JPS6344519A - Patch - Google Patents
PatchInfo
- Publication number
- JPS6344519A JPS6344519A JP61188977A JP18897786A JPS6344519A JP S6344519 A JPS6344519 A JP S6344519A JP 61188977 A JP61188977 A JP 61188977A JP 18897786 A JP18897786 A JP 18897786A JP S6344519 A JPS6344519 A JP S6344519A
- Authority
- JP
- Japan
- Prior art keywords
- adhesive
- lipophilic
- patch
- sensitive adhesive
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001070 adhesive effect Effects 0.000 claims description 76
- 239000000853 adhesive Substances 0.000 claims description 75
- 239000004615 ingredient Substances 0.000 claims description 34
- 239000003814 drug Substances 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 7
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 abstract description 5
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 abstract description 5
- 108010010803 Gelatin Proteins 0.000 abstract description 3
- 229920000159 gelatin Polymers 0.000 abstract description 3
- 239000008273 gelatin Substances 0.000 abstract description 3
- 235000019322 gelatine Nutrition 0.000 abstract description 3
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 3
- 229920003052 natural elastomer Polymers 0.000 abstract description 3
- 229920001194 natural rubber Polymers 0.000 abstract description 3
- 229920003051 synthetic elastomer Polymers 0.000 abstract description 3
- 239000005061 synthetic rubber Substances 0.000 abstract description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 abstract description 2
- 150000002148 esters Chemical class 0.000 abstract description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract description 2
- 239000004820 Pressure-sensitive adhesive Substances 0.000 abstract 5
- 239000000758 substrate Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 12
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 10
- -1 etc.) Chemical compound 0.000 description 7
- 239000000499 gel Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 229960001047 methyl salicylate Drugs 0.000 description 6
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 5
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 5
- 239000005844 Thymol Substances 0.000 description 5
- 229960000790 thymol Drugs 0.000 description 5
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229920001971 elastomer Polymers 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 4
- 239000005060 rubber Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 3
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 229960000846 camphor Drugs 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229940041616 menthol Drugs 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical compound C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 244000043261 Hevea brasiliensis Species 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 229960001067 hydrocortisone acetate Drugs 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 238000004898 kneading Methods 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920003002 synthetic resin Polymers 0.000 description 2
- 239000000057 synthetic resin Substances 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 2
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
- CPHGOBGXZQKCKI-UHFFFAOYSA-N 4,5-diphenyl-1h-imidazole Chemical compound N1C=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 CPHGOBGXZQKCKI-UHFFFAOYSA-N 0.000 description 1
- IYLLULUTZPKQBW-UHFFFAOYSA-N Acrinol Chemical compound CC(O)C(O)=O.C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3N=C21 IYLLULUTZPKQBW-UHFFFAOYSA-N 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 244000203593 Piper nigrum Species 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- LRJOMUJRLNCICJ-JZYPGELDSA-N Prednisolone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O LRJOMUJRLNCICJ-JZYPGELDSA-N 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 229960005274 benzocaine Drugs 0.000 description 1
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- FACXGONDLDSNOE-UHFFFAOYSA-N buta-1,3-diene;styrene Chemical compound C=CC=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 FACXGONDLDSNOE-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 229940007061 capsicum extract Drugs 0.000 description 1
- 239000001943 capsicum frutescens fruit extract Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940106164 cephalexin Drugs 0.000 description 1
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229910052956 cinnabar Inorganic materials 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 229960001193 diclofenac sodium Drugs 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- LPEPZBJOKDYZAD-UHFFFAOYSA-N flufenamic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 LPEPZBJOKDYZAD-UHFFFAOYSA-N 0.000 description 1
- 229960004369 flufenamic acid Drugs 0.000 description 1
- 229960001347 fluocinolone acetonide Drugs 0.000 description 1
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000007757 hot melt coating Methods 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 1
- 229960001907 nitrofurazone Drugs 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 229920001083 polybutene Polymers 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920005990 polystyrene resin Polymers 0.000 description 1
- 150000003097 polyterpenes Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960002800 prednisolone acetate Drugs 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229960004880 tolnaftate Drugs 0.000 description 1
- FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野）
本発明は貼付剤に関し、更に詳しくは薬効成分を含有し
た親水性粘着剤部と薬効成分を含有した親油性粘着剤部
とを支持シート上に並べた貼付剤に関する。Detailed Description of the Invention [Field of Industrial Application] The present invention relates to a patch, and more specifically, a hydrophilic adhesive part containing a medicinal ingredient and a lipophilic adhesive part containing a medicinal ingredient are placed on a support sheet. Regarding patches arranged in.
