KR101022258B1 - Compositions for Improving Skin Conditions Comprising Extract of Phlomis umbrosa - Google Patents
Compositions for Improving Skin Conditions Comprising Extract of Phlomis umbrosa Download PDFInfo
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- KR101022258B1 KR101022258B1 KR1020100006585A KR20100006585A KR101022258B1 KR 101022258 B1 KR101022258 B1 KR 101022258B1 KR 1020100006585 A KR1020100006585 A KR 1020100006585A KR 20100006585 A KR20100006585 A KR 20100006585A KR 101022258 B1 KR101022258 B1 KR 101022258B1
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- extract
- composition
- present
- skin
- skin conditions
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Mycology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 길경 추출물, 백하수오 추출물, 속단 추출물 또는 이의 혼합물을 포함하는 피부 상태 개선용 조성물에 관한 것이다. 본 발명의 조성물은 피부 상태, 특히 피부 노화를 억제 또는 치료하는 데 매우 유효하며, 유효성분으로 이용되는 성분들이 종래에 한약재로 이용되는 것이기 때문에 인체에 대하여 안전하다. 또한, 본 발명의 조성물은 경구 투여하는 경우에도 피부 노화를 억제하는 활성을 나타내어 식품으로 개발하는 경우에도 매우 유리하다.The present invention relates to a composition for improving skin conditions, including Gil-Gil extract, Baek-Sewao extract, Sok-Tang extract or mixtures thereof. The composition of the present invention is very effective for inhibiting or treating skin conditions, especially skin aging, and is safe for the human body because the ingredients used as active ingredients are conventionally used as herbal medicines. In addition, the composition of the present invention is very advantageous in the case of oral administration to develop a food to suppress the skin aging activity.
Description
본 발명은 피부 상태(skin conditions) 개선용 조성물에 관한 것으로서, 보다 상세하게는 길경 추출물, 백하수오 추출물, 속단 추출물 또는 이의 혼합물을 포함하는 피부 상태 개선용 조성물에 관한 것이다.The present invention relates to a composition for improving skin conditions, and more particularly, to a composition for improving skin conditions including a gilpyeong extract, a baekshou extract, a fast extract or a mixture thereof.
인간의 피부는 끊임없이 변화를 겪게 되며, 그 중 가장 대표적인 것이 노화에 의한 피부의 기능 저하 및 시각적인 아름다움의 감소이다. 피부의 노화는 크게 유전적 요소에 따른 내적 노화와 태양광선 등의 외부 환경적 요소에 따른 외적 노화로 구분된다. 이러한 외적 노화는 피부의 주름을 형성시키며, 대표적인 주름 형성의 인자로서 활성 산소, 자외선 및 콜라겐의 생합성 감소 등을 들 수 있다(Danielle, A study in the epidermiology of crow's feet., Ann . Intern . Med ., 75:873-880(1971); Grove et al., Optical profilometry; an objective method for quantification of facial wrinkles., J. Am . Acad . Dermatol ., 21:631-637( 1989)). 피부의 내적 노화의 경우 인위적인 조절이 불가능하나, 외적 노화의 경우 활성산소 제거, 섬유아세포의 증식 및 콜라겐의 생합성 촉진 등을 통하여 노화를 예방, 치료 또는 지연시킬 수 있다(Schwartz et al., Topical all-trans retinoic acid stimulates collagen synthesis in vivo., J. Invest . Dermatol ., 96(6):975-978(1991)).Human skin is constantly changing, the most representative of which is deterioration of the skin function due to aging and reduction of visual beauty. Skin aging is classified into internal aging due to genetic factors and external aging due to external environmental factors such as sunlight. Such external aging forms wrinkles on the skin, and the representative factors for wrinkle formation include reduction of biosynthesis of free radicals, ultraviolet rays and collagen (Danielle, A study in the epidermiology of crow's feet., Ann . Intern . Med . 75: 873-880 (1971); Grove et al., Optical profilometry; an objective method for quantification of facial wrinkles., J. Am . Acad . Dermatol . , 21: 631-637 (1989)). In the case of internal aging of the skin, artificial control is impossible, but in the case of external aging, aging can be prevented, treated or delayed by removing free radicals, proliferating fibroblasts and promoting collagen biosynthesis (Schwartz et al., Topical all). ... -trans retinoic acid stimulates collagen synthesis in vivo, J. Invest Dermatol, 96 (6): 975-978 (1991)).
