JPS63296804A - Flat membrane with protrusion and manufacture thereof - Google Patents
Flat membrane with protrusion and manufacture thereofInfo
- Publication number
- JPS63296804A JPS63296804A JP62131792A JP13179287A JPS63296804A JP S63296804 A JPS63296804 A JP S63296804A JP 62131792 A JP62131792 A JP 62131792A JP 13179287 A JP13179287 A JP 13179287A JP S63296804 A JPS63296804 A JP S63296804A
- Authority
- JP
- Japan
- Prior art keywords
- permeable membrane
- membrane
- flat
- microprotrusions
- flat membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 313
- 238000004519 manufacturing process Methods 0.000 title claims description 32
- 238000000034 method Methods 0.000 claims abstract description 27
- -1 polypropylene Polymers 0.000 claims abstract description 22
- 239000004743 Polypropylene Substances 0.000 claims abstract description 20
- 229920001155 polypropylene Polymers 0.000 claims abstract description 20
- 230000001112 coagulating effect Effects 0.000 claims abstract 2
- 239000000463 material Substances 0.000 claims description 64
- 239000000853 adhesive Substances 0.000 claims description 24
- 230000001070 adhesive effect Effects 0.000 claims description 24
- 238000000926 separation method Methods 0.000 claims description 14
- 229920005989 resin Polymers 0.000 claims description 13
- 239000011347 resin Substances 0.000 claims description 13
- 229920000098 polyolefin Polymers 0.000 claims description 10
- 239000011550 stock solution Substances 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 9
- 239000004952 Polyamide Substances 0.000 claims description 8
- 229920002492 poly(sulfone) Polymers 0.000 claims description 8
- 229920002647 polyamide Polymers 0.000 claims description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 7
- 239000001913 cellulose Substances 0.000 claims description 7
- 229920002678 cellulose Polymers 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 7
- 239000004627 regenerated cellulose Substances 0.000 claims description 7
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 6
- 229920002635 polyurethane Polymers 0.000 claims description 5
- 239000004814 polyurethane Substances 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 239000003822 epoxy resin Substances 0.000 claims description 4
- 229920000647 polyepoxide Polymers 0.000 claims description 4
- 229920003051 synthetic elastomer Polymers 0.000 claims description 4
- 239000005061 synthetic rubber Substances 0.000 claims description 4
- 229920005992 thermoplastic resin Polymers 0.000 claims description 4
- 125000005396 acrylic acid ester group Chemical group 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 abstract description 26
- 210000004369 blood Anatomy 0.000 abstract description 17
- 239000008280 blood Substances 0.000 abstract description 17
- 125000006850 spacer group Chemical group 0.000 abstract description 12
- 238000001816 cooling Methods 0.000 abstract description 11
- 239000012766 organic filler Substances 0.000 abstract description 10
- 229940057995 liquid paraffin Drugs 0.000 abstract description 7
- 238000007711 solidification Methods 0.000 abstract description 5
- 230000008023 solidification Effects 0.000 abstract description 5
- 239000008188 pellet Substances 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 238000000465 moulding Methods 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 description 13
- 239000010839 body fluid Substances 0.000 description 13
- 239000000706 filtrate Substances 0.000 description 9
- 229920001187 thermosetting polymer Polymers 0.000 description 9
- 238000001914 filtration Methods 0.000 description 8
- 239000000306 component Substances 0.000 description 7
- 230000037452 priming Effects 0.000 description 7
- 230000005540 biological transmission Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000024203 complement activation Effects 0.000 description 5
- 239000003484 crystal nucleating agent Substances 0.000 description 5
- 238000000502 dialysis Methods 0.000 description 5
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 5
- 239000000945 filler Substances 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 239000012503 blood component Substances 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 239000000155 melt Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 238000000108 ultra-filtration Methods 0.000 description 3
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 2
- 238000001994 activation Methods 0.000 description 2
- 239000003114 blood coagulation factor Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229940087101 dibenzylidene sorbitol Drugs 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 239000005457 ice water Substances 0.000 description 2
- 238000004898 kneading Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 238000006722 reduction reaction Methods 0.000 description 2
- 239000003566 sealing material Substances 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000004804 winding Methods 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 1
- 208000000260 Warts Diseases 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 229920006397 acrylic thermoplastic Polymers 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004715 ethylene vinyl alcohol Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- RZXDTJIXPSCHCI-UHFFFAOYSA-N hexa-1,5-diene-2,5-diol Chemical compound OC(=C)CCC(O)=C RZXDTJIXPSCHCI-UHFFFAOYSA-N 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 230000031915 positive regulation of coagulation Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000010022 rotary screen printing Methods 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/06—Flat membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/08—Flat membrane modules
- B01D63/082—Flat membrane modules comprising a stack of flat membranes
- B01D63/084—Flat membrane modules comprising a stack of flat membranes at least one flow duct intersecting the membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/08—Coating a former, core or other substrate by spraying or fluidisation, e.g. spraying powder
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、平膜型透過膜およびその製造方法に関するも
のである。詳しく述べると本発明は、透析、限外濾過、
精密濾過等に用いられる平膜型透過膜において、モジュ
ール等に組入れた際に、処理液の安定した流路形成が容
易に行なえる平膜型透過膜に関するもである。DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a flat membrane type permeable membrane and a method for manufacturing the same. To be more specific, the present invention provides dialysis, ultrafiltration,
The present invention relates to a flat membrane type permeable membrane used for precision filtration and the like, which can easily form a stable flow path for a processing liquid when incorporated into a module or the like.
（従来の技術）
今日、透析、限外濾過、精密濾過等の物理的、化学約分
Ｍ操作において、各種の高分子透過膜が使用されている
。一般に高分子は、このような膜祠料として最適な材料
であるが、高分子透過膜は変形を生じやすい。例えば、
平膜型透過膜をモジュール等に組入れた場合には、透過
膜の変形により処理液の所定の流路を確保することが困
難となってくる。(Prior Art) Today, various polymer permeable membranes are used in physical and chemical reduction M operations such as dialysis, ultrafiltration, and microfiltration. Generally, polymers are the most suitable material for such membrane abrasive materials, but polymer permeable membranes are prone to deformation. for example,
When a flat membrane type permeable membrane is incorporated into a module or the like, it becomes difficult to secure a predetermined flow path for the processing liquid due to deformation of the permeable membrane.
このため従来、平膜型透過膜を血漿分離装置等のモジュ
ールに組入れる場合には、処理液の流路を形成させる為
に例えば第６図に示すような構成をする必要があった。For this reason, conventionally, when a flat membrane type permeable membrane is incorporated into a module such as a plasma separation device, it has been necessary to use a configuration as shown in FIG. 6, for example, in order to form a flow path for the processing liquid.
すなわち第６図に示す血漿分離装置においては、天板中
央部に体液流入口５１、天板外周部に血漿流出口５２お
よび側壁に体液流出口５３を備えた円筒状ケース本体５
４と周縁にＯリング５５を取り付けた底蓋体５６とより
なるケース内に、スクリーンメツシュよりなる濾液流路
形成板５７を上下２枚の平膜型透過膜５０ａ、５０ｂに
挟装し、その周縁部および中心開口部５８の周縁部をシ
ールするとともに、濾液通過孔５９の外周にシール材６
０を貼着してなる透過膜ユニット６１が、該透過膜ユニ
ツ１−６１に対応した中心開口部５８および濾液通過孔
５９を備えかつ両面に多数の凸部を備えた体液流路規制
板６２を挟んで複数積層されており、また前記透過膜ユ
ニット６１の最上部の上面とケースの上部内面および透
過膜ユニットの最下部の下面とケースの−〇 −
底部内面の間には、それぞれ該透過膜ユニツ１−６１に
対応した中央開口部５８および濾液通過孔５９を備えか
つ片面に多数の凸部を備えた体液流路規制板６３が配設
されている。That is, in the plasma separation apparatus shown in FIG. 6, a cylindrical case body 5 is provided with a body fluid inlet 51 at the center of the top plate, a plasma outlet 52 at the outer periphery of the top plate, and a body fluid outlet 53 at the side wall.
4 and a bottom lid body 56 with an O-ring 55 attached to the periphery, a filtrate flow path forming plate 57 made of screen mesh is sandwiched between two upper and lower flat membrane type permeable membranes 50a and 50b, In addition to sealing the peripheral edge of the central opening 58 and the peripheral edge of the central opening 58, a sealing material 6
A body fluid flow path regulating plate 62 is provided with a central opening 58 and a filtrate passage hole 59 corresponding to the permeable membrane unit 1-61, and a large number of convex portions on both sides. A plurality of layers are stacked with the permeable membrane unit 61 sandwiched therebetween, and between the uppermost surface of the permeable membrane unit 61 and the upper inner surface of the case, and between the lowermost surface of the lowermost part of the permeable membrane unit and the bottom inner surface of the case, there are A body fluid flow path regulating plate 63 is provided, which has a central opening 58 and a filtrate passage hole 59 corresponding to the membrane unit 1-61, and has a large number of convex portions on one side.
このように従来、平膜型透過膜は、モジュール等におい
て処理液の流路を形成させる為に、第６図に示す血漿分
離装置におけるように、透過膜の前後に、濾液流路形成
板５７のようなメツシュ板、あるいは体液流路規制板６
２．６３のようなドッｌ〜板等のスペーサーを必要とし
、多段に積層した場合、モジュールの大型化、組立工程
のＮＭ、化、プライミングボリュームの増大などという
問題が生じることになった。また、このようなモジュー
ルが人工透析、血漿分離、血液成分分画等の血液処理の
用途に用いられる場合、白液成分がメツシュ板、ドッｌ
−板等のスペーサーに接触するため、凝固因子か活性化
され易く血液凝固を引き起こすといった問題も生じるも
のであった。Conventionally, flat membrane type permeable membranes are equipped with filtrate flow path forming plates 57 before and after the permeable membrane, as in the plasma separation apparatus shown in FIG. A mesh plate such as or a body fluid flow path regulating plate 6
2.63 requires a spacer such as a dot plate or the like, and when stacked in multiple stages, problems such as an increase in the size of the module, a reduction in the assembly process to NM, and an increase in the priming volume arise. In addition, when such a module is used for blood processing applications such as artificial dialysis, plasma separation, and blood component fractionation, white liquid components are
- Since it comes into contact with a spacer such as a plate, there is a problem that coagulation factors are likely to be activated and cause blood coagulation.
