KR100846125B1 - 피페린을 유효성분으로 포함하는 피부주름 개선용 조성물 - Google Patents
피페린을 유효성분으로 포함하는 피부주름 개선용 조성물 Download PDFInfo
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- KR100846125B1 KR100846125B1 KR1020070031899A KR20070031899A KR100846125B1 KR 100846125 B1 KR100846125 B1 KR 100846125B1 KR 1020070031899 A KR1020070031899 A KR 1020070031899A KR 20070031899 A KR20070031899 A KR 20070031899A KR 100846125 B1 KR100846125 B1 KR 100846125B1
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- piperine
- cinnarin
- skin
- present
- Prior art date
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Abstract
Description
비율 | 농도(%) | 인시던스 (Incidence(%)) | 콜라겐합성증가율(%) | |
시나린 : 피페린 | 시나린 | 피페린 | ||
1 : 1 | 0.75 | 0.75 | 123 | 23 |
1:1.5 | 0.6 | 0.9 | 125 | 25 |
1.5:1 | 0.9 | 0.6 | 122 | 22 |
1 : 2 | 0.5 | 1.0 | 142 | 42 |
2 : 1 | 1.0 | 0.5 | 123 | 23 |
1 : 2.5 | 0.43 | 1.07 | 132 | 32 |
2.5 : 1 | 1.07 | 0.43 | 121 | 21 |
시나린 단독 | 1.5 | 0 | 118 | 18 |
피페린 단독 | 0 | 1.5 | 121 | 21 |
대조군 | 0 | 0 | 100 | - |
비율 | 농도(%) | 인시던스 (Incidence(%)) | 콜라게네이즈 억제율(%) | |
시나린 : 피페린 | 시나린 | 피페린 | ||
1 : 1 | 0.75 | 0.75 | 74 | 26 |
1:1.5 | 0.6 | 0.9 | 72 | 28 |
1.5:1 | 0.9 | 0.6 | 76 | 24 |
1 : 2 | 0.5 | 1.0 | 52 | 48 |
2 : 1 | 1.0 | 0.5 | 79 | 21 |
1 : 2.5 | 0.43 | 1.07 | 69 | 31 |
2.5 : 1 | 1.07 | 0.43 | 85 | 15 |
시나린 단독 | 1.5 | 0 | 91 | 11 |
피페린 단독 | 0 | 1.5 | 89 | 9 |
대조군 | 0 | 0 | 100 | - |
시험항목 | 비교 제조예 1 (정제수를 함유한 영양 크림) | 비교 제조예 2 (시나린 1.5% 함유) | 비교 제조예 3 (피페린 1.5% 함유) | 제조예 A (시나린 0.5% + 피페린 1.0% 함유) | 제조예 B (시나린 0.75% + 피페린 0.75% 함유) |
피부탄력도 | 3.1 | 3.3 | 3.5 | 4.2 | 3.7 |
성분 | 함량(중량%) |
시나린(cynarin) | 0.50 |
피페린(piperine) | 1.00 |
호호바 오일 | 5.0 |
유동 파라핀 | 7.0 |
세틸아릴 알코올 | 2.0 |
폴리글리세릴-3 메칠 글루코스 디스테아레이 | 2.0 |
글리세릴 스테아레이트 | 0.5 |
스쿠알란 | 3.0 |
프로필렌글리콜 | 4.0 |
글리세린 | 5.0 |
트리에탄올 아민 | 0.3 |
카르복시 비닐폴리머 | 0.3 |
토코페릴 아세테이트 | 0.2 |
방부제, 향 | 미량 |
정제수 | 잔량 |
합계 | 100 |
성분 | 함량(중량%) |
시나린(cynarin) | 0.50 |
피페린(piperine) | 1.00 |
EDTA | 0.05 |
피이지 1500 | 4.00 |
카보머 | 0.16 |
1,3 부틸렌 글라이콜 | 3.00 |
폴리옥시에틸렌 하이드로제네이티드 캐스터 오일 | 0.45 |
트리에탄올아민 | 0.12 |
방부제, 향, 색소 | 미량 |
정제수 | 잔량 |
합계 | 100 |
성분 | 함량(중량%) |
시나린(cynarin) | 0.50 |
피페린(piperine) | 1.00 |
글리세린 | 2.00 |
1,3 부틸렌글라이콜 | 3.00 |
EDTA | 0.05 |
에탄올 | 7.00 |
폴리옥시에틸렌 하이드로제네이티드 캐스터 오일 | 0.40 |
방부제, 향, 색소 | 미량 |
정제수 | 잔량 |
합계 | 100 |
성분 | 함량 (중량%) |
시나린(cynarin) | 0.50 |
피페린(piperine) | 1.00 |
글리세린 | 3.00 |
카보머 | 0.10 |
산탄검 | 0.05 |
1,3 부틸렌 글라이콜 | 3.00 |
폴리글리세린-3 메칠글루코스 디스테아레이트 | 1.50 |
글리세린 스테아레이트 | 0.50 |
세테아릴 알코올 | 0.30 |
호호바 오일 | 3.00 |
유동 파라핀 | 2.00 |
