KR100734193B1 - 항우울제의 제어된 전달 - Google Patents
항우울제의 제어된 전달 Download PDFInfo
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- KR100734193B1 KR100734193B1 KR1020017005537A KR20017005537A KR100734193B1 KR 100734193 B1 KR100734193 B1 KR 100734193B1 KR 1020017005537 A KR1020017005537 A KR 1020017005537A KR 20017005537 A KR20017005537 A KR 20017005537A KR 100734193 B1 KR100734193 B1 KR 100734193B1
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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Abstract
Description
정제 파라미터(약물 층)의 초기 조정을 수행하여 균일한 표적 약물 층 중량, 전형적으로 각각의 정제 중 약물 100 mg으로 코어를 생성했다. 약물 층을 삼투성 층에 결합시키는 정제 파라미터의 제 2 층 (삼투성 푸쉬 층) 조정을 수행하여 일정한 최종 코어 중량, 두께, 경도, 및 파쇄성을 갖는 코어를 생성했다. 충진 공간 및/또는 힘 설정을 변화시켜서 이전의 파라미터를 조정할 수 있다. 약물 100 mg 의 표적량을 함유하는 전형적인 정제는 길이가 대략 0.465 인치이고 직경이 대략 0.188 인치일 것이다.
Claims (27)
- 제 1 항에 있어서, 화합물이 2-[3-[4-(3-클로로페닐)-피페라지닐]프로필]-5-에틸-4-(2-페녹시에틸)-2H-1,2,4-트리아졸-3(4H)-온인 것을 특징으로 하는 제형.
- 제 1 항에 있어서, 화합물이 2-[3-[4-(3-클로로페닐)-피페라지닐]프로필]-5-에틸-4-(2-페녹시에틸)-2H-1,2,4-트리아졸-3(4H)-온 히드로클로라이드인 것을 특징으로 하는 제형.
- 제 1 항에 있어서, 연장된 시간이 6 시간 이상인 것을 특징으로 하는 제형.
- 제 1 항에 있어서, 연장된 시간이 8 시간 이상인 것을 특징으로 하는 제형.
- 제 1 항에 있어서, 연장된 시간이 10 시간 이상인 것을 특징으로 하는 제형.
- 제 1 항에 있어서, 화합물이 3 mg/시 이상의 속도로 방출되는 것을 특징으로 하는 제형.
- 제 7 항에 있어서, 연장된 시간이 6 시간 이상인 것을 특징으로 하는 제형.
- 삭제
- 삭제
- 삭제
- 제 1 항에 있어서, 벽과 약물 층 사이에 유동 촉진 층을 포함하는 것을 특징으로 하는 제형.
- 제 1 항 내지 제 8 항 및 제 12 항 중 어느 한 항에 있어서, 화합물이 실질적으로 건조한 상태 또는 현탁액 또는 슬러리로 분배되는 것을 특징으로 하는 제형.
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 제 1 항에 있어서, 제형이 화합물 50 내지 1200 mg 을 함유하는 것을 특징으로 하는 제형.
- 제 1 항에 있어서, 제형이 삼투성 물질을 포함하는 것을 특징으로 하는 제형.
- 제 1 항에 있어서, 연장된 시간에 걸쳐 대상자의 혈장 내의 정상 상태의 화합물 농도가 5 ng/ml 내지 2500 ng/ml 로 유지되고, [Cmax - Cmin]/Cmin 로부터 형성된 몫이 3 이하인 것을 특징으로 하는 제형.
- 삭제
- 삭제
- 제 23 항에 있어서, 몫이 2 이하인 것을 특징으로 하는 제형.
- 제 23 항에 있어서, 몫이 1 이하인 것을 특징으로 하는 제형.
