KR101230423B1 - System for signal detection of specimen using magnetic resistance sensor and Detecting Method of the same - Google Patents
System for signal detection of specimen using magnetic resistance sensor and Detecting Method of the same Download PDFInfo
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Abstract
The present invention applies a magnetoresistance (MR) sensor for sensing the magnetic component of the sample to which the magnetic particles are coupled and an external magnetic field in the first direction and the second direction of the magnetoresistance sensor, and the entrance and exit space of the sample fixing unit is formed therein. Comprising an external magnetic field applying device, the second direction external magnetic field applying device provides a detection system using a magnetoresistive sensor having a device capable of varying the direction of the applied magnetic field and a detection method using the same.
According to the present invention, while providing a signal detection system of the specimen using a magnetoresistive sensor, by applying the direction of the magnetic field applied to the magnetoresistive sensor in the Y-axis direction and Z-axis direction of the magnetoresistance sensor to maximize the sensitivity performance of the sensor In particular, by scanning the Z-axis (vertical magnetic field) while the sample (sample) is stopped, the information of the sample can be read, and the magnetic field scan replaces the sample scan using the existing motor. When scanning a sample using a conventional motor, there is an effect of minimizing noise of a signal due to noise and vibration generated.
Description
The present invention relates to a high sensitivity inspection system and method for quantitatively measuring magnetic particles using a magnetoresistive sensor.
In general, a magnetic sensor cartridge (magnetic sensor) is a sensor cartridge for measuring the size and direction of the magnetic field or the line of magnetic force, the magnetic field is measured by changing the properties of various materials due to the influence of the magnetic field. Hall elements or magnetoresistive (MR) elements are made using the Hall effect, magnetoresistance effect, etc., and they are also used to manufacture VTRs (Video Tape Recorders) and tape recorders. The substance affected by the magnetic field is basically to apply a magnetic field to the detection object coupled to the magnetic particles to detect the change in the magnetic field.
The above-described magnetic particles are manufactured from magnetite, and have been studied and used for a long time in the field of biochemistry, because they are very promising as tags for detecting the presence of bound objects by coating the surface of the particles with a biomaterial of interest. come. However, since magnetic signals from very small volumes of magnetic particles are extremely small, the manufacture of magnetic detectors remains a difficult challenge and is being studied in various ways.
Apparatus and method related to this are based on Superconducting Quantum Interference Devices (hereinafter referred to as “SQUID”), but due to the general complexity and cryogenic elements of SQUID, This method is not suitable. More traditional methods include some form of force magnetometer, but there are limitations to quantitative or high sensitivity measurements. Thereafter, as a method for quantitatively measuring local accumulation of magnetic particles, a method using a hall sensor or a giant magneto-resistance (hereinafter referred to as “GMR”) sensor has been proposed. However, there are many limitations to the practical use in terms of inaccuracy of sensitivity and construction of measurement equipment.
The present invention has been made in order to solve the above problems, an object of the present invention is to provide a signal detection system of a specimen using a magnetoresistive sensor, the direction of the magnetic field applied to the magnetoresistive sensor in the Y-axis direction of the magnetoresistive sensor The sensor's sensitivity performance can be maximized by applying it in the direction of Z and Z. In particular, the Z-axis (vertical magnetic field) can be scanned while the sample (the sample) is stopped so that the information of the sample can be read. The present invention provides a detection system and method capable of minimizing a noise of a signal due to noise and vibration generated when a sample is scanned using a conventional motor by replacing a sample scan using a conventional motor.
As a means for solving the above problems, the present invention provides a magnetoresistance (MR) sensor for detecting the magnetic component of the sample to which the magnetic particles are coupled; An external magnetic field applying device applying an external magnetic field in the first direction and the second direction of the magnetoresistive sensor and having an entrance space of the specimen fixing unit formed therein, wherein the second direction external magnetic field applying device is applied. It is possible to provide a detection system using a magnetoresistive sensor that is a device capable of varying the direction of the magnetic field.
The external magnetic field applying device may further include: a first applying unit configured to apply a magnetic field to the magnetoresistive sensor in a horizontal direction (Y axis) in a first direction; And a second application unit configured to apply a magnetic field to the magnetoresistive sensor in a vertical direction (Z axis) in a second direction.
In addition, the sample fixing unit for fixing the sample is a measuring cartridge or a membrane, and during the measurement to implement a scan by continuously varying the magnetic field of the second application unit in a state in which the measuring cartridge or membrane is fixed in the entry and exit space It is preferable to form a detection system using a magnetoresistive sensor.
