JPS643172A - Cycloheptimidazole derivative - Google Patents
Cycloheptimidazole derivativeInfo
- Publication number
- JPS643172A JPS643172A JP15731687A JP15731687A JPS643172A JP S643172 A JPS643172 A JP S643172A JP 15731687 A JP15731687 A JP 15731687A JP 15731687 A JP15731687 A JP 15731687A JP S643172 A JPS643172 A JP S643172A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- ncq
- methoxyphenyl
- react
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I [R1 is H, lower alkyl, cycloalkyl, aryl which may be substituted, heterocyclic group which may be substituted; R2 is R1 except H atom] and its salt.
EXAMPLE: 1, 2-Dihydro-1-( 4-methoxyphenyl )-2-( 4-methoxyphenyl )cyclo-heptimida zole hydrochloride.
USE: Medicines. Anti-inflammatory or analgesic.
PREPARATION: For example, an isocyanate or isothiocyanate of the formula: R1NCQ1 (Q1 is O, S) or R2NCQ1 is allowed to react with an amine of the formu la NH2-R1 or NH2-R2 to form a urea or thiourea of formula IV. The product is subjected to dehydration or dehydrosulfidization to give a novel carbodiimide derivative of formula II, and the product is allowed to react with 2-aminotropon of formula III in the absence or presence of an anhydrous solvent such as tolu ene at room temperature or under heating to effect dehydrative condensation reaction to give the compound of formula I.
COPYRIGHT: (C)1989,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62-157316A JPH013172A (en) | 1987-06-24 | Cycloheptoimidazole derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62-157316A JPH013172A (en) | 1987-06-24 | Cycloheptoimidazole derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS643172A true JPS643172A (en) | 1989-01-06 |
JPH013172A JPH013172A (en) | 1989-01-06 |
Family
ID=
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4949097A (en) * | 1988-06-10 | 1990-08-14 | Minolta Camera Kabushiki Kaisha | Thermal printer |
US8420634B2 (en) | 2007-09-24 | 2013-04-16 | Rottapharm S.P.A. | Amidine, thiourea and guanidine derivatives of 2-aminobenzothiazoles and aminobenzothiazines for their use as pharmacological agents for the treatment of neurodegenerative pathologies |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4949097A (en) * | 1988-06-10 | 1990-08-14 | Minolta Camera Kabushiki Kaisha | Thermal printer |
US8420634B2 (en) | 2007-09-24 | 2013-04-16 | Rottapharm S.P.A. | Amidine, thiourea and guanidine derivatives of 2-aminobenzothiazoles and aminobenzothiazines for their use as pharmacological agents for the treatment of neurodegenerative pathologies |
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