（従来の技術）
親油性粘着剤部と親水性ゲル部とを支持シート上に交互
に並べた貼付剤（実公昭５８−４９００号公報）が従来
知られている。(Prior Art) A patch (Japanese Utility Model Publication No. 58-4900) in which lipophilic adhesive parts and hydrophilic gel parts are arranged alternately on a support sheet is conventionally known.
この貼付剤は、薬効成分を含有しない帯状の親水性ゲル
部と薬効成分を含有して付着性がある帯状の親油性粘着
剤部とを交互に縞状に配列するか、方形状とした該親水
性ゲル部の周囲を該親油性粘着剤部で取囲んでいる。This patch consists of a band-shaped hydrophilic gel part that does not contain a medicinal ingredient and a band-shaped lipophilic adhesive part that contains a medicinal ingredient and has adhesive properties, which are arranged alternately in a striped pattern or in a rectangular shape. The hydrophilic gel part is surrounded by the lipophilic adhesive part.
（発明が解決しようとする問題点）
しかしながら、この貼付剤は親水性ゲル部に薬効成分を
含まず、薬効成分を含有するのはゴムなどの親油性ポリ
マーからなる親油性粘着剤部であるから、その薬効成分
は放出が緩慢で放出量も少なく、しかも放出面積自体は
通常貼付面の半分以下である。(Problems to be Solved by the Invention) However, this patch does not contain any medicinal ingredients in the hydrophilic gel part, and it is the lipophilic adhesive part made of lipophilic polymer such as rubber that contains the medicinal ingredients. The medicinal ingredients are released slowly and the amount released is small, and the release area itself is usually less than half of the surface to which it is applied.
従ってその治療効果は充分とは言い難く、特に初期にお
いては充分な治療効果が得られない。Therefore, its therapeutic effect cannot be said to be sufficient, especially in the early stages.
本発明の目的は、この不備な点をＭ消し、一定量の薬効
成分を長時間にわたって放出し続け、しかも初期の放出
量を犬にすることにより充分な治療効果をあげることが
可能な貼付剤を提供することにある。The purpose of the present invention is to eliminate this deficiency by creating a patch that can continuously release a certain amount of medicinal ingredients over a long period of time, and can achieve sufficient therapeutic effects by controlling the initial release amount to the dog. Our goal is to provide the following.
（問題点を解決するための手段）
本発明者らは、従来の貼付剤の不備な点を解消すべく鋭
意研究した結果、薬効成分を含有した親水性粘着剤部と
薬効成分を含有した親油性粘着剤部とを支持シート上に
配置することにより、長時間にわたって一定量の薬効成
分を放出し続け、しかも初期の放出量を大にすることが
可能な貼付剤を得ることに成功し、本発明を完成した。(Means for Solving the Problems) As a result of intensive research to resolve the deficiencies of conventional patches, the present inventors have developed a hydrophilic adhesive part containing a medicinal ingredient and a parent adhesive part containing a medicinal ingredient. By arranging the oil-based adhesive part on a support sheet, we succeeded in obtaining a patch that can continue to release a certain amount of medicinal ingredients over a long period of time and can increase the initial release amount. The invention has been completed.
本発明の目的物は、薬効成分を含有した一以上の親水性
粘着剤部と薬効成分を含有した一以上の親油性粘着剤部
とを支持シート上に存在させた貼付剤である。The object of the present invention is a patch in which one or more hydrophilic adhesive portions containing a medicinal ingredient and one or more lipophilic adhesive portions containing a medicinal ingredient are present on a support sheet.
