KR100459339B1 - 포도당 농도 측정 장치 - Google Patents
포도당 농도 측정 장치 Download PDFInfo
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- KR100459339B1 KR100459339B1 KR10-2002-0001047A KR20020001047A KR100459339B1 KR 100459339 B1 KR100459339 B1 KR 100459339B1 KR 20020001047 A KR20020001047 A KR 20020001047A KR 100459339 B1 KR100459339 B1 KR 100459339B1
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- Prior art keywords
- glucose
- glucose concentration
- spectral intensity
- loading
- absorption
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 233
- 239000008103 glucose Substances 0.000 title claims abstract description 233
- 238000001228 spectrum Methods 0.000 claims abstract description 106
- 238000011068 loading method Methods 0.000 claims abstract description 90
- 238000000862 absorption spectrum Methods 0.000 claims abstract description 89
- 238000005259 measurement Methods 0.000 claims abstract description 47
- 238000001514 detection method Methods 0.000 claims abstract description 45
- 238000011088 calibration curve Methods 0.000 claims abstract description 40
- 238000003860 storage Methods 0.000 claims abstract description 35
- 238000000034 method Methods 0.000 claims abstract description 23
- 238000012847 principal component analysis method Methods 0.000 claims abstract description 7
- 230000003595 spectral effect Effects 0.000 claims description 55
- 238000000513 principal component analysis Methods 0.000 claims description 40
- 238000010521 absorption reaction Methods 0.000 claims description 33
- 238000005102 attenuated total reflection Methods 0.000 claims description 32
- 238000004611 spectroscopical analysis Methods 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 3
- 238000004364 calculation method Methods 0.000 abstract description 33
- 238000013500 data storage Methods 0.000 abstract description 17
- 239000008280 blood Substances 0.000 description 31
- 210000004369 blood Anatomy 0.000 description 31
- 239000011159 matrix material Substances 0.000 description 29
- 238000012986 modification Methods 0.000 description 11
- 230000004048 modification Effects 0.000 description 11
- 238000010586 diagram Methods 0.000 description 10
- 239000013598 vector Substances 0.000 description 10
- 210000003811 finger Anatomy 0.000 description 8
- 238000003825 pressing Methods 0.000 description 7
- 239000004065 semiconductor Substances 0.000 description 7
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 150000002303 glucose derivatives Chemical class 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 229910003460 diamond Inorganic materials 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 229910001120 nichrome Inorganic materials 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- SBIBMFFZSBJNJF-UHFFFAOYSA-N selenium;zinc Chemical compound [Se]=[Zn] SBIBMFFZSBJNJF-UHFFFAOYSA-N 0.000 description 2
- HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 description 2
- 229910010271 silicon carbide Inorganic materials 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 210000004932 little finger Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Description
Claims (6)
- 중적외 광선을 출사하는 광원과, 상기 광원으로부터 출사된 광선이 입사되며 또한 측정 대상에 의한 흡수를 검출하는 전반사 감쇠(Attenuated Total Reflection ; ATR) 프리즘과, 상기 ART 프리즘을 통과한 광선의 스펙트럼 강도를 검출하는 스펙트럼 검출기를 포함하고, 전반사 감쇠 분광법(全反射減衰分光法)에 의해 중적외(中赤外) 영역에서의 포도당을 함유하는 시료(試料)의 흡수 스펙트럼 강도를 검출하는 검출 수단과;상기 검출 수단으로 검출된 흡수 스펙트럼 강도에 따라, 주성분 분석법에서의 포도당에 대응하는 로딩(loading)을 산출하는 수단과;상기 포도당에 대응하는 로딩을 기억하는 수단을 구비하는 포도당 농도 측정 장치.
