KR100645268B1 - 동물약품용 약제학적 조성물 - Google Patents
동물약품용 약제학적 조성물 Download PDFInfo
- Publication number
- KR100645268B1 KR100645268B1 KR1020050028262A KR20050028262A KR100645268B1 KR 100645268 B1 KR100645268 B1 KR 100645268B1 KR 1020050028262 A KR1020050028262 A KR 1020050028262A KR 20050028262 A KR20050028262 A KR 20050028262A KR 100645268 B1 KR100645268 B1 KR 100645268B1
- Authority
- KR
- South Korea
- Prior art keywords
- weight
- acetaminophen
- pharmaceutical composition
- polysorbate
- florfenicol
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims abstract description 38
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 20
- 229940079593 drug Drugs 0.000 title claims description 28
- 241001465754 Metazoa Species 0.000 title claims description 22
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims abstract description 74
- 229960005489 paracetamol Drugs 0.000 claims abstract description 37
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- 125000005456 glyceride group Chemical group 0.000 claims abstract description 16
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 15
- 235000010445 lecithin Nutrition 0.000 claims abstract description 15
- 239000000787 lecithin Substances 0.000 claims abstract description 15
- 229940067606 lecithin Drugs 0.000 claims abstract description 15
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229920000136 polysorbate Polymers 0.000 claims abstract description 11
- 229950008882 polysorbate Drugs 0.000 claims abstract description 11
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims description 8
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 7
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 6
- 229940068968 polysorbate 80 Drugs 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 4
- HFHFGHLXUCOHLN-UHFFFAOYSA-N 2-fluorophenol Chemical compound OC1=CC=CC=C1F HFHFGHLXUCOHLN-UHFFFAOYSA-N 0.000 claims description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 2
- 229940068977 polysorbate 20 Drugs 0.000 claims description 2
- -1 Polyethylene Polymers 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical group OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 abstract description 21
- 229960003760 florfenicol Drugs 0.000 abstract description 21
- 239000000203 mixture Substances 0.000 abstract description 10
- 239000007908 nanoemulsion Substances 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 230000035699 permeability Effects 0.000 abstract description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 10
- 239000004480 active ingredient Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- FZERHIULMFGESH-UHFFFAOYSA-N N-phenylacetamide Chemical compound CC(=O)NC1=CC=CC=C1 FZERHIULMFGESH-UHFFFAOYSA-N 0.000 description 4
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 229960001413 acetanilide Drugs 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000002445 nipple Anatomy 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000009278 visceral effect Effects 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 239000008384 inner phase Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000008385 outer phase Substances 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L21/00—Joints with sleeve or socket
- F16L21/06—Joints with sleeve or socket with a divided sleeve or ring clamping around the pipe-ends
- F16L21/065—Joints with sleeve or socket with a divided sleeve or ring clamping around the pipe-ends tightened by tangentially-arranged threaded pins
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B2/00—Friction-grip releasable fastenings
- F16B2/02—Clamps, i.e. with gripping action effected by positive means other than the inherent resistance to deformation of the material of the fastening
- F16B2/06—Clamps, i.e. with gripping action effected by positive means other than the inherent resistance to deformation of the material of the fastening external, i.e. with contracting action
- F16B2/065—Clamps, i.e. with gripping action effected by positive means other than the inherent resistance to deformation of the material of the fastening external, i.e. with contracting action using screw-thread elements
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L41/00—Branching pipes; Joining pipes to walls
- F16L41/02—Branch units, e.g. made in one piece, welded, riveted
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
성상 | 안정성(아세트아미노펜 함량%) | |||||||
상온 | 고온(45도) | |||||||
층분리 | 석출 | 초기 | 1년 | 2년 | 초기 | 1년 | 2년 | |
실시예1 | 양호 | 양호 | 100 | 100 | 100 | 100 | 100 | 100 |
실시예2 | 양호 | 양호 | 100 | 100 | 100 | 100 | 100 | 100 |
실시예3 | 양호 | 양호 | 100 | 100 | 100 | 100 | 100 | 100 |
성상 | 안정성(플로르페니콜 함량%) | |||||||
상온 | 고온(45도) | |||||||
층분리 | 석출 | 초기 | 1년 | 2년 | 초기 | 1년 | 2년 | |
실시예1 | 양호 | 양호 | 100 | 98 | 95 | 100 | 97 | 93 |
실시예2 | 양호 | 양호 | 100 | 99 | 94 | 100 | 98 | 91 |
실시예3 | 양호 | 양호 | 100 | 97 | 93 | 100 | 96 | 90 |
Claims (5)
- 플로르페니콜 5-40중량%, 2-피롤리디논(2-pyrrolidinone) 10-30중량%, 에탄올 10-30중량%, 레시틴 0.1-1중량%, 글리세라이드 10-30중량% 및 폴리솔베이트 10-30중량%를 포함하는 동물약품용 약제학적 조성물.
- 아세트아미노펜 5-40중량%, 2-피롤리디논(2-pyrrolidinone) 10-30중량%, 에탄올 10-30중량%, 레시틴 0.1-1중량%, 글리세라이드 10-30중량% 및 폴리솔베이트 10-30중량%를 포함하는 동물약품용 약제학적 조성물.
- 제 1 항 또는 제 2 항에 있어서,상기 글리세라이드는 PEG-6 카프릴릭/카프릭 글리세라이드(Polyethylene Glycol-6 Caprylic/Capric Glyceride)인 동물약품용 약제학적 조성물.
- 제 1 항 또는 제 2 항에 있어서,상기 폴리솔베이트는 폴리솔베이트 20(Polyoxyethylene (20) sorbitan monolaurate) 또는 폴리솔베이트 80(Polyoxyethylene (20) sorbitan monooleate)인 동물약품용 약제학적 조성물.
- 제 1 항 또는 제 2 항에 있어서,점도가 1.0 내지 15cPs(센티포아즈)인 동물약품용 약제학적 조성물.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020050028262A KR100645268B1 (ko) | 2005-04-04 | 2005-04-04 | 동물약품용 약제학적 조성물 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020050028262A KR100645268B1 (ko) | 2005-04-04 | 2005-04-04 | 동물약품용 약제학적 조성물 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20060105826A KR20060105826A (ko) | 2006-10-11 |
KR100645268B1 true KR100645268B1 (ko) | 2006-11-14 |
Family
ID=37635282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020050028262A KR100645268B1 (ko) | 2005-04-04 | 2005-04-04 | 동물약품용 약제학적 조성물 |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR100645268B1 (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2925335B1 (fr) * | 2007-12-21 | 2010-03-19 | Ceva Sante Animale | Compositions orales liquides de florfenicol diluables dans l'eau de boisson |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR960005705B1 (ko) * | 1990-08-29 | 1996-05-01 | 쉐링 코포레이션 | 플로르페니콜의 약제학적 조성물 |
KR100548948B1 (ko) | 2003-11-24 | 2006-02-02 | 주식회사 한동 | 플로르페니콜의 약제학적 조성물 |
-
2005
- 2005-04-04 KR KR1020050028262A patent/KR100645268B1/ko active IP Right Grant
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR960005705B1 (ko) * | 1990-08-29 | 1996-05-01 | 쉐링 코포레이션 | 플로르페니콜의 약제학적 조성물 |
KR100548948B1 (ko) | 2003-11-24 | 2006-02-02 | 주식회사 한동 | 플로르페니콜의 약제학적 조성물 |
Also Published As
Publication number | Publication date |
---|---|
KR20060105826A (ko) | 2006-10-11 |
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