KR100535554B1 - 소아과 수술에서의 레보부피바카인의 용도 - Google Patents
소아과 수술에서의 레보부피바카인의 용도 Download PDFInfo
- Publication number
- KR100535554B1 KR100535554B1 KR10-1999-7007973A KR19997007973A KR100535554B1 KR 100535554 B1 KR100535554 B1 KR 100535554B1 KR 19997007973 A KR19997007973 A KR 19997007973A KR 100535554 B1 KR100535554 B1 KR 100535554B1
- Authority
- KR
- South Korea
- Prior art keywords
- levobupivacaine
- bupivacaine
- hcl
- administration
- surgery
- Prior art date
Links
- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 title claims abstract description 44
- 229960004288 levobupivacaine Drugs 0.000 title claims abstract description 43
- 238000001356 surgical procedure Methods 0.000 title claims abstract description 12
- 206010002091 Anaesthesia Diseases 0.000 claims abstract description 5
- 230000037005 anaesthesia Effects 0.000 claims abstract description 5
- 230000036592 analgesia Effects 0.000 claims abstract description 4
- 238000001802 infusion Methods 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 23
- 229960003150 bupivacaine Drugs 0.000 description 19
- 238000002474 experimental method Methods 0.000 description 10
- 230000004083 survival effect Effects 0.000 description 10
- 210000003169 central nervous system Anatomy 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 230000000903 blocking effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 206010019909 Hernia Diseases 0.000 description 3
- 230000003444 anaesthetic effect Effects 0.000 description 3
- 231100000433 cytotoxic Toxicity 0.000 description 3
- 230000001472 cytotoxic effect Effects 0.000 description 3
- 230000001738 genotoxic effect Effects 0.000 description 3
- 208000019622 heart disease Diseases 0.000 description 3
- 230000002085 persistent effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- FMMWHPNWAFZXNH-UHFFFAOYSA-N Benz[a]pyrene Chemical compound C1=C2C3=CC=CC=C3C=C(C=C3)C2=C2C3=CC=CC2=C1 FMMWHPNWAFZXNH-UHFFFAOYSA-N 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 229940124558 contraceptive agent Drugs 0.000 description 2
- 239000003433 contraceptive agent Substances 0.000 description 2
- 239000003193 general anesthetic agent Substances 0.000 description 2
- 231100000025 genetic toxicology Toxicity 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 210000000278 spinal cord Anatomy 0.000 description 2
- 210000001364 upper extremity Anatomy 0.000 description 2
- 230000035899 viability Effects 0.000 description 2
- YHQDZJICGQWFHK-UHFFFAOYSA-N 4-nitroquinoline N-oxide Chemical compound C1=CC=C2C([N+](=O)[O-])=CC=[N+]([O-])C2=C1 YHQDZJICGQWFHK-UHFFFAOYSA-N 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 206010013710 Drug interaction Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 206010027603 Migraine headaches Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- LEBVLXFERQHONN-MRXNPFEDSA-N dextrobupivacaine Chemical compound CCCCN1CCCC[C@@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-MRXNPFEDSA-N 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 229960002428 fentanyl Drugs 0.000 description 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
- 229940005494 general anesthetics Drugs 0.000 description 1
- 231100000024 genotoxic Toxicity 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000004013 groin Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003601 intercostal effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 231100000299 mutagenicity Toxicity 0.000 description 1
- 230000007886 mutagenicity Effects 0.000 description 1
- 230000036438 mutation frequency Effects 0.000 description 1
- 231100000376 mutation frequency increase Toxicity 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 231100000628 reference dose Toxicity 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (6)
- 레보부피바카인을 활성성분으로 포함하는, 인간 소아과 수술에서 마취 또는 무통증을 제공하기 위한 약제학적 조성물.
- 제 1항에 있어서, 대상환자가 신생아인 약제학적 조성물.
- 제 1항에 있어서, 대상환자가 0.5 내지 12세인 약제학적 조성물.
