JPWO2020072478A5 - - Google Patents
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- Publication number
- JPWO2020072478A5 JPWO2020072478A5 JP2021542080A JP2021542080A JPWO2020072478A5 JP WO2020072478 A5 JPWO2020072478 A5 JP WO2020072478A5 JP 2021542080 A JP2021542080 A JP 2021542080A JP 2021542080 A JP2021542080 A JP 2021542080A JP WO2020072478 A5 JPWO2020072478 A5 JP WO2020072478A5
- Authority
- JP
- Japan
- Prior art keywords
- delivery device
- droplet delivery
- droplets
- ejected
- droplet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims 5
- 229920001600 hydrophobic polymer Polymers 0.000 claims 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 3
- 239000004696 Poly ether ether ketone Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- 229910052763 palladium Inorganic materials 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 229920002530 poly[4-(4-benzoylphenoxy)phenol] polymer Polymers 0.000 claims 2
- -1 polytetrafluoroethylene, siloxane Polymers 0.000 claims 2
- XTULMSXFIHGYFS-VLSRWLAYSA-N Fluticasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4[C@@H](F)C[C@H]3[C@@H]2C[C@H]1C)C(=O)SCF)C(=O)C1=CC=CO1 XTULMSXFIHGYFS-VLSRWLAYSA-N 0.000 claims 1
- WMWTYOKRWGGJOA-CENSZEJFSA-N Fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- 239000004697 Polyetherimide Substances 0.000 claims 1
- 229920001721 Polyimide Polymers 0.000 claims 1
- 239000004642 Polyimide Substances 0.000 claims 1
- 229920002367 Polyisobutene Polymers 0.000 claims 1
- 239000004699 Ultra-high molecular weight polyethylene (UHMWPE) Substances 0.000 claims 1
- 230000003213 activating Effects 0.000 claims 1
- 229930003827 cannabinoid Natural products 0.000 claims 1
- 239000003557 cannabinoid Substances 0.000 claims 1
- 230000002149 cannabinoid Effects 0.000 claims 1
- 229940065144 cannabinoids Drugs 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 229960001469 fluticasone furoate Drugs 0.000 claims 1
- 229960000289 fluticasone propionate Drugs 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229910001092 metal group alloy Inorganic materials 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 229920001601 polyetherimide Polymers 0.000 claims 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims 1
- 230000002685 pulmonary Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (11)
ハウジングと、
前記デバイスの空気流出口に位置決めされたマウスピースと、
低表面張力組成物を受容するために前記ハウジング内に配置された、または前記ハウジングと流体連通して配置されたリザーバと、
前記リザーバと流体連通し、かつ、前記液滴の放出流を生成するように構成された電子作動式エゼクタ機構と、
前記ハウジング内に位置決めされた少なくとも１つの差圧センサであって、前記マウスピース内での所定の圧力変化の検知時に前記エゼクタ機構を作動させ、それによって前記液滴の放出流を生成するように構成された、少なくとも１つの差圧センサと
を備え、
前記エゼクタ機構が、圧電アクチュエータおよび開口板を備え、前記開口板が、その厚さにわたって形成された複数の開口部、および、９０度よりも大きい表面接触角を提供するように構成された１つまたは複数の表面を有し、前記圧電アクチュエータが、前記液滴の放出流を生成するための振動数で開口板を振動させるように動作可能であり、
前記エゼクタ機構が、前記液滴の放出流を生成するように構成され、使用中に前記液滴の放出流の質量の少なくとも約５０％が、呼吸に適した範囲内で前記対象者の前記肺系統へ送達されるように、前記液滴の少なくとも約５０％が、約６ミクロン未満の平均放出液滴直径を有する、液滴送達デバイス。 An electronically actuated droplet delivery device for delivering a low surface tension composition as an ejected stream of droplets to the pulmonary system of a subject, comprising:
a housing;
a mouthpiece positioned at the air outlet of the device;
a reservoir disposed within or in fluid communication with the housing for receiving a low surface tension composition;
an electronically actuated ejector mechanism in fluid communication with the reservoir and configured to generate an ejected stream of droplets;
at least one differential pressure sensor positioned within the housing for activating the ejector mechanism upon detection of a predetermined pressure change within the mouthpiece, thereby producing an ejected stream of droplets; at least one differential pressure sensor;
one wherein the ejector mechanism comprises a piezoelectric actuator and an aperture plate, the aperture plate configured to provide a plurality of apertures formed through its thickness and a surface contact angle greater than 90 degrees; or having a plurality of surfaces, wherein the piezoelectric actuator is operable to vibrate the aperture plate at a frequency to produce the ejected stream of droplets;
The ejector mechanism is configured to generate the ejected stream of droplets, wherein during use at least about 50% of the mass of the ejected stream of droplets is ejected from the lungs of the subject within a respirable range. A droplet delivery device, wherein at least about 50% of said droplets have a mean ejected droplet diameter of less than about 6 microns, as delivered to a system.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862739740P | 2018-10-01 | 2018-10-01 | |
| US62/739,740 | 2018-10-01 | ||
| PCT/US2019/054042 WO2020072478A1 (en) | 2018-10-01 | 2019-10-01 | Delivery of low surface tension compositions to the pulmonary system via electronic breath actuated droplet delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022508519A JP2022508519A (en) | 2022-01-19 |
