JPS6463520A - Prolactin secretion inhibitor - Google Patents
Prolactin secretion inhibitorInfo
- Publication number
- JPS6463520A JPS6463520A JP12041188A JP12041188A JPS6463520A JP S6463520 A JPS6463520 A JP S6463520A JP 12041188 A JP12041188 A JP 12041188A JP 12041188 A JP12041188 A JP 12041188A JP S6463520 A JPS6463520 A JP S6463520A
- Authority
- JP
- Japan
- Prior art keywords
- effective ingredient
- secretion inhibitor
- compound
- prolactin secretion
- hydroxymercaptomethylergoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To obtain a prolactin secretion inhibitor that contains D-6-n-propyl-8β- hydroxymercaptomethylergoline as an effective ingredient together with inactive carriers, and excels in therapy of postpartum hyperlactation, galactorrhea, etc. CONSTITUTION: This prolactin secretion inhibitor contains a new compound, D-6-n-propyl-8β-hydroxymercaptomethylergoline, or its pharmacologically permissible acid addition salt as an effective ingredient together with inactive carriers. This prolactin secretion inhibitor is administered preferably by oral dosage in a dose of 0.01-0.5mg per kg of body weight in the form of a fitting-type gelatin capsule in which the effective ingredient is sealed as a mixture with a standard pharmacological excipient. The above-mentioned effective ingredient compound is synthesized, for example, by a reaction of a compound of formula I (Q is an eliminating group; X is H, Cl or Br; R<2> is H, ethyl, etc.) with a compound of formula II (Y is O, S, etc.).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12041188A JPH0240647B2 (en) | 1978-02-08 | 1988-05-17 | PURORAKUCHIN BUNPYOKUSEIZAI |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/875,978 US4166182A (en) | 1978-02-08 | 1978-02-08 | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
JP1180879A JPS54115400A (en) | 1978-02-08 | 1979-02-02 | 66nnpropyll88methoxymethyl or methylmercapto methylergolenes and their relative compounds |
JP12041188A JPH0240647B2 (en) | 1978-02-08 | 1988-05-17 | PURORAKUCHIN BUNPYOKUSEIZAI |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6463520A true JPS6463520A (en) | 1989-03-09 |
JPH0240647B2 JPH0240647B2 (en) | 1990-09-12 |
Family
ID=27279592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12041188A Expired - Lifetime JPH0240647B2 (en) | 1978-02-08 | 1988-05-17 | PURORAKUCHIN BUNPYOKUSEIZAI |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0240647B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11507361A (en) * | 1995-06-07 | 1999-06-29 | アルザ コーポレイション | A new formulation for percutaneous release of pergolide |
JP2002535403A (en) * | 1999-01-27 | 2002-10-22 | ポリ・インドウストリア・キミカ・ソチエタ・ペル・アチオニ | Method for producing alkylmercaptomethylergoline derivative |
-
1988
- 1988-05-17 JP JP12041188A patent/JPH0240647B2/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11507361A (en) * | 1995-06-07 | 1999-06-29 | アルザ コーポレイション | A new formulation for percutaneous release of pergolide |
JP2002535403A (en) * | 1999-01-27 | 2002-10-22 | ポリ・インドウストリア・キミカ・ソチエタ・ペル・アチオニ | Method for producing alkylmercaptomethylergoline derivative |
Also Published As
Publication number | Publication date |
---|---|
JPH0240647B2 (en) | 1990-09-12 |
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