- 중적외 광선을 출사하는 광원과, 상기 광원으로부터 출사된 광선이 입사되며 또한 측정 대상에 의한 흡수를 검출하는 전반사 감쇠(ATR) 프리즘과, 상기 ART 프리즘을 통과한 광선의 스펙트럼 강도를 검출하는 스펙트럼 검출기를 포함하고, 전반사 감쇠 분광법에 의해 중적외 영역에서의 포도당을 함유하는 시료의 흡수 스펙트럼 강도를 검출하는 검출 수단과;상기 검출 수단으로 검출된 흡수 스펙트럼 강도에 따라, 주성분 분석법에서의 포도당에 대응하는 로딩을 산출하는 수단과;상기 흡수 스펙트럼 강도 및 로딩에 따라, 당해 흡수 스펙트럼 강도의 로딩에 의한 전개 계수로서의 스코어를 결정하는 스코어 결정 수단과;상기 스코어와 포도당 농도를 대응시키는 검량선(檢量線)을 기억하는 검량선 기억 수단을 구비하는 포도당 농도 측정 장치.
- 제2항에 있어서,상기 스코어 결정 수단으로 결정된 스코어에 대하여 상기 검량선을 참조하여, 포도당 농도를 결정하는 농도 결정 수단을 구비하는 포도당 농도 측정 장치.
- 포도당을 함유하는 시료의, 주성분 분석법에서의 포도당에 대응하는 로딩을 기억하는 수단과;스코어와 포도당 농도를 대응시키는 검량선을 기억하는 검량선 기억 수단과;중적외 광선을 출사하는 광원과, 상기 광원으로부터 출사된 광선이 입사되며 또한 측정 대상에 의한 흡수를 검출하는 전반사 감쇠(ATR) 프리즘과, 상기 ART 프리즘을 통과한 광선의 스펙트럼 강도를 검출하는 스펙트럼 검출기를 포함하고, 전반사 감쇠 분광법에 의해 중적외 영역에서의 포도당을 함유하는 시료의 흡수 스펙트럼 강도를 검출하는 검출 수단과;상기 로딩 및 흡수 스펙트럼 강도에 따라, 당해 흡수 스펙트럼 강도의 로딩에 의한 전개 계수로서의 스코어를 결정하는 스코어 결정 수단과;상기 스코어 결정 수단으로 결정된 스코어에 대하여 상기 검량선을 참조하여, 포도당 농도를 결정하는 농도 결정 수단을 구비하는 포도당 농도 측정 장치.
- 중적외 광선을 출사하는 광원과, 상기 광원으로부터 출사된 광선이 입사되며 또한 측정 대상에 의한 흡수를 검출하는 전반사 감쇠(ATR) 프리즘과, 상기 ART 프리즘을 통과한 광선의 스펙트럼 강도를 검출하는 스펙트럼 검출기를 포함하고, 전반사 감쇠 분광법에 의해 중적외 영역에서의 포도당을 함유하는 시료의 흡수 스펙트럼 강도를 검출하는 검출 수단과;상기 흡수 스펙트럼 강도로부터 배경 물질의 흡수 스펙트럼을 뺌으로써, 포도당의 스펙트럼 강도를 결정하는 스펙트럼 강도 결정 수단과;상기 스펙트럼 강도와 포도당 농도를 대응시키는 검량선을 기억하는 검량선 기억 수단을 구비하는 포도당 농도 측정 장치.
