JPS6445376A - Production of 1,5-benzothiazepine derivative - Google Patents

Production of 1,5-benzothiazepine derivative

Info

Publication number
JPS6445376A
JPS6445376A JP62202027A JP20202787A JPS6445376A JP S6445376 A JPS6445376 A JP S6445376A JP 62202027 A JP62202027 A JP 62202027A JP 20202787 A JP20202787 A JP 20202787A JP S6445376 A JPS6445376 A JP S6445376A
Authority
JP
Japan
Prior art keywords
compound
expressed
formula
cerebral
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62202027A
Other languages
Japanese (ja)
Inventor
Hirozumi Inoue
Tsunehiro Harada
Masaaki Nagasawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP62202027A priority Critical patent/JPS6445376A/en
Priority to IE194988A priority patent/IE61168B1/en
Priority to FI883115A priority patent/FI883115A/en
Priority to IL86978A priority patent/IL86978A0/en
Priority to CA000571438A priority patent/CA1337346C/en
Priority to CN88104387A priority patent/CN1030570C/en
Priority to BG85116A priority patent/BG50501A3/en
Priority to GR880100515A priority patent/GR1000385B/en
Priority to NO883525A priority patent/NO170017C/en
Priority to KR1019880010209A priority patent/KR890003722A/en
Priority to AT0202388A priority patent/AT395010B/en
Priority to HU584688A priority patent/HU203741B/en
Priority to HU431688A priority patent/HU201917B/en
Priority to ES8802522A priority patent/ES2007990A6/en
Priority to SU884356317A priority patent/SU1709908A3/en
Priority to PT88250A priority patent/PT88250B/en
Publication of JPS6445376A publication Critical patent/JPS6445376A/en
Priority to NO913388A priority patent/NO913388D0/en
Priority to NO922253A priority patent/NO172286C/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Abstract

PURPOSE:To readily obtain the titled compound useful as a medicinal compound having excellent hypotensive, cerebral coronary vasodilator and/or blood platelet agglutination inhibitory action, by reacting a specific compound with amines as raw materials. CONSTITUTION:An compound expressed by formula I (R<1> is lower alkyl or lower alkoxy; R<2> is H or lower alkanoyl; either of R<3> and R<4> is lower alkyl or halogen and the other is H; X' is reactive residue) is reacted with an amine expressed by formula II (R<5> and R<6> are lower alkyl) or salt thereof in a suitable solvent in the presence or absence of a deacidifying agent, preferably at ambient temperature - while being heated to afford the aimed compound, expressed by formula III and useful for treating.preventing cerebropathy, such as cerebral vasospasm, cerebral ischemia or cerebral infraction, and cardiopathy, such as angina pectoris. The above-mentioned compound is treated with an acid to provide an acid addition salt. Furthermore, since the aforementioned reaction proceeds without accompanying racemization, the aimed compound can also be obtained as an optically active substance by using the optically active compound expressed by formula I.
JP62202027A 1987-08-12 1987-08-12 Production of 1,5-benzothiazepine derivative Pending JPS6445376A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
JP62202027A JPS6445376A (en) 1987-08-12 1987-08-12 Production of 1,5-benzothiazepine derivative
IE194988A IE61168B1 (en) 1987-08-12 1988-06-27 Process for preparing 1.5-benzothiazepine derivatives
FI883115A FI883115A (en) 1987-08-12 1988-06-29 FOERFARANDE FOER FRAMSTAELLNING AV 1,5-BENSOTIAZEPINDERIVAT.
IL86978A IL86978A0 (en) 1987-08-12 1988-07-04 Preparation of 1,5-benzothiazepine derivatives
CA000571438A CA1337346C (en) 1987-08-12 1988-07-07 Process for preparing 1,5-benzothiazepine derivatives
CN88104387A CN1030570C (en) 1987-08-12 1988-07-11 Process for preporing 1.5-benzothiazepine eerivatives
BG85116A BG50501A3 (en) 1987-08-12 1988-08-02 Method for 1, 5- benzthiazepine derivatives production
GR880100515A GR1000385B (en) 1987-08-12 1988-08-04 Preparation method for 1,5-benzodiapezine derivatives
NO883525A NO170017C (en) 1987-08-12 1988-08-09 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1,5-BENZOTIAZEPINE DERIVATIVES
KR1019880010209A KR890003722A (en) 1987-08-12 1988-08-10 Method for preparing 1,5-benzothiazepine derivative
AT0202388A AT395010B (en) 1987-08-12 1988-08-11 METHOD FOR PRODUCING 1,5-BENZOTHIAZEPINE DERIVATIVES AND THEIR SALTS
HU584688A HU203741B (en) 1987-08-12 1988-08-11 New process for producing halogeno-1,5-benzothiazepine derivatives
HU431688A HU201917B (en) 1987-08-12 1988-08-11 Process for producing 1,5-benzothiazepine derivatives and pharmaceutical compositions comprising such compounds as active ingredient
ES8802522A ES2007990A6 (en) 1987-08-12 1988-08-11 Production of 1,5-benzothiazepine derivative
SU884356317A SU1709908A3 (en) 1987-08-12 1988-08-11 Method for the synthesis of 1,5-bensothiazepine derivatives or theirs pharmaceutically acceptable acid-additive salts
PT88250A PT88250B (en) 1987-08-12 1988-08-11 PROCESS FOR THE PREPARATION OF 1,5-BENZOTIAZEPINE DERIVATIVES
NO913388A NO913388D0 (en) 1987-08-12 1991-08-29 PROCEDURE FOR THE PREPARATION OF 1,5-BENZOTIAZEPINE DERIVATIVES.
NO922253A NO172286C (en) 1987-08-12 1992-06-09 PROCEDURE FOR THE PREPARATION OF 1,5-BENZOTIAZEPINE DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62202027A JPS6445376A (en) 1987-08-12 1987-08-12 Production of 1,5-benzothiazepine derivative

