JPS6468376A - Quaternary derivative of noroxymorhone reducing nausea and vomiting - Google Patents

Quaternary derivative of noroxymorhone reducing nausea and vomiting

Info

Publication number: JPS6468376A
Authority: JP; Japan
Prior art keywords: noroxymorhone; vomiting; quaternary derivative; reducing nausea; nausea
Prior art date: 1987-09-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP62330356A

Other languages

Japanese (ja)

Other versions

JP2625457B2 (en

Inventor

Ai Goorudobaagu Reon

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Chicago

Original Assignee

University of Chicago

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-03

Filing date

1987-12-28

Publication date

1989-03-14

1987-09-03 Priority claimed from US07/092,470 external-priority patent/US4861781A/en

1987-12-28 Application filed by University of Chicago filed Critical University of Chicago

1989-03-14 Publication of JPS6468376A publication Critical patent/JPS6468376A/en

1997-07-02 Application granted granted Critical

1997-07-02 Publication of JP2625457B2 publication Critical patent/JP2625457B2/en

2012-07-02 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine

JP62330356A 1987-09-03 1987-12-28 Drugs to prevent or reduce nausea or vomiting Expired - Lifetime JP2625457B2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US92470		1987-09-03
US07/092,470 US4861781A (en)	1986-03-07	1987-09-03	Quaternary derivatives of noroxymorphone which relieve nausea and emesis

Publications (2)

Publication Number	Publication Date
JPS6468376A true JPS6468376A (en)	1989-03-14
JP2625457B2 JP2625457B2 (en)	1997-07-02

Family

ID=22233375

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP62330356A Expired - Lifetime JP2625457B2 (en)	1987-09-03	1987-12-28	Drugs to prevent or reduce nausea or vomiting

Country Status (6)

Country	Link
JP (1)	JP2625457B2 (en)
KR (1)	KR890004704A (en)
CA (1)	CA1315689C (en)
DK (1)	DK167340B1 (en)
NZ (1)	NZ222911A (en)
PH (1)	PH22582A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6451806B2 (en)	1999-09-29	2002-09-17	Adolor Corporation	Methods and compositions involving opioids and antagonists thereof
US6469030B2 (en)	1999-11-29	2002-10-22	Adolor Corporation	Methods for the treatment and prevention of ileus
WO2007043518A1 (en) *	2005-10-11	2007-04-19	Toray Industries, Inc.	Therapeutic agent for nausea and/or vomiting
JP2010535814A (en) *	2007-08-09	2010-11-25	レンセラールポリテクニックインスティチュート	Quaternary opioid carboxamide
US9669096B2 (en)	2003-04-08	2017-06-06	Progenics Pharmaceuticals, Inc.	Stable pharmaceutical formulations of methylnaltrexone
US9724343B2 (en)	2008-09-30	2017-08-08	Wyeth, Llc	Peripheral opioid receptor antagonists and uses thereof
US9879024B2 (en)	2007-03-29	2018-01-30	Progenics Pharmaceuticals., Inc.	Crystal forms of (R)-N-methylnaltrexone bromide and uses thereof

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6274591B1 (en)	1997-11-03	2001-08-14	Joseph F. Foss	Use of methylnaltrexone and related compounds
US8518962B2 (en)	2005-03-07	2013-08-27	The University Of Chicago	Use of opioid antagonists
US9662325B2 (en)	2005-03-07	2017-05-30	The University Of Chicago	Use of opioid antagonists to attenuate endothelial cell proliferation and migration
MX2007010833A (en)	2005-03-07	2009-02-17	Univ Chicago	Use of opioid antagonists to attenuate endothelial cell proliferation and migration.
US8524731B2 (en)	2005-03-07	2013-09-03	The University Of Chicago	Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057325A1 (en)	2005-05-25	2007-11-28	Progenics Pharm Inc	SYNTHESIS OF (S) -N-METHYLNTREXONE, PHARMACEUTICAL COMPOSITIONS AND USES
AR057035A1 (en)	2005-05-25	2007-11-14	Progenics Pharm Inc	SYNTHESIS OF (R) -N-METHYLNTREXONE, PHARMACEUTICAL COMPOSITIONS AND USES
AU2008233129B2 (en)	2007-03-29	2014-03-20	Progenics Pharmaceuticals, Inc.	Peripheral opioid receptor antagonists and uses thereof
ES2540551T3 (en)	2007-03-29	2015-07-10	Wyeth Llc	Peripheral opioid receptor antagonists and uses thereof
CN101959892B (en)	2008-02-06	2014-01-08	普罗热尼奇制药公司	Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone
JP5647098B2 (en)	2008-03-21	2014-12-24	ザユニヴァーシティーオヴシカゴ	Treatment with opioid antagonists and mTOR inhibitors

