KR101213303B1 - Micro-patterned device and method for compensating distortion of optical coherent tomography image using the same - Google Patents
Micro-patterned device and method for compensating distortion of optical coherent tomography image using the same Download PDFInfo
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- KR101213303B1 KR101213303B1 KR1020100113262A KR20100113262A KR101213303B1 KR 101213303 B1 KR101213303 B1 KR 101213303B1 KR 1020100113262 A KR1020100113262 A KR 1020100113262A KR 20100113262 A KR20100113262 A KR 20100113262A KR 101213303 B1 KR101213303 B1 KR 101213303B1
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Abstract
The micropatterned tool includes a body configured to be inserted into a living body; And it may include a micro pattern consisting of a plurality of identification areas formed on the surface of the body. An optical coherence tomography (OCT) image correction method includes the steps of: inserting a tool in a living body containing a micro-pattern having a predetermined size; Acquiring an optical coherence tomography image of the living body inserted into the tool; Comparing the size of the region corresponding to the micro pattern with the predetermined size in the obtained image; And correcting distortion of the image by using the result of the comparing step.
Description
Embodiments relate to a micropatterned tool and a method of correcting an optical coherence tomography (OCT) image using the same.
Due to the development of science and technology, X-ray imaging, ultrasonic imaging, computerized tomography, and magnetic resonance imaging can observe the internal structure of living organisms and materials in a non-destructive and non-invasive way. Various internal transmission images and tomography image acquisition equipment, such as imaging (MRI), have been studied and used in various fields. However, such a conventional biomedical CT using various media has many problems such as harmfulness to living body and difficulty in realizing high resolution. In particular, equipment such as an X-ray camera or MRI has a problem such as requiring a professional equipment management personnel due to the high price, large volume and high risk.
Optical coherence tomography (OCT) is a next-generation tomography imaging apparatus that uses light to obtain an internal image without damaging the inside of a living tissue and material in real time. In particular, by using an interference light source with a short wavelength, a tomographic image of a finer part of a tissue can be obtained with high resolution up to a sub-micro region, and the difference between soft tissues that are difficult to analyze with other tomography apparatuses can be distinguished. Since it can be done, it has the advantage of obtaining more accurate images.
However, the optical coherence tomography system is sensitive to the focus of the light and the transmittance characteristics of the medium, so that even if the medium is composed of the same components, different images can be obtained depending on the depth of transmission. There is a limit to obtaining data. Optical coherence tomography system is basically a device that transmits light to the inside of the medium to be measured and processes the light reflected by the medium to express the image. Therefore, when the intensity of the reflected light is changed according to the transmittance of the medium and the focal length of the light, It can have many effects on tomographic images. In particular, since the optical coherence tomography system is sensitive to the attenuation of the light intensity according to the depth of transmission, a method of configuring an additional module or an image processing filter in the optical coherence tomography system ultimately corrects the distortion of the image. Comes with difficulty.
According to an aspect of the present invention, by utilizing the implantation tool having a micro pattern of a predetermined size, the ratio due to the influence of the transmittance and focal length of the medium in the image obtained through optical coherence tomography (OCT) Uniformity and distortion can be reduced, and as a result, a method of correcting an optical coherence tomography image, which can be more accurately analyzed, and a micropatterned tool used therein can be provided.
According to one embodiment, a micropatterned tool includes: a body configured to be inserted into a living body; And it may include a micro pattern consisting of a plurality of identification areas formed on the surface of the body.
According to an embodiment, a method of correcting an optical coherence tomography (OCT) image may include: inserting a tool including a micro pattern having a predetermined size into a living body; Acquiring an optical coherence tomography image of the living body inserted into the tool; Comparing the size of the region corresponding to the micro pattern with the predetermined size in the obtained image; And correcting distortion of the image by using the result of the comparing step.
According to an aspect of the present invention, in the optical coherence tomography (OCT) system, even if the medium consisting of the same components due to the focal length effect and transmittance effect overcomes the conventional problem represented by different images depending on the depth of transmission In addition, nonuniformity and distortion of the optical coherence tomography image may be alleviated. The micro-patterned tool and the optical coherence tomography image correction method according to an aspect of the present invention are widely used for the analysis of results and error checking of experimental data using application equipment in other fields as well as medical non-invasive equipment. Can be.
FIG. 1 is a photograph of an optical coherence tomography (OCT) image taken after a micro patterned tool is inserted into a living body according to an exemplary embodiment.
2 is a perspective view of a micropatterned tool according to one embodiment.
3 is a perspective view of a micropatterned tool according to another embodiment.
4 is a flowchart of a method of correcting an optical coherence tomography image, according to an exemplary embodiment.
Hereinafter, some embodiments of the present invention will be described in detail with reference to the drawings.
FIG. 1 is a photograph of an optical coherence tomography (OCT) image taken after a micro patterned tool is inserted into a living body according to an exemplary embodiment. 1 exemplarily shows a photographed result after inserting a micro patterned
2 is a perspective view of a micropatterned tool according to one embodiment.
