JPS63190605A - Steam sterilization of hollow yarn-type ultrafiltration membrane module - Google Patents
Steam sterilization of hollow yarn-type ultrafiltration membrane moduleInfo
- Publication number
- JPS63190605A JPS63190605A JP2223787A JP2223787A JPS63190605A JP S63190605 A JPS63190605 A JP S63190605A JP 2223787 A JP2223787 A JP 2223787A JP 2223787 A JP2223787 A JP 2223787A JP S63190605 A JPS63190605 A JP S63190605A
- Authority
- JP
- Japan
- Prior art keywords
- water
- steam
- air
- valve
- sterilization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 26
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 23
- 239000012528 membrane Substances 0.000 title claims abstract description 17
- 238000000108 ultra-filtration Methods 0.000 title claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000012466 permeate Substances 0.000 claims abstract description 7
- 239000011550 stock solution Substances 0.000 claims abstract description 4
- 239000012510 hollow fiber Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000004971 Cross linker Substances 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、原水を限外濾過して除菌及び除パイロジエン
を行なう中空糸型限外濾過膜モジュールの蒸気滅菌に関
し、さらに詳細には、中空糸型限外濾過膜モジュールを
損傷することのない蒸気滅菌方法に関するものである。Detailed Description of the Invention (Field of Industrial Application) The present invention relates to steam sterilization of a hollow fiber ultrafiltration membrane module that performs sterilization and pyrogen removal by ultrafiltration of raw water, and more specifically, The present invention relates to a steam sterilization method that does not damage hollow fiber ultrafiltration membrane modules.
（従来技術）
従来の限外濾過装置の滅菌方法としては、次亜塩素酸ナ
トリウム、ホルマリン、過酸化水素などの薬剤による方
法と９０℃程度の熱水による加熱方法がある。しかし、
薬品による方法は薬剤が装置のデッドスペース部へ十分
に浸透しないための滅菌不十分とか滅菌後架剤を洗浄す
るのに時間がかかるといった問題がある。また、９０℃
程度の熱水の場合は、耐熱性の芽胞形成菌が確実には滅
菌出来ないという問題がある。(Prior Art) Conventional methods for sterilizing ultrafiltration devices include methods using chemicals such as sodium hypochlorite, formalin, and hydrogen peroxide, and heating methods using hot water at about 90°C. but,
Methods using chemicals have problems such as insufficient sterilization because the chemicals do not sufficiently penetrate into the dead space of the device, and that it takes time to clean the crosslinker after sterilization. Also, 90℃
In the case of moderately hot water, there is a problem that heat-resistant spore-forming bacteria cannot be reliably sterilized.
（発明が解決しようとする問題点）
これらの従来方法の欠点を解決するために蒸気滅菌が考
えられた。′特開昭６１−２４２６０４では蒸気滅菌の
前に、限外濾過装置内の原水及び減水を抜き去り、蒸気
を１次側より２次側へ通過させることが、また特開昭６
１−２４２６０５では、蒸気滅菌後の負圧を防止するた
めに、蒸気滅菌終了後、５０℃〜８０℃以上の加圧熱水
を原水側から供給することが記述されている。しかし蒸
気滅菌をする毎に、加圧熱水を作ったり、又、モジュ−
ルからの水抜きをすることは非常に手間がかかる。本発
明者らも蒸気滅菌のテストを行なった。(Problems to be Solved by the Invention) Steam sterilization was considered to solve the drawbacks of these conventional methods. 'Japanese Patent Application Laid-Open No. 61-242604 discloses that before steam sterilization, the raw water and reduced water in the ultrafiltration device are removed and the steam is passed from the primary side to the secondary side.
1-242605 describes that pressurized hot water of 50° C. to 80° C. or higher is supplied from the raw water side after steam sterilization in order to prevent negative pressure after steam sterilization. However, each time steam sterilization is performed, pressurized hot water must be made, and the module must be sterilized.
Draining water from the tank is very time consuming. The inventors also conducted steam sterilization tests.
その方法は、モジュールから水抜きを行なわないで、水
の入ったまま蒸気を通して滅菌し、滅菌終了後、直ちに
２５℃前後の水を装置に入れた。この場合の問題として
は、蒸気を通す時はあまり問題がないが、水を入れると
きに問題があった。即ち、蒸気の充満している場所に水
が入っていくと激しく凝縮がおこり、そのために中空糸
束が揺さぶられるために、中空糸がその接着界面付近で
損傷することがある点である。The method involved sterilizing the module by passing steam through it without draining the water, and immediately after sterilization, water at around 25° C. was poured into the device. In this case, there was no problem when passing steam, but there was a problem when adding water. That is, when water enters a steam-filled area, it condenses violently, which shakes the hollow fiber bundle, which can cause damage to the hollow fibers near their adhesive interfaces.
