JPWO2011070612A1 - コンタクトレンズパッケージの製造方法 - Google Patents
コンタクトレンズパッケージの製造方法 Download PDFInfo
- Publication number
- JPWO2011070612A1 JPWO2011070612A1 JP2010519037A JP2010519037A JPWO2011070612A1 JP WO2011070612 A1 JPWO2011070612 A1 JP WO2011070612A1 JP 2010519037 A JP2010519037 A JP 2010519037A JP 2010519037 A JP2010519037 A JP 2010519037A JP WO2011070612 A1 JPWO2011070612 A1 JP WO2011070612A1
- Authority
- JP
- Japan
- Prior art keywords
- contact lens
- silicone hydrogel
- phosphoric acid
- package
- pressure steam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 31
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 168
- 239000000017 hydrogel Substances 0.000 claims abstract description 95
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 91
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 84
- 230000001954 sterilising effect Effects 0.000 claims abstract description 75
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 74
- 238000003860 storage Methods 0.000 claims abstract description 69
- 238000000034 method Methods 0.000 claims abstract description 51
- 239000003755 preservative agent Substances 0.000 claims abstract description 22
- 230000002335 preservative effect Effects 0.000 claims abstract description 18
- 239000000243 solution Substances 0.000 claims description 59
- 239000003761 preservation solution Substances 0.000 claims description 40
- 230000000087 stabilizing effect Effects 0.000 claims description 15
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- 238000012360 testing method Methods 0.000 description 19
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 16
- 230000004308 accommodation Effects 0.000 description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
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- 230000000052 comparative effect Effects 0.000 description 6
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- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
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- UURVHRGPGCBHIC-UHFFFAOYSA-N 3-(ethenoxycarbonylamino)propanoic acid 4-[[[[[[[[[[[[[[[[[[[[[[[[[[[4-ethenoxycarbonyloxybutyl(dimethyl)silyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]oxy-dimethylsilyl]butyl ethenyl carbonate 1-ethenylpyrrolidin-2-one ethenyl N-[3-tris(trimethylsilyloxy)silylpropyl]carbamate Chemical compound C=CN1CCCC1=O.OC(=O)CCNC(=O)OC=C.C[Si](C)(C)O[Si](CCCNC(=O)OC=C)(O[Si](C)(C)C)O[Si](C)(C)C.C[Si](C)(CCCCOC(=O)OC=C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)CCCCOC(=O)OC=C UURVHRGPGCBHIC-UHFFFAOYSA-N 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 229920005613 synthetic organic polymer Chemical class 0.000 description 1
- 238000004154 testing of material Methods 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B25/00—Packaging other articles presenting special problems
- B65B25/008—Packaging other articles presenting special problems packaging of contact lenses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2585/00—Containers, packaging elements or packages specially adapted for particular articles or materials
- B65D2585/54—Containers, packaging elements or packages specially adapted for particular articles or materials for articles of special shape not otherwise provided for
- B65D2585/545—Contact lenses
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Eyeglasses (AREA)
- Packaging Frangible Articles (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Description
Methods of measurement for contact lens, 4.3 Diameters and widths 」に記載の方法に基づく一般的な測定方法である。