Referring to FIG. 2, the micro-patterned tool may include a
The
The
The
However, the shape of the micropattern shown and described herein is merely exemplary, and may use other different types of micropatterns identifiable in optical coherence tomography images.
3 is a perspective view of a micropatterned tool according to another embodiment. In the description of the embodiment illustrated in FIG. 3, descriptions that may be easily understood by those skilled in the art from the embodiment illustrated in FIG. 2 will be omitted.
Referring to FIG. 3, the micropatterned tool includes a
The
4 is a flowchart of a method of correcting an optical coherence tomography image, according to an exemplary embodiment. The correction method of the optical coherence tomography image according to the embodiment is for compensating for an error in the obtained image according to the transmission depth of the light beam with respect to the measurement object. To this end, before performing the measurement on the measurement object, a non-uniformity and distortion of the image may be compensated for by using a previously prepared micropatterned tool.
First, the micro-patterned tool can be inserted into a living body to be measured (S1). The micropatterned tool is prepared before the measurement of the measurement object, and the size of the micropattern may be predetermined and known in advance. A detailed configuration of the tool having a micro pattern is the same as that described above with reference to FIGS. 1 to 3, and thus a detailed description thereof will be omitted.
Next, an optical coherence tomography image of the object may be acquired in the state where the micro-patterned tool is inserted into the measurement target body (S2).
Next, the size of the area corresponding to the micro pattern in the acquired image may be compared with the actual size of the micro pattern known in advance (S3). If there is no distortion in the image, the actual size of the micro-pattern and the size of the image will be the same.However, in optical coherence tomography, the depth of the reflected light varies depending on the transmittance of the medium and the focal length of the light. As a result, the image representation is different and distortion occurs.
In order to compensate for the distortion, the optical coherence tomography image may be corrected using the comparison result in step S3 (S4). That is, distortion of the optical coherence tomography image may be corrected by mapping a region corresponding to the micro pattern in the optical coherence tomography image to the actual shape of the micro pattern previously recognized.
In addition, the distortion of the entire area of the image may be corrected based on the micro pattern. That is, the optical angle tomography image is used to calculate the insertion angle of the tool that has been firstly micropatterned, and then the direction and / or distortion of the entire area of the image is processed by using the length information of the micropattern as a reference. Can be corrected using (image processing).
As a result, by using the correction method of the optical coherence tomography image according to the embodiment, it is possible to reduce the nonuniformity and distortion caused by the influence of the transmittance and focal length of the medium in the image obtained through optical coherence tomography When analyzing, more accurate interpretation is possible. Therefore, the method of correcting the optical coherence tomography image may be widely used for analyzing results of errors and checking errors of experimental data using medical non-invasive equipment as well as application equipment in other fields.
Although the present invention described above has been described with reference to the embodiments illustrated in the drawings, this is merely exemplary, and it will be understood by those skilled in the art that various modifications and variations may be made therefrom. However, such modifications should be considered to be within the technical protection scope of the present invention. Therefore, the true technical protection scope of the present invention will be defined by the technical spirit of the appended claims.
Claims (11)
It includes a micro pattern consisting of a plurality of identification areas formed on the surface of the body,
Wherein each identification region comprises a protrusion or depression.
And the size of each identification area is between 10 μm and 100 μm.
A micro pattern comprising a plurality of identification regions formed on a surface of the body;
A metallic material located on each identification area; And
A micropatterned tool comprising a biocompatible material coated on the metallic material.
The metallic material is a micro-patterned tool, characterized in that the reflectance difference of more than 90% based on the reflectance of the body to be inserted into the body within the wavelength range of 0.6 ㎛ to 1.3 ㎛.
The metallic material is a micro-patterned tool, characterized in that the difference in reflectance of 90% or more based on the reflectance of the body within the wavelength range of 0.6 ㎛ to 1.3 ㎛.
And the metallic material comprises at least one selected from the group consisting of gold, platinum, nickel, aluminum, copper, iridium and iridium oxide.
And said body is made of a transparent material.
The body is a micro patterned tool, characterized in that it comprises a PMMA.
Acquiring an optical coherence tomography image of the living body inserted into the tool;
Comparing the size of the region corresponding to the micro pattern with the predetermined size in the obtained image; And
And correcting the distortion of the image by using the result of the comparing step.
Correcting the image,
Calculating an insertion angle of the tool with respect to the living body based on the micro pattern; And
And correcting the distortion of the entire area of the image based on the region corresponding to the micro pattern in the image.
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Citations (2)
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JP2009036589A (en) | 2007-07-31 | 2009-02-19 | Omron Corp | Target for calibration and device, method and program for supporting calibration |
US7580504B2 (en) | 2000-08-29 | 2009-08-25 | Imaging Therapeutics, Inc. | Calibration devices and methods of use thereof |
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US7580504B2 (en) | 2000-08-29 | 2009-08-25 | Imaging Therapeutics, Inc. | Calibration devices and methods of use thereof |
JP2009036589A (en) | 2007-07-31 | 2009-02-19 | Omron Corp | Target for calibration and device, method and program for supporting calibration |
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