스쿠알란 | 3.00 |
디메치콘 | 0.50 |
토코페릴아세테이트 | 0.20 |
트리에탄올아민 | 0.10 |
방부제, 향, 색소 | 미량 |
정제수 | 잔량 |
합계 | 100 |
성분 | 함량(중량 %) |
시나린(cynarin) | 0.50 |
피페린(piperine) | 1.00 |
EDTA | 0.02 |
1,3 부틸렌 글라이콜 | 4.00 |
카보머 | 0.60 |
글리세린 | 5.00 |
하이드록시에틸 셀룰로오스 | 0.15 |
트리에탄올 아민 | 0.50 |
트리클로산 | 0.20 |
에탄올 | 5.00 |
폴리옥시 에틸렌하이드로제네이티드 캐스터 오일 | 4.00 |
방부제, 향, 색소 | 미량 |
정제수 | 잔량 |
합계 | 100 |
성분 | 함량 (중량%) |
시나린(cynarin) | 0.50 |
피페린(piperine) | 1.00 |
EDTA | 0.05 |
포타슘-세틸포스페이트 | 0.30 |
글리세린 | 5.00 |
1,3 부틸렌 글라이콜 | 4.00 |
글리세릴스테아레이트/피이지-100 스테아레이트 | 0.50 |
소르비탄스테아레이트 | 0.30 |
호호바 오일 | 0.50 |
마카데미아 넛 오일 | 0.50 |
토코페릴아세테이트 | 0.50 |
부틸레이티드하이드록시 톨루엔 | 0.05 |
디메치콘 | 3.00 |
폴리아크릴아마이드/C13-14 이소파라핀/라우레쓰-7 | 1.50 |
글리세릴폴리메타아크릴레이트/프로필렌 글라이콜 | 5.00 |
에탄올 | 3.00 |
방부제, 향, 색소 | 미량 |
정제수 | 잔량 |
합계 | 100 |
성분 | 비교 제조예 1 | 비교 제조예 2 | 비교 제조예 3 |
함량(중량 %) | 함량(중량 %) | 함량(중량 %) | |
시나린(cynarin) | 0.0 | 1.5 | 0.0 |
피페린(piperine) | 0.0 | 0.0 | 1.5 |
호호바 오일 | 5.0 | 5.0 | 5.0 |
유동 파라핀 | 7.0 | 7.0 | 7.0 |
세틸아릴 알코올 | 2.0 | 2.0 | 2.0 |
폴리글리세릴-3 메칠 글루코스 디스테아레이트 | 2.0 | 2.0 | 2.0 |
글리세릴 스테아레이트 | 0.5 | 0.5 | 0.5 |
스쿠알란 | 3.0 | 3.0 | 3.0 |
프로필렌 글리콜 | 4.0 | 4.0 | 4.0 |
글리세린 | 5.0 | 5.0 | 5.0 |
트리 에탄올 아민 | 0.3 | 0.3 | 0.3 |
카르복시 비닐폴리머 | 0.3 | 0.3 | 0.3 |
토코페릴 아세테이트 | 0.2 | 0.2 | 0.2 |
방부제, 향 | 미량 | 미량 | 미량 |
정제수 | 잔량 | 잔량 | 잔량 |
합계 | 100 | 100 | 100 |
시험물질 | 반응이 나타난 피검자 수 | 평균반응도 | ||||||||
1주 | 2주 | 3주 | ||||||||
1차 | 2차 | 3차 | 4차 | 5차 | 6차 | 7차 | 8차 | 9차 | ||
± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ± + ++ | ||
대조군 (스쿠알렌) | 2 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.18 |
시나린함유 조성물(1.5%) [시험군 1] | 2 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.18 |
시나린함유 조성물 (6%) [시험군 2] | 2 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.18 |
시나린 함유 조성물(12%) [시험군 3] | 2 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.18 |
피페린함유 조성물(1.5%) [시험군 1] | 2 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.18 |
피페린함유 조성물(6.0%) [시험군 4] | 2 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.18 |
피페린함유 조성물(12%) [시험군 5] | 2 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.18 |
시나린(0.5%)+피페린(1.0%) [시험군 6] | 2 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.18 |
시나린(2.0%)+피페린(4.0%) [시험군 7] | 2 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.18 |
시나린(4.0%)+피레린(8.0%) [시험군 8] | 2 - - | 0 - - | - - - | - - - | - - - | - - - | - - - | - - - | - - - | 0.18 |
피검인원 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | - |
Claims (10)
- 피페린(piperine) 및 시나린(cynarin)을 유효성분으로 포함하는 피부주름 개선용 조성물.