- 제 1항 내지 제 3항 중 어느 하나의 항에 있어서, 투여가 경막외 주입에 의한 것인 약제학적 조성물.
- 제 1항 내지 제 3항 중 어느 하나의 항에 있어서, 투여가 상부 또는 하부 말단 차단으로 이루어지는 약제학적 조성물.
- 제 1항 내지 제 3항 중 어느 하나의 항에 있어서, 수술 후의 통증 제어에 사용되는 약제학적 조성물.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9704351.7A GB9704351D0 (en) | 1997-03-03 | 1997-03-03 | Levobupivacaine and its use |
GB9704351.7 | 1997-03-03 | ||
PCT/GB1998/000664 WO1998038999A1 (en) | 1997-03-03 | 1998-03-03 | The use of levobupivacaine in paediatric surgery |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20000075894A KR20000075894A (ko) | 2000-12-26 |
KR100535554B1 true KR100535554B1 (ko) | 2005-12-08 |
Family
ID=10808602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR10-1999-7007973A KR100535554B1 (ko) | 1997-03-03 | 1998-03-03 | 소아과 수술에서의 레보부피바카인의 용도 |
Country Status (21)
Country | Link |
---|---|
US (1) | US5910502A (ko) |
EP (1) | EP0981348B1 (ko) |
JP (1) | JP2001513814A (ko) |
KR (1) | KR100535554B1 (ko) |
CN (1) | CN1107504C (ko) |
AT (1) | ATE240731T1 (ko) |
AU (1) | AU719483B2 (ko) |
BR (1) | BR9808302A (ko) |
CA (1) | CA2279498C (ko) |
DE (1) | DE69814852T2 (ko) |
DK (1) | DK0981348T3 (ko) |
ES (1) | ES2199424T3 (ko) |
GB (1) | GB9704351D0 (ko) |
HK (1) | HK1022649A1 (ko) |
HU (1) | HU224227B1 (ko) |
IL (1) | IL131086A0 (ko) |
NO (1) | NO324215B1 (ko) |
PL (1) | PL190896B1 (ko) |
PT (1) | PT981348E (ko) |
WO (1) | WO1998038999A1 (ko) |
ZA (1) | ZA981780B (ko) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4575592B2 (ja) | 1997-11-14 | 2010-11-04 | パシラ ファーマシューティカルズ インコーポレーテッド | 多小胞リポソームの製造 |
IL140899A0 (en) | 1998-07-17 | 2002-02-10 | Skyepharma Inc | Lipid/polymer containing pharmaceutical compositions and processes for the preparation thereof |
EP1395243A2 (en) * | 2001-05-31 | 2004-03-10 | SkyePharma Inc. | Encapsulation of nanosuspensions in liposomes and microspheres |
CN1703197A (zh) * | 2001-11-14 | 2005-11-30 | 阿尔扎有限公司 | 可注射的长效组合物和其使用 |
US20070196415A1 (en) * | 2002-11-14 | 2007-08-23 | Guohua Chen | Depot compositions with multiple drug release rate controls and uses thereof |
AU2002359407B2 (en) * | 2001-11-14 | 2008-02-28 | Durect Corporation | Catheter injectable depot compositions and uses thereof |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
MXPA05001242A (es) * | 2002-07-31 | 2005-06-08 | Alza Corp | Composiciones de deposito inyectable y usos de las mismas. |
EP1539101B1 (en) * | 2002-07-31 | 2009-01-07 | ALZA Corporation | Injectable multimodal polymer depot compositions and uses thereof |
US20060142234A1 (en) * | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
CN105764491A (zh) | 2013-12-09 | 2016-07-13 | 度瑞公司 | 药物活性剂复合物、聚合物复合物,以及包括其的组合物和方法 |
CN115666621A (zh) | 2020-01-13 | 2023-01-31 | 度勒科特公司 | 具有减少的杂质的持续释放药物递送***及相关方法 |
US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE40994T1 (de) * | 1983-08-01 | 1989-03-15 | Astra Laekemedel Ab | L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung. |
