JPS6464659A - Preparation of safe and effective powder formulation - Google Patents

Preparation of safe and effective powder formulation

Info

Publication number
JPS6464659A
JPS6464659A JP22164787A JP22164787A JPS6464659A JP S6464659 A JPS6464659 A JP S6464659A JP 22164787 A JP22164787 A JP 22164787A JP 22164787 A JP22164787 A JP 22164787A JP S6464659 A JPS6464659 A JP S6464659A
Authority
JP
Japan
Prior art keywords
surface area
particles
lot
specific surface
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP22164787A
Other languages
Japanese (ja)
Inventor
Atsushi Watanabe
Tadako Oonuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KENBI KOGAKU KENKYUSHO KK
Original Assignee
KENBI KOGAKU KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KENBI KOGAKU KENKYUSHO KK filed Critical KENBI KOGAKU KENKYUSHO KK
Priority to JP22164787A priority Critical patent/JPS6464659A/en
Publication of JPS6464659A publication Critical patent/JPS6464659A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE:To control the dissolving speed of a powder mixture to water, by roughly dividing the crystal particles in each lot of a drug crystal powder hardly soluble in water into two or more particle groups according to a specific surface area and mixing other one or more lot different in the specific surface area or content of a particle group. CONSTITUTION:A powder of a hardly water-soluble drug is suspended in proper immersion liquid for measuring refractive index using a polarization microscope to be pressed on slide glass by cover glass and upper and lower nicols (polarizing filters) are inserted to perform observation. Magnification is respectively set to about 40, 100, 200 according to a purpose. A crystal habit parameter is used to make it possible to calculate a volume V, a surface area S and a specific surface area SSA according to formulae V=abc, S=2(ab+bc+ca), SSA=2(ab+bc+ca)/abcrho (rho: density). For example, a parameter (b) is actually measured with respect to all of crystal particles appearing in a visual field of 100 magnifications and the particles are successively divided into 5 groups according to the sizes of (b) and the number of particles are substituted with respect to the b-value of each group to calculate an average value. This particle size distribution graph is formed at every lot and a safe and effective preparation is formed in relation to the data of biological utilization capacity.
JP22164787A 1987-09-03 1987-09-03 Preparation of safe and effective powder formulation Pending JPS6464659A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP22164787A JPS6464659A (en) 1987-09-03 1987-09-03 Preparation of safe and effective powder formulation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22164787A JPS6464659A (en) 1987-09-03 1987-09-03 Preparation of safe and effective powder formulation

Publications (1)

Publication Number Publication Date
JPS6464659A true JPS6464659A (en) 1989-03-10

Family

ID=16770058

Family Applications (1)

Application Number Title Priority Date Filing Date
JP22164787A Pending JPS6464659A (en) 1987-09-03 1987-09-03 Preparation of safe and effective powder formulation

Country Status (1)

Country Link
JP (1) JPS6464659A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750913A (en) * 1980-09-09 1982-03-25 Bayer Ag Nifedipin-containing solid medicine and manufacture
JPS60158101A (en) * 1983-12-30 1985-08-19 ヘキスト・アクチエンゲゼルシヤフト Water-hard soluble vermifuge blends and manufacture

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750913A (en) * 1980-09-09 1982-03-25 Bayer Ag Nifedipin-containing solid medicine and manufacture
JPS60158101A (en) * 1983-12-30 1985-08-19 ヘキスト・アクチエンゲゼルシヤフト Water-hard soluble vermifuge blends and manufacture

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