Publications (1)

Publication Number Publication Date
JPS6445376A true JPS6445376A (en) 1989-02-17

Family

ID=16450708

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62202027A Pending JPS6445376A (en) 1987-08-12 1987-08-12 Production of 1,5-benzothiazepine derivative

Country Status (14)

Country Link
JP (1) JPS6445376A (en)
KR (1) KR890003722A (en)
CN (1) CN1030570C (en)
AT (1) AT395010B (en)
BG (1) BG50501A3 (en)
CA (1) CA1337346C (en)
ES (1) ES2007990A6 (en)
FI (1) FI883115A (en)
GR (1) GR1000385B (en)
IE (1) IE61168B1 (en)
IL (1) IL86978A0 (en)
NO (1) NO170017C (en)
PT (1) PT88250B (en)
SU (1) SU1709908A3 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225174A (en) * 1983-06-03 1984-12-18 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation
JPS60202871A (en) * 1984-03-10 1985-10-14 Tanabe Seiyaku Co Ltd 1,5-benzothiazepine derivative and its preparation
JPS60204776A (en) * 1984-03-30 1985-10-16 Roller Japan Kk 1,5-benzothiazepine derivative
JPS61103877A (en) * 1984-10-24 1986-05-22 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1236467A (en) * 1967-10-28 1971-06-23 Tanabe Seiyaku Co Benzothiazepine derivatives
US3895006A (en) * 1974-04-19 1975-07-15 Squibb & Sons Inc 5-(Substituted amino)alkyl)-2-aryl-3-halo-1,5-benzothiazepin-4(5H)-ones
SE449611B (en) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co SET TO MAKE 1,5-BENZOTIAZEPINE DERIVATIVES
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225174A (en) * 1983-06-03 1984-12-18 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation
JPS60202871A (en) * 1984-03-10 1985-10-14 Tanabe Seiyaku Co Ltd 1,5-benzothiazepine derivative and its preparation
JPS60204776A (en) * 1984-03-30 1985-10-16 Roller Japan Kk 1,5-benzothiazepine derivative
JPS61103877A (en) * 1984-10-24 1986-05-22 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation

Also Published As

Publication number Publication date
GR1000385B (en) 1992-06-30
BG50501A3 (en) 1992-08-14
PT88250A (en) 1989-06-30
AT395010B (en) 1992-08-25
KR890003722A (en) 1989-04-17
IE881949L (en) 1989-02-12
NO883525L (en) 1989-02-13
IL86978A0 (en) 1988-12-30
GR880100515A (en) 1989-05-25
SU1709908A3 (en) 1992-01-30
CN1030570C (en) 1995-12-27
CN1031229A (en) 1989-02-22
FI883115A (en) 1989-02-13
PT88250B (en) 1995-03-01
ATA202388A (en) 1992-01-15
NO170017C (en) 1992-09-02
NO170017B (en) 1992-05-25
CA1337346C (en) 1995-10-17
ES2007990A6 (en) 1989-07-01
IE61168B1 (en) 1994-10-05
NO883525D0 (en) 1988-08-09
FI883115A0 (en) 1988-06-29

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