ATE210982T1 (de) * | 1993-10-13 | 2002-01-15 | Darwin Discovery Ltd | Analgetisches mittel und dessen verwendung |
WO1996032109A2 (en) * | 1995-04-13 | 1996-10-17 | Chiroscience Limited | Levobupivacaine and its use as an anaesthetic in pregnant women |
-
1997
- 1997-03-03 GB GBGB9704351.7A patent/GB9704351D0/en active Pending
-
1998
- 1998-03-03 DE DE69814852T patent/DE69814852T2/de not_active Expired - Lifetime
- 1998-03-03 HU HU0000963A patent/HU224227B1/hu active IP Right Grant
- 1998-03-03 PT PT98908230T patent/PT981348E/pt unknown
- 1998-03-03 WO PCT/GB1998/000664 patent/WO1998038999A1/en active IP Right Grant
- 1998-03-03 DK DK98908230T patent/DK0981348T3/da active
- 1998-03-03 JP JP53827698A patent/JP2001513814A/ja active Pending
- 1998-03-03 CA CA002279498A patent/CA2279498C/en not_active Expired - Lifetime
- 1998-03-03 EP EP98908230A patent/EP0981348B1/en not_active Expired - Lifetime
- 1998-03-03 BR BR9808302-3A patent/BR9808302A/pt not_active Application Discontinuation
- 1998-03-03 AU AU66310/98A patent/AU719483B2/en not_active Expired
- 1998-03-03 AT AT98908230T patent/ATE240731T1/de active
- 1998-03-03 CN CN98802993A patent/CN1107504C/zh not_active Expired - Lifetime
- 1998-03-03 ES ES98908230T patent/ES2199424T3/es not_active Expired - Lifetime
- 1998-03-03 PL PL335563A patent/PL190896B1/pl unknown
- 1998-03-03 ZA ZA981780A patent/ZA981780B/xx unknown
- 1998-03-03 IL IL13108698A patent/IL131086A0/xx not_active IP Right Cessation
- 1998-03-03 KR KR10-1999-7007973A patent/KR100535554B1/ko not_active IP Right Cessation
- 1998-03-03 US US09/034,070 patent/US5910502A/en not_active Expired - Lifetime
-
1999
- 1999-09-02 NO NO19994259A patent/NO324215B1/no not_active IP Right Cessation
-
2000
- 2000-03-21 HK HK00101736A patent/HK1022649A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2279498C (en) | 2009-05-26 |
PL190896B1 (pl) | 2006-02-28 |
AU719483B2 (en) | 2000-05-11 |
NO324215B1 (no) | 2007-09-10 |
HU224227B1 (hu) | 2005-06-28 |
GB9704351D0 (en) | 1997-04-23 |
EP0981348A1 (en) | 2000-03-01 |
CN1249683A (zh) | 2000-04-05 |
DE69814852D1 (de) | 2003-06-26 |
WO1998038999A1 (en) | 1998-09-11 |
HUP0000963A3 (en) | 2000-10-30 |
HK1022649A1 (en) | 2000-08-18 |
PL335563A1 (en) | 2000-05-08 |
CA2279498A1 (en) | 1998-09-11 |
NO994259L (no) | 1999-11-02 |
AU6631098A (en) | 1998-09-22 |
ATE240731T1 (de) | 2003-06-15 |
US5910502A (en) | 1999-06-08 |
DK0981348T3 (da) | 2003-09-15 |
ZA981780B (en) | 1999-03-03 |
PT981348E (pt) | 2003-09-30 |
HUP0000963A2 (hu) | 2000-09-28 |
DE69814852T2 (de) | 2004-01-22 |
CN1107504C (zh) | 2003-05-07 |
EP0981348B1 (en) | 2003-05-21 |
IL131086A0 (en) | 2001-01-28 |
JP2001513814A (ja) | 2001-09-04 |
NO994259D0 (no) | 1999-09-02 |
ES2199424T3 (es) | 2004-02-16 |
BR9808302A (pt) | 2000-05-16 |
KR20000075894A (ko) | 2000-12-26 |
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