（発明か解決しようとする問題点）
従って、本発明は、新規な平膜型透過膜およびその製造
方法を提供することを目的とする。本発明はまた、モジ
ュール等に組入れた際に、処理液の安定した流路形成か
容易に行なえる平膜型透過膜およびその製造方法を提供
することを目的とする。本発明はさらにモジュールに組
入れた際のモジュールの小型化、組立工程の簡略化、プ
ライミングボリュームの少量化などを可能とする平膜型
透過膜およびその製造方法を提供することを目的とする
。(Problems to be Solved by the Invention) Therefore, an object of the present invention is to provide a novel flat membrane type permeable membrane and a method for manufacturing the same. Another object of the present invention is to provide a flat membrane type permeable membrane that can easily form a stable flow path for a processing liquid when incorporated into a module or the like, and a method for manufacturing the same. A further object of the present invention is to provide a flat membrane type permeable membrane and a method for manufacturing the same, which make it possible to reduce the size of the module when assembled into a module, simplify the assembly process, and reduce the priming volume.
（問題点を解決するための手段）
上記諸目的は、少なくと一方の面に複数の微小突起を有
することを特徴とする平膜型透過膜により達成される。(Means for Solving the Problems) The above objects are achieved by a flat membrane-type permeable membrane characterized by having a plurality of microprotrusions on at least one surface.
本発明はまた、微小突起の高さが３０〜１０００μ雇で
あり、また微小突起の設けられた面の表面積に対する微
小突起部位の占有面積が０．５〜５０％である平膜型透
過膜を示すものである。本発明はまた、微小突起部位か
透過膜本体と同−材質により構成されているものである
平膜型透過膜を示すものである。本発明はまた微小突起
部位か透過膜本体と別材質により構成されているもので
ある平膜型透過膜を示すものである。本発明はまた、透
過膜本体および微小突起部位か再生セルロースＭ、セル
ロース誘導体系、ポリビニルアルコール系、ポリスルボ
ン系、ポリ（メタ）アクリル系、ポリアミド系およびポ
リオレフィン系からなる群から選ばれてなる高分子によ
り構成されているものである平膜型透過膜を示ずもので
ある。本発明はさらに透過膜本体および微小突起部位が
ポリプロピレンにより構成されているものである平膜型
透過膜を示すもので必る。本発明はまた透過膜本体が再
生セルロース系、セルロース誘導体系、ポリビニルアル
コール系、ポリスルボン系、ポリ（メタ）アクリル系、
ポリアミド系およびポリオレフィン系からなる群から選
ばれてなる高分子により構成されており、また微小突起
部位か透過膜本体を構成する拐質と相溶性もしくは接着
性を有する熱可塑性樹脂、熱ないし電磁波硬化性樹脂、
または合成ゴムより構成されるものである平膜型透過膜
を示すものである。本発明はさらに透過膜 ９一
本体がポリプロピレンにより構成され、また微小突起部
位かポリウレタン、エポキシ樹脂またはアクリル酸エス
テル樹脂により構成されているちのて必る平膜型透過膜
を示すものて必る。本発明はさらにまた平均細孔径がＯ
，ＯＱＩ〜５μｍて必る平膜型透過膜を示すものである
。本発明はさらに血漿分離用膜として用いられるもので
必る平膜型透過膜を示すものである。The present invention also provides a flat membrane type permeable membrane in which the height of the microprotrusions is 30 to 1000 μm, and the area occupied by the microprotrusions is 0.5 to 50% of the surface area of the surface on which the microprotrusions are provided. It shows. The present invention also provides a flat membrane type permeable membrane in which the microprojections are made of the same material as the membrane main body. The present invention also provides a flat membrane type permeable membrane in which the microprojections are made of a different material from the permeable membrane main body. The present invention also provides that the permeable membrane body and the microprotrusion portions are made of polymers selected from the group consisting of regenerated cellulose M, cellulose derivatives, polyvinyl alcohols, polysulfones, poly(meth)acrylics, polyamides, and polyolefins. This figure does not show a flat membrane type permeable membrane, which is composed of the following. The present invention further provides a flat membrane type permeable membrane in which the permeable membrane main body and the microprotrusions are made of polypropylene. The present invention also provides that the permeable membrane main body is based on regenerated cellulose, cellulose derivative, polyvinyl alcohol, polysulfone, poly(meth)acrylic,
A thermoplastic resin that is composed of a polymer selected from the group consisting of polyamides and polyolefins, and that is compatible with or adhesive to microprotrusions or particles that make up the permeable membrane body, and is cured by heat or electromagnetic waves. resin,
Alternatively, it refers to a flat membrane-type permeable membrane made of synthetic rubber. The present invention further requires a flat membrane-type permeable membrane in which the main body of the permeable membrane 9 is made of polypropylene, and the microprojections are made of polyurethane, epoxy resin, or acrylic acid ester resin. The present invention further provides that the average pore diameter is O.
, OQI ~ 5 μm, indicating a flat membrane type transmission membrane. The present invention further provides a flat membrane type permeable membrane that is used as a plasma separation membrane.
上記諸目的はまた、平膜状となした未凝固の原液を凝固
させて製膜する際、該平膜状の未凝固の原液の少なくと
も一方の面を、複数の微小な窪みを有する型面に接触さ
せながら凝固させ、透過膜の少なくとも一方の面に複数
の微小突起を形成することを特徴とする平膜型透過膜の
製造方法により達成される。The above objects also provide that, when forming a film by solidifying an unsolidified stock solution in the form of a flat film, at least one surface of the unsolidified stock solution in the form of a flat film is formed into a mold surface having a plurality of minute depressions. This is achieved by a method for manufacturing a flat membrane type permeable membrane, which is characterized by forming a plurality of microprojections on at least one surface of the permeable membrane.
本発明また、微小な窪みの深ざが３０〜１０００μｍで
あり、また型面の表面積に対する微小な窪みの部位の占
有面積が０．５〜５０％である型を用いるものである平
膜型透過膜の製造方法を示すものである。本発明はさら
に、複数の微小な窪みを有する型面かローラー面である
平膜型透過膜の製造方法を示すものである。The present invention also provides a flat membrane type transmission using a mold in which the depth of the minute depressions is 30 to 1000 μm, and the area occupied by the minute depressions is 0.5 to 50% of the surface area of the mold surface. The method for manufacturing the membrane is shown. The present invention further provides a method for manufacturing a flat membrane type permeable membrane, which is a mold surface or roller surface having a plurality of minute depressions.
上記諸口的はざらに、製膜された透過膜の少なくとも一
方の面に、該透過膜を構成する材質と相溶性もしくは接
着性を有する材質の未凝固物を注入してなる複数の微小
な窪みを有する型面を接触させ、該未凝固物を凝固させ
て透過膜の少なくとも一方の面に複数の微小突起を形成
することを特徴とする平膜型透過膜の製造方法によって
達成される。In general, a plurality of minute depressions are formed by injecting an unsolidified material of a material that is compatible or adhesive with the material constituting the permeable membrane into at least one surface of the permeable membrane that has been formed. This is achieved by a method for producing a flat membrane type permeable membrane, which comprises bringing mold surfaces having a .
本発明はまた微小な窪みの深ざが３０〜１０００μ空で
おり、また型面の表面積に対する微小な窪みの部位の占
有面積が０．５〜５０％である型を用いるものである平
膜型透過膜の製造方法を示すものである。本発明はざら
に、透過膜を構成する材質と相溶性もしくは接着性を有
する材質の未凝固物として、熱ないし電磁波硬化性樹脂
原料を用い、透過膜の面と接触させた後、加熱ないしは
電磁波照射により硬化させて透過膜に微小突起を付着形
成するものである平膜型透過膜の製造方法を示すもので
ある。なお電磁波照射とは光、赤外線、紫外線等を照射
するものをいう。The present invention also uses a flat membrane type mold in which the depth of the minute depressions is 30 to 1000 μm, and the area occupied by the minute depressions is 0.5 to 50% of the surface area of the mold surface. This figure shows a method for manufacturing a permeable membrane. Broadly speaking, the present invention uses a heat or electromagnetic wave curable resin raw material as an unsolidified material that is compatible or adhesive with the material constituting the transparent membrane, and after bringing it into contact with the surface of the transparent membrane, heating or electromagnetic wave This figure shows a method for manufacturing a flat membrane-type transparent membrane, which is a method for forming microprotrusions on a transparent membrane by curing it by irradiation. Note that electromagnetic wave irradiation refers to irradiation of light, infrared rays, ultraviolet rays, etc.
（作用）
しかして、本発明の平膜型透過膜は、少なくとも一方の
面に複数の微小突起を有することを特徴とするものであ
るから、モジュール等において該透過膜を積層した際、
透過膜本体同士は、透過膜表面上に複数存在する前記微
小突起により直接接触することなく離間され、しかも前
記微小突起により透過膜の変形か規制されるため透過膜
本体同士の間隔は常に一定に保たれることになる。この
ように本発明の平膜型透過膜を用いてモジュール等を組
立てた場合、透過膜表面上に複数存在する微小な突起が
、メツシュ板、ドツト板等のスペーサーと同様の役割を
はたし、このようなスペーサーを介在させなくても、透
過膜本体間に安定した適正な処理液の流路を確保できる
こととなる。従って、従来、スペーサーを必要とするこ
とによって生じていたモジュールの大型化、組立工程の
複雑化、プライミングボリュームの増大などという−１
２＝
問題か、本発明の平膜型透過膜を用いることによって解
消できるものとなる。(Function) Since the flat membrane type permeable membrane of the present invention is characterized by having a plurality of microprotrusions on at least one surface, when the permeable membrane is stacked in a module etc.
The permeable membrane bodies are separated from each other without direct contact by the plurality of microprotrusions on the surface of the permeable membrane, and the deformation of the permeable membrane is regulated by the microprotrusions, so the distance between the permeable membrane bodies is always constant. It will be preserved. In this way, when a module or the like is assembled using the flat membrane type permeable membrane of the present invention, the multiple minute protrusions on the surface of the permeable membrane play the same role as spacers such as mesh plates and dot plates. Even without intervening such a spacer, a stable and appropriate flow path for the processing liquid can be ensured between the permeable membrane bodies. Therefore, conventionally, the need for spacers has resulted in larger modules, more complicated assembly processes, and increased priming volume.
2 = This problem can be solved by using the flat membrane type permeable membrane of the present invention.
以下、本発明を実施態様に基づきより詳細に説明する。Hereinafter, the present invention will be explained in more detail based on embodiments.
本発明の平膜型透過膜は、例えば、第１８−ｄ図に示す
ように、少なくとも一方の面に複数の微小突起２を有す
ることを特徴とするものである。The flat membrane type permeable membrane of the present invention is characterized by having a plurality of microprotrusions 2 on at least one surface, as shown in FIG. 18-d, for example.
