KR100483328B1 - Composition for Promotion of Fatigue Recovery And Process for Preparation Thereof, Medicine of Fatigue Recovery Using The Same - Google Patents

Composition for Promotion of Fatigue Recovery And Process for Preparation Thereof, Medicine of Fatigue Recovery Using The Same Download PDF

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KR100483328B1
KR100483328B1 KR10-2002-0076360A KR20020076360A KR100483328B1 KR 100483328 B1 KR100483328 B1 KR 100483328B1 KR 20020076360 A KR20020076360 A KR 20020076360A KR 100483328 B1 KR100483328 B1 KR 100483328B1
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fatigue
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김형민
홍승헌
구현나
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Abstract

본 발명은 유효 성분으로써 고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염, 산약 등을 함유하는 피로 회복에 증진 효과를 가지는 피로 회복 기능을 가지는 조성물 및 그 제조 방법과 이를 이용한 피로 회복제에 관한 것이다.The present invention relates to a composition having a fatigue restoring function having an enhancement effect on fatigue recovery containing high purity chitosan, shiitake mushroom extract, garlic extract, bamboo salt, powder, etc. as an active ingredient, and a method for preparing the same and a fatigue recovering agent using the same .

본 발명은 상기 고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염 및 산약으로 조성되며, 각각은 1∼10 : 0.5∼5 : 0.5∼5 : 0.1∼1 : 0.1∼1의 중량비로 조성된다.The present invention is composed of the high-purity chitosan, shiitake mushroom extract, garlic extract, bamboo salt and powder, each of which is composed of a weight ratio of 1 to 10: 0.5 to 5: 0.5 to 5: 0.1 to 1: 0.1 to 1.

Description

피로 회복 기능을 가지는 조성물 및 그 제조 방법과 이를 이용한 피로 회복제{Composition for Promotion of Fatigue Recovery And Process for Preparation Thereof, Medicine of Fatigue Recovery Using The Same}Composition for Promotion of Fatigue Recovery and Process for Use thereof and Fatigue Recovery Agent Using the Same

본 발명은 피로 회복 기능을 가지는 조성물 및 그 제조 방법과 이를 이용한 피로 회복제에 관한 것으로, 보다 상세하게는 유효성분으로써 고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염, 산약 등을 함유하는 피로 회복에 증진효과를 가지는 피로 회복 기능을 가지는 조성물 및 그 제조 방법과 이를 이용한 피로 회복제에 관한 것이다.The present invention relates to a composition having a fatigue recovery function, a method for producing the same, and a fatigue recovery agent using the same, and more particularly, to fatigue recovery containing high purity chitosan, shiitake mushroom extract, garlic extract, bamboo salt, powder, etc. as an active ingredient. The present invention relates to a composition having a fatigue recovery function having a promoting effect, a preparation method thereof, and a fatigue recovery agent using the same.

일반적으로, 피로(疲勞, fatigue)란 운동을 하거나 작업을 할 때 평소보다 곤란을 느끼고 노력을 해도 결과가 의도하는 데로 성과를 올리지 못하는 상태라고 할 수 있다. 이러한 정도를 지나서 노동이나 운동을 중지하여 일정한 휴식을 취하여도 피로 상태가 회복되지 않고, 그 것이 오랫동안 계속될 때 이를 과로(over work)라 한다.In general, fatigue can be said to be a state in which exercise or work feels more difficult than usual and effort does not produce results as intended. After this degree, even if you stop working or exercising and take a certain rest, your fatigue does not recover, and when it lasts for a long time, it is called overwork.

즉, 피로는 근육의 수축 또는 자극에 대한 반응의 감소이며, 근 피로는 중추신경계인 뇌와 척수로부터 근육에 이르는 신경 전도의 활성력이 소실되는 현상이다. 따라서 피로는 근육과 신경계통에 밀접한 관계를 맺고 있다.That is, fatigue is a decrease in response to muscle contraction or stimulation, and muscle fatigue is a phenomenon in which the force of nerve conduction from the brain and spinal cord, which are the central nervous system, to the muscle is lost. Fatigue is thus closely related to muscle and nervous system.

피로의 원인은 육체적 과로 후 일시적으로 나타났다가 휴식을 취하면 바로 회복되는 정상적인 생리적 반응에서부터 각종 기질적 질환이나 정신적 질환의 병적인 경우까지 다양하다. 이렇듯 피로는 어떠한 질환에 의해서도 야기될 수 있는 증상이지만 임상적으로 기질적 원인과 정신 심리적 원인으로 대별 할 수 있으며, 아래와 같이 분류할 수 있다.The causes of fatigue vary from normal physiological reactions that occur temporarily after physical overwork and then recover immediately after rest, to pathological cases of various organic and mental diseases. As such, fatigue is a symptom that can be caused by any disease, but it can be classified into clinically and organic psychological and psychological causes.

1) 작업량 과도 등의 일상생활1) Daily life such as excessive workload

2) 신경증, 정신병 등의 정신과적 질환2) Psychiatric diseases such as neurosis and psychosis

3) 내분비대사질환(당뇨병, 갑상선 기능 항진증, 기능 저하증 등), 심장질환(고혈압, 동맥경화증, 심부전증), 호흡기질환(만성기관지염, 폐기종 등), 혈액질환(철결핍성 빈혈 등), 악성신생물질환 등의 기질적 질환3) endocrine metabolic diseases (diabetes, hyperthyroidism, hypofunction), heart diseases (hypertension, arteriosclerosis, heart failure), respiratory diseases (chronic bronchitis, emphysema, etc.), blood diseases (iron deficiency anemia, etc.), malignant kidney Organic diseases such as biological diseases

4) 약물의 사용4) use of drugs

그리고, 단기간(1∼2주)의 피로는 급성 기질적 이상에 의한 경우가 많으며, 수개월 씩 지속되는 피로는 만성질환, 내분비학적 변화에 따른 수가 많다. 피로가 수년씩이나 지속되는 것은 성격 장애로 인한 정서 이상 내지 적응 이상일 수가 많다.In addition, short-term (1 to 2 weeks) fatigue is often caused by acute temporal abnormalities, and fatigue that lasts for several months is often due to chronic diseases and endocrine changes. Many years of fatigue can be emotional or adaptive disorders caused by personality disorders.