本発明において、薬効成分とは、経皮吸収させることが
できる薬物か、または貼付剤に常用されている薬物であ
る。たとえば、フルチフステロイド類（プレドニゾロン
、酢酸プレドニゾロン、ヒドロコルチゾン、酢酸ヒドロ
コルチゾン、酢酸プロピオン酸ヒドロコルチゾン、ベタ
メタシン、吉草酸ベタメタシン、フルオシノロンアセト
ニド。In the present invention, the medicinal ingredient is a drug that can be absorbed transdermally or a drug that is commonly used in patches. For example, flutifosteroids (prednisolone, prednisolone acetate, hydrocortisone, hydrocortisone acetate, hydrocortisone acetate propionate, betamethacin, betamethacin valerate, fluocinolone acetonide.
デキサメタシンなど）、麻酔薬（ペンシカイン。dexamethacin), anesthetics (pensicaine, etc.).
リドカイン、アミノ安息香酸エチルなど）、抗ヒスタミ
ン薬（塩酸ジフェンヒドラミン、塩酸イソサイベンジル
、ジフェンヒドラミン、ジフェニールイミダゾールなど
）、抗菌薬（塩化ベンザルコニウム、ニトロフランなど
）、抗真菌薬（ナイスクチン、ウンデシレン酸、トルナ
フテートなト）、鎮痛消炎薬（インドメタシン、ジクロ
フエナックナトリ°ウム、フルフェナム酸、サリチル酸
ナトリウム、オウバク末、水溶性アズレンな、！’）、
抗ＩＪ質（エリスロマイシン、クロラムフェニコール、
セファレキシン、テトラサイタリン、ネオマイシン、ペ
ニシリン、ペニシリンＧ−１−トリウムなど）、貼付剤
常用薬（カンフル、メントール、灼附子、紫根、ハツカ
油、チモール、アクリノール、ロートエキス、トウガラ
シエキスなど）などである。lidocaine, ethyl aminobenzoate, etc.), antihistamines (diphenhydramine hydrochloride, isocybenzyl hydrochloride, diphenhydramine, diphenylimidazole, etc.), antibacterial agents (benzalkonium chloride, nitrofuran, etc.), antifungal agents (nicecutin, undecylenic acid, etc.) , tolnaftate), analgesic and anti-inflammatory drugs (indomethacin, diclofenac sodium, flufenamic acid, sodium salicylate, Oubac powder, water-soluble azulene,!'),
Anti-IJ substances (erythromycin, chloramphenicol,
cephalexin, tetracytalline, neomycin, penicillin, penicillin G-1-thorium, etc.), and commonly used patch drugs (camphor, menthol, cinnabar, purple root, pepper oil, thymol, acrinol, rotisserie extract, capsicum extract, etc.), etc. .
粘着剤とは、常用の親油性粘着性物質または親水性粘着
性物質に前記薬効成分およびその他必要な成分を混練し
たものをいう。The adhesive refers to a commonly used lipophilic adhesive substance or hydrophilic adhesive substance mixed with the medicinal ingredients and other necessary ingredients.
その他必要な成分としては賦形剤（たとえば、カオリン
、ベントナイト、酸化チタン、酸化亜鉛、炭酸カルシウ
ム、メタケイ酸アルミン醸マグネシウムなど）、粘着性
付与成分（たとえば、ロジン、変性ロジン、水添ロジン
、石油系樹脂、クマロンインデン樹脂、ポリテルペン樹
脂、ポリスチレン樹脂、ヒドロアビエチルアルコール、
ポリブテン、液状イソプレンなど）、酸化防止剤、香料
、着色剤などを用いることができる。Other necessary ingredients include excipients (e.g., kaolin, bentonite, titanium oxide, zinc oxide, calcium carbonate, magnesium aluminium metasilicate, etc.), tackifying ingredients (e.g., rosin, modified rosin, hydrogenated rosin, petroleum system resin, coumaron indene resin, polyterpene resin, polystyrene resin, hydroabiethyl alcohol,
Polybutene, liquid isoprene, etc.), antioxidants, fragrances, colorants, etc. can be used.
親油性粘着性物質としては、たとえば、天然ゴム、合成
ゴム（インブレンゴム、スチレン−イソプレン−スチレ
ン共重合体、スチレン−ブタジェン−スチレン共重合体
、スチレン−ブタジェンゴムなど）、ポリアクリル酸エ
ステルなどを用いることができる。As the lipophilic adhesive substance, for example, natural rubber, synthetic rubber (inbrene rubber, styrene-isoprene-styrene copolymer, styrene-butadiene-styrene copolymer, styrene-butadiene rubber, etc.), polyacrylic acid ester, etc. can be used. Can be done.