本発明の平膜型透過膜において微小突起２の設けられる
面は、第１ａ、ｃ図に示すように膜の一方の面のみてお
っても、第１ｂ、ｄ図に示すように膜の両方の面でおっ
てもよく、透過膜の設定位置、用途等に応じて変更され
、また微小突起２の形状もトッド状、線状、格子状等が
適用され特に限定されるものではないか、微小突起２の
高ざｈは３０〜１０００４ｍ、より好ましくは６０〜２
００μ空でおることが望ましく、また微小突起２の設け
られた面の表面積に対する微小突起２部位の占有面積は
０．５〜５０％、より好ましくは１．０〜２０％である
ことが望ましい。すなわち、微小突起２の高ざｈか３０
μ頒未満でおると微小突起２のスペーサーとしての作用
が十分とならず、安定した流路厚を確保することが難し
く、一方微小突起２の高さｈが１０００μｍを越えると
微小突起２の変形が大きく誤差を生じやすくなり、さら
にプライミングボリュームの面で問題が生じるためてあ
り、また微小突起部位２の占有面積が０゜５％未満であ
ると、透過膜の変形を十分に規制することかできず、一
方占有面積が５０％を越えると、有効透過面積が減少し
て十分な透過性能を得ることができなくなる虞れが生じ
るためである。In the flat membrane type permeable membrane of the present invention, the surface on which the microprotrusions 2 are provided may be on one side of the membrane as shown in Figures 1a and 1c, or on both sides of the membrane as shown in Figures 1b and d. It may be changed in accordance with the set position of the permeable membrane, the purpose, etc., and the shape of the microprotrusions 2 may be toad-like, linear, grid-like, etc., and is not particularly limited. The height h of the microprotrusion 2 is 30 to 10004 m, more preferably 60 to 2 m.
It is desirable that the space be 00μ, and the area occupied by the microprotrusions 2 is preferably 0.5 to 50%, more preferably 1.0 to 20%, of the surface area of the surface on which the microprotrusions 2 are provided. That is, the height h of the microprotrusion 2 is 30
If the height h of the microprotrusions 2 is less than 1000 μm, the microprotrusions 2 will not function sufficiently as spacers, making it difficult to ensure a stable channel thickness.On the other hand, if the height h of the microprotrusions 2 exceeds 1000μm, the microprotrusions 2 will deform. This tends to cause large errors, and furthermore, problems arise in terms of priming volume.Furthermore, if the area occupied by the microprotrusions 2 is less than 0.5%, it may be difficult to sufficiently control the deformation of the permeable membrane. On the other hand, if the occupied area exceeds 50%, the effective transmission area will decrease and there is a risk that sufficient transmission performance will not be obtained.
また、本発明の平膜型透過膜において微小突起２部位は
、第１ａ−ｂ図に示すように透過膜本体１と同一材質に
より構成することも、また第１Ｃ〜ｄ図に示すように透
過膜本体１と切材質により構成することも可能であるが
、好ましくは、微小突起２部位はそのヤング率１．０Ｘ
１０８〜２． ＯＸ １０＋ｏ ｄｙｎｅ／ ｃｔｔｉ
、より好ましくは１．０Ｘ１０６〜１．０Ｘ１０９ｄｙ
ｎｅ／ ｃｔｉである材質により構成されることが望ま
しい。その理由は、該平膜型透過膜をモジュール等にお
いて積層した際、透過膜本体２同士の間隔により形成さ
れる流路厚を押圧により挟めやすくかつ弛緩させたとき
に、流路が可逆的に自己復元し、所望の透過量を得やす
くするためである。Further, in the flat membrane type permeable membrane of the present invention, the two microprotrusions may be made of the same material as the permeable membrane main body 1 as shown in FIGS. 1a-b, or as shown in FIGS. 1C-d. Although it is possible to construct the membrane body 1 and the cut material, preferably, the minute protrusions 2 have a Young's modulus of 1.0X.
108-2. OX 10+o dyne/ctti
, more preferably 1.0X106 to 1.0X109dy
It is preferable to use a material that is ne/cti. The reason for this is that when the flat membrane type permeable membranes are stacked in a module etc., when the thickness of the flow path formed by the interval between the permeable membrane bodies 2 is easily pinched and relaxed by pressure, the flow path becomes reversible. This is to make it easier to self-restore and obtain a desired amount of permeation.
一般に、このような積層型のモジュールにおいては、処
理液の流路厚を薄くすればするほど物質透過特性か優れ
ていることが知られているが、押圧により流路厚を変化
させた場合に、微小突起２部位が上記したような範囲を
越えるヤング率を有する材質により構成されていると所
望の流路厚に調節することが困難となり、所望の透過量
を得ることかできない虞れが生じる。In general, it is known that the thinner the channel thickness of the processing liquid in such a stacked module, the better the material permeation properties.However, when the channel thickness is changed by pressing, If the two microprotrusions are made of a material with a Young's modulus exceeding the above range, it will be difficult to adjust the channel thickness to the desired thickness, and there is a risk that the desired amount of permeation may not be obtained. .
本発明の平膜型透過膜は、透過膜本体１の膜性状に応じ
て、例えば透析膜、限外濾過膜、精密濾過膜等、透過性
のある各種の膜として適応され得るが、特に血漿分離膜
として用いられる場合においては、極めて優れた性能を
発揮する。なお、本発明の平膜型透過膜においてその平
均細孔径は０４００１〜５μｍ程度である。The flat membrane type permeable membrane of the present invention can be applied as various permeable membranes, such as a dialysis membrane, an ultrafiltration membrane, and a precision filtration membrane, depending on the membrane properties of the permeable membrane main body 1. When used as a separation membrane, it exhibits extremely excellent performance. In addition, the average pore diameter of the flat membrane type permeable membrane of the present invention is about 04001 to 5 μm.
また、本発明の平膜型透過膜を構成する材質としては透
過膜を形成できる高分子材料であれば、特に限定されず
、その用途に応じて好ましい材質が用いられるが、第１
ａ〜ｂ図に示されるように透過膜本体１と微小突起２部
位が同一の材質により構成される場合においては、例え
ば、再生セルロース系、セルロース誘導体系、ポリビニ
ルアルコール系、ポリスルホン系、ポリ（メタ）アクリ
ル系、ポリアミド系あるいはポリオレフィン系などの材
質が用いられる。これらのうち、平膜型透過膜が血漿分
離膜等の医療用途のものである場合においては、十分な
物質透過特性、機械的強度、耐熱性、耐薬品性等の諸物
性を備え、かつ血液等の処理液に対しても比較的に不活
性な材質であるポリプロピレンが特に好ましい材質であ
る。一方、第１ｃｍｄ図に示されるように透過膜本体１
と微小突起２部位か別の材質により構成される場合にお
いては、透過膜本体１は、上記したものと同様に、例え
ば再生セルロース系、セルロース誘導体系、ポリビニル
アルコール系、ポリスルホン系、ポリ（メタ〉アクリル
系、ポリアミド系あるいはポリオレフィン系などの材質
により構成され、−万機小突起２部位は、透過膜本体を
構成する材質と相溶性もしくは接着性を有する各種の熱
可塑性樹脂、熱ないし電磁波硬化性樹脂、合成ゴムなど
により構成される。これらのうち平膜型透過膜が血漿分
離膜等の医療用途のものである場合においては、透過膜
本体１は十分な物質透過特性、機械的強度、耐熱性、耐
薬品性等の諸物性を備え、かつ血液等の処理液に対して
も比較的に不活性な材質であるポリプロピレンにより構
成され、−万機小突起２部位は適度な弾性を有し、かつ
血液等の処理液に対しても比較的不活性な材質であるポ
リウレタン、エポキシ樹脂、アクリル酸エステル樹脂等
により構成されることが望まれる。Further, the material constituting the flat membrane type permeable membrane of the present invention is not particularly limited as long as it is a polymeric material that can form a permeable membrane, and a preferable material may be used depending on the application.
As shown in figures a to b, when the permeable membrane main body 1 and the two microprotrusions are made of the same material, for example, regenerated cellulose, cellulose derivative, polyvinyl alcohol, polysulfone, poly(metallic), etc. ) Materials such as acrylic, polyamide, or polyolefin are used. Among these, when flat membrane permeable membranes are used for medical purposes such as plasma separation membranes, they must have sufficient physical properties such as sufficient material permeation characteristics, mechanical strength, heat resistance, and chemical resistance, and A particularly preferred material is polypropylene, which is relatively inert to processing liquids such as the like. On the other hand, as shown in the 1st cmd figure, the permeable membrane main body 1
In the case where the two microprotrusions are made of another material, the permeable membrane main body 1 may be made of a material similar to that described above, such as regenerated cellulose, cellulose derivative, polyvinyl alcohol, polysulfone, poly(meth), etc. It is made of a material such as acrylic, polyamide, or polyolefin, and the two small protrusions are made of various thermoplastic resins that are compatible with or adhesive to the material that makes up the permeable membrane body, or that are heat or electromagnetic wave curable. It is composed of resin, synthetic rubber, etc. When the flat membrane type permeable membrane is for medical purposes such as plasma separation membranes, the permeable membrane main body 1 has sufficient material permeation properties, mechanical strength, and heat resistance. It is made of polypropylene, which is a material that has various physical properties such as hardness and chemical resistance, and is relatively inert to processing liquids such as blood, and the two small projections have moderate elasticity. It is also desirable that the material be made of polyurethane, epoxy resin, acrylic ester resin, etc., which are relatively inert to processing liquids such as blood.
以上のような構成を有する平膜型透過膜は、次のように
して製造され得る。すなわち、平膜状となした未凝固の
原液を凝固させて製膜する際、該平膜状の未凝固の原液
の少なくとも一方の面を、複数の微小な窪みを有する型
面に接触させながら凝固させ、透過膜の少なくとも一方
の面に複数の微小突起を形成するものである。この製造
方法は、透過膜本体１および微小突起部位２が透過膜を
形成し得、かつ溶融物、溶液等の流動状態から冷却同化
、溶媒抽出、脱誘導体化等の何らかの凝固過程において
固化する材質によって構成されるものである場合におい
ては、いずれも適用でき、また物質透過性の付与が、溶
媒抽出、充填剤除去、機械的延伸等のいかなる手段であ
るかを問わない。The flat membrane type permeable membrane having the above configuration can be manufactured as follows. That is, when forming a film by solidifying an unsolidified stock solution in the form of a flat film, at least one surface of the unsolidified stock solution in the form of a flat film is brought into contact with a mold surface having a plurality of minute depressions. It is solidified to form a plurality of microprotrusions on at least one surface of the permeable membrane. In this manufacturing method, the permeable membrane main body 1 and the microprotrusion parts 2 are made of a material that can form a permeable membrane and that solidifies in some solidification process such as cooling assimilation, solvent extraction, derivatization, etc. from a fluid state of a melt or solution. In the case where the material is composed of the following, any method can be applied, and it does not matter whether the material permeability is imparted by any means such as solvent extraction, filler removal, mechanical stretching, etc.