최근 피부노화 지연 등을 목적으로 한 특정의 생리활성 물질을 함유하는 기능성 화장료에 대한 관심이 높아지고 또 많은 연구가 행해지고 있다.In recent years, interest in functional cosmetics containing specific bioactive substances for the purpose of delaying skin aging, etc. has been increasing and many studies have been conducted.
대한민국 특허 제733334호는 사상자 추출물의 나노리포좀을 함유하는 피부노화 방지를 위한 화장료 조성물을 개시하고 있으며, 대한민국 특허 제681702호는 만삼 추출물을 유효 성분으로 포함하는 피부 노화 방지용 화장료 조성물을 개시하고 있다.Republic of Korea Patent No. 733334 discloses a cosmetic composition for preventing skin aging containing nano liposomes of the casualty extract, Republic of Korea Patent No. 617082 discloses a cosmetic composition for preventing skin aging comprising a ginseng extract as an active ingredient.
또한, 대한민국 특허 제468434호는 비타민 Ｃ 또는 그 유도체 및 빈랑자 추출물을 함유하는 피부노화 방지용 화장료 조성물을 개시하고 있고, 대한민국 특허 제602813호는 석창포 추출물을 포함하는 피부노화 방지용 조성물을 개시하고 있다.
In addition, Korean Patent No. 468434 discloses a skin aging preventing cosmetic composition containing a vitamin C or a derivative thereof and betel nut extract, and Korean Patent No. 602813 discloses a skin aging preventing composition comprising an extract of Sorrow.
본 명세서 전체에 걸쳐 다수의 논문 및 특허문헌이 참조되고 그 인용이 표시되어 있다. 인용된 논문 및 특허문헌의 개시 내용은 그 전체로서 본 명세서에 참조로 삽입되어 본 발명이 속하는 기술 분야의 수준 및 본 발명의 내용이 보다 명확하게 설명된다.Numerous papers and patent documents are referenced and cited throughout this specification. The disclosures of the cited papers and patent documents are incorporated herein by reference in their entirety to better understand the state of the art to which the present invention pertains and the content of the present invention.
본 발명자들은 피부 상태(skin conditions)를 개선할 수 있는 조성물을 개발하고자 노력한 결과, 종래 한약재로 이용되고 있는 길경, 백하수오 및 속단에서 얻은 추출물이 피부 노화 방지 등과 같은 피부 상태의 개선에 매우 우수한 효과를 발휘한다는 것을 발견함으로써, 본 발명을 완성하게 되었다.The present inventors have tried to develop a composition that can improve skin conditions, and as a result, the extracts obtained from Kilkyung, Baeksewao and Sokdan, which are used as traditional herbal medicines, are very effective in improving skin conditions such as anti-aging of skin. The present invention has been completed by discovering that the present invention is exhibited.
따라서 본 발명의 목적은 피부 상태 개선용 조성물을 제공하는 데 있다.
Therefore, it is an object of the present invention to provide a composition for improving skin conditions.
본 발명의 다른 목적 및 이점은 하기의 발명의 상세한 설명, 청구범위 및 도면에 의해 보다 명확하게 된다.Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.
본 발명의 양태에 따르면, 본 발명은 길경 추출물, 백하수오 추출물, 속단 추출물 또는 이의 혼합물을 포함하는 피부 상태 개선용 조성물을 제공한다.
According to an aspect of the present invention, the present invention provides a composition for improving skin conditions, including Gil-Gyeong extract, Baek Sewao extract, Sok-Tang extract or a mixture thereof.
본 발명자들은 피부 상태(skin conditions)를 개선할 수 있는 조성물을 개발하고자 노력한 결과, 종래 한약재로 이용되고 있는 길경, 백하수오 및 속단에서 얻은 추출물이 피부 노화 방지 등과 같은 피부 상태의 개선에 매우 우수한 효과를 발휘한다는 것을 발견하였다.The present inventors have tried to develop a composition that can improve skin conditions, and as a result, the extracts obtained from Kilkyung, Baeksewao and Sokdan, which are used as traditional herbal medicines, are very effective in improving skin conditions such as anti-aging of skin. Was found to exert.
본 발명에서 이용되는 길경(Platycodon grandiflorum)은 초롱꽃과 (Campanulaceae)에 속하는 다년생 초본인 도라지의 뿌리이며, 주성분은 플라티코디온-A, C, D1 및 D2, 플라티코디게닌, 폴리갈락신-D1 및 D2 등 10여 종의 사포닌 배당체와 플라티코딘이고 이외에도 베튜린, 이누틴, 피토스테롤 등의 성분을 함유하며, 거담, 진해, 항염증, 해열 작용 등을 한다고 알려져 있다.Gilyeong ( Platycodon grandiflorum ) used in the present invention is the root of the perennial herbaceous bellflower belonging to Campanulaceae, the main components are Platicodione-A, C, D1 and D2, Platicodigenin, polygalaxin-D1 And about 10 kinds of saponin glycosides such as D2 and platicodine, and other ingredients such as betulin, inutin, and phytosterol.
