JPS63160645A - Body stay tube - Google Patents
Body stay tubeInfo
- Publication number
- JPS63160645A JPS63160645A JP61309418A JP30941886A JPS63160645A JP S63160645 A JPS63160645 A JP S63160645A JP 61309418 A JP61309418 A JP 61309418A JP 30941886 A JP30941886 A JP 30941886A JP S63160645 A JPS63160645 A JP S63160645A
- Authority
- JP
- Japan
- Prior art keywords
- indwelling tube
- tcp
- cylindrical body
- indwelling
- ceramic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000919 ceramic Substances 0.000 claims description 22
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 13
- 229940126585 therapeutic drug Drugs 0.000 claims description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 11
- 230000036262 stenosis Effects 0.000 description 10
- 208000037804 stenosis Diseases 0.000 description 10
- 239000002246 antineoplastic agent Substances 0.000 description 9
- 230000003902 lesion Effects 0.000 description 8
- 229940041181 antineoplastic drug Drugs 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 210000000013 bile duct Anatomy 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- -1 polyethylene Polymers 0.000 description 3
- 230000002966 stenotic effect Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 229920003002 synthetic resin Polymers 0.000 description 3
- 239000000057 synthetic resin Substances 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 230000000916 dilatatory effect Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 208000007217 Esophageal Stenosis Diseases 0.000 description 1
- 229930192392 Mitomycin Natural products 0.000 description 1
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 206010030194 Oesophageal stenosis Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 238000012277 endoscopic treatment Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229960004857 mitomycin Drugs 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、悪性腫瘍などによって狭窄を生じている病巣
に使用される体内留置管に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an indwelling tube used in a lesion that is stenosed due to a malignant tumor or the like.
癌などの疾病によって体腔の一部に狭窄を生じた場合、
狭窄部を広げるために体内留置管が使用されている。従
来の体内留置管は、例えば合成樹脂などからなり両端が
開口するチューブ状のものであり、狭窄部に挿入される
ことによって狭窄部を内側から押し広げるとともに、体
腔の連通状態を確保するようにしている。When a part of a body cavity becomes narrowed due to a disease such as cancer,
An indwelling tube is used to widen the stenosis. Conventional internal indwelling tubes are made of, for example, synthetic resin and are tube-shaped with both ends open, and when inserted into a stenosis, they push the stenosis open from the inside and ensure communication between body cavities. ing.
従来の体内留置管は、狭窄部を拡張することはできるが
、病巣自体を積極的に治療するものではなかった。この
ため体内に留置した時点では効果が認められても疾病の
進行を食上めることができず、この点に改善の余地があ
った。Conventional indwelling tubes can dilate stenotic areas, but they do not actively treat the lesion itself. For this reason, even if the drug is effective when placed in the body, it cannot stop the progression of the disease, and there is room for improvement in this respect.
従って本発明の目的とするところは、狭窄部の拡張と同
時に、狭窄の原因となっている病巣の治療も行なえるよ
うな体内留置管を得ることにある。Accordingly, it is an object of the present invention to provide an indwelling tube that can be used to dilate a stenosis and simultaneously treat the lesion causing the stenosis.
本発明の体内留置管１は、両端が開口した筒状の本体２
を有しミこの筒状本体２の少なくとも一部分に多孔質セ
ラミックスを用い、かつこの多孔質セラミックスに治療
用薬剤を含浸させたことを特徴とするものである。上記
セラミックスとしては、リン酸三石灰の一種である多孔
質β−ＴＣＰが好適である。The indwelling tube 1 of the present invention has a cylindrical main body 2 with both ends open.
The cylindrical body 2 of the microorganism is characterized in that at least a portion of the cylindrical body 2 is made of porous ceramics, and the porous ceramics is impregnated with a therapeutic drug. Porous β-TCP, which is a type of trilime phosphate, is suitable as the ceramic.
上記構成の体内留置管は、癌等の腫瘍ができて狭窄を生
じている部位に挿入される。狭窄部は、筒状の本体によ
って押し拡げられ、体腔の連通状態を維持する。これと
同時に、多孔質セラミックスから薬剤が徐々に染み出す
ことにより、病巣の治療が行なわれる。The indwelling tube configured as described above is inserted into a site where a tumor such as cancer has formed and is causing stenosis. The narrowed portion is pushed open by the cylindrical main body to maintain communication between the body cavities. At the same time, the drug gradually seeps out of the porous ceramic, thereby treating the lesion.
