JPS6463520A - Prolactin secretion inhibitor - Google Patents

Prolactin secretion inhibitor

Info

Publication number
JPS6463520A
JPS6463520A JP12041188A JP12041188A JPS6463520A JP S6463520 A JPS6463520 A JP S6463520A JP 12041188 A JP12041188 A JP 12041188A JP 12041188 A JP12041188 A JP 12041188A JP S6463520 A JPS6463520 A JP S6463520A
Authority
JP
Japan
Prior art keywords
effective ingredient
secretion inhibitor
compound
prolactin secretion
hydroxymercaptomethylergoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12041188A
Other languages
Japanese (ja)
Other versions
JPH0240647B2 (en
Inventor
Shii Koonfuerudo Edomondo
Jiei Batsuha Nikorasu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/875,978 external-priority patent/US4166182A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to JP12041188A priority Critical patent/JPH0240647B2/en
Publication of JPS6463520A publication Critical patent/JPS6463520A/en
Publication of JPH0240647B2 publication Critical patent/JPH0240647B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To obtain a prolactin secretion inhibitor that contains D-6-n-propyl-8β- hydroxymercaptomethylergoline as an effective ingredient together with inactive carriers, and excels in therapy of postpartum hyperlactation, galactorrhea, etc. CONSTITUTION: This prolactin secretion inhibitor contains a new compound, D-6-n-propyl-8β-hydroxymercaptomethylergoline, or its pharmacologically permissible acid addition salt as an effective ingredient together with inactive carriers. This prolactin secretion inhibitor is administered preferably by oral dosage in a dose of 0.01-0.5mg per kg of body weight in the form of a fitting-type gelatin capsule in which the effective ingredient is sealed as a mixture with a standard pharmacological excipient. The above-mentioned effective ingredient compound is synthesized, for example, by a reaction of a compound of formula I (Q is an eliminating group; X is H, Cl or Br; R<2> is H, ethyl, etc.) with a compound of formula II (Y is O, S, etc.).
JP12041188A 1978-02-08 1988-05-17 PURORAKUCHIN BUNPYOKUSEIZAI Expired - Lifetime JPH0240647B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12041188A JPH0240647B2 (en) 1978-02-08 1988-05-17 PURORAKUCHIN BUNPYOKUSEIZAI

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/875,978 US4166182A (en) 1978-02-08 1978-02-08 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
JP1180879A JPS54115400A (en) 1978-02-08 1979-02-02 66nnpropyll88methoxymethyl or methylmercapto methylergolenes and their relative compounds
JP12041188A JPH0240647B2 (en) 1978-02-08 1988-05-17 PURORAKUCHIN BUNPYOKUSEIZAI

Publications (2)

Publication Number Publication Date
JPS6463520A true JPS6463520A (en) 1989-03-09
JPH0240647B2 JPH0240647B2 (en) 1990-09-12

Family

ID=27279592

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12041188A Expired - Lifetime JPH0240647B2 (en) 1978-02-08 1988-05-17 PURORAKUCHIN BUNPYOKUSEIZAI

Country Status (1)

Country Link
JP (1) JPH0240647B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11507361A (en) * 1995-06-07 1999-06-29 アルザ コーポレイション A new formulation for percutaneous release of pergolide
JP2002535403A (en) * 1999-01-27 2002-10-22 ポリ・インドウストリア・キミカ・ソチエタ・ペル・アチオニ Method for producing alkylmercaptomethylergoline derivative

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11507361A (en) * 1995-06-07 1999-06-29 アルザ コーポレイション A new formulation for percutaneous release of pergolide
JP2002535403A (en) * 1999-01-27 2002-10-22 ポリ・インドウストリア・キミカ・ソチエタ・ペル・アチオニ Method for producing alkylmercaptomethylergoline derivative

Also Published As

Publication number Publication date
JPH0240647B2 (en) 1990-09-12

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