또한, 본 발명에서 이용되는 백하수오 (Cynanchum wilfordii)는 마디풀과 (Polygonaceae)에 속하는 다년생 초본으로, 그 높이는 1-3 m에 달하며 뿌리는 덩이뿌리로서 비후하다. 백하수오의 주성분은 시난코톡신, 피토토코톡신 등이며, 강장 및 강정제로 사용된다.In addition, Baek Shou ( Cynanchum) used in the present invention wilfordii ) is a perennial herb that belongs to the Polygonaceae, its height is 1-3 m, and its root is thick as a tuber. The main constituents of Baek Shao Shou are Sinan Cotoxin and Phytotocotoxin, which are used as tonics and tonics.
또한, 본 발명에서 이용되는 속단 (Phlomis umbrosa)은 꿀풀과 (Labiatae)에 속하는 다년생 초본으로, 그 높이는 70-150 ㎝이며 비대한 덩이뿌리가 5개 정도 달린다. 잎을 식용으로 이용하고 뿌리 및 뿌리줄기를 약용으로 이용한다. In addition, Phlomis used in the present invention ( Phlomis umbrosa ) is a perennial herb belonging to Lamitae (Labiatae), its height is 70-150 cm, and has about 5 large tubers. The leaves are used for food and the roots and rhizomes are used for medicinal purposes.
본 발명자들은 길경, 백하수오 및 속단 추출물을 모두 포함하는 조성물이 상승적인(synergic) 작용을 하여 피부 상태를 크게 개선한다는 것을 발견하였으며, 이는 하기 실시예에서 입증되어 있다.The inventors have found that a composition comprising all of Gil-Gil, Baek-Shi-Oh and Sok-Tang extract has a synergic action to significantly improve skin condition, which is demonstrated in the following examples.
본 발명에서 이용되는 백하수오 및 속단 추출물은 백하수오 또는 속단의 다양한 기관, 조직 (예: 뿌리, 잎, 꽃, 줄기, 과실 및 종자 등) 등을 이용하여 수득할 수 있으며, 가장 바람직하게는 백하수오 또는 속단의 뿌리로부터 얻은 추출물이다.White sewage and genus extract used in the present invention can be obtained using various organs, tissues (e.g. roots, leaves, flowers, stems, fruits and seeds, etc.) of white sesame or genus, most preferably white It is an extract obtained from the root of sewage or genus.
상기 길경 추출물, 백하수오 추출물 또는 속단 추출물은 다양한 추출 용매, 예를 들어, (a) 물, (b) 탄소수 1-4의 무수 또는 함수 저급 알코올 (메탄올, 에탄올, 프로판올, 부탄올 등), (c) 상기 저급 알코올과 물과의 혼합용매, (d) 아세톤, (e) 에틸 아세테이트, (f) 클로로포름, (g) 1,3-부틸렌글리콜, (h) 부틸 아세테이트를 추출 용매로 하여 길경, 백하수오 또는 속단으로부터 얻을 수 있다. 가장 바람직하게는, 본 발명의 추출물은 물을 추출 용매로 하여 얻어진 것이다. 한편, 본 발명의 추출물은 상기한 추출 용매뿐만 아니라, 다른 추출 용매를 이용하여도 실질적으로 동일한 효과를 나타내는 추출물이 얻어질 수 있다는 것은 당업자에게 자명한 것이다.The Gil-Gil extract, Baek Shou extract or Fast extract extract may be prepared in various extraction solvents such as (a) water, (b) anhydrous or hydrous lower alcohols (methanol, ethanol, propanol, butanol, etc.) having 1 to 4 carbon atoms, (c) ) A mixed solvent of the lower alcohol and water, (d) acetone, (e) ethyl acetate, (f) chloroform, (g) 1,3-butylene glycol, (h) butyl acetate as an extraction solvent, Obtained from Baek Sewao or Sok. Most preferably, the extract of the present invention is obtained using water as the extraction solvent. On the other hand, it will be apparent to those skilled in the art that the extract of the present invention can be obtained in addition to the above-described extraction solvents, extracts having substantially the same effect using other extraction solvents.