さらにこの製造方法において適用される複数の微小な窪
みを有する型面を持つ型の形状としては特に限定されず
平板状の型でもまたローラー状の型であってもよく、未
凝固の原液の凝固工程に応じて適当なものを選択するこ
とができる。この複数の微小な窪みを有する型面は、未
凝固の原液が凝固されて成膜された際、透過膜表面上に
写し取られて、透過膜表面上に所望の微小突起を形成す
るものであるから、得ようとする微小突起の形状に応じ
て、例えば微小な窪みの深さが３０〜１０００μｍ、好
ましくは６０〜２００μｍであり、また型面の表面積に
対する微小な窪みの部位の占有面積が０．５〜５０％、
好ましくは１．０〜２０％であるような型面とすること
か望ましい。Furthermore, the shape of the mold having a mold surface with a plurality of minute depressions applied in this manufacturing method is not particularly limited, and may be a flat mold or a roller mold, and solidification of the unsolidified stock solution is possible. An appropriate one can be selected depending on the process. This mold surface with multiple minute depressions is copied onto the surface of the permeable membrane when the unsolidified stock solution is solidified to form a film, forming desired microprotrusions on the surface of the permeable membrane. Therefore, depending on the shape of the microprotrusions to be obtained, the depth of the microscopic depressions is, for example, 30 to 1000 μm, preferably 60 to 200 μm, and the area occupied by the microscopic depressions relative to the surface area of the mold surface is 0.5-50%,
It is desirable that the mold surface is preferably 1.0 to 20%.
本発明の製造方法をさらに詳細に説明するために、ポリ
プロピレンを用いて充填剤除去により平膜型透過膜を製
造する場合を例にとり、その製造工程を述べるか、もち
ろん本発明の製造方法はこのような実施態様に何ら限定
されるものではない。In order to explain the manufacturing method of the present invention in more detail, we will take as an example the case where a flat membrane type permeable membrane is manufactured by removing the filler using polypropylene, and describe the manufacturing process. The present invention is not limited to such embodiments.
まず、ポリプロピレン、該ポリプロピレンの溶融下で該
ポリプロピレンに均一に分散し得かつ使用する抽出液に
対して易溶性である有機充填剤および結晶核形成剤を混
練してなる原料配合物を溶融状態で、第２図に示すよう
に王ダイ３から平膜状に吐出させ、この吐出された未凝
固膜４を型ロール５ａ 、 ５１）間に通す。なお、こ
の型ロールしａ。First, a raw material mixture prepared by kneading polypropylene, an organic filler and a crystal nucleating agent that can be uniformly dispersed in the polypropylene when the polypropylene is melted and is easily soluble in the extract liquid used is melted. As shown in FIG. 2, a flat film is discharged from a king die 3, and the discharged uncoagulated film 4 is passed between mold rolls 5a and 51). In addition, this mold roll a.
５１）の表面には第３図に示ずように複数の微小な窪み
６か設けられている。しかしなから透過膜の一方の而の
みに微小突起２を設けようとする場合には、未凝固膜４
を複数の微小な窪み６を表面に有する型ロール５ａと平
滑な表面を有するロールとの間に通過させることもてき
る。続いて未凝固膜４を冷却同化液７と接触させること
により、冷却同化して表面に複数の微小突起２を付与し
てなる凝固膜８とし、さらに、前記ポリオレフィンを溶
解せす、かつ前記有機充填剤を溶解する抽出液９と接触
させ、有機充填剤を抽出除去して透過性を付与して微小
突起１を有する平膜型透過膜１０を得る。As shown in FIG. 3, a plurality of minute depressions 6 are provided on the surface of 51). However, if the microprotrusions 2 are to be provided only on one side of the permeable membrane, the uncoagulated membrane 4
It is also possible to pass the mold roll 5a between a mold roll 5a having a plurality of minute depressions 6 on its surface and a roll having a smooth surface. Subsequently, the unsolidified film 4 is brought into contact with a cooled assimilation liquid 7 to form a solidified film 8 having a plurality of microprotrusions 2 on its surface by cooling and assimilation, and furthermore, the polyolefin is dissolved and the organic The organic filler is brought into contact with an extraction liquid 9 that dissolves the filler, and the organic filler is extracted and removed to impart permeability, thereby obtaining a flat membrane-type permeable membrane 10 having microprotrusions 1.
また、上記のごとき構成を有する平膜型透過膜は、以下
のようにしても製造され得る。すなわち、成膜された透
過膜の少なくとも一方の面に、該透過膜を構成する材質
と相溶性もしくは接着性を有する材質の未凝固物を注入
してなる複数の微小な窪みを有する型面を接触させ、該
未凝固物を凝固させて透過膜の少なくとも一方の面に複
数の微小突起を形成するものである。この製造方法は、
透過膜本体１か透過膜を形成し得る材質によって構成さ
れ、−万機小突起２部位が透過膜本体１を構成する材質
と相溶性もしくは接着性を有し、溶融物、未硬化物等の
流動状態から冷却固化、熱ないし電磁波硬化等の何らか
の）疑固過程において固化する＋Ａ質によって構成され
る場合においてはいすれも適用でき、また透過膜本体１
の製膜方法、条件に関してはいかなるものであるかを問
わない。Further, a flat membrane type permeable membrane having the above configuration can also be manufactured as follows. That is, a mold surface having a plurality of minute depressions formed by injecting an unsolidified material of a material that is compatible or adhesive with the material constituting the permeable film is formed on at least one surface of the formed permeable film. A plurality of microprotrusions are formed on at least one surface of the permeable membrane by bringing the membrane into contact with the membrane and solidifying the unsolidified material. This manufacturing method is
The permeable membrane body 1 is made of a material capable of forming a permeable membrane, and the two small protrusions are compatible or adhesive with the material constituting the permeable membrane body 1, and are free of melted materials, uncured materials, etc. Any of these can be applied in cases where the membrane is composed of +A material that solidifies from a fluid state through cooling solidification, heat or electromagnetic wave hardening, etc.), and the permeable membrane body 1
It does not matter what the film forming method and conditions are.
しかしながら、微小突起２部位を構成する材質として熱
ないしは電磁波硬化性樹脂を用いれば、透過膜本体１と
接触させた後、加熱ないしは電磁波照射することにより
硬化させて、容易に透過膜本体１に微小突起２を付着形
成することかできるために特に好ましい。さらに本製造
方法において適用される複数の微小な窪みを有する型面
を持つ型の形状としては、前記の製造方法と同様に待に
限定されず、平板状のものであってもローラー状の型で
あってもよい。この型面の微小な窪みは、該窪みに注入
された未凝固物か、透過膜本体１と接触後凝固して透過
膜本体１表面上に所望の微小突起を形成するために設け
られているものであるから、得ようとする微小突起の形
状に応じて、例えば微小な窪みの深さが３０〜１０００
μｍ、好ましくは６０〜２００μｍあり、また型面の表
面積に対する１散小な窪みの部位の占有面積か０．５〜
５０％、好ましく１ユ１．０〜２０％であるような型面
とすることが望ましい。However, if heat- or electromagnetic wave-curable resin is used as the material constituting the two microprotrusions, it can be hardened by heating or electromagnetic wave irradiation after contact with the transparent membrane body 1, and the micro-projections can be easily formed into the transparent membrane body 1. This is particularly preferred since the protrusions 2 can be formed by adhesion. Furthermore, the shape of the mold having a mold surface with a plurality of minute depressions applied in this manufacturing method is not limited to a flat mold as in the above manufacturing method, and even a flat mold can be used. It may be. The minute depressions on the mold surface are provided so that the unsolidified material injected into the depressions solidifies after contact with the membrane body 1 to form desired minute protrusions on the surface of the membrane body 1. Therefore, depending on the shape of the microprotrusion to be obtained, for example, the depth of the microscopic depression may be 30 to 1,000 mm.
μm, preferably 60 to 200 μm, and the area occupied by the small depressions relative to the surface area of the mold surface is 0.5 to 0.5 μm.
It is desirable that the mold surface is 50%, preferably 1.0 to 20%.
本発明の製造方法をさらに詳細に説明するために、製膜
されたポリプロピレン透過膜に熱硬化性接着剤を用いて
、微小突起を付与することにより平膜型透過膜を製造す
る場合を例にとり、その製造工程を述べるが、もちろん
本発明の製造方法はこのような実施態様に限定されるも
のではない。In order to explain the manufacturing method of the present invention in more detail, we will take as an example the case where a flat membrane type permeable membrane is manufactured by adding microprotrusions to a formed polypropylene permeable membrane using a thermosetting adhesive. , the manufacturing process will be described, but of course the manufacturing method of the present invention is not limited to such embodiments.
まずポリプロピレン、該ポリプロピレンの溶融下で該ポ
リプロピレンに均一に分散し得かつ使用する抽出液に対
して易溶性である有機充填剤および結晶核形成剤を混練
してなる原料配合物を溶融状態てＴダイから平膜状に吐
出させ、この吐出された未凝固膜を冷却固化液と接触さ
せて冷却固化し、さらに前記ポリオレフィンを溶解せず
、かつ前記性ぼ充填剤を溶解する抽出液と接触させ有機
充填剤を抽出除去して透過膜本体１となる平滑な透過膜
１１を得る。次にこの平滑な透過膜１１を、第３図に示
すように表面に複数の微小な窪み６を有する型ロール５
とピンチロール１２の間を第４図に示すように通過させ
る。型ロール５は、その−部が熱硬化性接着剤１３中に
浸漬されており、該型ロール５の回転によって型ロール
５の表面には、該熱硬化性接着剤１３が付着しているが
、型ロール５の表面に接して設けられたドクターナイフ
１４によって微小な窪み６内に入り込んだ熱硬化性接着
剤１３以外は掻き取られる。従って、型ロール５はその
微小な窪み６のみに熱硬化性接着剤１３を注入した状態
において平滑な透過膜１１と接触することとなる。平滑
な透過膜ゴ１と型ロール５を接触させた後、適当な加熱
手段（図示せず）を用いて熱硬化性接着剤１３を硬化さ
せると、平滑な透過膜１１の表面には、型ロール５の微
小な窪み６内にあった熱硬化性接着剤１３が付着・硬化
して微小突起が形成されることとなる。このようにして
製造された微小突起を有する平膜型透過膜１０は巻取り
ロール］５によって巻き取られる。First, a raw material mixture prepared by kneading polypropylene, an organic filler and a crystal nucleating agent that can be uniformly dispersed in the polypropylene while the polypropylene is melted and is easily soluble in the extract liquid used is melted. A flat film is discharged from the die, and the discharged uncoagulated film is brought into contact with a cooling solidification liquid to be cooled and solidified, and further brought into contact with an extraction liquid that does not dissolve the polyolefin and dissolves the wart filler. The organic filler is extracted and removed to obtain a smooth permeable membrane 11 that becomes the permeable membrane main body 1. Next, as shown in FIG.
and the pinch rolls 12 as shown in FIG. The lower part of the mold roll 5 is immersed in the thermosetting adhesive 13, and as the mold roll 5 rotates, the thermosetting adhesive 13 is attached to the surface of the mold roll 5. Then, a doctor knife 14 provided in contact with the surface of the mold roll 5 scrapes off everything except the thermosetting adhesive 13 that has entered into the minute depressions 6. Therefore, the mold roll 5 comes into contact with the smooth permeable membrane 11 with the thermosetting adhesive 13 injected only into the minute depressions 6 thereof. After bringing the smooth permeable film 11 into contact with the mold roll 5, when the thermosetting adhesive 13 is cured using an appropriate heating means (not shown), the mold is formed on the surface of the smooth permeable film 11. The thermosetting adhesive 13 present in the minute depressions 6 of the roll 5 adheres and hardens to form minute protrusions. The flat membrane type permeable membrane 10 having microprotrusions manufactured in this manner is wound up by a winding roll]5.
