

In the multichannel absorbance analyzing system according to the second embodiment of the present invention, the first optical fiber attaching portion 251 and the second optical fiber attaching portion 252 are positioned in the same direction so that the length of the analyzing system can be shortened and compact There is an advantage.

FIG. 8 is a perspective view showing the appearance of a multi-channel absorbance analyzing system of the present invention, FIG. 9 is a perspective view showing the internal structure of a multi-channel absorbance analyzing system according to a third embodiment of the present invention, and FIG. 10 is a bottom view of FIG. .

8 to 10, the multi-channel absorbance analyzing system according to the third embodiment of the present invention includes a light source unit (not shown) for providing a light beam responsive to a sample of the sample cartridge 10, An input side condenser lens 320 for condensing the light beam of the light source unit; an optical filter 330 for filtering the light beam condensed by the input side condenser lens 320; An input side optical module 350 for branching and guiding a light beam provided by the light pipe 340 to each channel of the sample cartridge 10 and a light pipe 340 for guiding the light beam provided from the light pipe 340 to the input side optical module 350, An input side cylinder lens 360 for collecting the light beams diffused through the plurality of output side converging lenses 370 and irradiating each channel of the sample cartridge 10, An optical module 380, It includes a learning module 380 for receiving the light beam via the light amount change measured for measuring a light amount change unit 390. Since the light source unit is the same as that of the first embodiment described above, it is omitted from the drawings.

A mounting plate 1 is installed inside the main body of the multi-channel absorbance analysis system, and the above-mentioned components 320-390 are mounted on the mounting plate 1. [

The multichannel absorbance analyzing system according to the third embodiment of the present invention is characterized in that a plurality of through holes 2 are formed in a mounting plate 1 and an input side optical module 350 is inserted into the through holes 2 The light pipe 340 is disposed on the lower surface of the mounting plate 1 and the output side optical module 380 is mounted on the upper surface of the mounting plate 1 positioned directly above the light pipe 340. [ And a light beam direction changing unit 5 is provided between the output side optical module 380 and the light amount variation measuring unit 390 so that the light amount change measuring unit 390 is appropriately arranged, Can be configured to be shorter and more compact.

Although not shown in the figure, an annular member having a metal film is provided on the inner peripheral surface of the through hole 2, a locking protrusion having a locking groove is formed on the outer peripheral surface of the input side optical module 350, The locking projection may be formed so that the input side optical module 350 is pushed into the through hole 2 without any separate fastening means so that the input side optical module 350 is assembled (fastened).

The metal film also serves to prevent wear of the through hole 2 and can be replaced with another one having a different thickness, so that the input side optical module can be firmly assembled after the assembly even if an assembly tolerance occurs.

As described above, according to the present invention, a multi-channel cartridge is used in which a light beam is divided into individual channels of a sample cartridge and irradiated. Then, the light beams collected by the output-side collecting lens are collected into one bundle, It is possible to precisely analyze a large amount of samples in a short time, and it is possible to secure the reliability of the product by improving the accuracy of analysis while simplifying the entire configuration and arrangement.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, Various modifications and variations are possible within an even range.

10: Sample cartridge
20: optical attenuator
21: Light attenuation filter
110: Light source unit
120: input side condensing lens
130: Optical filter
140: light pipe
150: input side optical module
151: first optical fiber mounting portion
152: second optical fiber mounting portion
160: input side cylinder lens
170: output side condensing lens
180: Output side optical module
181: first optical fiber mounting portion
182: second optical fiber mounting portion
190: Light quantity variation measuring unit
250: Input side optical module
251: a first optical fiber mounting portion
252: second optical fiber mounting portion
253: Fiber optic cable
C: Light source control unit
P:

Claims (11)

