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Denka Co Ltd
Original Assignee
Denki Kagaku Kogyo KK
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Priority to JP62199144ApriorityCriticalpatent/JPS6442441A/en
Publication of JPS6442441ApublicationCriticalpatent/JPS6442441A/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Abstract
PURPOSE:To obtain a macrophage activator, containing, human lymphotoxin as an active ingredient and capable of imparting chemotaxis to macrophages and accelerating antitumor action. CONSTITUTION:A macrophage activator containing human lymphotoxin (h-LT), preferably rh-LT-1 expressed by formula I (R is formula II) which is h-LT (hereinafter referred to as rh-LT) prepared by using a genetic manipulation technique in aspects of ensuring homogeneous h-LT in an amount so as to enable cancer clinical application, rh-LT-2 expressed by formula III or rh-LT-3 expressed by formula IV as an active ingredient. Methods for activating macrophages collected from an animal abdominal cavity, blood, lung, etc., with the h-LT in.vivo and administering the activated macrophages to a cancerated animal, directly administering the h-LT thereto, accumulating the macrophages in tumorous parts, etc., are used as a method for activating the macrophage and treating cancer.