1987
- 1987-10-09 CA CA000548964A patent/CA1315689C/en not_active Expired - Lifetime
- 1987-12-07 PH PH36178A patent/PH22582A/en unknown
- 1987-12-14 NZ NZ222911A patent/NZ222911A/en unknown
- 1987-12-28 JP JP62330356A patent/JP2625457B2/en not_active Expired - Lifetime
- 1987-12-29 KR KR1019870015208A patent/KR890004704A/en not_active Application Discontinuation
- 1987-12-30 DK DK693387A patent/DK167340B1/en not_active IP Right Cessation

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6451806B2 (en)	1999-09-29	2002-09-17	Adolor Corporation	Methods and compositions involving opioids and antagonists thereof
US6469030B2 (en)	1999-11-29	2002-10-22	Adolor Corporation	Methods for the treatment and prevention of ileus
US7696220B2 (en)	2000-04-27	2010-04-13	Adolor Corporation	Methods for the treatment or inhibition of ileus
US9669096B2 (en)	2003-04-08	2017-06-06	Progenics Pharmaceuticals, Inc.	Stable pharmaceutical formulations of methylnaltrexone
US10376584B2 (en)	2003-04-08	2019-08-13	Progenics Pharmaceuticals, Inc.	Stable pharmaceutical formulations of methylnaltrexone
WO2007043518A1 (en) *	2005-10-11	2007-04-19	Toray Industries, Inc.	Therapeutic agent for nausea and/or vomiting
US9879024B2 (en)	2007-03-29	2018-01-30	Progenics Pharmaceuticals., Inc.	Crystal forms of (R)-N-methylnaltrexone bromide and uses thereof
JP2010535814A (en) *	2007-08-09	2010-11-25	レンセラールポリテクニックインスティチュート	Quaternary opioid carboxamide
US9724343B2 (en)	2008-09-30	2017-08-08	Wyeth, Llc	Peripheral opioid receptor antagonists and uses thereof

Also Published As

Publication number	Publication date
CA1315689C (en)	1993-04-06
DK693387D0 (en)	1987-12-30
NZ222911A (en)	1990-11-27
PH22582A (en)	1988-10-17
KR890004704A (en)	1989-05-09
DK693387A (en)	1989-03-04
DK167340B1 (en)	1993-10-18
JP2625457B2 (en)	1997-07-02

Legal Events

Date	Code	Title	Description
2004-04-20	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2005-04-26	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2006-04-25	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2007-04-24	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2007-12-28	EXPY	Cancellation because of completion of term
2008-03-05	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20080411 Year of fee payment: 11

Publication	Publication Date	Title
JPS6468376A (en)	1989-03-14	Quaternary derivative of noroxymorhone reducing nausea and vomiting
GB2333292B (en)	2000-01-26	Derivatives of hexaazoisowurtzitane
ZA878835B (en)	1988-05-25	Cephalosporin derivatives and their crystalline derivatives
YU146288A (en)	1990-10-31	Derivatives of benzimidazole-2-il-pyridinium
GB2225038B (en)	1992-08-12	Post support and method of making same
JPS6470453A (en)	1989-03-15	2-hydroxybenzophenonehydrazide and derivative
EP0552824A3 (en)	1993-09-15	Alkyl-phenylcarbamate derivative of polysaccharide
JPS6413084A (en)	1989-01-17	Indole alkaloid compound and use
GB2204313B (en)	1990-10-31	Novel bisbenzotrifluoride derivatives and method of preparing same
AU1471888A (en)	1988-10-20	Pillow elements and constructions
GB8720773D0 (en)	1987-10-14	Preparation of derivatives
JPS6442491A (en)	1989-02-14	Cephalosporin derivative and manufacture
IL85664A0 (en)	1988-08-31	Dicyanoethylaryl derivatives and their preparation
CS841188A1 (en)	1989-07-12	Method of trisdiethylaminosiliciumchloride preparation
IE872021L (en)	1988-01-28	Cephalosporins and derivatives
CS646887A1 (en)	1989-10-13	Method of n-phenylmaleinimide and its substituted derivatives preparation
KR900005282Y1 (en)	1990-06-15	Fabricated frame of ward-robe
HK1021820A1 (en)	2000-07-07	Derivatives of n-phenylpyrazoles
YU11688A (en)	1991-02-28	Derivatives of pyridazodiazepine
IE881760L (en)	1988-12-12	Derivatives of n-phenylpyrazoles
CS521788A1 (en)	1990-08-14	Derivatives of trimethoprine
CS449588A1 (en)	1990-03-14	Cephalosporin derivatives and method of their preparation
BG45919A1 (en)	1989-09-15	Derivative of benzaldehine and method for its preparation
IE881494L (en)	1988-11-19	Nitrogen-containing derivatives of epipodophyllotoxin¹glucosides
BG43923A1 (en)	1988-09-15	Derivatives of n- substituted- 2- oxazolidones and method for their preparation