JPS6416722A - Blood viscosity lowering agent - Google Patents
Blood viscosity lowering agentInfo
- Publication number
- JPS6416722A JPS6416722A JP62172921A JP17292187A JPS6416722A JP S6416722 A JPS6416722 A JP S6416722A JP 62172921 A JP62172921 A JP 62172921A JP 17292187 A JP17292187 A JP 17292187A JP S6416722 A JPS6416722 A JP S6416722A
- Authority
- JP
- Japan
- Prior art keywords
- cordalin
- drug
- corydalis
- lowering agent
- graucin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008280 blood Substances 0.000 title abstract 2
- 210000004369 blood Anatomy 0.000 title abstract 2
- GPTFURBXHJWNHR-UHFFFAOYSA-N protopine Chemical compound C1=C2C(=O)CC3=CC=C4OCOC4=C3CN(C)CCC2=CC2=C1OCO2 GPTFURBXHJWNHR-UHFFFAOYSA-N 0.000 abstract 4
- NWPRCRWQMGIBOT-UHFFFAOYSA-N 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CCO)C=N2 NWPRCRWQMGIBOT-UHFFFAOYSA-N 0.000 abstract 3
- 241000218176 Corydalis Species 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 229960005387 etofylline Drugs 0.000 abstract 3
- GTRPODKMSBFDOI-UHFFFAOYSA-N Protopine Natural products CN1Cc2c3OCOc3ccc2C4C1Cc5cc6OCOc6cc5C4=O GTRPODKMSBFDOI-UHFFFAOYSA-N 0.000 abstract 2
- ZAALQOFZFANFTF-UHFFFAOYSA-N Pseudoprotipine Natural products C1=C2C(=O)CC3=CC=4OCOC=4C=C3CN(C)CCC2=CC2=C1OCO2 ZAALQOFZFANFTF-UHFFFAOYSA-N 0.000 abstract 2
- AEQDJSLRWYMAQI-UHFFFAOYSA-N Tetrahydropalmatine Natural products C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- CHWPMFMUQATVNK-ARYYTZDLSA-N dihydrosporogen AO-1 Natural products O[C@H]1[C@]2(C(C)=C)O[C@@H]2[C@]2(C)[C@@H](C)[C@H](O)CCC2=C1 CHWPMFMUQATVNK-ARYYTZDLSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- AEQDJSLRWYMAQI-KRWDZBQOSA-N tetrahydropalmatine Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3C[C@H]2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-KRWDZBQOSA-N 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 241000218180 Papaveraceae Species 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012059 conventional drug carrier Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000004503 fine granule Substances 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940126701 oral medication Drugs 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
PURPOSE:To obtain a blood viscosity lowering agent useful for treating thrombosis, containing at least one of cordalin, tetrahydropalmatine, graucin and protopine as an active ingredient. CONSTITUTION:At least one of cordalin, tetrahydropalmatine, graucin and protopine, components of Corydalis Tubes of crude drug, tuber of plant of the genus Corydalis of the family Papaveraceae is used as a active ingredient and pharmaceutically manufactured as it is or blended with a conventional drug carrier and pharmaceutically manufactured by a conventional procedure to give the aimed substance. The substance can be prepared into an oral drug such as tablet, capsule, granule, fine granule or powder or parenteral drug such as injection or suppository. A dose is 30-400mg per adult daily in the case of oral administration and properly 5-45mg in the case of parenteral administration. The components such as cordalin, etc., are obtained by extracting Corydalis Tuber with a solvent such as water or methanol to give an extracted solution, concentrating, drying, separating and purifying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62172921A JPS6416722A (en) | 1987-07-13 | 1987-07-13 | Blood viscosity lowering agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62172921A JPS6416722A (en) | 1987-07-13 | 1987-07-13 | Blood viscosity lowering agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6416722A true JPS6416722A (en) | 1989-01-20 |
Family
ID=15950823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62172921A Pending JPS6416722A (en) | 1987-07-13 | 1987-07-13 | Blood viscosity lowering agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6416722A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1311486A1 (en) * | 2000-08-23 | 2003-05-21 | Lotus Pharmaceutical Co., Ltd. | Uses of thaliporphine or its derivatives in treatment of cardiac diseases and preparation of same |
| US8507017B2 (en) | 2003-02-07 | 2013-08-13 | Arizona Health Consulting Group, Llc | Method for decreasing nicotine and other substance use in humans |
-
1987
- 1987-07-13 JP JP62172921A patent/JPS6416722A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1311486A1 (en) * | 2000-08-23 | 2003-05-21 | Lotus Pharmaceutical Co., Ltd. | Uses of thaliporphine or its derivatives in treatment of cardiac diseases and preparation of same |
| EP1311486A4 (en) * | 2000-08-23 | 2004-03-31 | Lotus Pharmaceutical Co Ltd | Uses of thaliporphine or its derivatives in treatment of cardiac diseases and preparation of same |
| US8507017B2 (en) | 2003-02-07 | 2013-08-13 | Arizona Health Consulting Group, Llc | Method for decreasing nicotine and other substance use in humans |
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