피로의 원인과 관련하여 운동 능력이 저하되는 과정은 다음과 같다.Regarding the cause of fatigue, the process of declining exercise ability is as follows.

1) 젖산(lactate) 및 암모니아를 비롯한 부산물의 축적1) accumulation of by-products, including lactate and ammonia

2) 근 활동에 필요한 기질의 고갈(예 : 글리코겐)2) Depletion of the substrate required for muscle activity (eg glycogen)

3) 근육 내의 생화학적 구성요소 변화(예 : 전해질)3) changes in biochemical components in muscle (eg electrolyte)

4) 근 협응 과정의 혼란(예 : 중추신경계)4) confusion in the muscle coordination process (eg central nervous system)

또한, 근육 피로에 영향을 미치는 요인은 여러 가지가 있다. 운동 방식, 시간, 강도, 근육의 조성, 개인의 체력 정도, 개인의 신체 상태(수면, 우울, 시차 등)에 따라서 개인이 느끼는 피로도는 다르게 나타난다.In addition, there are many factors that affect muscle fatigue. Depending on the type of exercise, time, intensity, muscle composition, the level of physical fitness of the individual, and the physical condition of the individual (sleep, depression, parallax, etc.), the individual feels fatigue differently.

피로는 통증과 마찬가지로 '몸에 이상이 있으니 주의하라'는 신호인 일종의 생리적 방어현상이라고 할 수 있다. 피로 때문에 일상 생활에 고통을 느끼는 사람은 자신도 모르는 질환이 숨어 있을 수도 있고, 또 질병으로 발전할 수도 있다.Fatigue, like pain, is a kind of physiological defense that signals that there is something wrong with your body. A person who suffers from everyday life because of fatigue may be hiding a disease that he does not know or may develop into a disease.

근육 활동을 과도하게 하면 글리코겐은 혈액 중의 산소와 결합하여 에너지를 발생시키고 젖산과 탄산가스를 생성하는데, 이 두 가지 노폐물은 근육 활동을 방해한다. 이 것을 피로 물질이라고 한다.Too much muscle activity causes glycogen to combine with oxygen in the blood to generate energy and produce lactic acid and carbon dioxide, both of which interfere with muscle activity. This is called fatigue material.

피로의 원인을 알기 위해 필요한 혈액 검사 항목과 각 항목별로 관련된 질환은 다음과 같다.The blood test items needed to know the cause of fatigue and the diseases related to each item are as follows.

1) ESR - 염증 시 증가1) ESR-increase when inflammation

2) ALT(Alanine aminotransferase) - 간염이나 다른 간질환 시 증가2) ALT (Alanine aminotransferase)-increased when hepatitis or other liver diseases

3) Total protein, Albumin - 감소 시 일차 간질환, 염증, 흡수장애, 영양실조, 신장질환3) Total protein, albumin-decreased primary liver disease, inflammation, malabsorption, malnutrition, kidney disease

4) Globulin - 증가 시 간경화4) Globulin-cirrhosis with increase

5) ALP(Alkaline phosphatase) - 증가 시 간이나 담도, 골 질환5) Alkaline phosphatase (ALP)-Increased liver, biliary and bone disease

6) Calcium - 암성질환, 부갑상선 관련기능, 갑상선 기능, 신장질환, Mg 부족6) Calcium-Cancer disease, parathyroid-related functions, thyroid function, kidney disease, Mg deficiency

7) Phosphorus, LDH(Lactate dehydrogenase), Glucose - 당뇨병7) Phosphorus, Lactate dehydrogenase (LDH), Glucose-Diabetes

8) BUN - 신장질환8) BUN-Kidney Disease

9) Electrolyte, Creatine - 신장기능 장애9) Electrolyte, Creatine-Kidney Dysfunction

10) TSH - 갑상선 기능, 뇌하수체종양10) TSH-thyroid function, pituitary tumor

상기 항목 중에서 Total protein은 각종 효소와 호르몬의 기본 물질로 인식되는 물질로써, 운동 직후 감소하는 경향을 보이며, 크레아틴(creatine)은 근육과 혈액에 존재하는 물질로서 근육에 흡수되어 에너지를 발생시킨다.Total protein is a substance recognized as a basic substance of various enzymes and hormones, and shows a tendency to decrease immediately after exercise. Creatine is a substance present in muscle and blood and is absorbed by the muscle to generate energy.

그러나 근육질환이 있을 경우에는 근육으로의 흡수가 저하되어 혈 중 크레아틴(creatine) 농도가 증가한다. 또한 LDH는 운동이나 스트레스에 의해 상승하며, 이 물질이 증가하면 면역 기능 저하, 저항력 저하를 가져온다.However, in the case of muscle diseases, the absorption into the muscles is lowered, which increases the concentration of creatine in the blood. In addition, LDH is elevated by exercise or stress, and the increase in this substance leads to a decrease in immune function and resistance.

현대인들은 공해와 음주, 흡연 등에 의해 면역력이 많이 떨어져 있으며, 과중한 업무로 인해 만성 피로에 시달리는 직장인이 많다.Modern people have a lot of immunity due to pollution, drinking and smoking, and many workers suffer from chronic fatigue due to heavy work.

최근, 직장인 201명을 대상으로 약과 건강에 대한 리서치를 실시한 결과, 직장인들에게 '약국에서 가장 많이 구입하는 것은'란 질문에 대한 답변 중 1위가 감기약(50.2%), 2위가 진통제(19.4%), 다음으로 피로 회복제(10.9%)가 3위를 차지했다.According to a recent research on medicine and health among 201 employees, the number one answer to the question, `` The biggest thing to buy in pharmacies '' was cold medicine (50.2%), and the second was painkiller (19.4). %), Followed by fatigue recovery (10.9%).

그러나 약국이나 편의점에서 판매하는 이른 바 '피로 회복 드링크제'는 대부분 카페인, 타우린 등 각성 성분 물질이 들어있는 음료수일 뿐 의약품이 아니다.However, the so-called 'fatigue drink' sold at pharmacies and convenience stores is mostly a beverage containing arousal substances such as caffeine and taurine, and is not a medicine.

