JPS6447759A - Leukotriene antagonists and manufacture - Google Patents
Leukotriene antagonists and manufactureInfo
- Publication number
- JPS6447759A JPS6447759A JP63181945A JP18194588A JPS6447759A JP S6447759 A JPS6447759 A JP S6447759A JP 63181945 A JP63181945 A JP 63181945A JP 18194588 A JP18194588 A JP 18194588A JP S6447759 A JPS6447759 A JP S6447759A
- Authority
- JP
- Japan
- Prior art keywords
- compounds
- leukotriene antagonists
- manufacture
- preparation
- precursors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003199 leukotriene receptor blocking agent Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873724735 DE3724735A1 (de) | 1987-07-25 | 1987-07-25 | Leukotrienantagonisten, verfahren zu ihrer herstellung, ihre anwendung zur behandlung von krankheiten, sowie vorprodukte |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6447759A true JPS6447759A (en) | 1989-02-22 |
Family
ID=6332390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63181945A Pending JPS6447759A (en) | 1987-07-25 | 1988-07-22 | Leukotriene antagonists and manufacture |
Country Status (16)
Country | Link |
---|---|
US (1) | US4851440A (ja) |
EP (1) | EP0301401B1 (ja) |
JP (1) | JPS6447759A (ja) |
KR (1) | KR890001974A (ja) |
AT (1) | ATE69809T1 (ja) |
AU (1) | AU610201B2 (ja) |
DE (2) | DE3724735A1 (ja) |
DK (1) | DK412388A (ja) |
ES (1) | ES2040783T3 (ja) |
FI (1) | FI883455A (ja) |
GR (1) | GR3003525T3 (ja) |
IL (1) | IL87197A0 (ja) |
NO (1) | NO167799C (ja) |
NZ (1) | NZ225518A (ja) |
PT (1) | PT88074B (ja) |
ZA (1) | ZA885335B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012157760A1 (ja) * | 2011-05-19 | 2012-11-22 | 宇部興産株式会社 | 多価ビニル芳香族化合物およびその製造方法 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5286895A (en) * | 1992-02-19 | 1994-02-15 | Merck & Co., Inc. | Cholesterol lowering compounds |
KR100411191B1 (ko) * | 1996-06-12 | 2004-03-30 | 한솔제지주식회사 | 재활용이 용이한 방습지 |
US12037327B2 (en) * | 2018-05-04 | 2024-07-16 | Saint Louis University | Compounds and methods targeting GPER for treatment of diseases associated with calcium |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3867434A (en) * | 1971-11-04 | 1975-02-18 | Rorer Inc William H | Phenyl butyric acids and derivatives thereof |
US3894080A (en) * | 1970-05-05 | 1975-07-08 | Rorer Inc William H | Phenylacetic acids |
AT336589B (de) * | 1974-05-20 | 1977-05-10 | Thomae Gmbh Dr K | Verfahren zur herstellung von neuen biphenylderivaten |
US4513005A (en) * | 1981-06-18 | 1985-04-23 | Lilly Industries Limited | SRS-A antagonists |
US4785004A (en) * | 1985-12-23 | 1988-11-15 | Ciba-Geigy Corporation | Aromatic thioethers |
GB2190377A (en) * | 1986-05-14 | 1987-11-18 | Merck Frosst Canada Inc | Phenyldithiaalkanedioic acids as leukotriene antagonists |
-
1987
- 1987-07-25 DE DE19873724735 patent/DE3724735A1/de not_active Withdrawn
-
1988
- 1988-07-21 DE DE8888111746T patent/DE3866460D1/de not_active Expired - Fee Related
- 1988-07-21 EP EP88111746A patent/EP0301401B1/de not_active Expired - Lifetime
- 1988-07-21 FI FI883455A patent/FI883455A/fi not_active Application Discontinuation
- 1988-07-21 AT AT88111746T patent/ATE69809T1/de not_active IP Right Cessation
- 1988-07-21 ES ES198888111746T patent/ES2040783T3/es not_active Expired - Lifetime
- 1988-07-22 PT PT88074A patent/PT88074B/pt not_active IP Right Cessation
- 1988-07-22 IL IL87197A patent/IL87197A0/xx unknown
- 1988-07-22 US US07/222,975 patent/US4851440A/en not_active Expired - Fee Related
- 1988-07-22 DK DK412388A patent/DK412388A/da not_active Application Discontinuation
- 1988-07-22 ZA ZA885335A patent/ZA885335B/xx unknown
- 1988-07-22 NO NO883286A patent/NO167799C/no unknown
- 1988-07-22 AU AU19296/88A patent/AU610201B2/en not_active Ceased
- 1988-07-22 NZ NZ225518A patent/NZ225518A/xx unknown
- 1988-07-22 JP JP63181945A patent/JPS6447759A/ja active Pending
- 1988-07-23 KR KR1019880009266A patent/KR890001974A/ko not_active Application Discontinuation
-
1992
- 1992-01-08 GR GR910402037T patent/GR3003525T3/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012157760A1 (ja) * | 2011-05-19 | 2012-11-22 | 宇部興産株式会社 | 多価ビニル芳香族化合物およびその製造方法 |
Also Published As
Publication number | Publication date |
---|---|
IL87197A0 (en) | 1988-12-30 |
FI883455A (fi) | 1989-01-26 |
DE3866460D1 (de) | 1992-01-09 |
ATE69809T1 (de) | 1991-12-15 |
NO883286D0 (no) | 1988-07-22 |
NZ225518A (en) | 1990-08-28 |
US4851440A (en) | 1989-07-25 |
PT88074A (pt) | 1989-06-30 |
DE3724735A1 (de) | 1989-02-02 |
EP0301401A2 (de) | 1989-02-01 |
KR890001974A (ko) | 1989-04-07 |
NO883286L (no) | 1989-01-26 |
PT88074B (pt) | 1995-03-01 |
GR3003525T3 (ja) | 1993-03-16 |
ZA885335B (en) | 1989-03-29 |
NO167799B (no) | 1991-09-02 |
EP0301401A3 (en) | 1989-05-10 |
FI883455A0 (fi) | 1988-07-21 |
DK412388D0 (da) | 1988-07-22 |
ES2040783T3 (es) | 1993-11-01 |
DK412388A (da) | 1989-01-26 |
EP0301401B1 (de) | 1991-11-27 |
AU1929688A (en) | 1989-01-27 |
AU610201B2 (en) | 1991-05-16 |
NO167799C (no) | 1991-12-11 |
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