本発明の第１実施例につき、第１図および第２図を参照
して説明する。体内留置管１の本体２は、おおむね円筒
形をなしており、両端が開口するとともに、内部に中空
孔３を有している。この本体２は、軸線方向中間部に位
置する多孔質セラミックス製の円筒体４と、この円筒体
４の両端部に取着された抜は止め部材５．６とを備えて
構成される。この抜は止め部材５，６は、ポリエチレン
等のような可撓性を有する合成樹脂によって、両端が開
口するチューブ状に成形されている。抜は止め部材５，
６には、それぞれ外側を向いた抜脱防止用のフラップ７
．８が設けられている。一方の抜は止め部材５の端部９
は先細のテーバ状に成形されている。A first embodiment of the present invention will be described with reference to FIGS. 1 and 2. The main body 2 of the indwelling tube 1 has a generally cylindrical shape, is open at both ends, and has a hollow hole 3 inside. The main body 2 includes a cylindrical body 4 made of porous ceramics located at an axially intermediate portion, and removal prevention members 5.6 attached to both ends of the cylindrical body 4. The retaining members 5 and 6 are made of flexible synthetic resin such as polyethylene and are formed into a tube shape with both ends open. Removal stop member 5,
6 has flaps 7 facing outward to prevent slipping out.
．． 8 is provided. End portion 9 of one of the pull-out stopper members 5
is shaped like a tapered taper.
多孔質セラミックスからなる円筒体４には、好ましい例
として、体内で少しずつ溶出する多孔質β−ＴＣＰが使
われている。従ってこのセラミックス円筒体４は、多数
の微小な空孔部を備えている。この空孔部には、薬剤の
例としてマイトマイシンやアトリアジン、５−ＦＵなど
の抗癌剤が含浸させられている。For the cylindrical body 4 made of porous ceramics, porous β-TCP, which is eluted little by little within the body, is preferably used. Therefore, this ceramic cylindrical body 4 is provided with a large number of minute holes. The pores are impregnated with anticancer agents such as mitomycin, atriazine, and 5-FU.
上記構成の体内留置管１は、第２図に例示されるように
、例えば胆管１０の末端近くに癌等の病巣１１ができて
狭窄を生じた場合、狭窄部１２の拡張と治療のために使
用される。この場合、体内留置管１は開腹手術あるいは
経皮的内視鏡処置により、狭窄部１２を押し広げるよう
にして設置される。抜は止め部材５の挿入側の端部９は
先細テーバ状をなしているから、容易に挿入できる。こ
のように体内留置管１を狭窄部１２に留置することによ
り、体内留置管１の中空孔３を介して、胆管１０と十二
指腸側の体腔１３とを互いに連通状態にすることができ
る。この時、フラップ７．８は広がった状態にあるから
、留置管１が狭窄部１２から抜は落ちることなく、確実
に留置される。As illustrated in FIG. 2, the indwelling tube 1 having the above configuration is used for dilating and treating the narrowed portion 12 when a lesion 11 such as cancer is formed near the end of the bile duct 10 and a narrowing occurs. used. In this case, the indwelling tube 1 is placed in such a way as to push and widen the stenotic part 12 by open surgery or percutaneous endoscopic treatment. Since the insertion side end 9 of the removal preventing member 5 has a tapered shape, it can be easily inserted. By indwelling the indwelling tube 1 in the constricted portion 12 in this way, the bile duct 10 and the body cavity 13 on the duodenum side can be brought into communication with each other via the hollow hole 3 of the indwelling tube 1. At this time, since the flaps 7.8 are in an expanded state, the indwelling tube 1 is securely indwelled without falling out of the constricted portion 12.
上記留置管１のセラミックス円筒体４には、上述した抗
癌剤が含浸させられており、しかもセラミックス円筒体
４の材料には体内で溶出可能なβ−ＴＣＰが使用されて
いるため、含浸された抗癌剤はこの円筒体４から少量ず
つ溶は出し、病巣１１に直接吸収される。従って、単に
狭窄部１２を拡張できるだけでなく、病巣１１の治療も
同時に行なえる。The ceramic cylindrical body 4 of the indwelling tube 1 is impregnated with the above-mentioned anticancer agent, and since the material of the ceramic cylindrical body 4 is β-TCP which can be eluted in the body, the impregnated anticancer agent The solution is released little by little from this cylindrical body 4 and absorbed directly into the lesion 11. Therefore, not only can the stenosis 12 be expanded, but also the lesion 11 can be treated at the same time.
しかもセラミックス円筒体４にβ−ＴＣＰを使用し、そ
の空孔部に抗癌剤を含浸させているため、種々の空孔率
のβ−ＴＣＰを用いることによって、抗癌剤の徐放速度
を調整することが可能である。Moreover, since β-TCP is used for the ceramic cylinder 4 and the pores are impregnated with the anticancer drug, the sustained release rate of the anticancer drug can be adjusted by using β-TCP with various porosity. It is possible.
