JPS6485072A - Recombinant vaccinia virus - Google Patents

Recombinant vaccinia virus

Info

Publication number
JPS6485072A
JPS6485072A JP62240514A JP24051487A JPS6485072A JP S6485072 A JPS6485072 A JP S6485072A JP 62240514 A JP62240514 A JP 62240514A JP 24051487 A JP24051487 A JP 24051487A JP S6485072 A JPS6485072 A JP S6485072A
Authority
JP
Japan
Prior art keywords
vaccinia virus
originated
recombinant
recombinant vector
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62240514A
Other languages
Japanese (ja)
Inventor
Asato Kojima
Takeshi Kurata
Atsushi Yasuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KOKURITSU YOBOU EISEI KENKYUSHO
Zeon Corp
National Institutes of Health NIH
Original Assignee
KOKURITSU YOBOU EISEI KENKYUSHO
Nippon Zeon Co Ltd
National Institutes of Health NIH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KOKURITSU YOBOU EISEI KENKYUSHO, Nippon Zeon Co Ltd, National Institutes of Health NIH filed Critical KOKURITSU YOBOU EISEI KENKYUSHO
Priority to JP62240514A priority Critical patent/JPS6485072A/en
Publication of JPS6485072A publication Critical patent/JPS6485072A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PURPOSE:To produce tat protein in high expressivity, by using a cDNA coding tat protein originated from human immunodeficiency syndrome virus HIV and synthesizing a recombinant vaccinia virus by integrating said cDNA in a specific region. CONSTITUTION:The 1st recombinant vector is prepared by integrating a DNA region nonessential to the proliferation of vaccinia virus. A region coding tat protein originated from HIV is inserted to the downstream of the promoter of the 1st recombinant vector to obtain the 2nd recombinant vector. The 2nd recombinant vector is introduced into a cultural cell of an animal infected with vaccinia virus to induce a homologous recombination between the vector DNA and the virus genom DNA to construct the objective recombinant vaccinia virus. The cultured animal cell is e.g. TK-143 originated from human osteosarcoma and FL originated from human amnion.
JP62240514A 1987-09-25 1987-09-25 Recombinant vaccinia virus Pending JPS6485072A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62240514A JPS6485072A (en) 1987-09-25 1987-09-25 Recombinant vaccinia virus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62240514A JPS6485072A (en) 1987-09-25 1987-09-25 Recombinant vaccinia virus

Publications (1)

Publication Number Publication Date
JPS6485072A true JPS6485072A (en) 1989-03-30

Family

ID=17060653

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62240514A Pending JPS6485072A (en) 1987-09-25 1987-09-25 Recombinant vaccinia virus

Country Status (1)

Country Link
JP (1) JPS6485072A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012137071A2 (en) 2011-04-06 2012-10-11 Biovaxim Limited Pharmaceutical compositions for preventing and/or treating an hiv disease in humans

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012137071A2 (en) 2011-04-06 2012-10-11 Biovaxim Limited Pharmaceutical compositions for preventing and/or treating an hiv disease in humans

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