JPS6452753A - Prostaglandin e and antiulcer agent containing same - Google Patents

Prostaglandin e and antiulcer agent containing same

Info

Publication number
JPS6452753A
JPS6452753A JP63018326A JP1832688A JPS6452753A JP S6452753 A JPS6452753 A JP S6452753A JP 63018326 A JP63018326 A JP 63018326A JP 1832688 A JP1832688 A JP 1832688A JP S6452753 A JPS6452753 A JP S6452753A
Authority
JP
Japan
Prior art keywords
formula
alkyl
compound
antiulcer agent
lactol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63018326A
Other languages
Japanese (ja)
Other versions
JPH0688966B2 (en
Inventor
Ryuzo Ueno
Takashi Ueno
Kazue Kato
Tomio Oda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ueno Seiyaku Oyo Kenkyujo KK
R Tech Ueno Ltd
Original Assignee
Ueno Seiyaku Oyo Kenkyujo KK
R Tech Ueno Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ueno Seiyaku Oyo Kenkyujo KK, R Tech Ueno Ltd filed Critical Ueno Seiyaku Oyo Kenkyujo KK
Priority to JP1832688A priority Critical patent/JPH0688966B2/en
Publication of JPS6452753A publication Critical patent/JPS6452753A/en
Publication of JPH0688966B2 publication Critical patent/JPH0688966B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The compound of formula I [X is group of formula II-V; R1 is H, 1-4C alkyl, benzyl, phenyl, trialkylsilyl, tetrahydro-pyranyl, hydroxyalkyl or alkoxyalkyl; R2 is H or methyl; R3 is R2 or hydroxymethyl; R4 and R5 are R2, OH or halogen; R6 is 1-5C alkyl or alkoxy- 1-5C alkyl which may have branch or double bond (the bond between 2- and 3-C atoms may be double bond) (excluding the compound wherein R1, R2, R4 and R5 are H, R6 is n-butyl and R3 is OH)]. EXAMPLE:13,14-Dihydro-15-keto-16R,S-methyl PGE2. USE:An antiulcer agent absolutely free from from central or peripheral physiological actions a side effect or having remarkably suppressed above actions. PREPARATION:The compound of formula I can be produced by preparing a lactol of formula VII from Corey lactone of formula VI and introducing an alpha-chain into the lactol by Wittig reaction.
JP1832688A 1987-01-28 1988-01-28 Prostaglandin Es and antiulcer drug containing the same Expired - Lifetime JPH0688966B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1832688A JPH0688966B2 (en) 1987-01-28 1988-01-28 Prostaglandin Es and antiulcer drug containing the same

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP62-18820 1987-01-28
JP1882087 1987-01-28
JP6535287 1987-03-18
JP62-65352 1987-03-18
JP1832688A JPH0688966B2 (en) 1987-01-28 1988-01-28 Prostaglandin Es and antiulcer drug containing the same

Publications (2)

Publication Number Publication Date
JPS6452753A true JPS6452753A (en) 1989-02-28
JPH0688966B2 JPH0688966B2 (en) 1994-11-09

Family

ID=27282170

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1832688A Expired - Lifetime JPH0688966B2 (en) 1987-01-28 1988-01-28 Prostaglandin Es and antiulcer drug containing the same

Country Status (1)

Country Link
JP (1) JPH0688966B2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0232055A (en) * 1988-07-19 1990-02-01 Ono Pharmaceut Co Ltd 16,16-difluoro-15-oxo-15-deoxy pge derivative
US5159844A (en) * 1990-04-20 1992-11-03 Comau Spa Method and a device for checking fixtures used in machines or stations in production lines or installations
EP0690049A2 (en) 1994-06-03 1996-01-03 R-Tech Ueno Ltd. Agent for treating hepato biliary diseases
JP2008535774A (en) * 2005-04-12 2008-09-04 スキャンポ・アーゲー Combination of prostaglandin compounds and proton pump inhibitors for the treatment of gastrointestinal disorders
JP2009007360A (en) * 1999-07-14 2009-01-15 Sucampo Ag External secretion disorder treating agent
JP2010532314A (en) * 2007-07-03 2010-10-07 スキャンポ・アーゲー Pharmaceutical combination of NSAID and prostaglandin compound

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0232055A (en) * 1988-07-19 1990-02-01 Ono Pharmaceut Co Ltd 16,16-difluoro-15-oxo-15-deoxy pge derivative
US5159844A (en) * 1990-04-20 1992-11-03 Comau Spa Method and a device for checking fixtures used in machines or stations in production lines or installations
EP0690049A2 (en) 1994-06-03 1996-01-03 R-Tech Ueno Ltd. Agent for treating hepato biliary diseases
JP2009007360A (en) * 1999-07-14 2009-01-15 Sucampo Ag External secretion disorder treating agent
JP2008535774A (en) * 2005-04-12 2008-09-04 スキャンポ・アーゲー Combination of prostaglandin compounds and proton pump inhibitors for the treatment of gastrointestinal disorders
JP2013121972A (en) * 2005-04-12 2013-06-20 Sucampo Ag Combined use of prostaglandin compound and proton pump inhibitor for treatment of gastrointestinal disorder
JP2010532314A (en) * 2007-07-03 2010-10-07 スキャンポ・アーゲー Pharmaceutical combination of NSAID and prostaglandin compound

Also Published As

Publication number Publication date
JPH0688966B2 (en) 1994-11-09

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