しかもβ−ＴＣＰ製の円筒体４は生体との親和性に優れ
ている。また、β−ＴＣＰはその表面側から徐々に溶出
するため、円筒体４の表面に胆汁の成分が付着しにくい
。従って空孔部の開口が詰まりに＜＜、長期間にわたっ
て有効に作用することができる。なお、β−ＴＣＰは生
体吸収性を有し、いずれは消失するから、留置管１全体
をβ−ＴＣＰで作れば、疾病回復後に除去手術を行なう
必要がない。Furthermore, the cylindrical body 4 made of β-TCP has excellent affinity with living organisms. Furthermore, since β-TCP is gradually eluted from the surface side, bile components are less likely to adhere to the surface of the cylindrical body 4. Therefore, the opening of the pore can effectively prevent clogging for a long period of time. Note that β-TCP is bioabsorbable and will eventually disappear, so if the entire indwelling tube 1 is made of β-TCP, there is no need to perform removal surgery after recovery from the disease.
第３図は本発明の第２実施例を示すもので、この場合、
本体２の大部分はポリエチレン等のような可撓性をもつ
合成樹脂によってチューブ状に成形されている。この本
体２の両端部には、抜脱防止用のフラップ７．８が一体
に成形されている。FIG. 3 shows a second embodiment of the present invention, in which case:
Most of the main body 2 is formed into a tube shape from a flexible synthetic resin such as polyethylene. Flaps 7.8 for preventing slippage are integrally formed on both ends of the main body 2.
本体２の挿入側の端部９は、先細テーバ状に形成されて
いる。そして本体２の軸方向中間部分に、軸線方向に互
いに離間して複数個のセラミックスリング１５が埋設さ
れている。このセラミックスリング１５は、第１実施例
で述べたセラミックス円筒体４と同様にβ−ＴＣＰから
なり、その空孔部に抗癌剤等の薬剤が含浸させられてい
る。The insertion side end 9 of the main body 2 is formed into a tapered shape. A plurality of ceramic rings 15 are embedded in an axially intermediate portion of the main body 2, spaced apart from each other in the axial direction. This ceramic ring 15 is made of β-TCP similarly to the ceramic cylinder 4 described in the first embodiment, and its pores are impregnated with a drug such as an anticancer drug.
この第２実施例の体内留置管１も、第１実施例で述べた
と同様に狭窄部に留置されることによって、第１実施例
と同様の効果を奏することができる。しかもこの第２実
施例の本体２は、セラミックスリング１５を除く部分が
可撓性を有する材料でできているため、可撓性に富んで
いる。このため、内視鏡を用いた径口的処置によって狭
窄部に挿入することが可能である。The indwelling tube 1 of this second embodiment can also produce the same effects as the first embodiment by being indwelled in the stenotic region in the same manner as described in the first embodiment. Furthermore, the main body 2 of the second embodiment is highly flexible since the parts other than the ceramic ring 15 are made of a flexible material. Therefore, it is possible to insert it into the stenosis by a lumen procedure using an endoscope.
第４図に示された本発明の第３実施例は、第１実施例と
同様に抗癌剤を含浸させたβ−ＴＣＰからなるセラミッ
クス円筒体４の外周面側に、ラジオアイソトープを付与
したリング１６を埋設している。ラジオアイソトープは
、質量数１３１のよう素が適当である。この第３実施例
によれば、抗癌剤による治療に加えて放射線による治療
も同時に行なうことができる。円筒体４を構成している
β−ＴＣＰは、従来の体内留置管に使われている樹脂チ
ューブなどに比べて耐放射線性に優れているため、ラジ
オアイソトープのリング１６が埋設されていても劣化が
少ない。A third embodiment of the present invention shown in FIG. 4 is similar to the first embodiment, in which a ring 16 is provided with a radioisotope on the outer peripheral surface side of a ceramic cylinder 4 made of β-TCP impregnated with an anticancer drug. is buried. Iodine having a mass number of 131 is suitable as the radioisotope. According to this third embodiment, treatment with radiation can be performed simultaneously in addition to treatment with anticancer drugs. The β-TCP that makes up the cylindrical body 4 has superior radiation resistance compared to resin tubes used in conventional indwelling tubes, so even if the radioisotope ring 16 is buried, it will not deteriorate. Less is.