이와 같은 기존의 피로 회복제를 마시면 각성 성분 때문에 일시적으로 활력이 생기고 집중력이 높아지지만, 기존 피로 회복제 복용으로 혈 중 피로 물질이 감소하는 등과 같은 피로 회복 효과를 높였다는 연구 결과는 없다.Drinking such a conventional fatigue remedy temporarily increases vitality and concentration due to the arousal component, but there is no research showing that the fatigue relieving effect such as the reduction of blood substances in the blood by using the existing fatigue recuperative agent has been increased.

각성 성분이 든 제품을 자주 마시면 중독 성향을 보여 가슴이 뛰고 불안하고 오줌이 자주 마려워지는 등 부작용을 일으킬 수 있고 심하면 숙면을 방해한다.Frequent drinking of products containing arousal ingredients can cause side effects, such as heartburn, anxiety, and frequent urination, which can interfere with sound sleep.

따라서, 복용에 따른 부작용이 없으면서, 혈 중 피로 물질을 감소시켜서 실제로 피로를 회복시켜 주는 기능을 가지는 식품 의약 조성물 개발이 절실하였다.Therefore, there is an urgent need to develop a food and pharmaceutical composition having a function of actually recovering from fatigue by reducing blood substances in the blood without taking side effects.

따라서, 본 발명은 이러한 종래 기술의 문제점을 감안하여 안출된 것으로, 그 목적은 복용에 따른 부작용을 유발하지 않으면서 혈 중 피로 물질을 감소시켜 실제 피로 회복에 탁월한 효과를 나타내는 피로 회복 기능을 가지는 조성물 및 그 제조 방법과 이를 이용한 피로 회복제를 제공하는데 있다.Accordingly, the present invention has been made in view of the problems of the prior art, the purpose of which is to reduce the fatigue material in the blood without causing side effects due to taking a composition having a fatigue recovery function showing an excellent effect on the actual fatigue recovery And to provide a manufacturing method and a fatigue recovery agent using the same.

상기한 목적을 달성하기 위하여, 본 발명은 고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염, 산약을 함유하는 것을 특징으로 하는 피로 회복 기능을 가지는 조성물을 제공한다.In order to achieve the above object, the present invention provides a composition having a fatigue recovery function, characterized in that it contains a high purity chitosan, shiitake mushroom extract, garlic extract, bamboo salt, powder.

본 발명은 고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염, 산약을 함유하는 것을 특징으로 하는 피로 회복제를 아울러 제공한다.The present invention provides a fatigue recovery agent characterized in that it contains a high purity chitosan, shiitake mushroom extract, garlic extract, bamboo salt, acid powder.

그리고, 본 발명은 표고버섯, 마늘로부터 각각의 수추출물을 얻고, 산약을 분말 처리하여 물에 녹여서 산약액을 얻고, 죽염을 물에 녹여서 죽염액을 얻는 단계; 상기 표고버섯 수추출물, 마늘 수추출물, 산약액, 죽염액, 고순도 키토산을 혼합하여 조성물을 얻는 단계를 포함하는 것을 특징으로 하는 피로 회복 기능을 가지는 조성물 제조 방법을 제공한다.In addition, the present invention is to obtain each water extract from shiitake mushrooms, garlic, powdered powdered acid powder to dissolve in water to obtain a powdered acid solution, to obtain the bamboo salt by dissolving bamboo salt in water; It provides a composition manufacturing method having a fatigue recovery function comprising the step of obtaining the composition by mixing the shiitake mushroom extract, garlic extract, acid solution, bamboo salt solution, high purity chitosan.

상기 고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염, 산약은 각각 1∼10 : 0.5∼5 : 0.5∼5 : 0.1∼1 : 0.1∼1의 중량비로 조성되며, 상기와 같이 조성된 조성물은 액상 제제, 환제, 과립제, 정제, 캅셀제로 제조된다.The high-purity chitosan, shiitake mushroom extract, garlic extract, bamboo salt, and powder are each composed of a weight ratio of 1 to 10: 0.5 to 5: 0.5 to 5: 0.1 to 1: 0.1 to 1, and the composition as described above Prepared as liquid preparations, pills, granules, tablets, capsules.

(실시예)(Example)

이하에 상기한 본 발명을 바람직한 실시예가 도시된 첨부 도면을 참고하여 더욱 상세하게 설명한다.Hereinafter, with reference to the accompanying drawings showing a preferred embodiment of the present invention described above in more detail.

첨부한 도면, 도 1은 투여 2시간 후 쥐의 강제 수영 부하 시험에서 본 조성물에 의한 부동시간의 감소 효과(1 : 증류수, 2 : 10㎖/kg, 3 : 15㎖/kg, 4 : 25㎖/kg)를 나타낸 그래프, 도 2는 투여 2주 후 쥐의 강제 수영 부하 시험에서 본 조성물에 의한 부동시간의 감소효과(1 : 증류수, 2 : 10㎖/kg, 3 : 15㎖/kg, 4 : 25㎖/kg)를 나타낸 그래프이다.The accompanying drawings, Figure 1 shows the effect of reducing the immobility time (1: distilled water, 2: 10 ml / kg, 3: 15 ml / kg, 4: 25 ml) in the forced swimming load test of the rat 2 hours after administration / kg), Figure 2 shows the effect of reducing the immobility time (1: distilled water, 2: 10ml / kg, 3: 15ml / kg, 4) in the forced swimming load test of rats 2 weeks after administration : 25 ml / kg).

본 발명은 유효성분으로써 고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염 및 산약을 함유하는 피로 회복용 식품 조성물에 관한 것이다.The present invention relates to a fatigue-recovering food composition containing high purity chitosan, shiitake mushroom extract, garlic extract, bamboo salt, and powder as an active ingredient.

본 발명에 따른 조성물의 제 1유효성분인 고순도 키토산(Highly purified chitosan)은 다음과 같은 특징을 가지고 있다.Highly purified chitosan, which is the first active ingredient of the composition according to the present invention, has the following characteristics.

키토산은 천연물 중 유일하게 아미노기(NH2 +)라는 플러스(+)이온을 가지고 있어 화학적으로 (-)이온을 결합하기 쉬운 성질을 가지고 있다.Chitosan is the only natural product that has a positive (+) ion called an amino group (NH 2 + ), and thus has the property of easily bonding chemical (-) ions.