Claims (6)
- ソフトコンタクトレンズと保存液を収容領域内に密封したコンタクトレンズパッケージの製造方法であって、
前記ソフトコンタクトレンズとしてシリコーンハイドロゲルコンタクトレンズを用いると共に、前記保存液をリン酸を含んで構成する一方、該リン酸を含んで構成された該保存液と共に該シリコーンハイドロゲルコンタクトレンズを前記収容領域内に封入して高圧蒸気滅菌処理を行うことを特徴とするコンタクトレンズパッケージの製造方法。 - 前記保存液において前記リン酸の濃度が0.01〜1.0重量%である請求項1に記載のコンタクトレンズパッケージの製造方法。
- 前記保存液のpHが7.2〜8である請求項1又は2に記載のコンタクトレンズパッケージの製造方法。
- ソフトコンタクトレンズと保存液を収容領域内に密封したコンタクトレンズパッケージであって、
前記ソフトコンタクトレンズとしてシリコーンハイドロゲルコンタクトレンズを用いると共に、前記保存液がリン酸を含んで構成されている一方、該リン酸を含んで構成された該保存液と共に該シリコーンハイドロゲルコンタクトレンズが前記収容領域内に封入されて高圧蒸気滅菌処理されていると共にそのまま密封されていることを特徴とするコンタクトレンズパッケージ。 - 前記保存液の液量が0.15〜4mLである請求項4に記載のコンタクトレンズパッケージ。
- パッケージ内に保存液と共に密封したシリコーンハイドロゲル成型品を安定化させる方法であって、
前記保存液をリン酸を含んで構成する一方、該リン酸を含んで構成された該保存液と共に該シリコーンハイドロゲル成型品を前記パッケージ内に封入して高圧蒸気滅菌処理を行うことを特徴とするシリコーンハイドロゲル成型品を安定化させる方法。
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PCT/JP2009/006703 WO2011070612A1 (ja) | 2009-12-08 | 2009-12-08 | コンタクトレンズパッケージの製造方法 |
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JPWO2011070612A1 true JPWO2011070612A1 (ja) | 2013-04-22 |
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US (1) | US8512632B2 (ja) |
EP (1) | EP2511752B1 (ja) |
JP (1) | JP4700139B1 (ja) |
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EP2812826A1 (en) * | 2012-02-10 | 2014-12-17 | Johnson & Johnson Vision Care Inc. | A lens storage unit with programmable and communication elements for monitoring the condition of lenses and their response to geo-social phenomena |
US9439487B2 (en) * | 2013-03-15 | 2016-09-13 | Johnson & Johnson Vision Care, Inc. | Contact lens package with reduced head space |
US10368621B2 (en) | 2013-03-15 | 2019-08-06 | Johnson & Johnson Vision Care, Inc. | Contact lens package with reduced lens-package interactions and method of making |
JP1669253S (ja) * | 2020-03-10 | 2020-09-28 |
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Publication number | Priority date | Publication date | Assignee | Title |
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TW448205B (en) | 1996-05-23 | 2001-08-01 | Novartis Ag | Process for the manufacture of storage-stable hydrogel-moldings |
US6634748B1 (en) | 2000-11-15 | 2003-10-21 | Johnson & Johnson Vision Care, Inc. | Methods of stabilizing silicone hydrogels against hydrolytic degradation |
US20050196370A1 (en) * | 2003-03-18 | 2005-09-08 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
WO2005071467A1 (ja) | 2004-01-26 | 2005-08-04 | Kuraray Co., Ltd. | コンタクトレンズ洗浄用シート |
US20070149428A1 (en) * | 2005-12-14 | 2007-06-28 | Bausch & Lomb Incorporated | Method of Packaging a Lens |
TWI419719B (zh) | 2007-08-31 | 2013-12-21 | Novartis Ag | 隱形眼鏡產物 |
JP5033657B2 (ja) * | 2008-01-25 | 2012-09-26 | 株式会社メニコン | コンタクトレンズ用液剤及びコンタクトレンズ並びにコンタクトレンズに対する殺菌剤の付着防止方法 |
JP4869274B2 (ja) * | 2008-03-21 | 2012-02-08 | 株式会社メニコン | ソフトコンタクトレンズ包装製品及びソフトコンタクトレンズの包装方法 |
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2009
- 2009-12-08 US US13/513,016 patent/US8512632B2/en active Active
- 2009-12-08 WO PCT/JP2009/006703 patent/WO2011070612A1/ja active Application Filing
- 2009-12-08 JP JP2010519037A patent/JP4700139B1/ja active Active
- 2009-12-08 EP EP09852009.1A patent/EP2511752B1/en active Active
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JP4700139B1 (ja) | 2011-06-15 |
US8512632B2 (en) | 2013-08-20 |
WO2011070612A1 (ja) | 2011-06-16 |
US20120234702A1 (en) | 2012-09-20 |
EP2511752A1 (en) | 2012-10-17 |
EP2511752B1 (en) | 2014-10-15 |
EP2511752A4 (en) | 2013-04-24 |
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