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JP (1) | JP4711510B2 (ko) |
KR (2) | KR100734193B1 (ko) |
AT (1) | ATE323493T1 (ko) |
AU (1) | AU1230800A (ko) |
CA (1) | CA2349719C (ko) |
CY (1) | CY1105463T1 (ko) |
DE (1) | DE69930952T2 (ko) |
DK (1) | DK1126853T3 (ko) |
ES (1) | ES2260962T3 (ko) |
HK (1) | HK1038515A1 (ko) |
PT (1) | PT1126853E (ko) |
WO (1) | WO2000025790A1 (ko) |
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US20050232995A1 (en) * | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
ATE373472T1 (de) * | 2002-07-29 | 2007-10-15 | Alza Corp | Verfahren und dosierformen für die kontrollierte abgabe von paliperidon |
NZ537543A (en) * | 2002-07-29 | 2007-08-31 | Alza Corp | Formulations and high dose osmotic dosage forms for controlled delivery of topiramate |
WO2005072079A2 (en) | 2003-09-26 | 2005-08-11 | Alza Coporation | Drug coating providing high drug loading and methods for providing the same |
AU2004275835B2 (en) * | 2003-09-26 | 2011-06-23 | Alza Corporation | Controlled release formulations exhibiting an ascending rate of release |
CN101703488B (zh) * | 2008-12-16 | 2013-02-20 | 北京科信必成医药科技发展有限公司 | 具有润滑层结构的双层渗透泵控释片及其制备方法 |
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US5330762A (en) * | 1992-02-27 | 1994-07-19 | Alza Corporation | Tandospiaine antidepressive therapy |
WO1997047285A1 (en) * | 1996-06-10 | 1997-12-18 | Depomed, Inc. | Gastric-retentive oral controlled drug delivery system with enhanced retention properties |
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US5082668A (en) * | 1983-05-11 | 1992-01-21 | Alza Corporation | Controlled-release system with constant pushing source |
US5116852A (en) * | 1990-12-03 | 1992-05-26 | Bristol-Myers Squibb Co. | Treatment of sleep disorders |
ZA946663B (en) * | 1993-08-31 | 1995-03-31 | Alza Corp | Dispenser containing hydrophobic agent |
US5698224A (en) * | 1994-06-27 | 1997-12-16 | Alza Corporation | Tacrine therapy |
CA2160423A1 (en) * | 1994-11-02 | 1996-05-03 | Hemant N. Joshi | Salts of nefazodone having improved dissolution rates |
EP0977558B1 (en) * | 1996-02-15 | 2003-10-01 | Janssen Pharmaceutica N.V. | Use of 5ht4 receptor antagonists for overcoming gastrointestinal effects of serotonin reuptake inhibitors |
US6143325A (en) * | 1998-06-05 | 2000-11-07 | Bristol-Myers Squibb Company | Nefazodone dosage form |
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1999
- 1999-10-26 WO PCT/US1999/025017 patent/WO2000025790A1/en not_active Application Discontinuation
- 1999-10-26 CA CA002349719A patent/CA2349719C/en not_active Expired - Lifetime
- 1999-10-26 DK DK99971322T patent/DK1126853T3/da active
- 1999-10-26 AT AT99971322T patent/ATE323493T1/de active
- 1999-10-26 PT PT99971322T patent/PT1126853E/pt unknown
- 1999-10-26 KR KR1020017005537A patent/KR100734193B1/ko active IP Right Grant
- 1999-10-26 AU AU12308/00A patent/AU1230800A/en not_active Abandoned
- 1999-10-26 DE DE69930952T patent/DE69930952T2/de not_active Expired - Lifetime
- 1999-10-26 JP JP2000579231A patent/JP4711510B2/ja not_active Expired - Lifetime
- 1999-10-26 KR KR1020077006959A patent/KR20070040421A/ko not_active Application Discontinuation
- 1999-10-26 EP EP99971322A patent/EP1126853B1/en not_active Expired - Lifetime
- 1999-10-26 ES ES99971322T patent/ES2260962T3/es not_active Expired - Lifetime
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2002
- 2002-01-15 HK HK02100276A patent/HK1038515A1/xx not_active IP Right Cessation
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2006
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5330762A (en) * | 1992-02-27 | 1994-07-19 | Alza Corporation | Tandospiaine antidepressive therapy |
WO1997047285A1 (en) * | 1996-06-10 | 1997-12-18 | Depomed, Inc. | Gastric-retentive oral controlled drug delivery system with enhanced retention properties |
Also Published As
Publication number | Publication date |
---|---|
EP1126853B1 (en) | 2006-04-19 |
ATE323493T1 (de) | 2006-05-15 |
HK1038515A1 (en) | 2002-03-22 |
JP4711510B2 (ja) | 2011-06-29 |
WO2000025790A1 (en) | 2000-05-11 |
DE69930952D1 (de) | 2006-05-24 |
KR20010075677A (ko) | 2001-08-09 |
CA2349719C (en) | 2009-06-02 |
DK1126853T3 (da) | 2006-08-14 |
CA2349719A1 (en) | 2000-05-11 |
DE69930952T2 (de) | 2006-08-31 |
KR20070040421A (ko) | 2007-04-16 |
ES2260962T3 (es) | 2006-11-01 |
CY1105463T1 (el) | 2010-04-28 |
EP1126853A1 (en) | 2001-08-29 |
JP2002528505A (ja) | 2002-09-03 |
AU1230800A (en) | 2000-05-22 |
PT1126853E (pt) | 2006-07-31 |
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