즉, 아미노기(NH2 +)라는 플러스(+)이온을 가지고 있는 키토산은 체내에서 (-)이온의 성질을 가지고 있는 유해한 중금속, 세균, 바이러스, 다이옥신 등과 결합하여 체외로 배출 시키는 특징이 있다.In other words, chitosan having a positive (+) ion called an amino group (NH 2 + ) is characterized in that it is released into the body in combination with harmful heavy metals, bacteria, viruses, dioxins, etc., having the properties of (-) ions in the body.

또한 키토산의 효능인 암의 억제작용, 암의 전이 방지, 혈당 상승 억제, 콜레스테롤 억제, 혈압 상승 억제, 산성 체질 개선, 세포의 활성화, 간 기능 강화, 면역 기능 강화, 유해 물질 중금속 제거, 장내 유효균의 증가 등의 효과가 탁월한 것으로 알려져 있다.In addition, the effects of chitosan inhibit cancer, prevent cancer metastasis, suppress blood sugar rise, inhibit cholesterol, increase blood pressure, improve acid constitution, activate cells, enhance liver function, enhance immune function, remove heavy metals, and intestinal effective bacteria. It is known that the effect of the increase is excellent.

위와 같은 효능 및 특징을 갖기 위해서는 키토산이 가지고 있는 활성을 최대한 발휘 할 수 있는 고순도 키토산으로 탈아세틸화도가 99.7%이상이면서 항균 및 면역력이 뛰어난 분자량 8~15만이며 키토산 함량 90% 이상이다.In order to have the above effects and characteristics, it is a high-purity chitosan that can exert the activity of chitosan to the maximum. The deacetylation degree is 99.7% or more, the antibacterial and immunity is excellent, the molecular weight is 8-150,000, and the chitosan content is 90% or more.

본 발명에서는 위와 같은 조건을 갖춘 고순도 키토산을 이용하였다.In the present invention, high purity chitosan having the above conditions was used.

본 발명에 따른 조성물의 제 2유효 성분인 표고버섯(Lentinus edodes)은 참나무류, 밤나무, 서어나무 등의 활엽수에 기생하는 담자균류 주름버섯목 느타리과에 속하며, 한명(漢名)은 향심이다.Shiitake mushroom ( Lentinus edodes ), the second active ingredient of the composition according to the present invention, belongs to the basidiomycetes fold fungi parasitic on hardwoods, such as oaks, chestnuts, and cypresses, one of which is fragrant.

현재까지 보고된 바로는, 항암 및 항종양 작용, 혈압 강하 및 혈 중 콜레스테롤(cholesterol) 강하 작용, 인터페론 생성 촉진 작용, 당뇨병, 비만증, 동맥 경화, 고혈압 개선 작용, 장기를 튼튼하게 하고, 두진(痘疹) 치료 작용, 풍파혈(風破血)을 다스리고, 두독(痘毒) 치료 작용, 구루병 예방 및 빈혈 치료 작용, 항바이러스 작용 등이 있다.To date, anti-cancer and anti-tumor effects, lowering blood pressure and lowering blood cholesterol, promoting interferon production, diabetes, obesity, atherosclerosis, hypertension, strengthening organs疹) curative action, rubbing the blood (Wind 破血), and toxin treatment (두), rickets disease prevention and anemia treatment, antiviral action.

본 발명에 따른 조성물의 제 3유효성분인 마늘(Allium sativum L.)은 백합과 (百合科) 파속에 속하는 인경채소로서 영명(英名)은 Garlic, 한명(漢名)은 대산 (大蒜) 또는 호(葫)라고 한다.Garlic ( Allium sativum L. ), the third active ingredient of the composition according to the present invention, belongs to the genus Liliaceae, and the English name is Garlic, one is Daesan or Ho It is called (葫).

마늘의 알려진 기능에는 암 예방, 혈 중 콜레스테롤 감소, 정장, 항균 및 살충, 항혈전, 결핵 예방 및 치료, 감기 예방 및 치료, 혈압 조절, 류머티스 관절염 치료, 케토스테로이드(ketosteroid)의 배설 촉진, 자궁 수축(uterine contraction), 식욕 증진, 피로 회복, 강장 작용 등이 있다.Garlic's known functions include cancer prevention, blood cholesterol reduction, formalities, antibacterial and insecticidal, antithrombotic, tuberculosis prevention and treatment, cold prevention and treatment, blood pressure control, rheumatoid arthritis treatment, facilitation of ketosteroid excretion, uterine contraction uterine contraction, increased appetite, fatigue, and tonic.

본 발명에 따른 조성물의 제 4유효 성분인 죽염(Bamboo salt)은 청정 해역에서 채취한 천일염을 왕대나무에 다져 넣어 황토 가마에서 8∼10시간 동안 850℃의 열로 구워 내면 대나무의 진액이 천일염에 스며들어 소금 덩어리로 합성된다.Bamboo salt, which is the fourth active ingredient of the composition according to the present invention, is made by smelting sun salt collected from clean sea water into royal bamboo and baked in an ocher kiln for 8 to 10 hours with heat of 850 ° C. For salt is synthesized into chunks of salt.

이 소금 덩어리를 다시 분말로 만들어 다시 대나무에 다져 넣고 불을 때서 굽기를 여덟 번 반복한다. 마지막 아홉 번째는 송진 가루를 이용하여(소나무 장작불) 약 1500℃ 이상의 극강한 고열로 온도를 높여 주면 죽염이 쇳물처럼 녹아 내린다.Put the salt mass back into powder, chop it back into the bamboo, and burn it eight times while it is on fire. The ninth is using rosin powder (pine wood fire), when the temperature is raised to extreme high heat of about 1500 ℃ or higher, bamboo salt dissolves like water.

이렇게 용융되어 굳어진 죽염석을 미세한 분말과 적당한 입자 상태로 만든 것이 죽염이다. 죽염의 알려진 효능으로는 위장을 튼튼히 하며, 해열, 정혈, 소염 작용, 기를 정화하고 악취를 제거한다. 또한 백혈구를 증강시키고 살균, 해독, 식욕 촉진과 체질 개선 등이 있다.Bamboo salt formed by melting and solidifying the bamboo salt into fine powder and proper particle state is bamboo salt. Known effects of bamboo salts are to strengthen the stomach, fever, blood clots, anti-inflammatory action, cleanse the qi and remove odors. It also enhances white blood cells, sterilization, detoxification, appetite and constitution.

