JPS6413062A - Production of anilinoalkanecarboxylic acids - Google Patents
Production of anilinoalkanecarboxylic acidsInfo
- Publication number
- JPS6413062A JPS6413062A JP16701887A JP16701887A JPS6413062A JP S6413062 A JPS6413062 A JP S6413062A JP 16701887 A JP16701887 A JP 16701887A JP 16701887 A JP16701887 A JP 16701887A JP S6413062 A JPS6413062 A JP S6413062A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- expressed
- compound expressed
- chlorobenzotrifluoride
- catalyst
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE:To industrially and advantageously obtain the titled compounds useful as an intermediate for insecticides in high purity, by condensing inexpensive p-chlorobenzotrifluoride with D-valines in the presence of a catalyst in a polar solvent and then carrying out nuclear chlorination. CONSTITUTION:P-chlorobenzotrifluoride expressed by formula I is subjected to condensation reaction with a compound expressed by formula II (R is lower alkyl; M is H, Na, or K; asymmetric carbon atom indicates R, S or RS structure), such as K salt of D-valine, in an aprotic polar solvent, such as N- methylpyrrolidone, in the presence of a catalyst, such as salt of Cu or Ni, e.g. CuCl2 in an amount of 0.5-30mol% based on the compound expressed by formula I, preferably at 100-180 deg.C for 1-15hr to form a compound expressed by formula III, which is then subjected to nuclear chlorination with a nuclear chlorinating agent, such as N-chlorosuccinimide, in a solvent, such as CCl4, preferably at 0-100 deg.C to afford the aimed compounds, expressed by formula IV and useful as an intermediate for synthetic pyrethroid insecticides.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16701887A JPS6413062A (en) | 1987-07-06 | 1987-07-06 | Production of anilinoalkanecarboxylic acids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16701887A JPS6413062A (en) | 1987-07-06 | 1987-07-06 | Production of anilinoalkanecarboxylic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6413062A true JPS6413062A (en) | 1989-01-17 |
Family
ID=15841863
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16701887A Pending JPS6413062A (en) | 1987-07-06 | 1987-07-06 | Production of anilinoalkanecarboxylic acids |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6413062A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5366868A (en) * | 1990-08-30 | 1994-11-22 | Kyoto Daiichi Kagaku Co., Ltd. | Multilayer analytical element for assaying fructosamine |
-
1987
- 1987-07-06 JP JP16701887A patent/JPS6413062A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5366868A (en) * | 1990-08-30 | 1994-11-22 | Kyoto Daiichi Kagaku Co., Ltd. | Multilayer analytical element for assaying fructosamine |
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