本発明らは、この点について鋭意検討した結果、本発明
を完成させた。The present inventors have completed the present invention as a result of intensive study on this point.
（問題点を解決するための手段）
即ち、本発明は中空糸内側を原液の流路、中空糸外側を
透過液の流路として使用する中空糸型限外濾過膜モジュ
ールにおいて、蒸気で滅菌した後、蒸気の供給を止め、
原液側から空気を供給し、空気の一部を膜を透過させて
透過側の空間を満たしたのち、原液側より水を供給して
モジュールの温度を下げることを特徴とする中空糸型限
外濾過膜モジュールの蒸気滅菌方法である。(Means for Solving the Problems) That is, the present invention provides a hollow fiber type ultrafiltration membrane module in which the inside of the hollow fiber is used as a flow path for the stock solution and the outside of the hollow fiber is used as a flow path for the permeate. After that, stop the steam supply,
Hollow fiber type limiter characterized by supplying air from the raw solution side, allowing part of the air to pass through the membrane to fill the space on the permeation side, and then supplying water from the raw solution side to lower the temperature of the module. This is a steam sterilization method for a filtration membrane module.
本発明のポイントは、蒸気滅菌が終了したら、蒸気の供
給を止め、すぐに原液側より空気を供給することで、こ
れにより空気の一部が限外濾過膜を透過して、透過側へ
入っていくので、蒸気が凝縮して負圧になることがない
。通常、水に濡れた限外濾過膜は空気を全く通さないが
、膜が蒸気滅菌の直後には膜がドライ状態にあるので、
空気を通すようになる。The key point of the present invention is to stop the supply of steam and immediately supply air from the raw solution side after steam sterilization is completed, so that some of the air passes through the ultrafiltration membrane and enters the permeate side. This prevents the steam from condensing and creating negative pressure. Normally, an ultrafiltration membrane that is wet with water does not allow any air to pass through it, but immediately after the membrane is steam sterilized, it is in a dry state, so
Allows air to pass through.
このように空気が原液側、透過側に満たされた状態にな
ってから、水を供給すると中空糸の動揺は全くなくなり
、このための中空糸の損傷は生じない。また空気は原液
側から入れてやればよく、透過側を菌で汚染する心配も
ないので、空気を無菌にする必要もない。When water is supplied after the raw solution side and the permeate side are filled with air in this manner, the hollow fibers do not move at all, and no damage to the hollow fibers occurs. Furthermore, since air can be introduced from the stock solution side and there is no need to worry about contaminating the permeate side with bacteria, there is no need to make the air sterile.
（発明の効果）
本発明による中空糸型限外濾過膜モジュールの蒸気滅菌
方法によれば、中空糸を損傷する心配もなしに、また負
圧の発生の心配もなく蒸気滅菌を行なうことができる。(Effects of the Invention) According to the method for steam sterilizing a hollow fiber type ultrafiltration membrane module according to the present invention, steam sterilization can be performed without worrying about damaging the hollow fibers or generating negative pressure. .
（実施例）
次に実施例によってこの発明をさらに具体的に説明する
。(Example) Next, the present invention will be explained in more detail with reference to Examples.
実施例１
第１図に基づいて本発明による蒸気滅菌方法の一実施例
を説明する。Example 1 An example of the steam sterilization method according to the present invention will be described based on FIG.