親水性粘着性物質としては、たとえば、ポリビニルアル
コール、ゼラチン、ポリアクリル酸、ポリアクリル酸ナ
トリウム、ポリメタアクリル酸などおよびその架橋ゲル
、液状インブレンゴムの一部架橋体および架橋体のエマ
ルジョン、前記合成ゴムのエマルジョンなどを用いるこ
とができる。Examples of hydrophilic adhesive substances include polyvinyl alcohol, gelatin, polyacrylic acid, sodium polyacrylate, polymethacrylic acid, etc. and crosslinked gels thereof, partially crosslinked liquid inbrene rubber and emulsions of crosslinked products, and the synthetic rubbers mentioned above. An emulsion or the like can be used.
就中、ポリアクリル酸ナトリウムを公知の架橋剤でゲル
化したものを用いることが好ましい。Among these, it is preferable to use sodium polyacrylate gelled with a known crosslinking agent.
本発明の貼付剤は、薬効成分を含有した親水性粘着剤部
と薬効成分を含有した親油性粘着剤部とを適宜組み合わ
せて支持シート上に配列したものである。The adhesive patch of the present invention has a hydrophilic adhesive part containing a medicinal ingredient and a lipophilic adhesive part containing a medicinal ingredient, appropriately combined and arranged on a support sheet.
相隣り合う粘着剤部は異種の粘着剤部であって、しかも
相互間に空隙部をつくることなく接合していることが好
ましい。It is preferable that adjacent adhesive parts are different types of adhesive parts, and that they are joined without creating a gap between them.
異種の粘着剤部を着色して適宜組み合わせ配列すること
により、貼付剤の粘着面は美しい縞模様、市松模様、水
玉模様などを呈し、商品価値が高まる。By coloring different types of adhesive parts and arranging them in appropriate combinations, the adhesive surface of the patch exhibits beautiful striped, checkered, or polka dot patterns, increasing its commercial value.
本発明の貼付剤は、たとえば特願昭６１−１５３８４５
号公報記載の方法により製造することができる。The adhesive patch of the present invention is disclosed in, for example, Japanese Patent Application No. 61-153845.
It can be produced by the method described in the publication.
すなわち、カレンダー・ロール法またはホットメルト・
コーティング法により剥離シートに、薬剤を含有した親
油性または親水性粘着剤部を一個以上任意の形状で設け
、支持シートには剥離シート上の粘着剤部に対応する部
分を空けて他の部分にその粘着剤とは異種の粘着剤部を
設けた後、両シートを貼合わせて一体化し、異種の粘着
剤部が両シートの間に存在する粘着剤を得ることができ
る。i.e. calender roll method or hot melt method.
One or more drug-containing lipophilic or hydrophilic adhesive parts are provided on the release sheet using a coating method in any desired shape, and the support sheet is provided with a part corresponding to the adhesive part on the release sheet and other parts are left open. After providing an adhesive portion of a different type from the adhesive, both sheets are laminated and integrated to obtain an adhesive in which a different type of adhesive portion is present between the two sheets.
ここにおいて剥離シートはポリエチレン、ポリ塩化ビニ
ル、ポリエステルなどの合成樹脂フィルム、紙、アルミ
ニウム箔またはこれらのラミネートシートなどにシリコ
ンなどで剥離処理したものを用いる。Here, the release sheet used is a synthetic resin film such as polyethylene, polyvinyl chloride, polyester, etc., paper, aluminum foil, or a laminate sheet thereof, which has been subjected to release treatment with silicone or the like.
支持シートは不織布、綿布、ネル、和紙などの繊維布、
ポリエチレン、ポリ塩化ビニル、ポリエステル、ポリプ
ロピレンなどの合成樹脂フィルム、アルミニウム箔また
はこれらのラミネートシートを用いる。The support sheet is made of fiber cloth such as non-woven fabric, cotton cloth, flannel, Japanese paper, etc.
A synthetic resin film such as polyethylene, polyvinyl chloride, polyester, or polypropylene, aluminum foil, or a laminate sheet thereof is used.
前記粘着剤は、たとえば次の方法により調製することが
できる。The adhesive can be prepared, for example, by the following method.