In addition, the first application unit and the second application unit may be formed integrally.
In addition, the first application unit, the magnetic field generating unit is applied to any one or a plurality selected from the solenoid coil, Helmholtz coil, electromagnet yoke, permanent magnet to apply a fixed magnetic field, the second application The unit may be implemented such that the magnetic field generating unit is configured of any one or a plurality of solenoid coils, Helmholtz coils, and electromagnet yokes to apply a variable magnetic field.
In particular, the magnetoresistive sensor may use a magnetoresistive sensor that is a giant magnetoresistive sensor (GMR).
In addition, the magnetic field generated in the second application unit may be formed by a direct current (DC) current. In addition, the sample may be a biomaterial including an antigen.
In addition, the range of the magnetic field applied to the first application unit or the range in which the magnetoresistive sensor MR can react is 2 to 40 gauss, and the magnetic field applied to the second application unit is 1000 to 2000 gauss. May be applied in the range of.
In addition, the magnetic particles included in the specimen may have a magnetization value of 10 ~ 100emu / g, the magnetic particles may be implemented to have superparamagnetism or paramagnetism.
The detection can be performed by the following steps using the above-described detection system.
Specifically, in the detection method of applying a magnetic field to an external magnetic field to perform a quantitative measurement of a sample by a magnetoresistance sensor, applying an induction magnetic field to the sample in the horizontal direction (Y axis) of the sample, While applying the DC magmetic field to magnetize the magnetic particles in a state where the movement is fixed to the measurement position in the vertical direction (Z-axis) of the magnetoresistance sensor, by varying the current to form the magnetic field in the vertical direction By measuring the intensity and frequency of the magnetic field applied to the sample, the measurement can be performed by scanning the sample.
In particular, the value of the point where the hysteresis section is minimized in the characteristic curve of the magnetoresistive sensor is selected as the value in the horizontal direction, and the value of the magnetic field in the vertical direction is selected as the maximum value in the section where the characteristic of the magnetoresistive sensor does not change. Thus, the optimum point of the magnetic field of the vertical and horizontal components can be determined as the measuring point.
In addition, the range of the magnetic field in the horizontal direction (Y-axis) or the magnetic resistance sensor (MR) is 2 to 40 Gauss (Gauss), the magnetic field applied to the vertical direction (Z-axis) is 1000 ~ 2000 It can be implemented by scanning the specimen by continuously varying in the range of Gauss.
According to the present invention, while providing a signal detection system of the specimen using a magnetoresistive sensor, by applying the direction of the magnetic field applied to the magnetoresistive sensor in the Y-axis direction and Z-axis direction of the magnetoresistance sensor to maximize the sensitivity performance of the sensor In particular, by scanning the Z-axis (vertical magnetic field) while the sample (sample) is stopped, the information of the sample can be read, and the magnetic field scan replaces the sample scan using the existing motor. When scanning a sample using a conventional motor, there is an effect of minimizing noise of a signal due to noise and vibration generated.
In addition, although the spatial volume of the equipment to implement due to the conventional motor sample scan was large, the device itself can be minimized by scanning using the vertical magnetic field variable method of the present invention, when a constant magnetic field is applied through a magnet It is difficult to control the strength of the magnetic field according to each sample because the strength is determined, in the present invention has the advantage that the strength of the magnetic field can be adjusted according to the characteristics of the sample is implemented to apply a variety of applications.
Specifically, the DC magnetic field is applied to the magnetoresistive sensor to saturate magnetization of the superparamagnetic magnetic particles, and the magnetic field is applied to the Y axis to maximize the sensitivity performance of the magnetoresistive sensor.
The detection system according to the present invention mounts a specimen on a specimen holding unit and applies an external magnetic field in two directions of a magnetoresistive sensor through an external magnetic field application device, and then detects a magnetic signal for a specimen combined with a magnetic component in the magnetic sensor. Allows separation and analysis of electrical components.
In particular, two magnetic field applying units using any one of solenoid, helmholtz, electromagnet, magnet yoke, and permanent magnet may apply the external magnetic field value to maximize the magnetization value of the magnetic particles and minimize the effect on the magnetic sensor. It is effective to maximize the efficiency of detection.
