JPS6442448A - Novel lignan - Google Patents

Novel lignan

Info

Publication number
JPS6442448A
JPS6442448A JP19819587A JP19819587A JPS6442448A JP S6442448 A JPS6442448 A JP S6442448A JP 19819587 A JP19819587 A JP 19819587A JP 19819587 A JP19819587 A JP 19819587A JP S6442448 A JPS6442448 A JP S6442448A
Authority
JP
Japan
Prior art keywords
formula
compound expressed
expressed
lignan
hakugomishi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP19819587A
Other languages
Japanese (ja)
Inventor
Yukinobu Iketani
Heihachiro Taguchi
Hiromi Sasaki
Masaki Yuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tsumura and Co
Original Assignee
Tsumura and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsumura and Co filed Critical Tsumura and Co
Priority to JP19819587A priority Critical patent/JPS6442448A/en
Publication of JPS6442448A publication Critical patent/JPS6442448A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A lignan expressed by formula I (R1 and R2 are OH or together form methylenedioxyl; R3-R5 are OH or OCH3; R6 and R7 are H or OH). EXAMPLE:(+)-(6S,7S,R-biar)-5,6,7,8-Tetrahydro-1,3,12-trimethoxy-10,11- methylene dioxy-6,7-dimethyl-2,6-dibenzo[a,c]cyclooctenediol. USE:A medicine and remedy for inflammatory diseases capable of exhibiting inhibitory action of 5-lipoxygenase. PREPARATION:For example, HAKUGOMISHI (dried fruit of Schizandra chinensis Baill.) is extracted with lower hydrocarbons while warm and the solvents are then distilled away to provide a residue, which is subsequently dissolved in water, subjected to steam distillation and column chromatography using silica gel and developed with a solvent, such as n-hexane, to afford a compound expressed by formula II. The resultant compound expressed by formu la II is used as a raw material, incubated by adding a hepatic homogenate, reacted, separated and purified while confirming the compound expressed by formula I by thin layer chromatography to provide the aimed compound expressed by formula I.
JP19819587A 1987-08-10 1987-08-10 Novel lignan Pending JPS6442448A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP19819587A JPS6442448A (en) 1987-08-10 1987-08-10 Novel lignan

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19819587A JPS6442448A (en) 1987-08-10 1987-08-10 Novel lignan

Publications (1)

Publication Number Publication Date
JPS6442448A true JPS6442448A (en) 1989-02-14

Family

ID=16387052

Family Applications (1)

Application Number Title Priority Date Filing Date
JP19819587A Pending JPS6442448A (en) 1987-08-10 1987-08-10 Novel lignan

Country Status (1)

Country Link
JP (1) JPS6442448A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61282315A (en) * 1985-06-07 1986-12-12 Tsumura Juntendo Inc Remedy for hepatic insufficiency

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61282315A (en) * 1985-06-07 1986-12-12 Tsumura Juntendo Inc Remedy for hepatic insufficiency

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