본 발명에 따른 조성물의 제 5유효 성분인 산약(Dioscorea batatas)은 마의 한명(漢名)으로써, 마과(Dioscoreaceae)에 속한다. 산약은 허로손상(虛勞損傷)을 낫게 하며, 기운을 보하고 살지게 하며(향약집성방), 요통, 현기증을 낫게 하며, 오장을 보하고 번열을 없앤다(명의별록). 또한 헛배가 부르며 입맛이 없는 식욕부진에 효과가 있다(의방유취). 본초강목에서는 허로와 몸이 쇠약한 것을 보하며, 오장을 튼튼히 하여 기력을 증강시키고 근육과 뼈를 강하게 하며, 정신을 편하게 한다고 설명이 되어있다.The fifth active ingredient ( Dioscorea batatas ) of the composition according to the present invention is one of the hemps and belongs to the family Dioscoreaceae. Reagents heal wounds, rejuvenate and live (harmfulness), lower back pain, dizziness, erect intestines, and eliminate heat. It is also called flatulence and has an effect on loss of appetite that has no appetite. The herbaceous hardwood has been shown to weaken the body and body, and has been explained to strengthen the five intestines to increase energy, strengthen muscles and bones, and relax the mind.

본 발명에 따른 조성물의 제조 원료는 고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염, 산약이며, 각각의 조성비는 고순도 키토산 : 표고버섯 수추출물 : 마늘 수추출물 : 죽염 : 산약이 각각 1∼10 : 0.5∼5 : 0.5∼5 : 0.1∼1 : 0.1∼1의 중량비로 이루어진다.The raw materials for the preparation of the composition according to the present invention are high purity chitosan, shiitake mushroom water extract, garlic water extract, bamboo salt and acid extract, and the composition ratio of each is high purity chitosan: shiitake mushroom water extract: garlic water extract: bamboo salt: acid powder is 1 to 10, respectively. It consists of a weight ratio of: 0.5-5: 0.5-5: 0.1-1: 0.1-1.

상기 언급한 생약들의 조성비는 반복된 실험 결과를 토대로 얻어진 것이며, 그 하한치보다 낮을 경우에는 그 성분의 약리 효과가 감소하며, 그 상한치보다 높을 경우에는 타성분의 약리 효과가 감소될 수 있어 조성물의 상승 작용 및 협동 작용이 저하될 우려가 있기 때문에 상기와 같이 한정하였다.The composition ratio of the above-mentioned herbal medicines is obtained based on the repeated test results, and when the lower limit is lower than the lower limit, the pharmacological effect of the component is decreased, and when higher than the upper limit, the pharmacological effect of the other components may be reduced, thereby increasing the composition Since the action and the cooperative action may be lowered, they are limited as described above.

이하, 본 발명을 하기 실시예에 의하여 보다 구체적으로 설명하지만, 이들에 의해 본 발명의 범위가 어떤 식으로든 제한되는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited by them in any way.

1. 제 1실시예 : 액제의 제조1. Example 1 Preparation of Liquid

표고버섯 10g에서 8.85cc 수추출물을 얻었고, 마늘 1통에서 28cc의 수추출물을 얻었다. 그리고 산약은 잘 말려서 가루를 내어 물에 녹였다. 이 것을 v/v로 계산하여 10㎎/㎖ 농도의 고순도 키토산 3㎖, 10㎎/㎖ 농도의 표고버섯 수추출물 3㎖, 10㎎/㎖ 농도의 마늘 수추출물 3㎖, 10㎎/㎖ 농도의 죽염 0.5㎖, 10㎎/㎖ 농도의 산약 0.5㎖을 각각 섞어 액제로 만들었다.Water extract of 8.85cc was obtained from 10g of shiitake mushrooms, and 28cc of water extract was obtained from one bucket of garlic. The medicine was dried well, powdered, and dissolved in water. This was calculated as v / v, and 3 ml of 10 mg / ml high-purity chitosan, 3 ml of 10 mg / ml shiitake mushroom extract, 3 ml of 10 mg / ml garlic extract, and 10 mg / ml 0.5 ml of bamboo salt and 0.5 ml of 10 mg / ml powder were mixed to form a liquid.

2. 제 2실시예 : 기타 제제의 제조2. Second Example: Preparation of Other Formulations

상기 제 1실시예에서 제조된 액제를 이용하여 일반적으로 알려진 방법에 따라 환제, 과립제, 정제, 캡슐제를 제조하였다.Pills, granules, tablets, capsules were prepared according to a generally known method using the liquid preparation prepared in the first embodiment.

따라서, 상기 조성물을 이용하여 환제, 과립제, 정제, 캡슐제 등을 제조하기 위해서는 약제학적으로나 식품으로 허용되는 담체를 추가로 함유한다.Therefore, in order to prepare the pills, granules, tablets, capsules, etc. using the composition, it further contains a pharmaceutically or food acceptable carrier.

즉, 본 발명의 조성물과 혼합되어 사용될 수 있는 즉, 약제학적으로 허용되는 담체는 약제학적 분야에서 통상적인 것으로, 예를 들면 경구투여용 제제의 경우에는 결합제, 활택제, 붕해제, 부형제, 가용화제, 안정화제 등이 있으며, 이들을 이용하여 상기 조성물과 혼합하여 필요에 따라서는 환제, 과립제, 정제 또는 캡슐제 형태로 제조할 수 있고, 경우에 따라서는 다른 제형으로 바꾸어 사용할 수도 있다.That is, pharmaceutically acceptable carriers that can be used in admixture with the compositions of the present invention are conventional in the pharmaceutical art, for example in the case of oral preparations, binders, lubricants, disintegrants, excipients, solubles There are a topical agent, a stabilizer and the like, and these may be mixed with the composition to produce a pill, granule, tablet or capsule, if necessary, and may be used in other formulations.