In addition, the present invention is to combine the giant magneto-resistance cartridge (Giant Magneto Resistance Cartridge) of the cartridge type for the biosensor cartridge with the measurement processing unit to detect and sense the sample combined with the magnetic component to be separated and analyzed as an electrical component When applying a large magnetoresistive device manufactured by the existing semiconductor unit process as a biosensor, quantitative analysis by improving the sensitivity of the small amount of the detector by non-contacting the sensing element and the sample This can be done smoothly.
In addition, the present invention can be used as a non-contact giant magneto-resistance sensor (Giant Magneto Resistance) to perform a bio-diagnosis through sensing the sample. Therefore, the membrane used for the point of care testing (POCT) can be installed in the specimen diagnostic kit to develop a measuring instrument for effective membrane measurement.
Furthermore, the present invention can overcome the detection range limited only to the size of the sensing element, and can distinguish noise between frequencies by a dynamic scanning method, thereby enabling quantitative measurement analysis.
1 is a conceptual diagram illustrating a sensing principle of a magnetoresistive sensor used in the present invention.
2 is a block diagram of a basic detection system according to the present invention.
3A is a conceptual diagram illustrating a magnetic field tensioning method of a conventional hall sensor.
3B and 3C are conceptual views illustrating a magnetic field applying method of the magnetoresistive sensor according to the present invention.
4A and 4B are conceptual views of main parts of a detection system including an external magnetic field applying device according to the present invention.
5 is a characteristic curve of a method for finding an optimal point of a magnetic field of horizontal and vertical components according to the present invention.
Hereinafter, with reference to the accompanying drawings will be described in detail the configuration and operation according to the present invention. In the description with reference to the accompanying drawings, the same components are given the same reference numerals regardless of the reference numerals, and duplicate description thereof will be omitted. The terms first, second, etc. may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another.
According to the present invention, unlike the conventional technology of performing a scan while moving a sample or a scanner by using a motor to read information of a sample (sample) to be measured, the vertical magnetic field is scanned while the sample is stopped. By reading the information, it minimizes the noise of the signal due to the vibration and noise of the motor during the conventional scan, and it is possible to adjust the strength of the magnetic field according to the characteristics of the sample. It is the summary to offer.
1 is a conceptual diagram illustrating a sensing principle of a magnetoresistive sensor used in the present invention. However, for convenience of description, the sensing principle using a giant magneto resistance (GMR) of the magnetoresistive sensor will be described as an example.
This shows a spin-valve type Giant Magneto Resistance (GMR) device. As shown, the magnetoresistive sensor has a nonmagnetic metal layer sandwiched between two ferromagnetic metal layers. The magnetic force of the ferromagnetic metal layer of the first layer is fixed, and the magnetic force of the ferromagnetic material of the second layer is variably adjusted. When the first layer and the magnetic force are parallel, the principle that only electrons spin-oriented in a specific direction passes through the conductor. That is, according to the alignment of the magnetization directions of the two ferromagnetic layers, a difference in electrical resistance, or a potential difference, induced inside the material is generated and recognized as a digital signal. The case where an interlayer material is a conductor corresponds to a GMR device.
Referring to Figure 2 will be described the configuration of the basic detection system according to the present invention.
Detection system according to the present invention is a magnetic resistance (MR)
That is, the specimen is mounted on the
In addition, the
Therefore, the external magnetic field applying device constituting the measurement system is implemented to apply the external magnetic field in the first direction and the second direction of the
Therefore, the
In addition, the
3A to 3C, the gist according to the present invention will be described in detail with a GMR sensor as an exemplary embodiment of the present invention.
FIG. 3A illustrates a conventional Hall sensor. In the related art, a DC magnetic field is applied using a permanent magnet in the vertical direction B ext of the sensor to saturate the superparamagnetic magnetic particles. The Hall sensor was operated by exciting and deflecting an AC bias current applied in a direction I c perpendicular to the magnetic field. V H is the electromotive force generated when applying a current perpendicular to the magnetic field. In this conventional technique, since the magnetic field is applied only in the vertical direction of the sensor, there is a problem that the detection performance is inferior.
3B and 3C illustrate a conceptual diagram of a GMR sensor as one embodiment of a magnetoresistive sensor according to the present invention, which is a conceptual diagram of a magnetoresistive sensor in a detection device to which the magnetoresistive sensor is applied. In the conceptual diagram shown, the arrow is centered on a sensor composed of a stack of thin film materials, and the horizontal direction (X axis direction) of the thin film material, the horizontal direction (Y axis direction) of the thin film material, and the vertical direction (Z axis direction) of the thin film material. Indicates. Such a GMR sensor is very strong only in the magnetic field perpendicular to the sensor (Y axis) and slightly in the direction parallel to the sensor (X axis), while in the direction perpendicular to the sensor (Z axis). It is not affected at all. In addition, for the magnetic field in the Y-axis direction, it is possible to adjust the bias (biasing) within a unique linear range (linear range).