もちろん、平滑な透過膜１１の両方の面に、熱硬化性接
着剤１３を注入してなる複数の微小な窪み６を有する型
ロール５を接触させて、両方の面にＷ数の微小な突起を
有する平膜型透過膜１０を製造することもできる。Of course, a mold roll 5 having a plurality of minute depressions 6 formed by injecting thermosetting adhesive 13 is brought into contact with both surfaces of the smooth permeable membrane 11, and minute protrusions of W number are formed on both surfaces. It is also possible to manufacture a flat membrane type permeable membrane 10 having the following.
このようにして得られる平膜型透過膜は、上記したよう
に、透過膜本体１の膜性状に応じて各種の用途に用いら
れるが、特に以下に示すように血漿分離膜等としてモジ
ュールに組入れられた場合に優れた性能を発揮する。第
５図は、本発明の平膜型透過膜を組入れてなる積層型の
血漿分離装置を示すものである。この血漿分離装置にお
いては、上板中央部に体液流入口２つ、上板外周部に血
漿流出口２２および側壁に体液流出口２３を備えた円筒
状ケース本体２４と周縁に０リング２５を取付［プた底
蓋体２６とよりなるケース内に、両方の面に複数の微小
突起２を有してなる本発明に係る平膜型透過膜１Ｑａ、
１０ｂを上下２枚組合せ、その周縁部および中心開口部
２８の周縁部をシールするとともに、濾液通過孔２９の
外周にシール拐３０を貼着してなる透過膜ユニット３１
が複数積層されてなるものである。上述したように本発
明の平膜型透過膜１０を用いると、透過膜表面上に存在
する複数の微小突起により、透過膜本体１同士は直接接
触することなく離間され、しかもこの微小突起２により
透過膜本体同士の間隔は常に一定に保たれることとなり
、透過膜ユニツ１へ３１間において微小突起の間隔によ
り形成される体液流路および各透過膜ユニット３１の内
部において微小突起２の間隔により形成される濾液流路
は、適正に確保される。また最上部の透過膜ユニット３
１上面とケースの上部内面および最下部の透過膜ユニッ
ト３１の下面とケースの底部内面の間において微小突起
２の間隔により形成される体液流路も適正に確保される
。このように本発明の平膜型透過膜１０ａ、１０ｂを用
いた場合、所定の流路を確保するために、メツシュ板、
ドツト板等のスペーサーを必要とせず、このためより限
られた容積内で効率のよい物質透過を行うことができ、
組立工程も容易で、またプライミングボリュームも低く
おさえることかできる。この血漿分離装置を用いて、血
漿を分離する場合について説明すると、人体からの血液
は、体液流入口２つより中央開口部２Ｂを通り、透過膜
ユニツ１〜３１間において微小突起２の間隔により形成
される体液流路を流通する。この流通過程で血液は透過
膜ユニツ１へ３１の平膜型透過膜１０ａ、１０ｂにより
濾過され、濾液である血漿は、透過膜ユニツ１〜３１内
より濾液通過孔２９を通り、血漿流出口２２より排出さ
れる。一方、濾過された血液は、体液流出口２３より排
出される。The flat membrane type permeable membrane obtained in this way can be used for various purposes depending on the membrane properties of the permeable membrane body 1, as described above, but in particular it can be incorporated into a module as a plasma separation membrane etc. as shown below. It exhibits excellent performance when FIG. 5 shows a stacked plasma separation device incorporating the flat membrane type permeable membrane of the present invention. In this plasma separator, a cylindrical case body 24 has two body fluid inlets at the center of the upper plate, a plasma outlet 22 at the outer periphery of the upper plate, and a body fluid outlet 23 at the side wall, and an O-ring 25 is attached to the periphery. [Flat membrane type permeable membrane 1Qa according to the present invention having a plurality of microprotrusions 2 on both surfaces in a case consisting of a flat bottom lid body 26,
A permeable membrane unit 31 is formed by combining two upper and lower membranes 10b, sealing the periphery thereof and the periphery of the center opening 28, and pasting a seal 30 on the outer periphery of the filtrate passage hole 29.
It is made by laminating multiple layers. As described above, when the flat membrane type permeable membrane 10 of the present invention is used, the permeable membrane bodies 1 are separated from each other without direct contact with each other due to the plurality of microprotrusions present on the surface of the permeable membrane, and moreover, the microprotrusions 2 The interval between the permeable membrane bodies is always kept constant, and the body fluid flow path formed by the interval between the microprotrusions 2 between the permeable membrane units 1 and 31 and the interval between the microprotrusions 2 inside each permeable membrane unit 31 is maintained constant. The formed filtrate channel is properly secured. Also, the top permeable membrane unit 3
1 and the upper inner surface of the case, and between the lower surface of the lowermost permeable membrane unit 31 and the bottom inner surface of the case, the body fluid flow path formed by the spacing between the minute protrusions 2 is also properly secured. When using the flat membrane type permeable membranes 10a and 10b of the present invention as described above, in order to secure a predetermined flow path, a mesh plate,
There is no need for a spacer such as a dot plate, which allows efficient material permeation within a more limited volume.
The assembly process is easy, and the priming volume can be kept low. To explain the case where plasma is separated using this plasma separator, blood from the human body passes through the central opening 2B from the two body fluid inlets, and is separated by the spacing between the microprotrusions 2 between the permeable membrane units 1 to 31. The body fluid flows through the formed body fluid channel. In this distribution process, blood is filtered to the permeable membrane unit 1 by the flat membrane type permeable membranes 10a and 10b of 31, and the plasma, which is the filtrate, passes through the filtrate passage hole 29 from inside the permeable membrane units 1 to 31, and passes through the plasma outlet 22. more excreted. On the other hand, the filtered blood is discharged from the body fluid outlet 23.
（実施例）
以下、本発明を実施例に基づき、ざらに具体的に説明す
る。(Examples) Hereinafter, the present invention will be roughly described in detail based on Examples.
実施例１
メルトフローインデックス（Ｍ、１．）が３０および０
．３のポリプロピレン（重量圧１００：４０の混合物）
１００重量部当り、有機充１眞剤として流動パラフィン
（数平均分子量３２４ ） ４．１０重組部および結晶
核形成剤として１，３，２．４−シベンジリデンソルビ
］・−ル０．３６重量部を二軸押出機（他見鉄工（株）
製）で溶融混練しペレット化したものを上記押出機を田
いて１５０〜２００′Ｃて溶融し、スリン１〜幅０．６
８の丁ダイより空気中に押し出し、丁ダイ直下に置かれ
た２つの型ロール（直径０．２５ｍ、深さ０．１５＃の
半球状の窪みがロール表面積に対して２％の占有面積で
均一間隔で設けられている直径２００ｍｔｔｒのクロム
メッキロール）の間（０，２５ｍの隙間）を通過させ、
ポリエチレングリコールよりなる冷却同化液中に導き固
化した後巻取った。巻き取ったフィルム状物を一定長（
約２００Ｘ２００ｍ）に切断し、縦、横両方を固定し、
１，１．２−トリクロロ−Ｌ２，２− トリフルオロエ
タン（液温２５°Ｃ）に浸漬し流動パラフィンの抽出を
行ない、次いで１３５°Ｃの空気中で２分間熱処理を行
なった。得られた透過膜は、その表面に直径０．２５ｍ
、高さ０．１２＃の半球状の微小突起が形成された突起
付平膜状透過膜てあった。この透過膜を外径１０４ｍｍ
、内径２２ｍｍの円板状に打扱き、２枚を１組としてそ
の外周部と内周部を熱シールして透過膜ユニットとした
。この透過膜ユニットを第５図に示すように、円筒状の
ケース内に入れ、有効膜面積３５００ｒａ３の血漿分離
器を作成した。この血漿分離器に対して血流量１００ｍ
１／分で血液を流してその濾過量を測定し、また以下の
ようにして補体活性化成分Ｃ３ａを測定した。結果を第
１表に示す。Example 1 Melt flow index (M, 1.) is 30 and 0
．． 3 polypropylene (mixture of weight pressure 100:40)
Per 100 parts by weight, 4.10 parts by weight of liquid paraffin (number average molecular weight 324) as an organic filler and 0.36 parts by weight of 1,3,2.4-sibenzylidene sorbitol as a crystal nucleating agent. Twin-screw extruder (Tammi Tekko Co., Ltd.)
The mixture was melt-kneaded and pelletized using the above-mentioned extruder and melted at 150-200'C.
It was extruded into the air through a No. 8 die, and two mold rolls (a hemispherical depression with a diameter of 0.25 m and a depth of 0.15 # occupied by 2% of the roll surface area) were placed directly under the die. Pass through between (chrome-plated rolls with a diameter of 200 mttr) provided at uniform intervals (a gap of 0.25 m),
It was introduced into a cooling assimilation liquid made of polyethylene glycol and solidified, and then wound up. Roll up the film-like material to a certain length (
(approx. 200 x 200 m), fixed both vertically and horizontally,
The sample was immersed in 1,1,2-trichloro-L2,2-trifluoroethane (liquid temperature 25°C) to extract liquid paraffin, and then heat-treated in air at 135°C for 2 minutes. The obtained permeable membrane has a diameter of 0.25 m on its surface.
There was a flat membrane-like permeable membrane with protrusions on which hemispherical microprotrusions with a height of 0.12# were formed. This permeable membrane has an outer diameter of 104 mm.
A permeable membrane unit was prepared by punching into a disc shape with an inner diameter of 22 mm and heat-sealing the outer and inner circumferential parts of the two sheets into a set. As shown in FIG. 5, this permeable membrane unit was placed in a cylindrical case to create a plasma separator with an effective membrane area of 3500 ra3. Blood flow 100m for this plasma separator
Blood was flowed at a rate of 1/min to measure the amount of filtration, and complement activation component C3a was measured as follows. The results are shown in Table 1.
