KR101213303B1 - Micro-patterned device and method for compensating distortion of optical coherent tomography image using the same - Google Patents

Micro-patterned device and method for compensating distortion of optical coherent tomography image using the same Download PDF

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KR101213303B1
KR101213303B1 KR1020100113262A KR20100113262A KR101213303B1 KR 101213303 B1 KR101213303 B1 KR 101213303B1 KR 1020100113262 A KR1020100113262 A KR 1020100113262A KR 20100113262 A KR20100113262 A KR 20100113262A KR 101213303 B1 KR101213303 B1 KR 101213303B1
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South Korea
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image
micro
tool
optical coherence
coherence tomography
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KR1020100113262A
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Korean (ko)
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KR20120005362A (en
Inventor
조동일
서종모
정흠
이상민
구교인
박호수
홍석준
유형정
남현성
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서울대학교산학협력단
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Abstract

The micropatterned tool includes a body configured to be inserted into a living body; And it may include a micro pattern consisting of a plurality of identification areas formed on the surface of the body. An optical coherence tomography (OCT) image correction method includes the steps of: inserting a tool in a living body containing a micro-pattern having a predetermined size; Acquiring an optical coherence tomography image of the living body inserted into the tool; Comparing the size of the region corresponding to the micro pattern with the predetermined size in the obtained image; And correcting distortion of the image by using the result of the comparing step.

Description

MICRO-PATTERNED DEVICE AND METHOD FOR COMPENSATING DISTORTION OF OPTICAL COHERENT TOMOGRAPHY IMAGE USING THE SAME}

Embodiments relate to a micropatterned tool and a method of correcting an optical coherence tomography (OCT) image using the same.

Due to the development of science and technology, X-ray imaging, ultrasonic imaging, computerized tomography, and magnetic resonance imaging can observe the internal structure of living organisms and materials in a non-destructive and non-invasive way. Various internal transmission images and tomography image acquisition equipment, such as imaging (MRI), have been studied and used in various fields. However, such a conventional biomedical CT using various media has many problems such as harmfulness to living body and difficulty in realizing high resolution. In particular, equipment such as an X-ray camera or MRI has a problem such as requiring a professional equipment management personnel due to the high price, large volume and high risk.

Optical coherence tomography (OCT) is a next-generation tomography imaging apparatus that uses light to obtain an internal image without damaging the inside of a living tissue and material in real time. In particular, by using an interference light source with a short wavelength, a tomographic image of a finer part of a tissue can be obtained with high resolution up to a sub-micro region, and the difference between soft tissues that are difficult to analyze with other tomography apparatuses can be distinguished. Since it can be done, it has the advantage of obtaining more accurate images.

However, the optical coherence tomography system is sensitive to the focus of the light and the transmittance characteristics of the medium, so that even if the medium is composed of the same components, different images can be obtained depending on the depth of transmission. There is a limit to obtaining data. Optical coherence tomography system is basically a device that transmits light to the inside of the medium to be measured and processes the light reflected by the medium to express the image. Therefore, when the intensity of the reflected light is changed according to the transmittance of the medium and the focal length of the light, It can have many effects on tomographic images. In particular, since the optical coherence tomography system is sensitive to the attenuation of the light intensity according to the depth of transmission, a method of configuring an additional module or an image processing filter in the optical coherence tomography system ultimately corrects the distortion of the image. Comes with difficulty.

According to an aspect of the present invention, by utilizing the implantation tool having a micro pattern of a predetermined size, the ratio due to the influence of the transmittance and focal length of the medium in the image obtained through optical coherence tomography (OCT) Uniformity and distortion can be reduced, and as a result, a method of correcting an optical coherence tomography image, which can be more accurately analyzed, and a micropatterned tool used therein can be provided.

According to one embodiment, a micropatterned tool includes: a body configured to be inserted into a living body; And it may include a micro pattern consisting of a plurality of identification areas formed on the surface of the body.

According to an embodiment, a method of correcting an optical coherence tomography (OCT) image may include: inserting a tool including a micro pattern having a predetermined size into a living body; Acquiring an optical coherence tomography image of the living body inserted into the tool; Comparing the size of the region corresponding to the micro pattern with the predetermined size in the obtained image; And correcting distortion of the image by using the result of the comparing step.

According to an aspect of the present invention, in the optical coherence tomography (OCT) system, even if the medium consisting of the same components due to the focal length effect and transmittance effect overcomes the conventional problem represented by different images depending on the depth of transmission In addition, nonuniformity and distortion of the optical coherence tomography image may be alleviated. The micro-patterned tool and the optical coherence tomography image correction method according to an aspect of the present invention are widely used for the analysis of results and error checking of experimental data using application equipment in other fields as well as medical non-invasive equipment. Can be.