（親油性粘着剤）
前記親油性粘着物質に粘着性付与成分、賦形剤などを混
練した後、親油性薬効成分を混練して親油性粘着剤を得
る。(Lipophilic Adhesive) After kneading a tackifying component, an excipient, etc. into the lipophilic adhesive substance, a lipophilic medicinal ingredient is kneaded to obtain a lipophilic adhesive.
（親水性粘着剤）
前記親水性粘着物質（架橋ゲルとする必要がある場合に
は未架橋のもの）をアルコール類と混合し、更に賦形剤
などを加えて混練する。(Hydrophilic Adhesive) The hydrophilic adhesive substance (uncrosslinked if a crosslinked gel is required) is mixed with alcohol, and excipients are added and kneaded.
これに精製水を加え、架橋ゲルとする必要がある場合に
は架橋剤を加えてこれを混練し、更に親水性薬効成分を
混練して親水性粘着剤を得る。Purified water is added to this, and if it is necessary to form a crosslinked gel, a crosslinking agent is added and kneaded, and a hydrophilic medicinal ingredient is further kneaded to obtain a hydrophilic adhesive.
（発明の効果）
本発明の貼付剤は、薬効成分を含有する親油性粘着剤部
と薬効成分を含有する親水性粘着剤部を適宜組み合わせ
て支持シート上に配置することにより、一定量の薬効成
分の長時間持続放出と薬効成分の初期放出量の増大を可
能にするとともに、貼付剤の粘着面のすべてが薬効成分
の作用面となり、皮膚への付着面となることを可能にす
る。(Effects of the Invention) The patch of the present invention has a medicinal effect of a certain amount by appropriately combining a lipophilic adhesive part containing a medicinal ingredient and a hydrophilic adhesive part containing a medicinal ingredient and disposing them on a support sheet. This enables sustained release of ingredients over a long period of time and an increase in the initial release amount of medicinal ingredients, and also enables the entire adhesive surface of the patch to act as a surface for medicinal ingredients to adhere to the skin.
従って、本発明の貼付剤は他の貼付手段の助けを借りる
ことなく患部によく付着して使用に便利であり、しかも
治療効果が大で、医薬として有用である。Therefore, the adhesive patch of the present invention adheres well to the affected area without the aid of other adhesive means, is convenient to use, has great therapeutic effects, and is useful as a medicine.
また、異種の粘着剤部を異なる色に着色することにより
貼付剤の粘着面に美しい模様を現出して購買意欲をそそ
り、本発明の貼付剤の商品価値を高めることができる。In addition, by coloring different types of adhesive parts in different colors, a beautiful pattern appears on the adhesive surface of the patch, which can arouse the desire to purchase and increase the commercial value of the patch of the present invention.
（実施例）
以下、実施例および試験例を挙げて本発明を具体的に説
明する。(Example) Hereinafter, the present invention will be specifically explained with reference to Examples and Test Examples.
実施例１
（１）天然ゴム（素練り済）３０部に水添ロジン１０部
および精製ラノリン５部を加えて８０℃で練合し、これ
に更にカオリン２０部および酸化チタン３部を加えて練
合した。Example 1 (1) 10 parts of hydrogenated rosin and 5 parts of purified lanolin were added to 30 parts of natural rubber (masked) and kneaded at 80°C, and further 20 parts of kaolin and 3 parts of titanium oxide were added. We practiced.
練合槽内を４０〜５０°Ｃに冷却し、予めサリチル酸メ
チル１部、ｄＮ−カンフル０．５部、１−メントール２
部およびチモール０．３部を混合して溶液としたものを
これに加えて練合し、親油性粘着剤を得た。The inside of the kneading tank was cooled to 40 to 50°C, and 1 part of methyl salicylate, 0.5 part of dN-camphor, 1-menthol 2
A solution obtained by mixing 0.3 parts of thymol and 0.3 parts of thymol was added thereto and kneaded to obtain a lipophilic adhesive.