또한, 본 발명의 추출물은 상술한 추출 용매에 의한 추출물을 포함한다. 본 발명의 추출물은 감압 증류 및 동결 건조 또는 분무 건조 등과 같은 추가적인 과정에 의해 분말 상태로 제조될 수 있다.In addition, the extract of the present invention includes an extract by the aforementioned extraction solvent. Extracts of the present invention may be prepared in powder form by additional processes such as distillation under reduced pressure and freeze drying or spray drying.
본 발명의 바람직한 구현예에 따르면, 본 발명의 조성물에서 유효 성분으로서의 길경 추출물, 백하수오 추출물 또는 속단 추출물은 조성물의 총 중량에 대하여 0.10-80 중량%이다.According to a preferred embodiment of the present invention, the Giltyeong extract, Baekshou extract or Sokcho extract as active ingredients in the composition of the present invention is 0.10-80% by weight relative to the total weight of the composition.
본 발명의 바람직한 구현예에 따르면, 본 발명의 조성물은 화장료 조성물 또는 식품 조성물로 제조된다.According to a preferred embodiment of the present invention, the composition of the present invention is made of a cosmetic composition or a food composition.
본 발명의 화장품 조성물에 포함되는 성분은 유효 성분으로서의 길경 추출물, 백하수오 추출물 또는 속단 추출물 이외에 화장품 조성물에 통상적으로 이용되는 성분들을 포함하며, 예컨대 항산화제, 안정화제, 용해화제, 비타민, 안료 및 향료와 같은 통상적인 보조제, 그리고 담체를 포함한다.The components included in the cosmetic composition of the present invention include components commonly used in cosmetic compositions in addition to the gilyeong extract, white sewage extract or fast extract as active ingredients, and include, for example, antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings. Conventional adjuvants such as, and carriers.
본 발명의 피부 상태 개선용 조성물은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있으며, 예를 들어, 용액, 현탁액, 유탁액, 페이스트, 겔, 크림, 로션, 파우더, 비누, 계면활성제-함유 클린싱, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션 및 스프레이 등으로 제형화될 수 있으나, 이에 한정되는 것은 아니다. 보다 상세하게는, 유연 화장수, 영양 화장수, 영양 크림, 마사지 크림, 에센스, 아이 크림, 클렌징 크림, 클렌징 포옴, 클렌징 워터, 팩, 스프레이 또는 파우더의 제형으로 제조될 수 있다.The composition for improving skin condition of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactants -Can be formulated with, but not limited to, cleansing, oils, powder foundations, emulsion foundations, wax foundations, sprays, and the like. More specifically, it can be manufactured in the form of a soft lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder.
본 발명의 제형이 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.
본 발명의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.
When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.
본 발명의 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 있다.When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.
본 발명의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.
본 발명의 제형이 계면-활성제 함유 클린징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성 유, 라놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
본 발명의 화장료 조성물은 피부 상태 개선의 용도를 갖는다. 본 명세서에서 용어 “피부 상태 개선”은, 피부노화 방지, 피부 주름 개선 및 피부 보습 개선 등을 포괄적으로 포함하는 의미를 갖는다. 본 발명의 화장료 조성물은 피부 주름 개선, 보습력 향상 및 피부 탄력 개선 등을 통하여 피부 노화를 방지하며, 전체적으로 피부의 상태를 개선하며 이와 같은 사실은 하기의 실시예에 입증되어 있다.The cosmetic composition of the present invention has a use for improving skin condition. As used herein, the term "improvement of skin condition" has a meaning including comprehensively preventing skin aging, improving skin wrinkles, and improving skin moisturizing. The cosmetic composition of the present invention prevents skin aging through improvement of skin wrinkles, moisturizing and skin elasticity, and improves the condition of the skin as a whole. Such facts are demonstrated in the following examples.
본 발명의 조성물이 식품 조성물로 제조되는 경우, 유효성분으로서 길경, 백하수오 또는 길경 추출물뿐만 아니라, 식품 제조 시에 통상적으로 첨가되는 성분을 포함하며, 예를 들어, 단백질, 탄수화물, 지방, 영양소, 조미제 및 향미제를 포함한다. 상술한 탄수화물의 예는 모노사카라이드, 예를 들어, 포도당, 과당 등; 디사카라이드, 예를 들어 말토스, 슈크로스, 올리고당 등; 및 폴리사카라이드, 예를 들어 덱스트린, 사이클로덱스트린 등과 같은 통상적인 당 및 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 향미제로서 천연 향미제 [타우마틴, 스테비아 추출물 (예를 들어 레바우디오시드 A, 글리시르히진 등]) 및 합성 향미제(사카린, 아스파르탐 등)를 사용할 수 있다.When the composition of the present invention is made of a food composition, as an active ingredient, as well as the gilyeong, baekshou or gilge extract, it contains components that are commonly added during food production, for example, proteins, carbohydrates, fats, nutrients, Seasonings and flavoring agents. Examples of the above carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose, oligosaccharides and the like; And sugars such as conventional sugars such as polysaccharides such as dextrin, cyclodextrin and the like and xylitol, sorbitol, erythritol. As the flavoring agent, natural flavoring agents (tauumatin, stevia extract (for example rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be used.