補体活性化成分Ｃ３ａの測定
健常人より採取した血液をガラス試験管に移し、３７℃
で１５分間加温し、血液を完全に凝固させた後血清を分
離した。遠心分離は冷却遠心機にて４°Ｃ・３０００ｒ
ｐｍ ・２０分間の条件で行った。Measurement of complement activating component C3a Blood collected from a healthy person was transferred to a glass test tube and heated to 37°C.
After heating for 15 minutes to completely coagulate the blood, the serum was separated. Centrifugation is performed at 4°C and 3000r using a refrigerated centrifuge.
pm for 20 minutes.
分離された血清は速やかに氷水中に移した。上記のよう
にして得られた平膜型透過膜１０を設けた膜面積２４Ｃ
ＩＩ１２のミニモジュール７０を第７図に示す回路にセ
ットし、循環ポンプ７４を作動させて血清を５ｍｌ／ｍ
ｉｎで循環し、濾法例出ロア１より出てくる血清を１．
５ｍｌ毎にサンプリングし、ＲＩＡ法によりＣ３８ａ度
を測定した。Ｃ３ａは補体の活性過程に生じるものであ
り、これが少ないほど補体の活性化が少ないといえる。The separated serum was immediately transferred to ice water. Membrane area 24C provided with the flat membrane type permeable membrane 10 obtained as above
The mini module 70 of II12 is set in the circuit shown in FIG.
Serum circulates in the in and comes out from the filtration method example lower 1.
Samples were taken every 5 ml, and the C38a degree was measured by RIA method. C3a is generated during the complement activation process, and it can be said that the less C3a is present, the less complement activation occurs.
なお第７図において符号７２は３７°Ｃの加温槽、７３
は氷水を入れた冷却槽でおる。In addition, in FIG. 7, reference numeral 72 indicates a 37°C heating tank, and 73
Cool in a cooling tank filled with ice water.
実施例２
メルトフローインデックスが３０および０．５のポリプ
ロピレン（重量比１００ ： ４０の混合物）１００重
量部当り、有機充填剤として流動パラフィン（数平均分
子量３２４）４１０重量部および結晶核形成剤として１
，３，２．４−ジベンジリデンソルビトール０．３６重
量部を二軸押出機（他見鉄工（株）製）にて溶融混練し
、ペレット化した。Example 2 410 parts by weight of liquid paraffin (number average molecular weight 324) as an organic filler and 1 part by weight as a crystal nucleating agent per 100 parts by weight of polypropylene with a melt flow index of 30 and 0.5 (mixture by weight ratio 100:40)
, 0.36 parts by weight of 3,2.4-dibenzylidene sorbitol were melt-kneaded using a twin-screw extruder (manufactured by Tamami Tekko Co., Ltd.) and pelletized.
このペレットを上記押出機を用いて１５０〜２００′Ｃ
で溶融しＴダイより空気中に押出し、Ｔダイ直下に置か
れた冷却槽のガイドローラに落下後、ポリエチレングリ
コールよりなる冷却同化液中に導き固化した。さらに１
，１．２− トリクロロ−１，？、２−トリフルオロエ
タン（２５°Ｃ）に浸漬し流動パラフィンの抽出を行な
い、次いて１３５°Ｃの空気中で２分間熱処理を行い平
滑な面を有する透過膜を得た。このようにして得た透過
膜と、必らがしめウレタン系接着剤（日本ポリウレタン
工業■製）を塗布し表面に残った接着剤をドクターナイ
フで削って半球状の窪みに接着剤を注入した型板（直径
０．３Ｍ、深さ０．１５ｍの半球状の窪みが型板の表面
積に対して２％の占有面積で設けられている２００Ｘ２
００．ｓのシリコンゴム板）とを密着させ、約２０分後
型板から透過膜をはかした。得られた膜はその表面に直
径０．２８＃、高さ０．１２ｍｍの半球状の微小突起が
均一に形成された突起付平膜型透過膜であった。この透
過膜を用いて実施例１と同様にして血漿分離器を作成し
、この血漿分離器に実施例１と同様にして血液を流して
その濾過量を測定し、また実施例１と同様にして補体活
性化成分Ｃ３ａを測定した。結果を第１表に示す。The pellets were heated to 150 to 200'C using the extruder mentioned above.
It was melted and extruded into the air through a T-die, and after falling onto the guide rollers of a cooling tank placed directly below the T-die, it was introduced into a cooling assimilation liquid made of polyethylene glycol and solidified. 1 more
,1.2-trichloro-1,? The membrane was immersed in 2-trifluoroethane (25°C) to extract liquid paraffin, and then heat-treated in air at 135°C for 2 minutes to obtain a permeable membrane with a smooth surface. The thus obtained permeable membrane was coated with a urethane adhesive (manufactured by Nippon Polyurethane Industries), and the remaining adhesive on the surface was scraped off with a doctor knife, and the adhesive was injected into the hemispherical depression. Template (200 x 2 with a hemispherical depression of 0.3 m in diameter and 0.15 m in depth occupying 2% of the surface area of the template)
00. After about 20 minutes, the permeable membrane was removed from the template. The obtained membrane was a flat membrane-type permeable membrane with projections on the surface of which hemispherical minute projections with a diameter of 0.28 mm and a height of 0.12 mm were uniformly formed. A plasma separator was prepared using this permeable membrane in the same manner as in Example 1, blood was passed through this plasma separator in the same manner as in Example 1, and the amount of filtration was measured. Complement activating component C3a was measured. The results are shown in Table 1.
実施例３
メルトフローインデックスが３０および０．５のポリプ
ロピレン（重量比１０（Ｃ４０の混合物）１００重量部
当り、有機充填剤として流動パラフィン（数平均分子量
３２４）１０重量部および結晶核形成剤として１，３，
２．４−ジベンジリデンソルビトール０．３６重量部を
二軸押出機（他見鉄工（株）製）にて溶融混練し、ペレ
ット化した。Example 3 For every 100 parts by weight of polypropylene with a melt flow index of 30 and 0.5 (weight ratio 10 (mixture of C40)), 10 parts by weight of liquid paraffin (number average molecular weight 324) as an organic filler and 1 part by weight as a crystal nucleating agent. ,3,
0.36 parts by weight of 2.4-dibenzylidene sorbitol was melt-kneaded using a twin-screw extruder (manufactured by Tamami Tekko Co., Ltd.) and pelletized.
このペレットを上記押出機を用いて１５０〜２００′Ｃ
で溶融しＴダイより空気中に押出し、Ｔダイ直下に置か
れた冷却槽のガイドローラに落下後、ポリエチレングリ
コールよりなる冷却同化液中に導き固化した。さらに１
，１，２−トリクロロ−１，２，２−トリフルオロエタ
ン（２５°Ｃ）に浸漬し流動パラフィンの抽出を行ない
、次いで１３５℃の空気中で２分間熱処理を行い平滑な
面を有する透過膜を得た。このようにして得た透過膜の
表面に直径Ｑ、５ｍｍ、深さ０．１８ｍｍの孔が版面の
表面積に対して１５％の占有面積で設けられている印刷
版からなるロータリースクリーン印刷機（日本文化精工
■製〉を用い、紫外線硬化製樹脂（犬日本インキ側製）
を印刷し、印刷後ただちに２ｋｗ紫外線ランプ（日本文
化精工■製）を用い１０秒間紫外線を照射した。。得ら
れた膜はその表面に直径０．５２ｍ、高さ０．１２ａａ
の半球状の微小突起が均一に形成された突起付平膜型透
過膜であった。The pellets were heated to 150 to 200'C using the extruder mentioned above.
It was melted and extruded into the air through a T-die, and after falling onto the guide rollers of a cooling tank placed directly below the T-die, it was introduced into a cooling assimilation liquid made of polyethylene glycol and solidified. 1 more
, 1,2-trichloro-1,2,2-trifluoroethane (25°C) to extract liquid paraffin, and then heat-treated in air at 135°C for 2 minutes to obtain a permeable membrane with a smooth surface. I got it. A rotary screen printing machine (Japanese Made by Bunka Seiko ■, using ultraviolet curing resin (manufactured by Inu Nippon Ink)
Immediately after printing, ultraviolet rays were irradiated for 10 seconds using a 2 kW ultraviolet lamp (manufactured by Nippon Bunka Seiko ■). . The obtained membrane has a diameter of 0.52 m and a height of 0.12 aa on its surface.
It was a flat membrane-type permeable membrane with protrusions on which hemispherical microprotrusions were uniformly formed.
この透過膜を用いて実施例１と同様にして血漿分離器を
作成し、この血漿分離器に実施例１と同様１こして白液
を流してその濾過量を測定し、また実施例１と同様にし
て補体活性化成分Ｃ３ａを測定した。結果を第１表に示
す。Using this permeable membrane, a plasma separator was prepared in the same manner as in Example 1, and a white liquor was passed through this plasma separator in the same manner as in Example 1, and the amount of filtration was measured. Complement activating component C3a was measured in the same manner. The results are shown in Table 1.
比較例１
実施例２と同様にして得られた平滑な面を有する透過膜
を外径１０４簡、内径２２調の円盤状に打扱き、これを
２枚組合せ、間に濾液流路形成剤として線径０．０７ｍ
、目開き７０メツシユのポリエステル製メッシュ板２枚
をはさんで外周部と内周部をシールして透過膜ユニット
とした。この透過膜ユニットと、スペーサーとして直径
０．３ｍｍ、高さ０．１５ｍの半球状突起が表面積に対
して２％の占有面積で均一に形成されている厚ざ１緬の
エチレンビニルアルコールシート（外径１０４朧、内径
２２順の円盤状に打扱いたもの）とをシール材を介して
それぞれ２５層積層し、第６図に示すように円筒状のケ
ース内に入れ、有効膜面積３５００ｃｆｆｌの血漿分離
器を作成した。この血漿分離器に対して実施例１と同様
に白液を流しその濾過量を測定した。またミニモジュー
ルに組付ける平膜型透過膜を上記の平滑な面を有する透
過膜とする以外は実施例１と同様にして補体活性化成分
Ｃ３ａを測定した。結果を第１表に示す。Comparative Example 1 A permeable membrane with a smooth surface obtained in the same manner as in Example 2 was formed into a disk shape with an outer diameter of 104mm and an inner diameter of 22mm, and two of these were combined, and a filtrate channel forming agent was added between them. Wire diameter 0.07m
A permeable membrane unit was prepared by sandwiching two polyester mesh plates with an opening of 70 mesh and sealing the outer and inner circumferences. This permeable membrane unit and a 1-thick ethylene vinyl alcohol sheet (external 25 layers each were laminated via a sealing material and placed in a cylindrical case as shown in FIG. I created a separator. A white liquid was poured into this plasma separator in the same manner as in Example 1, and the amount of filtration was measured. Further, the complement activation component C3a was measured in the same manner as in Example 1, except that the flat membrane-type permeable membrane assembled into the mini module was the permeable membrane with the above-mentioned smooth surface. The results are shown in Table 1.
