JPS6426537A - Production of dibenzyls - Google Patents

Production of dibenzyls

Info

Publication number
JPS6426537A
JPS6426537A JP18444787A JP18444787A JPS6426537A JP S6426537 A JPS6426537 A JP S6426537A JP 18444787 A JP18444787 A JP 18444787A JP 18444787 A JP18444787 A JP 18444787A JP S6426537 A JPS6426537 A JP S6426537A
Authority
JP
Japan
Prior art keywords
medicines
metal hydroxide
dispersed
alkaline metal
mixed solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP18444787A
Other languages
Japanese (ja)
Inventor
Tsuneyuki Nagase
Yoshiharu Tategami
Mitsuaki Eto
Kimio Yasuda
Yorihiko Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanken Kako KK
Original Assignee
Sanken Kako KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanken Kako KK filed Critical Sanken Kako KK
Priority to JP18444787A priority Critical patent/JPS6426537A/en
Publication of JPS6426537A publication Critical patent/JPS6426537A/en
Pending legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE:To industrially and readily obtain dibenzyls useful as an intermediate for medicines in high yield, by oxidatively condensing a nitro group-substituted toluene based compound using a finely powdered alkaline metal hydroxide dispersed in a specific mixed solvent. CONSTITUTION:A nitro group-substituted toluene based compound, such as 2-nitrotoluene or 2-nitro-4-chlorotoluene, is oxidatively condensed using an alkaline metal hydroxide, such as NaOH, finely powdered and dispersed in a mixed solvent of an inert solvent selected from paraffinic hydrocarbons, such as paraffinic, isoparaffinic or cycloparaffinic hydrocarbons, e.g. n-decane, and ethers having 50-300 deg.C boiling point and alcohols, such as tertiary butyl alcohol or tertiary amyl alcohol, at 20:80-80:20% mixing ratio of -20-+30 deg.C by passing air or O2 therethrough to afford the aimed compound useful as an intermediate for medicines, such as psychotic therapeutic or local anesthetic agent.
JP18444787A 1987-07-22 1987-07-22 Production of dibenzyls Pending JPS6426537A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18444787A JPS6426537A (en) 1987-07-22 1987-07-22 Production of dibenzyls

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18444787A JPS6426537A (en) 1987-07-22 1987-07-22 Production of dibenzyls

Publications (1)

Publication Number Publication Date
JPS6426537A true JPS6426537A (en) 1989-01-27

Family

ID=16153306

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18444787A Pending JPS6426537A (en) 1987-07-22 1987-07-22 Production of dibenzyls

Country Status (1)

Country Link
JP (1) JPS6426537A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8668925B2 (en) 2003-12-12 2014-03-11 Bayer Intellectual Property Gmbh Transdermal delivery of hormones without the need of penetration enhancers

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8668925B2 (en) 2003-12-12 2014-03-11 Bayer Intellectual Property Gmbh Transdermal delivery of hormones without the need of penetration enhancers

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