예컨대, 본 발명의 식품 조성물이 드링크제로 제조되는 경우에는 본 발명의 길경, 백하수오 또는 길경 추출물 이외에 구연산, 액상과당, 설탕, 포도당, 초산, 사과산, 과즙, 두충 추출액, 대추 추출액, 감초 추출액 등을 추가로 포함시킬 수 있다.
For example, when the food composition of the present invention is prepared with a drinking agent, citric acid, liquid fructose, sugar, glucose, acetic acid, malic acid, fruit juice, tofu extract, jujube extract, licorice extract, etc. May be additionally included.
본 발명의 조성물은 피부 상태, 특히 피부 노화를 억제 또는 치료하는 데 매우 유효하며, 유효성분으로 이용되는 성분들이 종래에 한약재로 이용되는 것이기 때문에 인체에 대하여 안전하다. 또한, 본 발명의 조성물은 경구 투여하는 경우에도 피부 노화를 억제하는 활성을 나타내어 식품으로 개발하는 경우에도 매우 유리하다.The composition of the present invention is very effective for inhibiting or treating skin conditions, especially skin aging, and is safe for the human body because the ingredients used as active ingredients are conventionally used as herbal medicines. In addition, the composition of the present invention is very advantageous in the case of oral administration to develop a food to suppress the skin aging activity.
이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본 발명의 요지에 따라 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 당업계에서 통상의 지식을 가진 자에 있어서 자명할 것이다.
Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. .
실시예Example
실시예Example 재료 material
본 발명의 길경, 백하수오 및 속단은 경동 시장에서 구입하여 추출물 제조에 사용하였다.
Gilkyung, Baekshou and Sokdan of the present invention were purchased in the market of Gyeongdong and used for extract preparation.
실시예Example
1: One:
길경Street view
추출물을 포함하는 조성물의 제조 Preparation of the composition comprising the extract
건조된 길경 50 g을 물 1.5 ℓ에 넣고 상온 이상의 온도에서 약 2시간 동안 추출하여 수용성 추출액을 얻었다. 상기 추출액을 농축하여 이를 건조하여 하기 표 1에 나타난 양의 분말을 얻었다.50 g of dried road-length was added to 1.5 L of water and extracted at a temperature of about 2 hours or longer to obtain an aqueous extract. The extract was concentrated and dried to obtain a powder in the amount shown in Table 1 below.
실시예Example 2: 2: 백하수오Baek Ha Shou 추출물을 포함하는 조성물의 제조 Preparation of the composition comprising the extract
백하수오의 뿌리 부위를 사용하여 상기 실시예 1과 동일한 방법으로 백하수오 추출물을 제조하였다. 상기 백하수오 추출물의 양은 하기 표 2와 같다. White sewage extract was prepared in the same manner as in Example 1 using the root region of Baek sewage. The amount of the white sewage extract is shown in Table 2 below.
실시예Example 3: 속단 추출물을 포함하는 조성물의 제조 3: Preparation of a composition comprising a fast extract
속단 50 g에 증류수 1.5 ℓ를 첨가하고 80-90℃에서 2시간 동안 가열 및 추출하여 수용성 추출액 0.7 ℓ를 수득하였다. 수득한 추출액 0.7 ℓ를 상온에서 보관하였고, 잔존한 약재에 1차 추출 때에 가한 양의 반에 해당하는 증류수를 첨가하고, 2차 추출을 80-90℃에서 2시간 동안 가열 및 추출하였다. 1차 및 2차에 걸쳐서 얻어진 추출액 1 ℓ를 수집하고, 열로 가열 (90℃)하여 추출액의 부피를 최종 500 ㎖까지 농축시켰다.1.5 g of distilled water was added to 50 g of fast-acting, and heated and extracted at 80-90 ° C. for 2 hours to obtain 0.7 L of an aqueous extract. 0.7 L of the obtained extract was stored at room temperature, and distilled water corresponding to half of the amount added during the first extraction was added to the remaining medicinal herbs, and the second extraction was heated and extracted at 80-90 ° C. for 2 hours. One liter of the extract obtained over the first and second phases was collected and heated with heat (90 ° C.) to concentrate the volume of the extract to the final 500 ml.