■ ゼラチン４部、ポリアクリル酸ナトリウム１部およ
びカルボキシメチルセルロース２部にグリセリン１０部
およびプロピレングリコール１０部を加えて充分に練合
した後、カオリン１５部を加えて更に充分に練合した。(2) 10 parts of glycerin and 10 parts of propylene glycol were added to 4 parts of gelatin, 1 part of sodium polyacrylate, and 2 parts of carboxymethylcellulose and thoroughly kneaded, and then 15 parts of kaolin was added and further kneaded thoroughly.
次にこれに精製水５０部に酒石酸１部およびケイ酸アル
ミニウム０．１部を加えて練合し、予めサリチル酸メチ
ル１部、ｄｌ−カンフル０．５部およびｌ−メントール
１部を混合して溶液としたものをこれに加えて練合し親
水性粘着剤を得た。Next, 1 part of tartaric acid and 0.1 part of aluminum silicate were added to 50 parts of purified water and kneaded, and 1 part of methyl salicylate, 0.5 part of dl-camphor and 1 part of l-menthol were mixed in advance. A solution was added to this and kneaded to obtain a hydrophilic adhesive.
■ フレームに１ｃＴＩ＋間隔で巾１ｃｍのテフロン・
バンドを平行に多数取り付け、縦型３本ロールと組合わ
せて、ポリエステルフィルムの片面にシリコン処理を施
した剥離シートを進行許せながら、前記親油性粘着剤を
塗着し、巾１ｃＩＴ＋の帯状親油性粘着割部多数を１ｃ
Ｔｎ間隔で剥離シート上に設けた。■ Teflon with a width of 1cm at 1cTI + intervals on the frame.
Attach a large number of bands in parallel, combine them with three vertical rolls, apply the lipophilic adhesive on one side of the polyester film while allowing the silicone-treated release sheet to advance, and form a lipophilic strip with a width of 1 cIT+. 1c of adhesive split parts
They were provided on a release sheet at intervals of Tn.
一方、反対側にも同様の装置を設け、不織布シートを進
行きせながら、前記親水性粘着剤を塗着し、剥離シート
の帯状親油性粘着剤部に対応する部分から１ＣＩｌ′Ｉ
横に移動した位置に巾１ｃｍの帯状親水性粘着割部多数
を１国間隔で不織布シート上に設けた。On the other hand, a similar device was installed on the opposite side, and while advancing the nonwoven fabric sheet, the hydrophilic adhesive was applied, starting from the part corresponding to the band-shaped lipophilic adhesive part of the release sheet.
A large number of band-shaped hydrophilic adhesive split portions each having a width of 1 cm were provided on the nonwoven fabric sheet at intervals of one country at laterally moved positions.
このよう番こして製造した剥離シートと不織布支持シー
トを同時に両方向から進行きせて、２本のロールの間を
通して圧着し、多数の帯状親油性粘着剤部の空隙部に多
数の帯状親水性粘着剤部を嵌合して一体化きせた。The release sheet and nonwoven fabric support sheet produced in this way are simultaneously advanced from both directions and pressed between two rolls, and a large number of strips of hydrophilic adhesive are filled into the gaps between the strips of lipophilic adhesive. The parts were fitted and integrated.
これを更に進行きせながら、１４ｃ＋′ＩＩ×１０ｃｍ
のサイズに切断し、巾１ｃｒｌ′ｌの帯状親油性粘着剤
部と帯状親油性粘着剤部が交互に隙間なく縞状に並んだ
貼付剤１０枚を一組にして密封包装した。As this progresses further, 14c+'II x 10cm
A set of 10 adhesive patches each having a width of 1 crl'l, in which lipophilic adhesive strips and lipophilic adhesive strips were arranged alternately in a striped pattern without gaps, was sealed and packaged.
実施例２
（１） スチレン−イソプレン共重合体（Ｓ工Ｓゴム
）１０部に流動パラフィン１０部を浸みこませた後、約
１００°Ｃで練合し、これに水添ロジン２０部、亜鉛華
５部およびクエン酸１部を加えて練合した。Example 2 (1) After impregnating 10 parts of liquid paraffin into 10 parts of styrene-isoprene copolymer (S-S rubber), the mixture was kneaded at about 100°C, and 20 parts of hydrogenated rosin and zinc 5 parts of citric acid and 1 part of citric acid were added and kneaded.
