JPS6468396A - Novel peptide and amnesia alleviating drug comprising said peptide as active ingredient - Google Patents
Novel peptide and amnesia alleviating drug comprising said peptide as active ingredientInfo
- Publication number
- JPS6468396A JPS6468396A JP62225377A JP22537787A JPS6468396A JP S6468396 A JPS6468396 A JP S6468396A JP 62225377 A JP62225377 A JP 62225377A JP 22537787 A JP22537787 A JP 22537787A JP S6468396 A JPS6468396 A JP S6468396A
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- benzyloxycarbonyl
- amnesia
- formula
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound shown by formula I (Z is benzyloxycarbonyl; X is residue after removal of one H atom. from imino group of L-imino acid shown by formula II-VI). EXAMPLE:N-Benzyloxycarbonyl-prolyl-hydroxyproline shown by formula VII. USE:A drug for alleviating amnesia, having inhibitory action on prolyl endopeptidase. PREPARATION:For example, N-benzyloxycarbonyl-proline is dissolved in acetonitrile and dicyclohexylcarbodiimide is added to the solution while cooling the solution. A mixture of hydroxymethyl ester hydrochloride and triethylamine is added to the mixture, stirred, filtered and an oily substance is obtained from the collected organic layer. The oily substance is dissolved in THF, incorporated with sodium hydroxide, THF is distilled away, the water layer is washed with an ether, incorporated with hydrochloric acid, then with ethyl acetate and crystallized.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62225377A JP2515558B2 (en) | 1987-09-10 | 1987-09-10 | Novel peptide and anti-amnestic agent containing the same as active ingredient |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62225377A JP2515558B2 (en) | 1987-09-10 | 1987-09-10 | Novel peptide and anti-amnestic agent containing the same as active ingredient |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6468396A true JPS6468396A (en) | 1989-03-14 |
JP2515558B2 JP2515558B2 (en) | 1996-07-10 |
Family
ID=16828399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62225377A Expired - Lifetime JP2515558B2 (en) | 1987-09-10 | 1987-09-10 | Novel peptide and anti-amnestic agent containing the same as active ingredient |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2515558B2 (en) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0468469A2 (en) * | 1990-07-27 | 1992-01-29 | Japan Tobacco Inc. | Proline derivatives |
WO2004098591A2 (en) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
WO2005075436A2 (en) | 2004-02-05 | 2005-08-18 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
WO2008065141A1 (en) | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
WO2008104580A1 (en) | 2007-03-01 | 2008-09-04 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
WO2011029920A1 (en) | 2009-09-11 | 2011-03-17 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
EP2338490A2 (en) | 2003-11-03 | 2011-06-29 | Probiodrug AG | Combinations Useful for the Treatment of Neuronal Disorders |
WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
WO2011110613A1 (en) | 2010-03-10 | 2011-09-15 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
WO2014030746A1 (en) * | 2012-08-24 | 2014-02-27 | 味の素株式会社 | Acyl dipeptide derivative |
EP2865670A1 (en) | 2007-04-18 | 2015-04-29 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
EP3461819A1 (en) | 2017-09-29 | 2019-04-03 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
-
1987
- 1987-09-10 JP JP62225377A patent/JP2515558B2/en not_active Expired - Lifetime
Non-Patent Citations (3)
Title |
---|
ACTA CRYSTALLOGR SECT B=1982 * |
COLLECT CZECH CHEM COMMU=1975 * |
INT.J.PEPT.PROTEIN RES=1976 * |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0468469A2 (en) * | 1990-07-27 | 1992-01-29 | Japan Tobacco Inc. | Proline derivatives |
WO2004098591A2 (en) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
EP2338490A2 (en) | 2003-11-03 | 2011-06-29 | Probiodrug AG | Combinations Useful for the Treatment of Neuronal Disorders |
US7897633B2 (en) | 2004-02-05 | 2011-03-01 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
WO2005075436A2 (en) | 2004-02-05 | 2005-08-18 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
WO2008065141A1 (en) | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
WO2008104580A1 (en) | 2007-03-01 | 2008-09-04 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
EP2481408A2 (en) | 2007-03-01 | 2012-08-01 | Probiodrug AG | New use of glutaminyl cyclase inhibitors |
EP2865670A1 (en) | 2007-04-18 | 2015-04-29 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
WO2011029920A1 (en) | 2009-09-11 | 2011-03-17 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
WO2011110613A1 (en) | 2010-03-10 | 2011-09-15 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
WO2014030746A1 (en) * | 2012-08-24 | 2014-02-27 | 味の素株式会社 | Acyl dipeptide derivative |
US9464110B2 (en) | 2012-08-24 | 2016-10-11 | Ajinomoto Co., Inc. | Acyl dipeptide derivative |
EP3461819A1 (en) | 2017-09-29 | 2019-04-03 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
Also Published As
Publication number | Publication date |
---|---|
JP2515558B2 (en) | 1996-07-10 |
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