− ３４ ＝
第１表に示す結果から明らかなように、本発明に係る平
膜型透過膜を用いた場合（実施例１〜３）においては、
従来の平滑な而を有する平膜型透過膜を用いた場合（比
較例１）と比較して、濾過量をほとんど低下させること
はなく、プライミング量を大幅に削減することかでき、
また、血液成分の活性化の惹起も非常に少ないものであ
った。- 34 = As is clear from the results shown in Table 1, when the flat membrane type permeable membrane according to the present invention was used (Examples 1 to 3),
Compared to the case of using a conventional flat membrane type permeable membrane with a smooth surface (Comparative Example 1), the amount of filtration is hardly reduced and the amount of priming can be significantly reduced.
In addition, the activation of blood components was extremely low.
（発明の効果）
以上述べたように本発明は、少なくとも一方の面に複数
の微小突起を有することを特徴とする平膜型透過膜であ
るから、モジュール等に組入れた際に、処理液の安定し
た流路形成が容易に行なえ、メツシュ板、ドツト板等の
スペーサーを必要としないために、処理能力を低下させ
ることなくモジュールを小型化でき、これゆえプライミ
ングボリュームを低下させることか可能であり、また組
立工程も簡単なものとなる。さらにこのようなモジュー
ルが人工透析、血暁分離、血液成分分画等の血液処理の
用途に用いられる場合には、本発明の平膜型透過膜かス
ペーサー等を必要としないためこのようなスペーサーと
の接触とにより生じる血液中の凝固因子の活性化という
問題も生じないものである。(Effects of the Invention) As described above, since the present invention is a flat membrane-type permeable membrane characterized by having a plurality of microprotrusions on at least one surface, when it is incorporated into a module etc. Because it is easy to form a stable flow path and there is no need for spacers such as mesh plates or dot plates, the module can be made smaller without reducing processing capacity, and therefore it is possible to reduce the priming volume. , the assembly process is also simplified. Furthermore, when such a module is used for blood processing applications such as artificial dialysis, blood separation, and blood component fractionation, the flat membrane type permeable membrane of the present invention does not require a spacer, so such a spacer may be used. The problem of activation of coagulation factors in blood caused by contact with blood does not arise.
さらに本発明の平膜型透過膜において、微小突起の高さ
が３０〜”１０００μｍであり、また微小突起の設けら
れた面の表面積に対する微小突起部位の占有面積が０．
５〜５０％であり、また微小突起部位がヤング率１．０
Ｘ１０６〜２．０Ｘ１０１０ ｄｙｎ／Ｃｍ２の材質に
より構成されているものであり、さらに透過膜本体およ
び微小突起部位が同一材質である場合において、該材質
が再生セルロース系、セルロース誘導体系、ポリビニル
アルコール系、ポリスルホン系、ポリ（メタ）アクリル
系、ポリアミ１〜系およびポリオレフィン系からなる群
から選ばれてなる高分子、より望ましくはポリプロピレ
ンである、おるいはまた透過膜本体と微小突起部位が別
祠貿でおる場合において、透過膜本体か再生セルロース
系、セルロース誘導体系、ポリじニルアルコール系、ポ
リスルホン糸、ポリ〈メタ）アクリル系、ポリアミド系
およびポリオレフィン＝ ３６−
系からなる群から選ばれてなる高分子、より望ましくは
ポリプロピレンより構成され、−万機小突起部位か透過
膜本体を構成する材質と相溶性もしくは接着性を有する
熱可塑性樹脂、熱ないし電磁波硬化性樹脂または合成ゴ
ム、より望ましくはポリウレタン、エポキシ樹脂または
アクリル酸エステル樹脂により構成されるものであると
、上記したような特性はより優れたものとなる。Further, in the flat membrane type permeable membrane of the present invention, the height of the microprotrusions is 30 to 1000 μm, and the area occupied by the microprotrusions relative to the surface area of the surface on which the microprotrusions are provided is 0.
5 to 50%, and the Young's modulus of the microprotrusions is 1.0.
It is composed of a material of A polymer selected from the group consisting of polysulfone, poly(meth)acrylic, polyamide, and polyolefin, more preferably polypropylene, or the permeable membrane body and the microprojections may be separated from each other. In the case where the permeable membrane main body is made of a polymer selected from the group consisting of regenerated cellulose, cellulose derivative, polyvinyl alcohol, polysulfone thread, poly(meth)acrylic, polyamide, and polyolefin, molecule, more preferably polypropylene, - a thermoplastic resin, heat or electromagnetic wave curable resin, or synthetic rubber, more preferably polyurethane, which is compatible with or adhesive to the material constituting the small protrusions or the permeable membrane body. , an epoxy resin, or an acrylic acid ester resin, the above-mentioned characteristics will be more excellent.
さら＆Ｊ、本発明は、平膜状となした未凝固の原液を凝
固させて製膜する際、該平膜状の未凝固の原液の少なく
とも一方の面を、複数の微小な窪みを有する型面に接触
させながら凝固させ、透過膜の少なくとも一方の而に、
複数の微小突起を形成することを特徴とする平膜型透過
膜の製造方法であるから、−ト記したような優れた構造
を有する平膜型透過膜を容易に形成することか可能であ
り、さらに、微小な窪みの深さが３０〜１０００μｍ１
型面の表面積に対する微小な窪み部位の占有面積か０．
５〜５０％である型を用い、また複数の微小な窪みを有
する型面がローラー面である場合には、より優れた性能
を有する平膜型透過膜を容易に製造することかできるも
のとなる。Sara & J, The present invention provides a method for forming a film by solidifying an unsolidified stock solution in the form of a flat film, by forming at least one surface of the unsolidified stock solution in the form of a flat film into a mold having a plurality of minute depressions. solidify while in contact with the surface, and on at least one side of the permeable membrane,
Since this is a method for producing a flat membrane-type transparent membrane characterized by the formation of a plurality of microprotrusions, it is possible to easily form a flat membrane-type transparent membrane having an excellent structure as described in (g). , furthermore, the depth of the minute depression is 30 to 1000 μm1
The area occupied by the minute depressions relative to the surface area of the mold surface is 0.
If a mold with a 5% to 50% ratio is used, and the mold surface with multiple minute depressions is a roller surface, it is possible to easily produce a flat membrane-type permeable membrane with better performance. Become.
さらにまた、本発明は製膜された透過膜の少なくとも一
方の而に、該透過膜を構成する材質と相溶性もしくは接
着性を有する材質の未凝固物を注入してなる複数の微小
な窪みを有する型面を接触させ、該未凝固物を凝固させ
て透過膜の少なくとも一方の面に複数の微小突起を形成
することを特徴とする平膜型透過膜の製造方法であるか
ら、上記したような優れた構造を有する平膜型透過膜を
容易に形成することが可能である。ざらに微小な窪みの
深さが３０〜１０００μｍであり、また型面の表面積に
対する微小な窪みの部位の占有面積が０．５〜５０％で
ある型を用い、また透過膜を構成する材質と相溶性もし
くは接着性を有する材質の未凝固物として、熱ないし電
磁波硬化性樹脂原料を用い、透過膜の面と接触させた後
、加熱ないしは電磁波照射により硬化させて透過膜に微
小突起を付着形成するものであると、より容易に優れた
構造を有する平膜型透過膜を得ることかできる。Furthermore, the present invention provides a plurality of minute depressions formed by injecting an unsolidified material of a material that is compatible or adhesive with the material constituting the permeable membrane into at least one of the formed permeable membranes. This is a method for producing a flat membrane type permeable membrane, which is characterized in that a plurality of microprotrusions are formed on at least one surface of the permeable membrane by bringing the unsolidified materials into contact with each other and solidifying the unsolidified material. It is possible to easily form a flat membrane type transmission membrane having an excellent structure. A mold is used in which the depth of the microscopic depressions is approximately 30 to 1000 μm, and the area occupied by the microscopic depressions is 0.5 to 50% of the surface area of the mold surface, and the material constituting the permeable membrane is A heat or electromagnetic wave curable resin raw material is used as an unsolidified material of a compatible or adhesive material, and after it is brought into contact with the surface of the transparent membrane, it is cured by heating or electromagnetic wave irradiation to form microprotrusions attached to the transparent membrane. By doing so, it is possible to more easily obtain a flat membrane type transmission membrane having an excellent structure.
第１０〜１図は、本発明の平膜型透過膜の一実施態様の
構造を示す拡大断面図、第２図は本発明の平膜型透過膜
の製造方法において用いられる装置の該略図、第３図は
本発明の平膜型透過膜の製造方法において用いられる型
ロールの表面形状を表わす模式的断面図、第４図は本発
明の別の平膜型透過膜の製造方法において用いられる装
置の該略図、第５図は本発明の平膜透過膜を用いた血漿
分離装置の分解斜視図、第６図は従来の平膜型透過膜を
用い１こ血漿分離装置の分前斜視図でおり、また第７図
は補体活性化成分Ｃ３ａの測定に用られた回路を示す図
面である。
１・・・透過膜本体、２・・・微小突起、３・・・丁ダ
イ、４・・・未凝固膜、５．５ａ 、５１）・・・型ロ
ール、６・・・微小な窪み、７・・・冷却同化液、８・
・・１疑固膜、 ９・・・抽出液、１０．１０ａ、１０
ｂ・・・平膜型透過膜、１１・・・平滑な透過膜、１２
・・・ピンチロール、１３・・・熱硬化性接着剤、１４
・・・ドクターナイフ、１５・・・巻取りロール、２４
・・・ケース本体、２６・・・底蓋体、３１・・・透過
膜ユニツ１〜。10 to 1 are enlarged sectional views showing the structure of one embodiment of the flat membrane type permeable membrane of the present invention, and Figure 2 is a schematic diagram of the apparatus used in the method for manufacturing the flat membrane type permeable membrane of the present invention, FIG. 3 is a schematic cross-sectional view showing the surface shape of a mold roll used in the method for manufacturing a flat membrane type permeable membrane of the present invention, and FIG. 5 is an exploded perspective view of a plasma separation device using the flat membrane permeable membrane of the present invention, and FIG. 6 is an exploded perspective view of a plasma separation device using a conventional flat membrane type permeable membrane. FIG. 7 is a diagram showing a circuit used for measuring complement activation component C3a. DESCRIPTION OF SYMBOLS 1... Permeable membrane main body, 2... Micro protrusion, 3... Dye, 4... Unsolidified membrane, 5.5a, 51)... Mold roll, 6... Minute depression, 7...Cooled assimilated liquid, 8.
...1 pseudosolid membrane, 9...extract liquid, 10.10a, 10
b...Flat membrane type permeable membrane, 11...Smooth permeable membrane, 12
... Pinch roll, 13 ... Thermosetting adhesive, 14
... Doctor knife, 15 ... Winding roll, 24
... Case body, 26 ... Bottom lid body, 31 ... Permeable membrane unit 1 -.