FIG. 1 is a photograph of an optical coherence tomography (OCT) image taken after a micro patterned tool is inserted into a living body according to an exemplary embodiment.
2 is a perspective view of a micropatterned tool according to one embodiment.
3 is a perspective view of a micropatterned tool according to another embodiment.
4 is a flowchart of a method of correcting an optical coherence tomography image, according to an exemplary embodiment.

Hereinafter, some embodiments of the present invention will be described in detail with reference to the drawings.

FIG. 1 is a photograph of an optical coherence tomography (OCT) image taken after a micro patterned tool is inserted into a living body according to an exemplary embodiment. 1 exemplarily shows a photographed result after inserting a micro patterned tool 101 into a human eye. As can be seen, the micro-patterned tool 101 can be clearly identified in the optical coherence tomography image. In addition, since the micropattern 101 is formed with a micropattern such as a fine grid or a fine shape, the insertion position and / or direction of the micropatterned tool 101 may be calculated using the micropattern 101. It will be described in detail below.

2 is a perspective view of a micropatterned tool according to one embodiment.

Referring to FIG. 2, the micro-patterned tool may include a body 210 and a micro pattern 200 formed on the body 210. The body 210 may be made of a material that is biocompatible for insertion into a living body for optical coherence tomography. In addition, the body 210 may be made of a transparent material. For example, the body 210 may be made of polymethyl methacrylate (PMMA), but is not limited thereto. The image of the object may be obtained through optical coherence tomography in a state in which the body 210 is inserted into the object to be measured.

The micro pattern 200 is a part for identifying a tool that becomes a micro pattern from the obtained optical coherence tomography image. The micro pattern 200 may be formed of one or more identification areas 201 and 202 formed on the surface of the body 210. That is, the one or more identification areas 201 and 202 may have a predetermined predetermined shape and / or size, and may be arranged regularly or irregularly to form the micro pattern 200. Using the micro-pattern 200 configured as described above, the insertion position and / or direction of the micro-patterned tool can be calculated. Each identification area 201, 202 may have a suitable size recognizable within the resolution limit of the optical coherence tomography equipment. In one embodiment, the size d 1 , d 2 of each identification area 201, 202 may be about 10 μm to about 100 μm, but is not limited thereto.

The micro pattern 200 including the plurality of identification areas 201 and 202 may be located on one or more surfaces of the body 210. For example, one group of identification areas 201 may be located on the side of the body 210, and another group of identification areas 202 may be located on the upper surface of the body 210. In addition, although not shown in the drawing, the identification area 202 may be formed on the lower surface of the body 210. By forming an identification area on a surface of one or more directions of the body 210 to form a micro pattern, an error according to an insertion direction of the body having become a micro pattern may be corrected.

The micro pattern 200 may have various shapes that can be identified in the optical coherence tomography image. For example, the identification area 201 formed on the side of the body 210 may be in the form of a protrusion having a triangular pillar shape. That is, a plurality of identification regions 201 protruding in a shape similar to a saw blade may be formed on the side of the body 210. In addition, the identification area 202 formed on the upper and / or lower surface of the body may be in the form of a depression having a rectangular cross section. That is, the plurality of identification regions 202 may be formed by being recessed in a lattice shape.

However, the shape of the micropattern shown and described herein is merely exemplary, and may use other different types of micropatterns identifiable in optical coherence tomography images.

3 is a perspective view of a micropatterned tool according to another embodiment. In the description of the embodiment illustrated in FIG. 3, descriptions that may be easily understood by those skilled in the art from the embodiment illustrated in FIG. 2 will be omitted.

Referring to FIG. 3, the micropatterned tool includes a metallic material 301 located in each identification area 202 of the micropattern 200 and a biocompatible material coated on the metallic material 301 (eg, parylene). It may further include -C (Parylene-C) (not shown). That is, after the metallic material 301 is coated on the surface of the body 210 according to the shape of the micro pattern 200, a biocompatible material may be applied. In FIG. 3, the metal material 301 and the identification region 202 are formed in the same rectangular shape. However, this is exemplary and the metallic material 301 and the identification area 202 may be formed in a triangle or other different shape.

The metallic material 301 is a material for making the micro pattern 200 appear more clearly in the optical coherence tomography image. For this purpose, the metallic material 301 is a body of the micro-patterned living body or micro-patterned tool into which the micro-patterned tool is to be inserted within the wavelength band of the near infrared ray (for example, about 0.6 to about 1.3 μm) used in optical coherence tomography. It may be made of a material having a relatively large difference in reflectance from 210. In one embodiment, the metallic material 301 may be made of a material having a reflectance difference of 90% or more relative to the cells of the living body into which the micropatterned tool is to be inserted and / or the body 210 of the tool. . For example, the metallic material 301 may be made of gold (Au), platinum (Pt), nickel (Ni), aluminum (Al), copper (Cu), iridium (Ir), iridium oxide, or other suitable metal. It is not limited to this.