次に予めサリチル酸メチル１部、ｄｌ−カンフル１部、
ｉ−メントール０．５部、チモール０．１部およびハツ
カ油０．５部を混合して溶液としたものをこれに加えて
約５０°Ｃで練合して親油性粘着剤を得た。Next, in advance, 1 part of methyl salicylate, 1 part of dl-camphor,
A solution prepared by mixing 0.5 part of i-menthol, 0.1 part of thymol and 0.5 part of peppermint oil was added thereto and kneaded at about 50°C to obtain a lipophilic adhesive.
（り ポリアクリル酸ナトリウム２．５部およびメチル
セルロース３部にグリセリン１０部を加えて充分に練合
し、精製水に酒石酸０．５部および酸化アルミニウム０
．１部を混合したものを加えて充分に練合した。Add 10 parts of glycerin to 2.5 parts of sodium polyacrylate and 3 parts of methylcellulose, mix well, add 0.5 parts of tartaric acid to purified water and 0.0 parts of aluminum oxide.
．． 1 part of the mixture was added and thoroughly kneaded.
次に予めサリチル酸メチル１部、ｉ−メントール０．５
部、チモール０．１部、ｄｊ２−カンフル１ｇｌ！およ
びハツカ油０．５部を混合して溶液としたものをこれに
加えて充分に練合し、親水性粘着剤を得た。Next, add 1 part of methyl salicylate and 0.5 i-menthol in advance.
part, thymol 0.1 part, dj2-camphor 1gl! A solution prepared by mixing and 0.5 part of peppermint oil was added thereto and sufficiently kneaded to obtain a hydrophilic adhesive.
０）前記親油性粘着剤を加温溶解してポンプでホットメ
ルト・コーティング・アプリケーターに送り、電子制御
の下に一辺２Ｃｒｌ′Ｉの正方形の親油性粘着剤部がそ
の４つのかどにおいて他のこれと合同の正方形の親油性
粘着剤部と連接するように進行するネルシート上に親油
性粘着剤部を設けた。0) The lipophilic adhesive is melted by heating and sent to a hot-melt coating applicator by a pump, and under electronic control, a square lipophilic adhesive part of 2 Crl'I on a side is attached to another part at its four corners. A lipophilic adhesive part was provided on the flannel sheet that progressed so as to be connected to the square lipophilic adhesive part congruent with the square shape of the lipophilic adhesive part.
この結果ネルシート上には上下左右に一つおきに空隙部
のある市松模様状の親油性粘着剤部が設けられた。As a result, a checkered pattern of lipophilic adhesive portions with voids at every other space on the top, bottom, right and left sides was provided on the flannel sheet.
一方、反対側にも同様の装置を設け、塩化ビニルシート
の片面にシリコン処理をした剥離シートを進行させなが
ら、親油性粘着剤部を設ける場合に準じて、ネルシート
の市松模様状の親油性結着剤部の空隙部に対応する剥離
シートの部分に前記親水性粘着剤を塗着し、市松模様状
の親水性粘着剤部を設けた。On the other hand, a similar device was installed on the opposite side, and while a silicone-treated release sheet was being advanced on one side of the vinyl chloride sheet, the checkered pattern of lipophilic bonds on the flannel sheet The hydrophilic adhesive was applied to the part of the release sheet corresponding to the voids in the adhesive part to provide a checkered pattern of hydrophilic adhesive parts.
このようにして製造した剥離シートとネルシートを進行
させながら２本のロールの間を通して圧着し、市松模様
状の親油性粘着剤部の空隙部に市松模様状の親水性粘着
剤部を嵌合して一体化させた。The release sheet and flannel sheet produced in this manner are passed between two rolls and pressed together, and the checkered hydrophilic adhesive part is fitted into the gap in the checkered lipophilic adhesive part. integrated.
これを更に進行きせながら、１４■Ｘ １０ｃｍのサイ
ズに切断し、−辺２ＣＩ１１の正方形状の親油性粘着剤
部と親水性粘着剤部とが市松模様状に並んだ貼付剤１０
枚を一組にして包装した。While this process was further progressed, it was cut into a size of 14 x 10 cm, and a patch 10 was prepared in which a square lipophilic adhesive part and a hydrophilic adhesive part with side 2CI11 were arranged in a checkerboard pattern.
The sheets were packaged as a set.