Therefore, the system design for the maximum performance of the GMR sensor is applied by applying a DC magnetic field in the Z-axis direction to saturate the superparamagnetic magnetic particles and applying the magnetic field in the Y-axis direction to improve the sensitivity performance of the sensor. It is essential to have maximum deflection control. In this case, the application of the magnetic field in the Y-axis direction is very effective in improving the signal-to-noise ratio by using an induced magnetic field generated through a DC current.
4A and 4B are principal part conceptual diagrams showing main parts of a measurement system according to the present invention.
Figure 4a (a) shows an embodiment of an external magnetic field applying apparatus according to the present invention, (b) is a conceptual diagram showing an operating state for measuring and fixing the specimen fixing unit.
That is, the illustrated external magnetic
In addition, the
FIG. 4B illustrates a conceptual diagram in which the direction of the magnetic field is modified by varying the current applied to the
As described above, in the above system, the DC magnetic field is applied in the Z-axis direction to saturate the superparamagnetic magnetic particles accumulated in the side flow membrane, and the magnetic field is applied in the Y-axis direction to sense the sensitivity of the sensor. Deflection control is performed to maximize performance. In this case, the application of the magnetic field in the Y-axis direction may apply an induced magnetic field generated through a DC current. That is, when the
In the present invention, the range of the magnetic field applied to the first application unit is 2 to 40 gauss, and the range of the magnetic field resistance sensor GMR is 2 to 300 gauss. In addition, the magnetic field applied to the second application unit is preferably applied in the range of 1000 ~ 2000 Gauss (Gauss).
Referring to FIG. 5, a method of determining a point at which the components of the horizontal magnetic field and the components of the vertical magnetic field are maximized to maximize the strength of the magnetic field and detecting the sample using the same will be described. Figure 5 shows the results of measuring the change of the magnetic field in the external magnetic field application device using an oscilloscope according to the present invention.
Considering the optimal point of the magnetic field of the horizontal and vertical components using the characteristic curve of the magnetoresistive sensor according to the present invention, it is to determine the point where the magnetic field of the horizontal vertical component maximizes the strength of the entire magnetic field. That is, if the magnetic field of the horizontal component is too strong, it is difficult to be affected by the vertical direction, and if the magnetic field of the vertical direction is too strong, the magnetic field component of the horizontal direction is lost. Therefore, the horizontal component should be adjusted to find the point where the hysterisis effect is minimized, and the vertical component should be selected to the maximum value within the range that does not affect the sensor. Of course, the horizontal magnetic field is not limited to 30 gauss, but is selected as the value of the point where the hysteresis section is minimized in the characteristic curve of the sensor. In the case of the vertical magnetic field, the characteristic of the sensor used does not change. The maximum value at is chosen.
Here, hysterisis does not coincide with the curve indicating the change in magnetic flux density when increasing the strength of magnetic field when magnetizing the iron core and the change in magnetic flux density when decreasing the strength of magnetic field. In other words, it becomes a ring-shaped curve through different paths. That is, minimizing the influence of hysteresis in the present invention means that when an AC current flows through a coil using an iron core, an amount of energy that is proportional to the hysteresis loop area of the iron core is lost, and a point for minimizing such hysteresis loss is selected. In the figure, point P represents the optimal point of the horizontal / vertical component magnetic field, the horizontal magnetic field is 2 to 40 gauss, and the vertical magnetic field is 1000 to 2000 gauss.
By using a constant horizontal magnetic field and a continuously varying vertical magnetic field in the measurement system according to the present invention, it can be applied to a stable detection system for reading information of a sample from a stationary state. That is, the sample is scanned using a motor to read the information of the existing kit, but the information of the sample is read by scanning the vertical magnetic field while the sample is stopped. The magnetic field scan replaces the sample scan (using the motor), which has the advantage of minimizing the noise of the signal due to the noise and vibration generated during the sample scan. In addition, although the spatial volume of the necessary equipment is large due to the existing sample scan, the detection system according to the present invention has the advantage that can minimize the device itself through the magnetic field scan. In addition, it is difficult to control the strength of the magnetic field according to each sample because the strength is determined when a certain magnetic field is applied through the magnet, the method of the present invention has the advantage that the strength of the magnetic field can be adjusted according to the characteristics of the sample Application is possible.