각 단계에서 수득한 추출액을 감압 건조(freeze dryer, Edwards USA)하여 분말을 얻었고, 분말의 중량을 기준으로 하여 추출 효율을 계산하였다(참조: 표 3).The extract obtained in each step was dried under reduced pressure (freeze dryer, Edwards USA) to obtain a powder, and the extraction efficiency was calculated based on the weight of the powder (see Table 3).
상기 표 3에서의 가열 및 추출 단계의 추출 효율은 매번 실시할 때마다 약간의 변동이 있었고, 일반적으로 18%-24%의 추출 효율을 나타내었다.
The extraction efficiencies of the heating and extraction steps in Table 3 were slightly varied with each run and generally showed an extraction efficiency of 18% -24%.
실험예Experimental Example 1: 섬유아세포 증식 효과 1: fibroblast proliferation effect
인간 정상 섬유아세포 (fibroblast, 한국세포주은행)를 96-웰 마이크로 플레이트(96-well microplate)의 각 웰에 1 x 104 세포가 되도록 접종하고, DMEM (Sigma사)에서 24시간 동안 37℃에서 배양하였다. 이어, 상기 실시예 1-3에서 제조한 추출물의 최종 농도가 0.005%, 0.01%, 0.05%, 0.1% 또는 1%가 되도록, 섬유아세포 배양 배지에 넣은 후 24시간 동안 배양하였다. 또한, 상기 추출물이 포함되지 않는 배양한 것을 대조군으로 사용하였다. 상기 세포를 배양한 후, MTT 용액(3-(4,5-디메틸티아졸-2-일) 2,5-디페닐테트라졸륨 브로마이드: 5 ㎎/㎖)을 각각의 배양된 세포에 10 ㎕씩 첨가하고, 4시간 동안 배양한 후, 배지를 제거하고, 각 웰 당 100 ㎕의 디메틸 설폭시드 용액을 가하고 20분 동안 진탕시켰다. 마이크로 플레이트 판독기(Molecular Devices, 미합중국)를 이용하여 570 nm에서 상층액의 흡광도를 측정하였다. 측정값을 하기의 수학식 1에 대입하여 세포 증식 효과를 산출하였다: 세포 증식 효과(%) = [(추출물 처리시의 흡광도-대조군의 흡광도)/대조군의 흡광도] x 100. 실험은 동일한 시료에 대하여 3회 반복(triplicate) 하였고, 그 평균 값을 얻었다.Human normal fibroblasts (fibroblasts) were seeded in each well of a 96-well microplate to 1 x 10 4 cells and incubated at 37 ° C. for 24 hours in DMEM (Sigma). It was. Then, the final concentration of the extract prepared in Example 1-3 was 0.005%, 0.01%, 0.05%, 0.1% or 1%, and cultured for 24 hours after the fibroblast culture medium. In addition, those cultured without the extract was used as a control. After incubating the cells, 10 μl of MTT solution (3- (4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide: 5 mg / ml) was added to each cultured cell. After addition and incubation for 4 hours, the medium was removed and 100 μl of dimethyl sulfoxide solution per well was added and shaken for 20 minutes. The absorbance of the supernatant was measured at 570 nm using a micro plate reader (Molecular Devices, USA). The cell proliferation effect was calculated by substituting the measured value into the following equation: Cell proliferation effect (%) = [(absorbance at extract treatment-absorbance of control) / absorbance of control] x 100. The experiment was performed on the same sample. Was repeated three times, and the average value was obtained.
실험 결과는 하기 표 4에 정리되어 있다.The experimental results are summarized in Table 4 below.
상기 표 4에서 볼 수 있듯이, 길경, 백하수오 및 속단 추출물 모두 농도-의존적으로 섬유아세포 증식 효과를 나타내었다. 특히, 길경 추출물이 가장 우수한 섬유아세포 증식 효과를 나타내어, 피부노화 방지 및 피부 주름 개선 효능이 있음을 알 수 있다.
As can be seen in Table 4, both Gil-Kyung, Baek-Sewao and Sok-Tak extract exhibited a concentration-dependent fibroblast proliferation effect. In particular, it can be seen that the gilyeong extract exhibits the most excellent fibroblast proliferation effect, and has the effect of preventing skin aging and improving skin wrinkles.
제형예Formulation example 1 One
상기에서 수득한 추출물을 포함하는 화장료 중 유연 화장수(스킨)의 제형예는 다음과 같다:Formulation examples of the flexible lotion (skin) in the cosmetic composition containing the extract obtained above are as follows:
제형예Formulation example 2 2
상기에서 수득한 추출물을 포함하는 화장료 중 밀크로션의 제형예는 다음과 같다:Formulation examples of the milk lotion in the cosmetic composition containing the extract obtained above are as follows:
제형예Formulation example 3 3
상기에서 수득한 추출물을 포함하는 화장료 중 영양크림의 제형예는 다음과 같다:Examples of the formulation of the nourishing cream in the cosmetic composition containing the extract obtained above are as follows:
제형예Formulation example 4 4
본 발명의 추출물을 함유한 화장료 중 맛사지 크림의 제형예는 다음과 같다:Examples of the formulation of the massage cream in the cosmetic composition containing the extract of the present invention are as follows:
제형예Formulation example 5 5
상기에서 수득한 추출물을 포함하는 화장료 중 팩의 제형예는 다음과 같다:Formulation examples of the pack in the cosmetic containing the extract obtained above are as follows:
실험예Experimental Example 2: 주름 개선 효과 평가 2: evaluation of wrinkle improvement effect
본 발명의 화장료의 주름 개선 효과를 실제 사용 테스트를 통하여 평가하였다. 제형예 3의 영양 크림을 사용하였다. 20명의 40-50세 여성을 무작위로 2개군으로 나누어 제형예 3의 크림을 매일 아침/저녁 2회씩 세안 후 크림 적당량을 눈가를 중심으로 2개월간 연속적으로 바르게 하였다. 각 피검자의 주름 개선 효과를 육안 관찰을 통하여 평가하였다. 실험 결과는 하기의 표 10에 기재되어 있다.The wrinkle improvement effect of the cosmetics of this invention was evaluated through the actual use test. The nutrition cream of Formulation Example 3 was used. Twenty 40-50 year old women were randomly divided into two groups, and the cream of Formulation Example 3 was washed twice daily for breakfast / evening, and then the appropriate amount of cream was applied continuously for 2 months around the eyes. Wrinkle improvement effect of each subject was evaluated through visual observation. The experimental results are shown in Table 10 below.
유효율(%)* efficacy
Yuhyoyul (%) *
(길경추출물 함유)Cream of Formulation Example 4
(With path extract)
(백하수오 추출물 함유)Cream of Formulation Example 4
(With white sewage extract)
(속단 추출물 함유)Cream of Formulation Example 4
(With fast extract)
(길경, 백하수오 및 속단 추출물 함유)Cream of Formulation Example 4
(Contains Gilkyung, Baek Sewao and Sokdan Extract)
*총 피검자 중에서 주름 개선 효과가 있는 것으로 판정된 피검자의 수의 비율 * Ratio of the number of subjects determined to have an anti-wrinkle effect among the total subjects
**추출물 대신에 증류수가 포함된 제형 이용
** Use formulation containing distilled water instead of extract
상기 표 10에서 볼 수 있듯이, 길경, 백하수오 및 속단 추출물 모두 실제 사람을 대상으로 한 실험에서 확실한 주름 개선 효과를 발휘하고 있다. 특히, 길경, 백하수오 및 속단 추출물 모두를 포함하는 크림 조성물의 경우, 매우 우수한 주름 개선 효과를 나타내었다.
As can be seen in Table 10, the Gilgyeong, Baek Sewao and Sokcho extract all exhibited a certain wrinkle improvement effect in the experiment on real people. In particular, in the case of a cream composition including all of Gil-Kil, Baek-Ha-Soh and Sok-Tan extract, it showed a very good wrinkle improvement effect.
실험예Experimental Example 3: 보습 효과(피부 도포) 3: moisturizing effect (skin application)
제형예 4의 영양 크림을 이용하여 보습 효과를 다음과 같이 평가하였다: 제형예 4의 크림 조성물에 대하여 피시험자 20명을 대상으로 관능 특성을 평가하였다. 크림 조성물을 피시험자의 손에 도포한 후, 미온수로 씻어 내었다. 평가항목은 피부에 보습감이 있다 및 보습효과가 지속되는가(lasting 효과) 이다.The moisturizing effect was evaluated using the nourishing cream of Formulation Example 4 as follows: The sensory properties of 20 creams were evaluated for the cream composition of Formulation Example 4. The cream composition was applied to the test subject's hands and then rinsed with lukewarm water. The evaluation items are moisturizing effect on the skin and lasting moisturizing effect.