3. 제 1실험예 : 쥐에서의 강제 수영 부하 시험3. Experimental Example 1: Forced Swimming Load Test in Rats

쥐의 수영 능력을 알아보기 위해서 ICR 계의 수컷(10∼12g) 흰쥐를 1군당 5마리씩 하여 물을 구강 투여한 대조군(1)과 본 발명의 조성물을 각각 10㎖/kg(2), 15㎖/kg(3), 25㎖/kg(4)을 각각 구강 투여한 군으로 분류하였다.In order to examine the swimming ability of the rats, ICR male (10-12g) rats were used in five rats per group, and the control group (1) orally administered with water (10) / kg (2), 15 ml, respectively. / kg (3) and 25ml / kg (4) were classified into oral administration groups, respectively.

대조군과 실험군 모두 생리 식염수와 사료를 자유롭게 공급하였으며 각 군을 다시 2시간, 2주로 나누어 수영 시간을 측정하였다.Both the control group and the experimental group were freely fed with saline and feed, and each group was divided into 2 hours and 2 weeks, and the swimming time was measured.

측정방법은 먼저, 아크릴 수조(지름 10cm, 높이 25cm)에 22∼23℃의 물을 10cm 높이로 채운다. 쥐를 물에 빠뜨려 6분간 관찰하되, 처음 2분은 방치해두고 남은 4분 동안 부동 시간을 측정한다. 여기서, 부동 시간이란 쥐가 수영을 하다 피로하여 더 이상 움직이지 않는 상태의 시간을 말한다.In the measuring method, first, an acrylic water tank (diameter 10 cm, height 25 cm) is filled with water of 22 to 23 ° C. to a height of 10 cm. Immerse the rat in water for 6 minutes, but leave the first 2 minutes and measure immobility time for the remaining 4 minutes. Here, the dead time refers to the time when the rat is no longer moving due to fatigue while swimming.

상기와 같은 실험에서, 투여 2시간 후의 결과는 물을 투여한 대조군에 비해 본 발명의 조성물을 투여한 실험군 쥐의 부동 시간은 10㎖/kg에서는 16.8초, 15㎖/kg에서는 23.6초, 25㎖/kg에서는 11.4초 감소되었다(도 1 참조). 또한 투여 2주 후의 결과는 물을 투여한 군에 비해 본 발명의 조성물을 투여한 쥐의 부동시간은 10㎖/kg에서는 13.2초, 15㎖/kg에서는 20.5초, 25㎖/kg에서는 6.1초 감소되었다(도 2 참조).In the above experiments, the results after 2 hours of administration were compared to the control group administered with water, and the immobility time of the experimental group rats administered the composition of the present invention was 16.8 seconds at 10 ml / kg, 23.6 seconds at 15 ml / kg, and 25 ml. / kg decreased 11.4 seconds (see Figure 1). In addition, the results after 2 weeks of administration showed that the rats administered the composition of the present invention had a 13.2 second at 10 ml / kg, 20.5 seconds at 15 ml / kg, and 6.1 seconds at 25 ml / kg compared to the water-administered group. (See FIG. 2).

결과적으로, 본 발명의 조성물을 15㎖/kg을 투여했을 경우 쥐의 수영 능력을 가장 많이 증가시켰으며, 그 효과는 투여 후 2시간에서도 확연히 관찰된다. 따라서 본 조성물에 의해 쥐의 지구력이 향상되었음을 알 수 있고, 피로 회복에 유용한 조성물임을 알 수 있다.As a result, administration of 15 ml / kg of the composition of the present invention most increased the swimming ability of the rat, the effect is clearly observed even 2 hours after administration. Therefore, it can be seen that the endurance of the rat is improved by the present composition, it can be seen that the composition useful for fatigue recovery.

4. 제 2실험예 : 혈청 내 총단백질(total protein) 증가 효과4. Experimental Example 2: Effect of Increasing Total Protein in Serum

본 실험에서는 대조군(1)에는 증류수를 투여하고, 실험군에는 상기 조성물을 2주 동안 10㎖/kg(2), 15㎖/kg(3), 25㎖/kg(4)을 각각 투여하고 강제 수영 부하 후 쥐를 마취시킨 다음, 심장에서 채혈하였다. 그리고 3,000rpm에서 15분간 냉장 원심 분리하여 혈청을 얻었다. 혈청 내 총단백질(total protein) 측정은 자동 생화학 분석기인 autoanalyzer(Hitachi 747, Hitachi, Japan)를 사용하였다. 총단백질(Total protein)은 각종 효소와 호르몬의 기본 물질로 인식되는 것으로, 운동 직후 감소하는 경향을 보인다.In the present experiment, distilled water was administered to the control group (1), and the experimental group was administered with 10 ml / kg (2), 15 ml / kg (3), and 25 ml / kg (4), respectively, for two weeks. Rats were anesthetized after the load and then blood drawn from the heart. And serum was obtained by refrigeration centrifugation for 15 minutes at 3,000rpm. Serum total protein was measured using autoanalyzer (Hitachi 747, Hitachi, Japan), an automatic biochemical analyzer. Total protein is recognized as the basic substance of various enzymes and hormones, and it tends to decrease immediately after exercise.

상기와 같은 실험 결과, 하기 표 1에 나타낸 바와 같이, 대조군(100%)에 비해 본 발명의 조성물을 투여한 군은 총단백질(total protein)이 각각 103.1%, 113%, 108.6% 증가됐음을 알 수 있다. 따라서, 본 발명의 조성물은 피로 회복에 효과가 있음을 알 수 있다.As a result of the above experiment, as shown in Table 1 below, the group administered with the composition of the present invention compared to the control group (100%) showed that the total protein (total protein) increased by 103.1%, 113%, and 108.6%, respectively. Can be. Therefore, it can be seen that the composition of the present invention is effective in fatigue recovery.