- 삭제
- 삭제
- 제 1 항에 있어서, 상기 시나린 및 피페린은 1:1.5-1:2.5의 중량비로 조성물에 포함되는 것을 특징으로 하는 조성물.
- 제 4 항에 있어서, 상기 시나린 및 피페린은 1:2의 중량비로 조성물에 포함되는 것을 특징으로 하는 조성물.
- 제 1 항에 있어서, 상기 시나린 및 피페린은 조성물의 총 중량을 기준으로 0.001-20.0 중량%로 포함되는 것을 특징으로 하는 조성물.
- 제 1 항 및 제 4 항 내지 제 6 항 중 어느 한 항에 있어서, 상기 조성물은 화장료 조성물인 것을 특징으로 하는 조성물.
- 제 7 항에 있어서, 상기 조성물은 용액, 현탁액, 유탁액, 페이스트, 겔, 크림, 로션, 파우더, 비누, 계면활성제-함유 클린싱, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션 및 스프레이로 구성된 군으로부터 선택되는 제형을 갖는 것을 특징으로 하는 조성물.
- 제 1 항 및 제 4 항 내지 제 6 항 중 어느 한 항에 있어서, 상기 조성물은 약제학적 조성물인 것을 특징으로 하는 조성물.
- 제 1 항 및 제 4 항 내지 제 6 항 중 어느 한 항에 있어서, 상기 조성물은 식품 조성물인 것을 특징으로 하는 조성물.
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WO2011110793A2 (fr) * | 2010-03-12 | 2011-09-15 | Societe Industrielle Limousine D'application Biologique, Dite Silab | Principe actif cosmetique raffermissant issu de piper nigrum, compositions cosmetiques l'incluant et utilisation |
ITTO20120714A1 (it) * | 2012-08-08 | 2014-02-09 | Minerva Res Labs Ltd | Integratore alimentare per migliorare la salute del tessuto connettivo |
KR20140057040A (ko) * | 2012-11-02 | 2014-05-12 | 연세대학교 산학협력단 | 피페린계 화합물을 유효성분으로 포함하는 피부노화 개선용 조성물 |
KR20150057913A (ko) * | 2013-11-18 | 2015-05-28 | 주식회사 엘지생활건강 | 항염증 또는 피부 미백용 조성물 |
KR20150087614A (ko) * | 2014-01-22 | 2015-07-30 | 주식회사 엘지생활건강 | 피페린을 유효성분으로 포함하는 체모 성장 억제용 조성물 |
WO2019027167A1 (ko) * | 2017-08-02 | 2019-02-07 | 포항공과대학교 산학협력단 | 피페로닐산을 유효성분으로 포함하는 항노화 또는 피부재생용 조성물 |
KR20220099773A (ko) * | 2021-01-07 | 2022-07-14 | 전남대학교산학협력단 | 세노테라피용 조성물 |
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WO2011110793A2 (fr) * | 2010-03-12 | 2011-09-15 | Societe Industrielle Limousine D'application Biologique, Dite Silab | Principe actif cosmetique raffermissant issu de piper nigrum, compositions cosmetiques l'incluant et utilisation |
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ITTO20120714A1 (it) * | 2012-08-08 | 2014-02-09 | Minerva Res Labs Ltd | Integratore alimentare per migliorare la salute del tessuto connettivo |
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KR102132833B1 (ko) | 2013-11-18 | 2020-07-13 | 주식회사 엘지생활건강 | 항염증 또는 피부 미백용 조성물 |
KR20150087614A (ko) * | 2014-01-22 | 2015-07-30 | 주식회사 엘지생활건강 | 피페린을 유효성분으로 포함하는 체모 성장 억제용 조성물 |
KR101587608B1 (ko) | 2014-01-22 | 2016-01-21 | 주식회사 엘지생활건강 | 피페린을 유효성분으로 포함하는 체모 성장 억제용 조성물 |
WO2019027167A1 (ko) * | 2017-08-02 | 2019-02-07 | 포항공과대학교 산학협력단 | 피페로닐산을 유효성분으로 포함하는 항노화 또는 피부재생용 조성물 |
US11439577B2 (en) | 2017-08-02 | 2022-09-13 | Hesed Bio Co., Ltd. | Anti-aging or skin-regenerating composition comprising piperonylic acid as effective ingredient |
KR20220099773A (ko) * | 2021-01-07 | 2022-07-14 | 전남대학교산학협력단 | 세노테라피용 조성물 |
KR102625575B1 (ko) * | 2021-01-07 | 2024-01-16 | 전남대학교산학협력단 | 세노테라피용 조성물 |
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