なお本発明の体内留置管１は、胆管以外の体腔に生じた
狭窄部に適用できるのは勿論であり、例えば食道癌によ
る食道狭窄拡張のための人工食道などにも適用できる。The indwelling tube 1 of the present invention can of course be applied to strictures occurring in body cavities other than bile ducts, and can also be applied, for example, to artificial esophagus for dilating esophageal stricture due to esophageal cancer.
また、多孔質セラミックスに含浸される薬剤は、抗癌剤
の代りに各種治療目的に合わせて選択すればよい。Furthermore, the drug to be impregnated into the porous ceramics may be selected in place of the anticancer drug depending on various therapeutic purposes.
本発明によれば、狭窄部を拡張できるだけでなく、狭窄
の原因となっている病巣の治療にも役立つ。また本発明
の体内留置管を構成する多孔質セラミックスにβ−ＴＣ
Ｐを使用した場合には、生体親和性に優れるとともに、
疾病回復後の除去手術を不要にすることが可能であり、
しかも空孔率などを変えることによって徐放速度を調整
することもできる。According to the present invention, it is possible not only to dilate a stenosis but also to treat the lesion causing the stenosis. In addition, β-TC is added to the porous ceramics constituting the indwelling tube of the present invention.
When P is used, it has excellent biocompatibility and
It is possible to eliminate the need for removal surgery after recovery from the disease,
Moreover, the sustained release rate can be adjusted by changing the porosity and the like.
第１図は本発明の第１実施例を示す体内留置管の断面図
、第２図は第１図に示された体内留置管の使用状態を示
す図、第３図は本発明の第２実施例を示す体内留置管の
断面図、第４図は本発明の第３実施例を示す断面図であ
る。
１・・・体内留置管、２・・・本体、４・・・セラミッ
クス円筒体、１５・・・セラミックスリング。
第１図
第２図
第３図
第４図FIG. 1 is a sectional view of an indwelling tube according to a first embodiment of the present invention, FIG. 2 is a diagram showing a state in which the indwelling tube shown in FIG. 1 is used, and FIG. A cross-sectional view of an indwelling tube showing an embodiment of the present invention. FIG. 4 is a cross-sectional view showing a third embodiment of the present invention. DESCRIPTION OF SYMBOLS 1... In-body indwelling tube, 2... Main body, 4... Ceramic cylindrical body, 15... Ceramic ring. Figure 1 Figure 2 Figure 3 Figure 4
Claims (2)
おいて、上記筒状本体の少なくとも一部分に多孔質セラ
ミックスを用い、かつこの多孔質セラミックスに治療用
薬剤を含浸させたことを特徴とする体内留置管。(1) An indwelling tube having a cylindrical body with both ends open, characterized in that at least a portion of the cylindrical body is made of porous ceramics, and the porous ceramics is impregnated with a therapeutic drug. Indwelling tube.
とを特徴とする特許請求の範囲第１項記載の体内留置管
。(2) The indwelling tube according to claim 1, characterized in that β-TCP is used for the porous ceramic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61309418A JPS63160645A (en) | 1986-12-24 | 1986-12-24 | Body stay tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61309418A JPS63160645A (en) | 1986-12-24 | 1986-12-24 | Body stay tube |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63160645A true JPS63160645A (en) | 1988-07-04 |
Family
ID=17992761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61309418A Pending JPS63160645A (en) | 1986-12-24 | 1986-12-24 | Body stay tube |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63160645A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5528297A (en) * | 1992-01-29 | 1996-06-18 | Deutsche Thomson-Brant Gmbh | Convertible video camera/projector |
| US6723120B2 (en) | 1997-04-15 | 2004-04-20 | Advanced Cardiovascular Systems, Inc. | Medicated porous metal prosthesis |
| US6805898B1 (en) | 2000-09-28 | 2004-10-19 | Advanced Cardiovascular Systems, Inc. | Surface features of an implantable medical device |
| US10028851B2 (en) | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
-
1986
- 1986-12-24 JP JP61309418A patent/JPS63160645A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5528297A (en) * | 1992-01-29 | 1996-06-18 | Deutsche Thomson-Brant Gmbh | Convertible video camera/projector |
| US6723120B2 (en) | 1997-04-15 | 2004-04-20 | Advanced Cardiovascular Systems, Inc. | Medicated porous metal prosthesis |
| US10028851B2 (en) | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
| US6805898B1 (en) | 2000-09-28 | 2004-10-19 | Advanced Cardiovascular Systems, Inc. | Surface features of an implantable medical device |
| US7335314B2 (en) | 2000-09-28 | 2008-02-26 | Advanced Cardiovascular Systems Inc. | Method of making an implantable medical device |
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