본 조성물에 의한 혈청 내 총단백질(total protein) 증가 효과Increase in total protein in serum by the composition 투여액(투여량)Dosage (dosage) 총단백질(g/㎗) Total protein (g / ㎗) 1. 증류수1. Distilled water 4.714 ± 0.164.714 ± 0.16 2. 조성물(10㎖/kg)2. Composition (10ml / kg) 4.864 ± 0.144.864 ± 0.14 3. 조성물(15㎖/kg)3. Composition (15ml / kg) 5.326 ± 0.175.326 ± 0.17 4. 조성물(25㎖/kg)4. Composition (25 ml / kg) 5.118 ± 0.115.118 ± 0.11

5. 제 3실험예 : 혈청 내 크레아틴(creatine) 감소 효과5. Experimental Example 3 Serum Creatine Reduction Effect

본 실험에서는 대조군(1)에는 증류수를 투여하고, 실험군에는 상기 조성물을 2주 동안 10㎖/kg(2), 15㎖/kg(3), 25㎖/kg(4)을 각각 투여하고 강제 수영을 시킨 후 쥐를 마취시킨 다음, 심장에서 채혈하였다. 그리고 3,000rpm에서 15분간 냉장 원심 분리하여 혈청을 얻었다. 혈청 내 크레아틴(creatine) 측정은 자동 생화학 분석기인 autoanalyzer(Hitachi 747, Hitachi, Japan)를 사용하였다. 크레아틴(Creatine)은 근육과 혈액에 존재하는 물질로써 근육에 흡수되어 에너지를 발생시킨다. 그러나 근육 질환이 있을 경우에는 근육으로의 흡수가 저하되어 혈 중 크레아틴(creatine) 농도가 증가하는 현상이 있다.In the present experiment, distilled water was administered to the control group (1), and the experimental group was administered with 10 ml / kg (2), 15 ml / kg (3), and 25 ml / kg (4), respectively, for two weeks. After anesthesia, the rats were anesthetized, and blood was collected from the heart. And serum was obtained by refrigeration centrifugation for 15 minutes at 3,000rpm. Serum creatine measurement was performed using autoanalyzer (Hitachi 747, Hitachi, Japan), an automatic biochemical analyzer. Creatine is a substance present in muscles and blood that is absorbed by muscles to generate energy. However, in the case of muscle disease, the absorption into the muscles is lowered and the creatine concentration in the blood is increased.

본 발명의 조성물을 투여한 군은 크레아틴(creatine)이 대조군(1)에 비하여 각각 94.4%(2), 97.2%(3), 91.7%(4) 감소됐음을 알 수 있다. 따라서, 본 발명의 조성물은 피로 회복에 효과가 있음을 알 수 있다.In the group to which the composition of the present invention was administered, it can be seen that creatine was reduced by 94.4% (2), 97.2% (3), and 91.7% (4), respectively, compared to the control group (1). Therefore, it can be seen that the composition of the present invention is effective in fatigue recovery.

본 조성물에 의한 혈청 내 크레아틴(creatine) 감소 효과Creatine Reduction Effect in Serum by the Composition 투여액(투여량)Dosage (dosage) 크레아틴(㎎/㎗)Creatine (mg / dl) 1. 증류수1. Distilled water 0.36 ± 0.010.36 ± 0.01 2. 조성물(10㎖/kg)2. Composition (10ml / kg) 0.34 ± 0.020.34 ± 0.02 3. 조성물(15㎖/kg)3. Composition (15ml / kg) 0.35 ± 0.020.35 ± 0.02 4. 조성물(25㎖/kg)4. Composition (25 ml / kg) 0.33 ± 0.010.33 ± 0.01

6. 제 4실험예 : 혈청 내 LDH 감소 효과6. Experimental Example 4 Serum LDH Reduction Effect

본 실험에서는 대조군(1)에는 증류수를 투여하고, 실험군에는 상기 조성물을 2주 동안 10㎖/kg(2), 15㎖/kg(3), 25㎖/kg(4)을 각각 투여하고 강제 수영을 시킨 후 쥐를 마취시킨 다음, 심장에서 채혈하였다. 그리고 3,000rpm에서 15분간 냉장 원심 분리하여 혈청을 얻었다. 혈청 내 LDH(lactate dehydrogenase) 측정은 자동생화학분석기인 autoanalyzer(Hitachi 747, Hitachi, Japan)를 사용하였다. LDH는 스트레스에 의해 상승하며, 이 물질이 증가하면 면역기능 저하, 저항력 저하를 가져온다.In the present experiment, distilled water was administered to the control group (1), and the experimental group was administered with 10 ml / kg (2), 15 ml / kg (3), and 25 ml / kg (4), respectively, for two weeks. After anesthesia, the rats were anesthetized, and blood was collected from the heart. And serum was obtained by refrigeration centrifugation for 15 minutes at 3,000rpm. Serum lactate dehydrogenase (LDH) was measured using autoanalyzer (Hitachi 747, Hitachi, Japan). LDH is elevated by stress, and an increase in this substance leads to a decrease in immune function and resistance.

상기와 같은 실험 결과, 하기 표 3에 나타낸 바와 같이, 대조군(1)에 비해 본 발명의 조성물을 투여한 군은 LDH가 각각 71.6%(2), 90.1%(3), 93.4%(4) 감소됐음을 알 수 있다. 따라서, 본 발명의 조성물은 피로 회복에 효과가 있음을 알 수 있다.As a result of the above experiments, as shown in Table 3 below, the group administered with the composition of the present invention compared to the control (1), LDH reduction of 71.6% (2), 90.1% (3), 93.4% (4) respectively You can see that. Therefore, it can be seen that the composition of the present invention is effective in fatigue recovery.

본 조성물에 의한 혈청 내 LDH 감소 효과LDH Reduction Effect in Serum by the Composition 투여액(투여량)Dosage (dosage) LDH(U/ℓ) LDH (U / ℓ) 1. 증류수1. Distilled water 1999.8 ± 104.61999.8 ± 104.6 2. 조성물(10㎖/kg)2. Composition (10ml / kg) 1432.6 ± 219.61432.6 ± 219.6 3. 조성물(15㎖/kg)3. Composition (15ml / kg) 1801.4 ± 142.61801.4 ± 142.6 4. 조성물(25㎖/kg)4. Composition (25 ml / kg) 1868.8 ± 205.31868.8 ± 205.3

상기한 바와 같이 이루어진 본 발명에 따른 피로 회복 기능을 가지는 조성물은 지구력 향상, 혈청 내 총단백질 증가, 크레아틴 감소, LDH 감소 등의 효과를 제공하며, 지구력의 향상은 면역 증강 효과와, 혈청 내 물질들은 피로와 직간접적으로 연관된다.The composition having a fatigue recovery function according to the present invention made as described above provides the effects of improving endurance, increasing total protein in serum, reducing creatine, reducing LDH, etc., improving endurance is immune enhancing effect, and substances in serum It is directly or indirectly associated with fatigue.

