JPS6452753A - Prostaglandin e and antiulcer agent containing same - Google Patents
Prostaglandin e and antiulcer agent containing sameInfo
- Publication number
- JPS6452753A JPS6452753A JP63018326A JP1832688A JPS6452753A JP S6452753 A JPS6452753 A JP S6452753A JP 63018326 A JP63018326 A JP 63018326A JP 1832688 A JP1832688 A JP 1832688A JP S6452753 A JPS6452753 A JP S6452753A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- compound
- antiulcer agent
- lactol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:The compound of formula I [X is group of formula II-V; R1 is H, 1-4C alkyl, benzyl, phenyl, trialkylsilyl, tetrahydro-pyranyl, hydroxyalkyl or alkoxyalkyl; R2 is H or methyl; R3 is R2 or hydroxymethyl; R4 and R5 are R2, OH or halogen; R6 is 1-5C alkyl or alkoxy- 1-5C alkyl which may have branch or double bond (the bond between 2- and 3-C atoms may be double bond) (excluding the compound wherein R1, R2, R4 and R5 are H, R6 is n-butyl and R3 is OH)]. EXAMPLE:13,14-Dihydro-15-keto-16R,S-methyl PGE2. USE:An antiulcer agent absolutely free from from central or peripheral physiological actions a side effect or having remarkably suppressed above actions. PREPARATION:The compound of formula I can be produced by preparing a lactol of formula VII from Corey lactone of formula VI and introducing an alpha-chain into the lactol by Wittig reaction.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1832688A JPH0688966B2 (en) | 1987-01-28 | 1988-01-28 | Prostaglandin Es and antiulcer drug containing the same |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62-18820 | 1987-01-28 | ||
JP1882087 | 1987-01-28 | ||
JP6535287 | 1987-03-18 | ||
JP62-65352 | 1987-03-18 | ||
JP1832688A JPH0688966B2 (en) | 1987-01-28 | 1988-01-28 | Prostaglandin Es and antiulcer drug containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6452753A true JPS6452753A (en) | 1989-02-28 |
JPH0688966B2 JPH0688966B2 (en) | 1994-11-09 |
Family
ID=27282170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1832688A Expired - Lifetime JPH0688966B2 (en) | 1987-01-28 | 1988-01-28 | Prostaglandin Es and antiulcer drug containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0688966B2 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0232055A (en) * | 1988-07-19 | 1990-02-01 | Ono Pharmaceut Co Ltd | 16,16-difluoro-15-oxo-15-deoxy pge derivative |
US5159844A (en) * | 1990-04-20 | 1992-11-03 | Comau Spa | Method and a device for checking fixtures used in machines or stations in production lines or installations |
EP0690049A2 (en) | 1994-06-03 | 1996-01-03 | R-Tech Ueno Ltd. | Agent for treating hepato biliary diseases |
JP2008535774A (en) * | 2005-04-12 | 2008-09-04 | スキャンポ・アーゲー | Combination of prostaglandin compounds and proton pump inhibitors for the treatment of gastrointestinal disorders |
JP2009007360A (en) * | 1999-07-14 | 2009-01-15 | Sucampo Ag | External secretion disorder treating agent |
JP2010532314A (en) * | 2007-07-03 | 2010-10-07 | スキャンポ・アーゲー | Pharmaceutical combination of NSAID and prostaglandin compound |
-
1988
- 1988-01-28 JP JP1832688A patent/JPH0688966B2/en not_active Expired - Lifetime
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0232055A (en) * | 1988-07-19 | 1990-02-01 | Ono Pharmaceut Co Ltd | 16,16-difluoro-15-oxo-15-deoxy pge derivative |
US5159844A (en) * | 1990-04-20 | 1992-11-03 | Comau Spa | Method and a device for checking fixtures used in machines or stations in production lines or installations |
EP0690049A2 (en) | 1994-06-03 | 1996-01-03 | R-Tech Ueno Ltd. | Agent for treating hepato biliary diseases |
JP2009007360A (en) * | 1999-07-14 | 2009-01-15 | Sucampo Ag | External secretion disorder treating agent |
JP2008535774A (en) * | 2005-04-12 | 2008-09-04 | スキャンポ・アーゲー | Combination of prostaglandin compounds and proton pump inhibitors for the treatment of gastrointestinal disorders |
JP2013121972A (en) * | 2005-04-12 | 2013-06-20 | Sucampo Ag | Combined use of prostaglandin compound and proton pump inhibitor for treatment of gastrointestinal disorder |
JP2010532314A (en) * | 2007-07-03 | 2010-10-07 | スキャンポ・アーゲー | Pharmaceutical combination of NSAID and prostaglandin compound |
Also Published As
Publication number | Publication date |
---|---|
JPH0688966B2 (en) | 1994-11-09 |
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