A light absorbance analyzing system for analyzing the absorbance of a sample by irradiating a light beam onto a sample cartridge having a plurality of channels containing a sample,
A light source unit for providing a light beam responsive to the sample of the sample cartridge;
An input side condenser lens for condensing the light beam of the light source unit;
An optical filter for filtering the light beam condensed by the input side condenser lens;
A light pipe for uniformizing a light beam passed through the optical filter;
An input side optical module for branching and guiding the light beam provided by the light pipe to each channel of the sample cartridge;
An input-side cylinder lens for collecting the light beams diffused through the input-side optical module and irradiating the light beams onto the respective channels of the sample cartridge;
A plurality of output side condenser lenses for condensing a light beam passing through each channel of the sample cartridge;
An output-side optical module for collecting the light beams condensed by the plurality of output-side condensing lenses into one bundle; And
And a light amount variation measurement unit that receives a light beam passed through the output side optical module and measures a light amount change,
A light source control unit for controlling the intensity of the light source is connected to the light source unit, a processing unit is provided between the light source control unit and the light amount change measurement unit, and an optical attenuator is installed at a position adjacent to the sample cartridge, And,
Wherein the output-side optical module includes: a first optical fiber mounting portion divided for each channel; And a second optical fiber mounting part for gathering in one bundle,
Wherein the light beam passing through the optical attenuator is input to the side of the first optical fiber mounting portion of the output side optical module and then outputted to the center of the second optical fiber mounting portion of the output side optical module, Channel optical absorbance analyzing system according to any one of claims 1 to 3, wherein the optical fiber module is output in a circular arrangement on a second optical fiber mounting portion of the optical module. delete The method according to claim 1,
Wherein the light attenuator outputs the light beam irradiated through the input side cylinder lens to the center of the output side optical module so that the light beam irradiated through the input side cylinder lens is directly received by the light amount variation measurement unit, Wherein the processing unit controls the light source control unit to adjust the light beam intensity of the light source unit in real time so as to maintain the light source under the same condition, when the change of the light beam of the light source unit is detected, . The method of claim 3,
Wherein the optical attenuator comprises a light attenuation filter for attenuating a light beam, the optical attenuator being detachable. The method according to claim 1,
The input side optical module
A first optical fiber mounting part installed adjacent to the light pipe; And
And a second optical fiber mounting part formed in a shape diffused from the first optical fiber mounting part and installed adjacent to the input side cylinder lens. The method according to claim 1,
The input side optical module
A first optical fiber mounting portion provided adjacent to the light pipe;
A second optical fiber mounting portion formed in a shape diffused from the first optical fiber mounting portion and disposed adjacent to the input side cylinder lens; And
And an optical fiber cable connecting the first optical fiber mounting part and the second optical fiber mounting part. delete delete The method according to claim 1,
Wherein the second optical fiber mounting part is formed in a circular shape so that light beams entering the lens of the light quantity variation measuring unit are introduced into the same channel under the same condition. The method according to claim 1,
Wherein the light amount change measuring unit is an image sensor. delete
KR1020140149728A 2014-10-31 2014-10-31 Multi channel absorbrance analysis system KR101537055B1 (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180001945A (en) * 2016-06-28 2018-01-05 한국과학기술연구원 Apparatus and method for measuring water pollution based on multi-wavelength light source
KR101845315B1 (en) * 2017-10-23 2018-04-04 주식회사 로탬 Portable diagnosis device
CN113358650A (en) * 2021-06-01 2021-09-07 浙江大学 96-hole microporous plate reader
KR102331711B1 (en) * 2020-08-21 2021-12-01 동아대학교 산학협력단 Multi channel flourmeter for point-of-care system based on Microfluidic chip fluorescence detection

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55125436A (en) * 1979-03-22 1980-09-27 Toshiba Corp Multi-item chemical analyzer
JP2003523510A (en) * 2000-02-15 2003-08-05 ベアリアン・オーストラリア・プロプライエタリー・リミテッド Method and apparatus for spectroscopic analysis
JP2009210323A (en) * 2008-03-03 2009-09-17 Nippon Sheet Glass Co Ltd Multichannel thermal lens spectrometry system and multichannel thermal lens spectrometry method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55125436A (en) * 1979-03-22 1980-09-27 Toshiba Corp Multi-item chemical analyzer
JP2003523510A (en) * 2000-02-15 2003-08-05 ベアリアン・オーストラリア・プロプライエタリー・リミテッド Method and apparatus for spectroscopic analysis
JP2009210323A (en) * 2008-03-03 2009-09-17 Nippon Sheet Glass Co Ltd Multichannel thermal lens spectrometry system and multichannel thermal lens spectrometry method

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180001945A (en) * 2016-06-28 2018-01-05 한국과학기술연구원 Apparatus and method for measuring water pollution based on multi-wavelength light source
KR101866922B1 (en) * 2016-06-28 2018-06-15 한국과학기술연구원 Apparatus and method for measuring water pollution based on multi-wavelength light source
KR101845315B1 (en) * 2017-10-23 2018-04-04 주식회사 로탬 Portable diagnosis device
KR102331711B1 (en) * 2020-08-21 2021-12-01 동아대학교 산학협력단 Multi channel flourmeter for point-of-care system based on Microfluidic chip fluorescence detection
CN113358650A (en) * 2021-06-01 2021-09-07 浙江大学 96-hole microporous plate reader
CN113358650B (en) * 2021-06-01 2024-04-16 浙江大学 96 hole micropore board reader

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