따라서, 본 발명은 피로 회복에 유용하게 작용하는 효과를 제공한다.Thus, the present invention provides an effect that acts usefully in fatigue recovery.

이상에서는 본 발명을 특정의 바람직한 실시예를 예로 들어 도시하고 설명하였으나, 본 발명은 상기한 실시예에 한정되지 아니하며 본 발명의 정신을 벗어나지 않는 범위 내에서 당해 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에 의해 다양한 변경과 수정이 가능할 것이다.In the above, the present invention has been illustrated and described with reference to specific preferred embodiments, but the present invention is not limited to the above-described embodiments and the general knowledge in the technical field to which the present invention pertains without departing from the spirit of the present invention. Various changes and modifications will be made by those who possess.

도 1은 투여 2시간 후 쥐의 강제 수영 부하 시험에서 본 조성물에 의한 부동시간의 감소 효과(1 : 증류수, 2 : 10㎖/kg, 3 : 15㎖/kg, 4 : 25㎖/kg)를 나타낸 그래프.Figure 1 shows the effect of reducing the immobility time (1: distilled water, 2: 10ml / kg, 3: 15ml / kg, 4: 25ml / kg) in the forced swimming load test of the rat 2 hours after administration Graph shown.

도 2는 투여 2주 후 쥐의 강제 수영 부하 시험에서 본 조성물에 의한 부동시간의 감소효과(1 : 증류수, 2 : 10㎖/kg, 3 : 15㎖/kg, 4 : 25㎖/kg)를 나타낸 그래프.Figure 2 shows the effect of reducing the immobility time (1: distilled water, 2: 10ml / kg, 3: 15ml / kg, 4: 25ml / kg) in the forced swimming load test of rats two weeks after administration Graph shown.

Claims (8)

고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염, 산약을 함유하는 것을 특징으로 하는 피로 회복 기능을 가지는 조성물.A composition having a fatigue recovery function, characterized by containing high purity chitosan, shiitake mushroom extract, garlic extract, bamboo salt, and acid powder. 제 1항에 있어서, 상기 고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염, 산약은 각각 1∼10 : 0.5∼5 : 0.5∼5 : 0.1∼1 : 0.1∼1의 중량비로 조성되는 것을 특징으로 하는 피로 회복 기능을 가지는 조성물.The method of claim 1, wherein the high-purity chitosan, shiitake mushroom extract, garlic extract, bamboo salt, and powder are each composed of a weight ratio of 1 to 10: 0.5 to 5: 0.5 to 5: 0.1 to 1: 0.1 to 1, respectively. A composition having a fatigue recovery function. 제 1항 또는 제 2항에 있어서, 액상 제제, 환제, 과립제, 정제, 캅셀제 형태 중 적어도 어느 한 형태로 제조되는 것을 특징으로 하는 피로 회복 기능을 가지는 조성물.The composition having a fatigue recovery function according to claim 1 or 2, wherein the composition is prepared in at least one of liquid, pills, granules, tablets and capsules. 고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염, 산약을 함유하는 것을 특징으로 하는 피로 회복제.A fatigue relieving agent comprising high purity chitosan, shiitake mushroom extract, garlic extract, bamboo salt, and acid powder. 제 4항에 있어서, 상기 고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염, 산약은 각각 1∼10 : 0.5∼5 : 0.5∼5 : 0.1∼1 : 0.1∼1의 중량비로 조성되는 것을 특징으로 하는 피로 회복제.The method of claim 4, wherein the high purity chitosan, shiitake mushroom extract, garlic extract, bamboo salt, and powder are each composed of a weight ratio of 1 to 10: 0.5 to 5: 0.5 to 5: 0.1 to 1: 0.1 to 1, respectively. Fatigue recovery agent. 제 4항 또는 제 5항에 있어서, 액상 제제, 환제, 과립제, 정제, 캅셀제 형태 중 적어도 어느 한 형태로 제조되는 것을 특징으로 하는 피로 회복제.The fatigue recovery agent according to claim 4 or 5, which is prepared in at least one of liquid form, pill, granule, tablet, capsule form. 표고버섯, 마늘로부터 각각의 수추출물을 얻고, 산약을 분말 처리하여 물에 녹여서 산약액을 얻고, 죽염을 물에 녹여서 죽염액을 얻는 단계;Obtaining respective water extracts from shiitake mushrooms and garlic, powdering the powdered acid powder to dissolve it in water to obtain a powdered acidic liquid, and dissolving the bamboo salt in water to obtain bamboo salt solution; 상기 표고버섯 수추출물, 마늘 수추출물, 산약액, 죽염액, 고순도 키토산을 혼합하여 조성물을 얻는 단계를 포함하는 것을 특징으로 하는 피로 회복 기능을 가지는 조성물 제조 방법.Method of producing a composition having a fatigue recovery function comprising the step of obtaining a composition by mixing the shiitake mushroom extract, garlic extract, acid solution, bamboo salt solution, high purity chitosan. 제 7항에 있어서, 상기 고순도 키토산, 표고버섯 수추출물, 마늘 수추출물, 죽염, 산약은 각각 1∼10 : 0.5∼5 : 0.5∼5 : 0.1∼1 : 0.1∼1의 중량비로 조성되는 것을 특징으로 하는 피로 회복 기능을 가지는 조성물 제조 방법.8. The method of claim 7, wherein the high purity chitosan, shiitake mushroom extract, garlic extract, bamboo salt, and powder are each composed of a weight ratio of 1 to 10: 0.5 to 5: 0.5 to 5: 0.1 to 1: 0.1 to 1, respectively. The composition manufacturing method which has a fatigue recovery function to be.
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KR101988959B1 (en) 2019-05-13 2019-06-14 주식회사 한미양행 Stress relieving or anti-fatigue composition containing enzymatic treatment white grub
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CN105125811A (en) * 2015-09-22 2015-12-09 齐国良 Chinese herbal preparation for replenishing qi to invigorate spleen and kidney
KR101988959B1 (en) 2019-05-13 2019-06-14 주식회사 한미양행 Stress relieving or anti-fatigue composition containing enzymatic treatment white grub
KR20220151393A (en) 2021-05-06 2022-11-15 도영복 Health functional tea composition for stress relief containing ginseng

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