Claims (17)
とを特徴とする平膜型透過膜。(1) A flat membrane-type permeable membrane characterized by having a plurality of microprotrusions on at least one surface.
た微小突起の設けられた面の表面積に対する微小突起部
位の占有面積が０．５〜５０％である特許請求の範囲第
１項に記載の平膜型透過膜。(2) The height of the microprotrusions is 30 to 1000 μm, and the area occupied by the microprotrusions is 0.5 to 50% of the surface area of the surface on which the microprotrusions are provided. flat membrane type permeable membrane.
されているものである特許請求の範囲第１項または第２
項に記載の平膜型透過膜。(3) Claims 1 or 2 in which the microprotrusions are made of the same material as the permeable membrane main body.
The flat membrane type permeable membrane described in .
れているものである特許請求の範囲第１項または第２項
に記載の平膜型透過膜。(4) The flat membrane type permeable membrane according to claim 1 or 2, wherein the microprotrusions are made of a material different from the permeable membrane main body.
０×１０＾１＾０ｄｙｎ／ｃｍ＾２の材質より構成され
ているものである特許請求の範囲第１項〜第４項のいず
れかに記載の平膜型透過膜。(5) The Young's modulus of the microprotrusion portion is 1.0×10^6~2.
The flat membrane type permeable membrane according to any one of claims 1 to 4, which is made of a material of 0x10^1^0 dyn/cm^2.
系、セルロース誘導体系、ポリビニルアルコール系、ポ
リスルホン系、ポリ（メタ）アクリル系、ポリアミド系
およびポリオレフィン系からなる群から選ばれてなる高
分子により構成されているものである特許請求の範囲第
３項または第５項に記載の平膜型透過膜。(6) The permeable membrane body and the microprojections are made of a polymer selected from the group consisting of regenerated cellulose, cellulose derivative, polyvinyl alcohol, polysulfone, poly(meth)acrylic, polyamide, and polyolefin. The flat membrane type permeable membrane according to claim 3 or 5, which is
により構成されているものである特許請求の範囲第６項
に記載の平膜型透過膜。(7) The flat membrane type permeable membrane according to claim 6, wherein the permeable membrane main body and the microprotrusion portions are made of polypropylene.
体系、ポリビニルアルコール系、ポリスルホン系、ポリ
（メタ）アクリル系、ポリアミド系およびポリオレフィ
ン系からなる群から選ばれてなる高分子により構成され
ており、また微小突起部位が透過膜本体を構成する材質
と相溶性もしくは接着性を有する熱可塑性樹脂、熱ない
し電磁波硬化性樹脂、または合成ゴムより構成されるも
のである特許請求の範囲第４項または第５項に記載の平
膜型透過膜。(8) The permeable membrane body is composed of a polymer selected from the group consisting of regenerated cellulose, cellulose derivative, polyvinyl alcohol, polysulfone, poly(meth)acrylic, polyamide, and polyolefin, In addition, the microprojections are made of thermoplastic resin, heat or electromagnetic wave curable resin, or synthetic rubber that is compatible or adhesive with the material constituting the permeable membrane main body. The flat membrane type permeable membrane according to item 5.
た微小突起部位がポリウレタン、エポキシ樹脂またはア
クリル酸エステル樹脂により構成されているものである
特許請求の範囲第８項に記載の平膜型透過膜。(9) The flat membrane type permeable membrane according to claim 8, wherein the permeable membrane main body is made of polypropylene, and the minute protrusions are made of polyurethane, epoxy resin, or acrylic acid ester resin.
求の範囲第１項〜第９項のいずれかに記載の平膜型透過
膜。(10) The flat membrane type permeable membrane according to any one of claims 1 to 9, having an average pore diameter of 0.001 to 5 μm.
請求の範囲第１項〜第８項のいずれかに記載の平膜型透
過膜。(11) The flat membrane type permeable membrane according to any one of claims 1 to 8, which is used as a plasma separation membrane.
する際、該平膜状の未凝固の原液の少なくとも一方の面
を、複数の微小な窪みを有する型面に接触させながら凝
固させ、透過膜の少なくとも一方の面に複数の微小突起
を形成することを特徴とする平膜型透過膜の製造方法。(12) When forming a film by coagulating the unsolidified stock solution in the form of a flat film, at least one surface of the unsolidified stock solution in the form of a flat film is brought into contact with a mold surface having a plurality of minute depressions. 1. A method for manufacturing a flat membrane type permeable membrane, which comprises solidifying the permeable membrane while solidifying the membrane to form a plurality of microprotrusions on at least one surface of the permeable membrane.
、また型面の表面積に対する微小な窪みの部位の占有面
積が０．５〜５０％である型を用いるものである特許請
求の範囲第１２項に記載の平膜型透過膜の製造方法。(13) A mold is used in which the depth of the minute depressions is 30 to 1000 μm, and the area occupied by the minute depressions is 0.5 to 50% of the surface area of the mold surface. 13. The method for producing a flat membrane type permeable membrane according to item 12.
ある特許請求の範囲第１２項または第１３項に記載の平
膜型透過膜の製造方法。(14) The method for manufacturing a flat membrane type permeable membrane according to claim 12 or 13, wherein the mold surface having a plurality of minute depressions is a roller surface.
透過膜を構成する材質と相溶性もしくは接着性を有する
材質の未凝固物を注入してなる複数の微小な窪みを有す
る型面を接触させ、該未凝固物を凝固させて透過膜の少
なくとも一方の面に複数の微小突起を形成することを特
徴する平膜型透過膜の製造方法。(15) A mold surface having a plurality of minute depressions formed by injecting an unsolidified material of a material that is compatible or adhesive with the material constituting the permeable film into at least one surface of the formed permeable film. A method for producing a flat membrane type permeable membrane, comprising: bringing the unsolidified material into contact with the membrane to solidify the unsolidified material to form a plurality of microprotrusions on at least one surface of the permeable membrane.
、また型面の表面積に対する微小な窪みの部位の占有面
積が０．５〜５０％である型を用いるものである特許請
求の範囲第１５項に記載の平膜型透過膜の製造方法。(16) A mold is used in which the depth of the minute depressions is 30 to 1000 μm, and the area occupied by the minute depressions is 0.5 to 50% of the surface area of the mold surface. The method for producing a flat membrane type permeable membrane according to item 15.
を有する材質の未凝固物として、熱ないしは電磁波硬化
性樹脂原料を用い、透過膜の面と接触させた後、加熱な
いしは電磁波照射により硬化させて透過膜に微小突起を
付着形成するものである特許請求の範囲第１５項または
第１６項に記載の平膜型透過膜の製造方法。(17) Heat or electromagnetic wave curable resin raw material is used as an unsolidified material that is compatible or adhesive with the material composing the transparent membrane, and after being brought into contact with the surface of the transparent membrane, it is cured by heating or electromagnetic wave irradiation. 17. The method of manufacturing a flat membrane type permeable membrane according to claim 15 or 16, wherein the microprotrusions are attached and formed on the permeable membrane.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62131792A JPS63296804A (en) | 1987-05-29 | 1987-05-29 | Flat membrane with protrusion and manufacture thereof |
| US07/445,670 US5094749A (en) | 1987-05-29 | 1988-05-30 | Knurled sheetlike permeable membrane, for production thereof, and body fluid filtering apparatus |
| DE88904656T DE3886053T2 (en) | 1987-05-29 | 1988-05-30 | Body fluid filters with permeable flat film membranes having protruding parts. |
| EP88904656A EP0392010B1 (en) | 1987-05-29 | 1988-05-30 | Body fluid filter having flat film permeative membranes having protrusions |
| PCT/JP1988/000529 WO1988009200A1 (en) | 1987-05-29 | 1988-05-30 | Flat film permeative membrane having protrusions, its production , and bodily fluid filter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62131792A JPS63296804A (en) | 1987-05-29 | 1987-05-29 | Flat membrane with protrusion and manufacture thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63296804A true JPS63296804A (en) | 1988-12-02 |
Family
ID=15066239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62131792A Pending JPS63296804A (en) | 1987-05-29 | 1987-05-29 | Flat membrane with protrusion and manufacture thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63296804A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010099591A (en) * | 2008-10-23 | 2010-05-06 | Nitto Denko Corp | Separation membrane element |
| JP2012066239A (en) * | 2010-08-24 | 2012-04-05 | Toray Ind Inc | Separation membrane and separation membrane element |
| WO2014003171A1 (en) * | 2012-06-28 | 2014-01-03 | 東レ株式会社 | Separation membrane and separation membrane element |
| CN105597543A (en) * | 2016-04-05 | 2016-05-25 | 成都美富特膜科技有限公司 | Spacing net structure for water treatment membrane stack |
| CN105617865A (en) * | 2016-04-05 | 2016-06-01 | 成都美富特膜科技有限公司 | Novel high-efficiency filtering water treatment membrane stack |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5624008A (en) * | 1979-08-02 | 1981-03-07 | Asahi Chem Ind Co Ltd | Selective permeable membrane and dialysis device comprising said membrane |
| JPS58163405A (en) * | 1982-03-24 | 1983-09-28 | Daicel Chem Ind Ltd | Semi-permeable membrane having selective permeability membrane, preparation thereof and filter type artificial kidney |
-
1987
- 1987-05-29 JP JP62131792A patent/JPS63296804A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5624008A (en) * | 1979-08-02 | 1981-03-07 | Asahi Chem Ind Co Ltd | Selective permeable membrane and dialysis device comprising said membrane |
| JPS58163405A (en) * | 1982-03-24 | 1983-09-28 | Daicel Chem Ind Ltd | Semi-permeable membrane having selective permeability membrane, preparation thereof and filter type artificial kidney |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010099591A (en) * | 2008-10-23 | 2010-05-06 | Nitto Denko Corp | Separation membrane element |
| JP2012066239A (en) * | 2010-08-24 | 2012-04-05 | Toray Ind Inc | Separation membrane and separation membrane element |
| WO2014003171A1 (en) * | 2012-06-28 | 2014-01-03 | 東レ株式会社 | Separation membrane and separation membrane element |
| JPWO2014003171A1 (en) * | 2012-06-28 | 2016-06-02 | 東レ株式会社 | Separation membrane and separation membrane element |
| CN105597543A (en) * | 2016-04-05 | 2016-05-25 | 成都美富特膜科技有限公司 | Spacing net structure for water treatment membrane stack |
| CN105617865A (en) * | 2016-04-05 | 2016-06-01 | 成都美富特膜科技有限公司 | Novel high-efficiency filtering water treatment membrane stack |
| CN105617865B (en) * | 2016-04-05 | 2018-03-02 | 成都美富特膜科技有限公司 | A kind of water process membrane stack of high efficiency filter |
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