KR101141558B1 - 축합 복소환 유도체, 그것을 함유하는 의약 조성물 및 그의약 용도 - Google Patents
축합 복소환 유도체, 그것을 함유하는 의약 조성물 및 그의약 용도 Download PDFInfo
- Publication number
- KR101141558B1 KR101141558B1 KR1020067018964A KR20067018964A KR101141558B1 KR 101141558 B1 KR101141558 B1 KR 101141558B1 KR 1020067018964 A KR1020067018964 A KR 1020067018964A KR 20067018964 A KR20067018964 A KR 20067018964A KR 101141558 B1 KR101141558 B1 KR 101141558B1
- Authority
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- South Korea
- Prior art keywords
- group
- inhibitors
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- acid
- alkyl
- Prior art date
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- 0 CC(*CN*)=C(C)P Chemical compound CC(*CN*)=C(C)P 0.000 description 2
- VUWMDLRKEQUSPZ-PJEQPVAWSA-N C[C@@H]([C@@H]([C@H]1O)O)O[C@H](CO)[C@H]1O Chemical compound C[C@@H]([C@@H]([C@H]1O)O)O[C@H](CO)[C@H]1O VUWMDLRKEQUSPZ-PJEQPVAWSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPJP-P-2004-00061428 | 2004-03-04 | ||
JP2004061428 | 2004-03-04 | ||
PCT/JP2005/004158 WO2005085237A1 (ja) | 2004-03-04 | 2005-03-03 | 縮合複素環誘導体、それを含有する医薬組成物およびその医薬用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20060129054A KR20060129054A (ko) | 2006-12-14 |
KR101141558B1 true KR101141558B1 (ko) | 2012-05-03 |
Family
ID=34918062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020067018964A KR101141558B1 (ko) | 2004-03-04 | 2005-03-03 | 축합 복소환 유도체, 그것을 함유하는 의약 조성물 및 그의약 용도 |
Country Status (12)
Country | Link |
---|---|
US (1) | US8058245B2 (pt) |
EP (1) | EP1721904A4 (pt) |
JP (1) | JP4950657B2 (pt) |
KR (1) | KR101141558B1 (pt) |
CN (1) | CN1934103B (pt) |
AU (1) | AU2005219779B2 (pt) |
BR (1) | BRPI0508259A (pt) |
CA (1) | CA2557269C (pt) |
NZ (1) | NZ549629A (pt) |
TW (1) | TW200540166A (pt) |
WO (1) | WO2005085237A1 (pt) |
ZA (1) | ZA200608028B (pt) |
Families Citing this family (79)
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WO2005085265A1 (ja) * | 2004-03-04 | 2005-09-15 | Kissei Pharmaceutical Co., Ltd. | 縮合ヘテロ環誘導体、それを含有する医薬組成物およびその医薬用途 |
RS52365B (en) | 2004-03-16 | 2012-12-31 | Boehringer Ingelheim International Gmbh | BENZOL DERIVATIVES SUBSTITUTED BY GLUCOPYRANOSIL, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS, THEIR USE AND THE PROCEDURE FOR THEIR PRODUCTION |
ATE407938T1 (de) | 2004-12-16 | 2008-09-15 | Boehringer Ingelheim Int | Glucopyranosyl-substituierte benzen-derivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür |
TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
DE602006009772D1 (de) | 2005-02-23 | 2009-11-26 | Boehringer Ingelheim Int | Glucopyranosylsubstituierte ((hetero)arylethynyl-benzyl)-benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose-cotransporters typ 2 (sglt2) |
WO2006108842A1 (en) | 2005-04-15 | 2006-10-19 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives as sglt inhibitors |
US7723309B2 (en) | 2005-05-03 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments |
UA91546C2 (uk) | 2005-05-03 | 2010-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ |
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ATE484499T1 (de) | 2005-08-30 | 2010-10-15 | Boehringer Ingelheim Int | Glucopyranosyl-substituierte benzyl-derivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür |
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US7745414B2 (en) | 2006-02-15 | 2010-06-29 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture |
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TWI432446B (zh) * | 2006-07-27 | 2014-04-01 | Chugai Pharmaceutical Co Ltd | 稠環螺酮縮醇衍生物、及其做為糖尿病治療藥之使用 |
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JP5758900B2 (ja) | 2009-09-30 | 2015-08-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル置換ベンジルベンゼン誘導体の調製方法 |
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US6683056B2 (en) * | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
WO2003087093A1 (en) * | 2002-04-08 | 2003-10-23 | Council Of Scientific And Industrial Research | Novel glucopyranoside, process for isolation thereof, pharmaceutical composition containing same and use thereof |
MXPA05009356A (es) * | 2003-03-14 | 2005-12-05 | Astellas Pharma Inc | Derivados de c-glicosido y sales de los mismos. |
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AR053329A1 (es) * | 2005-01-31 | 2007-05-02 | Tanabe Seiyaku Co | Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt) |
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- 2005-03-03 EP EP05720429A patent/EP1721904A4/en not_active Withdrawn
- 2005-03-03 BR BRPI0508259-5A patent/BRPI0508259A/pt not_active Application Discontinuation
- 2005-03-03 CA CA2557269A patent/CA2557269C/en not_active Expired - Fee Related
- 2005-03-03 WO PCT/JP2005/004158 patent/WO2005085237A1/ja active Application Filing
- 2005-03-03 KR KR1020067018964A patent/KR101141558B1/ko not_active IP Right Cessation
- 2005-03-03 NZ NZ549629A patent/NZ549629A/en not_active IP Right Cessation
- 2005-03-03 US US10/591,421 patent/US8058245B2/en not_active Expired - Fee Related
- 2005-03-03 ZA ZA200608028A patent/ZA200608028B/xx unknown
- 2005-03-03 JP JP2006510805A patent/JP4950657B2/ja not_active Expired - Fee Related
- 2005-03-03 CN CN2005800069650A patent/CN1934103B/zh not_active Expired - Fee Related
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KR20060057589A (ko) * | 2003-08-01 | 2006-05-26 | 다나베 세이야꾸 가부시키가이샤 | 나트륨-의존성 수송체에 대해 저해 활성을 갖는 신규화합물 |
KR100942622B1 (ko) * | 2003-08-01 | 2010-02-17 | 미쓰비시 타나베 파마 코퍼레이션 | 나트륨-의존성 수송체에 대해 저해 활성을 갖는 신규화합물 |
Also Published As
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AU2005219779A1 (en) | 2005-09-15 |
JPWO2005085237A1 (ja) | 2008-01-17 |
TW200540166A (en) | 2005-12-16 |
CN1934103A (zh) | 2007-03-21 |
TWI351400B (pt) | 2011-11-01 |
WO2005085237A1 (ja) | 2005-09-15 |
AU2005219779B2 (en) | 2011-04-14 |
US20070197450A1 (en) | 2007-08-23 |
ZA200608028B (en) | 2009-03-25 |
EP1721904A4 (en) | 2010-07-14 |
EP1721904A1 (en) | 2006-11-15 |
CN1934103B (zh) | 2011-06-01 |
US8058245B2 (en) | 2011-11-15 |
BRPI0508259A (pt) | 2007-07-31 |
NZ549629A (en) | 2010-06-25 |
CA2557269A1 (en) | 2005-09-15 |
CA2557269C (en) | 2012-12-04 |
JP4950657B2 (ja) | 2012-06-13 |
KR20060129054A (ko) | 2006-12-14 |
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