| JPWO2020072478A5 true JPWO2020072478A5 (en) | 2022-09-30 |
Family
ID=70054758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021542080A Pending JP2022508519A (en) | 2018-10-01 | 2019-10-01 | Delivery of low surface tension composition to the pulmonary system via an electrorespiratory aerosol inhalation device |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220001122A1 (en) |
| EP (1) | EP3860768B1 (en) |
| JP (1) | JP2022508519A (en) |
| CN (1) | CN112996605A (en) |
| AU (1) | AU2019352957A1 (en) |
| CA (1) | CA3113981A1 (en) |
| IL (1) | IL281937A (en) |
| WO (1) | WO2020072478A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017259982B2 (en) | 2016-05-03 | 2021-04-01 | Pneuma Respiratory, Inc. | Systems and methods for pulmonary health management |
| US11529476B2 (en) | 2017-05-19 | 2022-12-20 | Pneuma Respiratory, Inc. | Dry powder delivery device and methods of use |
| CA3077475A1 (en) | 2017-10-04 | 2019-04-11 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device and methods of use |
| EP4344719A3 (en) | 2017-10-17 | 2024-06-05 | Pneuma Respiratory, Inc. | Nasal drug delivery apparatus and methods of use |
| CA3082192A1 (en) | 2017-11-08 | 2019-05-16 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device with small volume ampoule and methods of use |
| US11517685B2 (en) | 2019-01-18 | 2022-12-06 | Qnovia, Inc. | Electronic device for producing an aerosol for inhalation by a person |
| US11690963B2 (en) | 2018-08-22 | 2023-07-04 | Qnovia, Inc. | Electronic device for producing an aerosol for inhalation by a person |
| WO2020264501A1 (en) * | 2019-06-27 | 2020-12-30 | Pneuma Respiratory, Inc. | Delivery of small droplets to the respiratory system via electronic breath actuated droplet delivery device |
| US20230233514A1 (en) | 2020-06-23 | 2023-07-27 | Flagship Pioneering, Inc. | Antiviral compounds and methods of using the same |
| WO2022271848A1 (en) | 2021-06-22 | 2022-12-29 | Pneuma Respiratory, Inc. | Droplet delivery device with push ejection |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU9089591A (en) * | 1990-12-17 | 1992-07-22 | Minnesota Mining And Manufacturing Company | Inhaler |
| GB2272389B (en) * | 1992-11-04 | 1996-07-24 | Bespak Plc | Dispensing apparatus |
| US6397838B1 (en) * | 1998-12-23 | 2002-06-04 | Battelle Pulmonary Therapeutics, Inc. | Pulmonary aerosol delivery device and method |
| EP1236517A1 (en) * | 2001-02-23 | 2002-09-04 | Microflow Engineering SA | Method of manufacturing a liquid droplet spray device and such spray device |
| JP2006507921A (en) * | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Method and apparatus for fluid dispersion |
| US7849850B2 (en) * | 2003-02-28 | 2010-12-14 | Battelle Memorial Institute | Nozzle for handheld pulmonary aerosol delivery device |
| US20050150489A1 (en) * | 2004-01-12 | 2005-07-14 | Steve Dunfield | Dispensing medicaments based on rates of medicament action |
| WO2010008424A2 (en) * | 2008-04-04 | 2010-01-21 | Novartis Ag | Aerosolization device |
| US11247003B2 (en) * | 2010-08-23 | 2022-02-15 | Darren Rubin | Systems and methods of aerosol delivery with airflow regulation |
| WO2013090468A1 (en) * | 2011-12-12 | 2013-06-20 | Corinthian Ophthalmic, Inc. | High modulus polymeric ejector mechanism, ejector device, and methods of use |
| CA2870966C (en) * | 2012-04-20 | 2021-07-27 | Eyenovia, Inc. | Spray ejector device and methods of use |
| US10105500B2 (en) * | 2012-05-09 | 2018-10-23 | Virginia Commonwealth University | Dry powder inhaler (DPI) designs for producing aerosols with high fine particle fractions |
| GB2551944B (en) * | 2015-12-18 | 2021-09-01 | Midatech Pharma Wales Ltd | Microparticle production process and apparatus |
| AU2017259982B2 (en) * | 2016-05-03 | 2021-04-01 | Pneuma Respiratory, Inc. | Systems and methods for pulmonary health management |
| CA3077475A1 (en) * | 2017-10-04 | 2019-04-11 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device and methods of use |
| CA3082192A1 (en) * | 2017-11-08 | 2019-05-16 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device with small volume ampoule and methods of use |
| KR20210009318A (en) * | 2018-05-16 | 2021-01-26 | 필립모리스 프로덕츠 에스.에이. | Nebulizer assembly with vibrating chamber |
-
2019
- 2019-10-01 AU AU2019352957A patent/AU2019352957A1/en active Pending
- 2019-10-01 WO PCT/US2019/054042 patent/WO2020072478A1/en unknown
- 2019-10-01 CA CA3113981A patent/CA3113981A1/en active Pending
- 2019-10-01 EP EP19868411.0A patent/EP3860768B1/en active Active
- 2019-10-01 JP JP2021542080A patent/JP2022508519A/en active Pending
- 2019-10-01 US US17/281,676 patent/US20220001122A1/en active Pending
- 2019-10-01 CN CN201980073544.1A patent/CN112996605A/en active Pending
-
2021
- 2021-03-31 IL IL281937A patent/IL281937A/en unknown
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