- 제5항에 있어서,상기 스펙트럼 강도 결정 수단으로 결정된 포도당의 스펙트럼 강도에 대하여 상기 검량선을 참조하여, 포도당 농도를 결정하는 농도 결정 수단을 구비하는 포도당 농도 측정 장치.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001236680A JP2003042948A (ja) | 2001-08-03 | 2001-08-03 | グルコース濃度測定装置 |
JPJP-P-2001-00236680 | 2001-08-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20030012791A KR20030012791A (ko) | 2003-02-12 |
KR100459339B1 true KR100459339B1 (ko) | 2004-12-03 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR10-2002-0001047A KR100459339B1 (ko) | 2001-08-03 | 2002-01-08 | 포도당 농도 측정 장치 |
Country Status (3)
Country | Link |
---|---|
US (1) | US7438855B2 (ko) |
JP (1) | JP2003042948A (ko) |
KR (1) | KR100459339B1 (ko) |
Families Citing this family (46)
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US6862534B2 (en) * | 2001-12-14 | 2005-03-01 | Optiscan Biomedical Corporation | Method of determining an analyte concentration in a sample from an absorption spectrum |
US7009180B2 (en) * | 2001-12-14 | 2006-03-07 | Optiscan Biomedical Corp. | Pathlength-independent methods for optically determining material composition |
US20050106749A1 (en) * | 2003-04-15 | 2005-05-19 | Braig James R. | Sample element for use in material analysis |
US20050037384A1 (en) * | 2003-04-15 | 2005-02-17 | Braig James R. | Analyte detection system |
WO2005050176A1 (ja) * | 2003-11-10 | 2005-06-02 | Zaidanhozin Sinsangyosozokenkyukiko | 可視光・近赤外分光分析方法及びその装置 |
JP4563075B2 (ja) * | 2004-05-14 | 2010-10-13 | 日本分光株式会社 | 血糖値測定装置 |
WO2006011487A1 (ja) | 2004-07-30 | 2006-02-02 | National University Corporation Chiba University | 赤外分光法を用いた血液中のグルコース濃度を測定する方法及びそれを用いた装置 |
GB0501826D0 (en) * | 2005-01-28 | 2005-03-09 | Melys Diagnostics Ltd | Apparatus for measurement of analyte concentration |
GB0608258D0 (en) * | 2006-04-26 | 2006-06-07 | Perkinelmer Singapore Pte Ltd | Spectroscopy using attenuated total internal reflectance (ATR) |
WO2008062439A2 (en) * | 2006-09-05 | 2008-05-29 | Bansod Prashant | Non-invasive blood glucose measurement using mid-infrared absorption spectroscopy |
JP2008061698A (ja) * | 2006-09-05 | 2008-03-21 | Ushio Inc | 血糖値測定装置 |
US20080269616A1 (en) * | 2006-11-17 | 2008-10-30 | Bloom Matthew M | Mir spectroscopy of tissue |
JP2008256398A (ja) * | 2007-04-02 | 2008-10-23 | Chiba Univ | 非侵襲血糖値測定方法 |
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US8718734B2 (en) * | 2007-11-07 | 2014-05-06 | The University Of Toledo | Non-invasive polarimetric apparatus and method for analyte sensing in birefringent media |
US9164073B1 (en) | 2008-02-11 | 2015-10-20 | Pavel Nosovitskiy | Multi-functional, discrete determination of concentrations of gases in a gaseous mixture |
US8185325B2 (en) * | 2008-02-11 | 2012-05-22 | Pavel Nosovitskiy | Multi-functional, discrete and mutually exclusive method for determining concentrations of gases in a gaseous mixture |
JP2010005047A (ja) * | 2008-06-25 | 2010-01-14 | Panasonic Electric Works Co Ltd | 光学式生体成分測定用の検量モデルの作成方法及び非侵襲血糖値測定装置 |
JP5376439B2 (ja) * | 2009-03-18 | 2013-12-25 | 株式会社フォトサイエンス | グルコース濃度測定装置 |
KR101041410B1 (ko) * | 2009-04-22 | 2011-06-14 | 주식회사 스필 | 대기 전력 차단 시스템에서 전기 기기의 제어 방법 및 그 장치 |
US8845100B2 (en) * | 2009-10-07 | 2014-09-30 | The University Of Toledo | Non-invasive ocular analyte sensing system |
JP5501797B2 (ja) * | 2010-02-24 | 2014-05-28 | 三井造船株式会社 | スペクトラム分析装置及びスペクトラム分析方法 |
US8645082B2 (en) | 2010-09-13 | 2014-02-04 | Mks Instruments, Inc. | Monitoring, detecting and quantifying chemical compounds in a sample |
WO2012049753A1 (ja) * | 2010-10-14 | 2012-04-19 | 株式会社日立製作所 | 生体情報取得解析装置 |
CN103815873B (zh) * | 2014-01-02 | 2016-04-06 | 深圳源动创新科技有限公司 | 手掌式多参数测量仪及其工作方法 |
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US7438855B2 (en) | 2008-10-21 |
KR20030012791A (ko) | 2003-02-12 |
US20030031597A1 (en) | 2003-02-13 |
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