JPWO2020106843A5 - - Google Patents
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- JPWO2020106843A5 JPWO2020106843A5 JP2021527959A JP2021527959A JPWO2020106843A5 JP WO2020106843 A5 JPWO2020106843 A5 JP WO2020106843A5 JP 2021527959 A JP2021527959 A JP 2021527959A JP 2021527959 A JP2021527959 A JP 2021527959A JP WO2020106843 A5 JPWO2020106843 A5 JP WO2020106843A5
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- Prior art keywords
- pharmaceutical composition
- engineered
- cells
- proteins
- exogenous polynucleotide
- Prior art date
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Claims (15)
前記改変T細胞がキメラ抗原受容体(CAR)及び1以上のタンパク質をコードする外因性ポリヌクレオチドを含み、前記1以上のタンパク質がIFNγを含む、医薬組成物。 A pharmaceutical composition comprising an engineered T cell,
A pharmaceutical composition, wherein said modified T cells comprise a chimeric antigen receptor (CAR) and an exogenous polynucleotide encoding one or more proteins, said one or more proteins comprising IFNγ .
Applications Claiming Priority (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862769987P | 2018-11-20 | 2018-11-20 | |
US62/769,987 | 2018-11-20 | ||
US201862774595P | 2018-12-03 | 2018-12-03 | |
US62/774,595 | 2018-12-03 | ||
US201962795810P | 2019-01-23 | 2019-01-23 | |
US62/795,810 | 2019-01-23 | ||
US201962828770P | 2019-04-03 | 2019-04-03 | |
US62/828,770 | 2019-04-03 | ||
US201962846563P | 2019-05-10 | 2019-05-10 | |
US62/846,563 | 2019-05-10 | ||
US201962848961P | 2019-05-16 | 2019-05-16 | |
US62/848,961 | 2019-05-16 | ||
US16/445,965 US10918667B2 (en) | 2018-11-20 | 2019-06-19 | Modified cell expressing therapeutic agent and uses thereof |
US16/445,965 | 2019-06-19 | ||
US201962889926P | 2019-08-21 | 2019-08-21 | |
US62/889,926 | 2019-08-21 | ||
US201962902766P | 2019-09-19 | 2019-09-19 | |
US62/902,766 | 2019-09-19 | ||
PCT/US2019/062417 WO2020106843A1 (en) | 2018-11-20 | 2019-11-20 | Modified cell expressing therapeutic agent and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022507830A JP2022507830A (en) | 2022-01-18 |
JPWO2020106843A5 true JPWO2020106843A5 (en) | 2022-11-29 |
Family
ID=70774027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021527959A Pending JP2022507830A (en) | 2018-11-20 | 2019-11-20 | Modified cells expressing therapeutic agents and their use |
Country Status (7)
Country | Link |
---|---|
US (2) | US20220000921A1 (en) |
EP (1) | EP3883585A4 (en) |
JP (1) | JP2022507830A (en) |
AU (1) | AU2019384145A1 (en) |
CA (1) | CA3120153A1 (en) |
SG (1) | SG11202105173VA (en) |
WO (1) | WO2020106843A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112739713A (en) | 2018-06-25 | 2021-04-30 | 华盛顿大学 | De novo design of potent and selective interleukin mimetics |
AU2019313339A1 (en) * | 2018-07-30 | 2021-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Interferon-gamma biased agonists |
EP3847195A4 (en) * | 2018-08-30 | 2022-09-07 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
US11866494B2 (en) * | 2018-08-31 | 2024-01-09 | Innovative Cellular Therapeutics Holdings, Ltd. | CAR T therapy through uses of co-stimulation |
US20210060069A1 (en) * | 2019-08-23 | 2021-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Coupled redirected cells and uses thereof |
JP2023503258A (en) * | 2019-11-14 | 2023-01-27 | ウェアウルフ セラピューティクス, インコーポレイテッド | Activatable cytokine polypeptides and methods of use thereof |
EP3892720A1 (en) | 2020-04-06 | 2021-10-13 | Innovative Cellular Therapeutics Holdings, Ltd. | Presenting cell and use thereof in cell therapy |
JP2024503703A (en) * | 2021-01-19 | 2024-01-26 | セネカ セラピューティクス、インク. | Armed Seneca Valley virus oncolytic therapy compositions and methods thereof |
US11633427B2 (en) * | 2021-02-05 | 2023-04-25 | Innovative Cellular Therapeutics Holdings, Ltd. | Vaccine and uses thereof in cell therapy |
CN113046320B (en) * | 2021-02-19 | 2023-04-14 | 中国医学科学院基础医学研究所 | CAR molecule with extracellular segment of V delta1 (GTM) V gamma4, CAR-T cell expressing same and application thereof |
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DE69936382T3 (en) * | 1998-05-15 | 2011-07-07 | Genentech, Inc., Calif. | THERAPEUTIC USES OF IL-17 HOMOLOGOUS POLYPEPTIDE |
US7038015B2 (en) * | 2001-04-06 | 2006-05-02 | Maxygen Holdings, Ltd. | Interferon gamma polypeptide variants |
EP1572242B1 (en) * | 2002-12-13 | 2014-04-16 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
AU2010205782A1 (en) * | 2009-01-16 | 2011-09-08 | Agirx Limited | Vaccine compositions |
AU2010241864B2 (en) * | 2009-04-30 | 2014-02-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inducible interleukin-12 |
US10117895B2 (en) * | 2010-11-17 | 2018-11-06 | Ben-Gurion University Of The Negev Research And Development Authority | T-cell therapy to neurodegenerative diseases |
EA201391059A1 (en) * | 2011-01-18 | 2014-05-30 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | COMPOSITIONS FOR CANCER TREATMENT AND METHODS OF THEIR APPLICATION |
US9629877B2 (en) * | 2013-05-14 | 2017-04-25 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (CAR) T-cells |
US11382963B2 (en) * | 2015-01-12 | 2022-07-12 | Pieris Pharmaceuticals Gmbh | Engineered T cells and uses therefor |
WO2017044487A1 (en) * | 2015-09-09 | 2017-03-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Genetic engineering of macrophages for immunotherapy |
EP3368559A4 (en) * | 2015-10-30 | 2020-01-15 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
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