In the foregoing detailed description of the present invention, specific examples have been described. However, various modifications are possible within the scope of the present invention. The technical idea of the present invention should not be limited to the embodiments of the present invention but should be determined by the equivalents of the claims and the claims.
110: external magnetic field application device
111: first authorization unit
111a: magnetic field generating unit
111b: magnetic energy transfer unit
112: second authorization unit
112a: magnetic field generating unit
112b: magnetic energy transfer unit
120: specimen fixing unit
121: sample (sample)
130: magnetoresistive sensor
Claims (15)
And an external magnetic field applying device applying an external magnetic field in the first direction and the second direction of the magnetoresistive sensor and having an entrance and exit space of the specimen fixing unit therein.
The second direction external magnetic field applying device is a signal detection system of a specimen using a magnetoresistive sensor which is a device capable of varying the direction of the applied magnetic field.
The external magnetic field applying device,
A first application unit for applying a magnetic field to the magnetoresistive sensor in a horizontal direction (Y axis) in a first direction;
A second application unit for applying a magnetic field to the magnetoresistive sensor in a vertical direction (Z axis) in a second direction;
Signal detection system of the specimen using a magnetoresistive sensor comprising a.
The sample fixing unit for fixing the sample is a measuring cartridge or a membrane,
The signal detection system of a specimen using a magnetoresistance sensor to implement a scan by continuously varying the magnetic field of the second application unit while the measurement cartridge or membrane is fixed inside the entry and exit space during measurement.
The first detection unit and the second application unit is a signal detection system of the specimen using a magnetoresistive sensor formed integrally.
The first application unit is a signal detection system of a specimen using a magnetoresistive sensor for applying a fixed magnetic field, the magnetic field generating unit is any one or more selected from solenoid coil, Helmholtz coil, electromagnet yoke, permanent magnet .
The second application unit is a signal detection system for a specimen using a magnetoresistive sensor for applying a variable magnetic field, the magnetic field generating unit is any one or a plurality selected from solenoid coil, Helmholtz coil, electromagnet yoke.
The magnetoresistive sensor is a signal detection system of the specimen using a magnetoresistive sensor which is a giant magnetoresistive sensor (GMR).
The magnetic field generated in the second application unit is a signal detection system for a specimen using a magnetoresistive sensor formed by a direct current (DC) current.
The sample is a signal detection system of the sample using a magnetoresistive sensor that is a biomaterial containing an antigen.
The range of the magnetic field applied to the first application unit or the range where the magnetoresistive sensor MR can react is 2 to 40 gauss, and the magnetic field applied to the second application unit is 1000 to 2000 gauss. Sample signal detection system using a resistance sensor.
The magnetic particle contained in the sample signal detection system of the specimen using a magnetoresistive sensor having a magnetization value of 10 ~ 100emu / g.
The magnetic particle is a signal detection system of a specimen using a magnetoresistive sensor having a superparamagnetism or paramagnetism.
Applying an induction magnetic field to the sample in the horizontal direction (Y axis) of the magnetoresistance sensor,
A DC magmetic field for magnetizing the magnetic particles is applied in the vertical direction (Z-axis) of the magnetoresistive sensor while the sample movement is fixed at the measurement position.
And varying the current forming the magnetic field in the vertical direction to vary the strength and frequency of the magnetic field applied to the sample to scan the sample to perform measurements.
The value of the point where the hysteresis section is minimized in the characteristic curve of the magnetoresistive sensor is selected as a value in the horizontal direction,
The magnetic field value in the vertical direction detects a signal of a specimen, by selecting a maximum value in a section in which the characteristics of the magnetoresistive sensor do not change and determining the optimum point of the magnetic field of the vertical and horizontal components as a measurement point. Way.
The range of the horizontal (Y-axis) magnetic field or the range in which the magnetoresistive sensor MR can react is formed to be 2 to 40 gauss.
The magnetic field applied in the vertical direction (Z-axis) is continuously variable in the range of 1000 ~ 2000 Gauss (Gauss) to scan the sample, the method of detecting a signal of the sample.
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KR102522016B1 (en) * | 2022-03-14 | 2023-04-14 | 태광물산 주식회사 | Magnetoresistive Sensor Apparatus for Precise Detection of Door Opening and Closing |
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