피부에 보습감이 있다, 보습 효과의 지속성이 풍부하다고 회답한 경우를 +5점, 보습감이 없다, 보습감이 지속되지 않는다 등의 상태가 발생하는 경우를 0점으로 하여 그 중간을 총 4단계로 평가하고 전원의 점수 합계를 평가 결과로 하였다. 따라서 점수가 높은 만큼 평가가 높은 것을 나타낸다.+5 points for cases where there is a feeling of moisturizing, rich persistence of the moisturizing effect, and if the condition such as no moisturizing feeling or moisturizing feeling does not persist, 0 points are evaluated. And the sum total of the score of all the power was made into evaluation result. Therefore, the higher the score, the higher the evaluation.
(길경 추출물 함유)Formulation Example 4
(With Gilkyung extract)
(백하수오 추출물 함유)Formulation Example 4
(With white sewage extract)
(속단 추출물 함유)Formulation Example 4
(With fast extract)
(길경, 백하수오 및 속단 추출물 함유)Formulation Example 4
(Contains Gilkyung, Baek Sewao and Sokdan Extract)
*추출물 대신에 증류수가 포함된 제형 이용 * Formulation containing distilled water instead of extract
상기 표 11에서 확인할 수 있듯이, 본 발명의 조성물은 보습력이 매우 우수하고, 피부에 적용 후 그 보습성이 오랫동안 지속되었다.
As can be seen in Table 11, the composition of the present invention is very excellent in the moisturizing power, the moisture retention after application to the skin lasted for a long time.
실험예Experimental Example 4: 보습 효과(경구 투여) 4: moisturizing effect (oral administration)
추출물을 유효성분으로 함유하는 본 발명의 조성물이 경구 투여하는 경우에도 보습 효과를 갖는지 확인하기 위해 다음과 같은 조성으로 식품 조성물을 제조하였다: 추출물 50 중량%, 해조칼슘 24 중량%, 아르기닌 16 중량% 및 라이신 10 중량%. In order to check whether the composition of the present invention containing the extract as an active ingredient has a moisturizing effect even when administered orally, a food composition was prepared with the following composition: 50% by weight of extract, 24% by weight of algae calcium, 16% by weight of arginine And 10% by weight of lysine.
제조한 식품 조성물을 피검자에게 투여한 후 다음과 같이 수분 보유능을 측정하였다. 30명의 피시험자를 선별하여 15명에게는 아침, 저녁으로 본 발명의 조성물을 매일 경구 투여하였다. 22℃ 및 상대습도 45%의 항온 항습실에서 20명의 피시험자 하박 안쪽에 경구 투여전, 투여후 20일 시점에서의 피부 수분 함량을 수분 함량측정기(corneometer)로 측정하였으며, 아무런 처리를 하지 않은 정상 피부를 대조군으로 사용하였다. 실험 결과는 표 12에 정리되어 있다.After administering the prepared food composition to the subject was measured for water retention as follows. Thirty subjects were selected and 15 were orally administered the composition of the present invention every morning and evening. In the constant temperature and humidity room of 22 ° C and 45% RH, skin moisture content at 20 days after oral administration was measured by a corneometer before oral administration of 20 subjects under the Habakkuk, and no skin was treated. Was used as a control. The experimental results are summarized in Table 12.
표 12에 기재된 바와 같이, 본 발명의 조성물을 투여했을 때 투여하지 않은 대조군에 비하여 피부의 전기 전도도가 높고, 우수한 보습 효과를 나타냄을 알 수 있었다. 따라서, 본 발명의 추출물은 경구 투여하는 경우에도 피부 보습에 우수한 효과를 나타냄을 알 수 있다.
As shown in Table 12, it was found that when the composition of the present invention was administered, the electrical conductivity of the skin was higher than that of the control group which was not administered, and showed an excellent moisturizing effect. Therefore, it can be seen that the extract of the present invention shows an excellent effect on skin moisturization even when administered orally.
이상으로 본 발명의 특정한 부분을 상세히 기술하였는 바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적인 기술은 단지 바람직한 구현 예일 뿐이며, 이에 본 발명의 범위가 제한되는 것이 아닌 점은 명백하다. 따라서, 본 발명의 실질적인 범위는 첨부된 청구항과 그의 등가물에 의하여 정의된다고 할 것이다.Having described the specific part of the present invention in detail, it is apparent to those skilled in the art that the specific technology is merely a preferred embodiment, and the scope of the present invention is not limited thereto. Thus, the substantial scope of the present invention will be defined by the appended claims and equivalents thereof.
Claims (4)
Skin moisturizing composition comprising a soybean root extract.
The composition of claim 1, wherein the composition is a cosmetic composition.
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