4 is a flowchart of a method of correcting an optical coherence tomography image, according to an exemplary embodiment. The correction method of the optical coherence tomography image according to the embodiment is for compensating for an error in the obtained image according to the transmission depth of the light beam with respect to the measurement object. To this end, before performing the measurement on the measurement object, a non-uniformity and distortion of the image may be compensated for by using a previously prepared micropatterned tool.

First, the micro-patterned tool can be inserted into a living body to be measured (S1). The micropatterned tool is prepared before the measurement of the measurement object, and the size of the micropattern may be predetermined and known in advance. A detailed configuration of the tool having a micro pattern is the same as that described above with reference to FIGS. 1 to 3, and thus a detailed description thereof will be omitted.

Next, an optical coherence tomography image of the object may be acquired in the state where the micro-patterned tool is inserted into the measurement target body (S2).

Next, the size of the area corresponding to the micro pattern in the acquired image may be compared with the actual size of the micro pattern known in advance (S3). If there is no distortion in the image, the actual size of the micro-pattern and the size of the image will be the same.However, in optical coherence tomography, the depth of the reflected light varies depending on the transmittance of the medium and the focal length of the light. As a result, the image representation is different and distortion occurs.

In order to compensate for the distortion, the optical coherence tomography image may be corrected using the comparison result in step S3 (S4). That is, distortion of the optical coherence tomography image may be corrected by mapping a region corresponding to the micro pattern in the optical coherence tomography image to the actual shape of the micro pattern previously recognized.

In addition, the distortion of the entire area of the image may be corrected based on the micro pattern. That is, the optical angle tomography image is used to calculate the insertion angle of the tool that has been firstly micropatterned, and then the direction and / or distortion of the entire area of the image is processed by using the length information of the micropattern as a reference. Can be corrected using (image processing).

As a result, by using the correction method of the optical coherence tomography image according to the embodiment, it is possible to reduce the nonuniformity and distortion caused by the influence of the transmittance and focal length of the medium in the image obtained through optical coherence tomography When analyzing, more accurate interpretation is possible. Therefore, the method of correcting the optical coherence tomography image may be widely used for analyzing results of errors and checking errors of experimental data using medical non-invasive equipment as well as application equipment in other fields.

Although the present invention described above has been described with reference to the embodiments illustrated in the drawings, this is merely exemplary, and it will be understood by those skilled in the art that various modifications and variations may be made therefrom. However, such modifications should be considered to be within the technical protection scope of the present invention. Therefore, the true technical protection scope of the present invention will be defined by the technical spirit of the appended claims.

Claims (11)

A body configured to be inserted into the living body; And
It includes a micro pattern consisting of a plurality of identification areas formed on the surface of the body,
Wherein each identification region comprises a protrusion or depression.
The method of claim 1,
And the size of each identification area is between 10 μm and 100 μm.
delete A body configured to be inserted into the living body;
A micro pattern comprising a plurality of identification regions formed on a surface of the body;
A metallic material located on each identification area; And
A micropatterned tool comprising a biocompatible material coated on the metallic material.
5. The method of claim 4,
The metallic material is a micro-patterned tool, characterized in that the reflectance difference of more than 90% based on the reflectance of the body to be inserted into the body within the wavelength range of 0.6 ㎛ to 1.3 ㎛.
5. The method of claim 4,
The metallic material is a micro-patterned tool, characterized in that the difference in reflectance of 90% or more based on the reflectance of the body within the wavelength range of 0.6 ㎛ to 1.3 ㎛.
5. The method of claim 4,
And the metallic material comprises at least one selected from the group consisting of gold, platinum, nickel, aluminum, copper, iridium and iridium oxide.
The method of claim 1,
And said body is made of a transparent material.
The method of claim 1,
The body is a micro patterned tool, characterized in that it comprises a PMMA.
Inserting into the living body a tool comprising a micro pattern having a predetermined size;
Acquiring an optical coherence tomography image of the living body inserted into the tool;
Comparing the size of the region corresponding to the micro pattern with the predetermined size in the obtained image; And
And correcting the distortion of the image by using the result of the comparing step.
The method of claim 10,
Correcting the image,
Calculating an insertion angle of the tool with respect to the living body based on the micro pattern; And
And correcting the distortion of the entire area of the image based on the region corresponding to the micro pattern in the image.
KR1020100113262A 2010-07-08 2010-11-15 Micro-patterned device and method for compensating distortion of optical coherent tomography image using the same KR101213303B1 (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009036589A (en) 2007-07-31 2009-02-19 Omron Corp Target for calibration and device, method and program for supporting calibration
US7580504B2 (en) 2000-08-29 2009-08-25 Imaging Therapeutics, Inc. Calibration devices and methods of use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7580504B2 (en) 2000-08-29 2009-08-25 Imaging Therapeutics, Inc. Calibration devices and methods of use thereof
JP2009036589A (en) 2007-07-31 2009-02-19 Omron Corp Target for calibration and device, method and program for supporting calibration

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