通常の使用時には原水人口弁１開放、蒸気人口弁２閉止
、空気人口弁３閉止として使用するので、限外濾過膜４
を配設したモジュール５内には水が充満している。蒸気
滅菌時、原水人口弁１を閉じ蒸気人口弁２を開くと蒸気
（１ｋｇ／ｃＩＩＩＧ）が流れ込み、全体の温度が上が
ってゆき、全系が水蒸気で満たされる。１ｋｇ／ｃ＋＋
１Ｇの蒸気は１２０’Ｃであるので、このまま１時間お
くことで全系が滅菌できる。次に、蒸気人口弁２を閉じ
、空気人口弁３を開けるとエア（１ｋｇ ／ ａｄ Ｇ
）が原水側に入り、さらに透過側へも入っていく。系
内に残っていた蒸気は次第に凝縮して、水蒸気圧は低下
していくが、その分を空気が補うので全圧は低下しない
。During normal use, the raw water population valve 1 is open, the steam population valve 2 is closed, and the air population valve 3 is closed, so the ultrafiltration membrane 4
The inside of the module 5 in which the is disposed is filled with water. During steam sterilization, when the raw water population valve 1 is closed and the steam population valve 2 is opened, steam (1 kg/cIIIG) flows in, the overall temperature rises, and the entire system is filled with water vapor. 1kg/c++
Since 1G steam has a temperature of 120'C, the entire system can be sterilized by leaving it as it is for 1 hour. Next, close the steam population valve 2 and open the air population valve 3 to release air (1kg/ad G
) enters the raw water side and further enters the permeate side. The steam remaining in the system gradually condenses and the water vapor pressure decreases, but the air compensates for this, so the total pressure does not decrease.
１５分経過後、空気人口弁３を閉じ、原水人口弁１を開
けて系内へ２５°Ｃの水を流入させて、全系の温度を低
下させた。この後、モジュールの性能検査を行なったが
全く問題なく、またリークも全くなかった。After 15 minutes, the air population valve 3 was closed and the raw water population valve 1 was opened to allow water at 25°C to flow into the system, thereby lowering the temperature of the entire system. After this, we performed a performance test on the module and found no problems and no leaks at all.
第１図は、実施例１の説明図である。
１・・・原水人口弁、２・・・蒸気人口弁、３・・・空
気人口弁、４・・・中空糸型限外濾過膜、５・・・モジ
ュール、６・・・スチームトラップ。FIG. 1 is an explanatory diagram of Example 1. DESCRIPTION OF SYMBOLS 1... Raw water population valve, 2... Steam population valve, 3... Air population valve, 4... Hollow fiber ultrafiltration membrane, 5... Module, 6... Steam trap.
Claims (1)
して使用する中空糸型限外濾過膜モジュールにおいて、
蒸気で滅菌した後、蒸気の供給を止め、原液側から空気
を供給し、空気の一部を膜を透過させて透過側の空間を
満たしたのち、原液側より水を供給してモジュールの温
度を下げることを特徴とする中空糸型限外濾過膜モジュ
ールの蒸気滅菌方法。In a hollow fiber ultrafiltration membrane module that uses the inside of the hollow fiber as a flow path for the stock solution and the outside of the hollow fiber as a flow path for the permeate,
After sterilization with steam, the supply of steam is stopped, air is supplied from the raw solution side, a part of the air is permeated through the membrane to fill the space on the permeation side, and water is supplied from the raw solution side to maintain the temperature of the module. A steam sterilization method for a hollow fiber ultrafiltration membrane module characterized by lowering the .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2223787A JPH084726B2 (en) | 1987-02-02 | 1987-02-02 | Method for steam sterilization of hollow fiber ultrafiltration membrane module |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2223787A JPH084726B2 (en) | 1987-02-02 | 1987-02-02 | Method for steam sterilization of hollow fiber ultrafiltration membrane module |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63190605A true JPS63190605A (en) | 1988-08-08 |
| JPH084726B2 JPH084726B2 (en) | 1996-01-24 |
Family
ID=12077186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2223787A Expired - Fee Related JPH084726B2 (en) | 1987-02-02 | 1987-02-02 | Method for steam sterilization of hollow fiber ultrafiltration membrane module |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH084726B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03280964A (en) * | 1990-03-29 | 1991-12-11 | Kawasumi Lab Inc | Manufacture of body fluid processing device |
| US5891340A (en) * | 1994-12-12 | 1999-04-06 | Nitto Denko Corporation | Method of cooling filtration apparatus after steam sterilization |
| WO2019229872A1 (en) * | 2018-05-30 | 2019-12-05 | 旭化成メディカル株式会社 | Leak detection device and leak detection method |
-
1987
- 1987-02-02 JP JP2223787A patent/JPH084726B2/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03280964A (en) * | 1990-03-29 | 1991-12-11 | Kawasumi Lab Inc | Manufacture of body fluid processing device |
| US5891340A (en) * | 1994-12-12 | 1999-04-06 | Nitto Denko Corporation | Method of cooling filtration apparatus after steam sterilization |
| WO2019229872A1 (en) * | 2018-05-30 | 2019-12-05 | 旭化成メディカル株式会社 | Leak detection device and leak detection method |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH084726B2 (en) | 1996-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |