JPS6447745A - Purification of 5-amino-2,4,6-triiodoisophthalic acid - Google Patents
Purification of 5-amino-2,4,6-triiodoisophthalic acidInfo
- Publication number
- JPS6447745A JPS6447745A JP20194187A JP20194187A JPS6447745A JP S6447745 A JPS6447745 A JP S6447745A JP 20194187 A JP20194187 A JP 20194187A JP 20194187 A JP20194187 A JP 20194187A JP S6447745 A JPS6447745 A JP S6447745A
- Authority
- JP
- Japan
- Prior art keywords
- aipa
- amino
- acid
- salt
- triiodoisophthalic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE:To obtain the titled compound in simple treatment and high purity and yield, by converting 5-amino-2,4,6-triiodoisophthalic acid to corresponding salt and then adding alcohols thereto and depositing crystal thereof in the presence of a strong acid. CONSTITUTION:5-Amino-2,4,6-triiodoisophthalic acid (AIPA) is converted to salt thereof with sodium hydroxide, ammonium hydroxide, etc. and alcohols such as methanol or ethanol corresponding to 5-60wt.% based on total water amount is added to the above-mentioned salt and the crystal of AIPA is deposited at pH adjusted to <=4 using a strong acid such as sulfuric acid at 20-60 deg.C to purify AIPA. AIPA is useful as an intermediate for Roentgen contrast medium having extremely low intravenous toxicity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20194187A JPH0729999B2 (en) | 1987-08-14 | 1987-08-14 | Method for purifying 5-amino-2,4,6-triiodoisophthalic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20194187A JPH0729999B2 (en) | 1987-08-14 | 1987-08-14 | Method for purifying 5-amino-2,4,6-triiodoisophthalic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6447745A true JPS6447745A (en) | 1989-02-22 |
JPH0729999B2 JPH0729999B2 (en) | 1995-04-05 |
Family
ID=16449316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP20194187A Expired - Fee Related JPH0729999B2 (en) | 1987-08-14 | 1987-08-14 | Method for purifying 5-amino-2,4,6-triiodoisophthalic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0729999B2 (en) |
-
1987
- 1987-08-14 JP JP20194187A patent/JPH0729999B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH0729999B2 (en) | 1995-04-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
LAPS | Cancellation because of no payment of annual fees |