試験例
実施例１で得た貼付剤の、結着剤部１４ｇ相当分を秤取
し、巾１ｃｍに細断してビスキングチューブ［透析膜：
三光純薬■製］に入れ、これを３７℃に加温した水１５
０ｍＱを入れたガラス容器に入れて３７°Ｃの水浴中で
振盪して薬効成分を放出させた。Test Example Weigh out an amount equivalent to 14 g of the binder portion of the patch obtained in Example 1, cut it into pieces with a width of 1 cm, and prepare a Visking tube [dialysis membrane:
made by Sanko Junyaku ■] and heated it to 37℃ 15
It was placed in a glass container containing 0 mQ and shaken in a water bath at 37°C to release the medicinal ingredients.
この放出液を２時間、５時間、８時間、１０時間毎にサ
ンプリングし、ガスクロマトグラフ法によりサリチル酸
メチルの放出量を測定してその累積放出率を求めた。This released liquid was sampled every 2 hours, 5 hours, 8 hours, and 10 hours, and the amount of methyl salicylate released was measured by gas chromatography to determine the cumulative release rate.
また対照として親水性粘着剤部にのみ薬効成分を含有き
せた実施例１の貼付剤（貼付剤Ａと称する）および親油
性粘着剤部にのみ薬効成分を含有きせた実施例１の貼付
剤（貼付剤Ｂと称する）について本発明の貼付剤と同様
の試験を行なった。As a control, the patch of Example 1 containing a medicinal ingredient only in the hydrophilic adhesive part (referred to as Patch A) and the patch of Example 1 containing a medicinal ingredient only in the lipophilic adhesive part (referred to as Patch A) Tests similar to those for the patch of the present invention were conducted on the patch (referred to as patch B).
その結果を第１図に示す。The results are shown in FIG.
第１図より、本発明の貼付剤は一定量の薬効成分を長時
間にわたって放出し続け、薬効成分の初期放出量も大で
あることがわかる。From FIG. 1, it can be seen that the patch of the present invention continues to release a certain amount of the medicinal ingredient over a long period of time, and the initial release amount of the medicinal ingredient is also large.
第１図は、本発明の貼付剤並びに対照の貼付剤Ａおよび
貼付剤Ｂのサリチル酸メチルの累積放出率を示すグラフ
である。FIG. 1 is a graph showing the cumulative release rate of methyl salicylate of the patch of the present invention and control patches A and B.
Claims (1)
効成分を含有した一以上の親油性粘着剤部とを支持シー
ト上に存在させた貼付剤。1) A patch in which one or more hydrophilic adhesive portions containing a medicinal ingredient and one or more lipophilic adhesive portions containing a medicinal ingredient are present on a support sheet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61188977A JPS6344519A (en) | 1986-08-12 | 1986-08-12 | Patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61188977A JPS6344519A (en) | 1986-08-12 | 1986-08-12 | Patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6344519A true JPS6344519A (en) | 1988-02-25 |
Family
ID=16233235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61188977A Pending JPS6344519A (en) | 1986-08-12 | 1986-08-12 | Patch |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6344519A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04238827A (en) * | 1991-01-11 | 1992-08-26 | Stanley Electric Co Ltd | Apparatus for dividing glass substrate for liquid crystal cell |
| US6534044B1 (en) | 1999-01-11 | 2003-03-18 | Showa Denko K.K | Cosmetic preparation, surface-hydrophobized silica-coated metal oxide particles, sol of silica-coated metal oxide, and processes for producing these |
| KR20030093615A (en) * | 2002-06-04 | 2003-12-11 | 한웅코텍 주식회사 | Hydrophilic gel sheet |
-
1986
- 1986-08-12 JP JP61188977A patent/JPS6344519A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04238827A (en) * | 1991-01-11 | 1992-08-26 | Stanley Electric Co Ltd | Apparatus for dividing glass substrate for liquid crystal cell |
| US6534044B1 (en) | 1999-01-11 | 2003-03-18 | Showa Denko K.K | Cosmetic preparation, surface-hydrophobized silica-coated metal oxide particles, sol of silica-coated metal oxide, and processes for producing these |
| KR20030093615A (en) * | 2002-06-04 | 2003-12-11 | 한웅코텍 주식회사 | Hydrophilic gel sheet |
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