JPS63148166A - Automatic chemical analyzer - Google Patents
Automatic chemical analyzerInfo
- Publication number
- JPS63148166A JPS63148166A JP61294643A JP29464386A JPS63148166A JP S63148166 A JPS63148166 A JP S63148166A JP 61294643 A JP61294643 A JP 61294643A JP 29464386 A JP29464386 A JP 29464386A JP S63148166 A JPS63148166 A JP S63148166A
- Authority
- JP
- Japan
- Prior art keywords
- dispensing nozzle
- reagent
- stirring
- sample
- reaction tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000126 substance Substances 0.000 title claims description 12
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 41
- 238000003756 stirring Methods 0.000 claims abstract description 41
- 239000007788 liquid Substances 0.000 abstract description 11
- 239000000203 mixture Substances 0.000 abstract description 5
- 238000000034 method Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00534—Mixing by a special element, e.g. stirrer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
- G01N2035/1058—General features of the devices using the transfer device for another function for mixing
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
【発明の詳細な説明】
［発明の目的］
（産業上の利用分野）
本発明は、サンプル分注用ノズル及び試薬分注用ノズル
を備えた自動化学分析装置に関する。DETAILED DESCRIPTION OF THE INVENTION [Object of the Invention] (Industrial Application Field) The present invention relates to an automatic chemical analyzer equipped with a sample dispensing nozzle and a reagent dispensing nozzle.
（従来の技術）
人体の血清等をサンプルとして用いこれに所望試薬を混
合して両者の反応状態を光学的に検出することにより゛
、血清内のたんはり但、コレステロール等の項目を測定
して診断に供するようにした自動化学分析装置が知られ
ている。第４図はこのような自動化学分析装置の従来例
を示す概略平面図で、矢印方向に回転する恒温槽１内の
恒温水２には複数の反応管３ａ、３ｂ、３ｃ、・・・が
配置され、恒温槽１と共に矢印方向に移動するようにな
っている。恒温槽１の周囲位置のＡ位置にはサンプル分
注用ノズル４が配置されＢ位置には第１試薬分注用ノズ
ル５が配置され、Ｃ位置には第２試薬分注用ノズル６が
配置され、Ｄ位置には撹拌子７が配置されている。恒温
槽１即ち反応管３が停止している状態で、Ａ位置に対向
している反応管にはサンプル分注用ノズル４によってサ
ンプルが分注され、Ｂ位置に対向している反応管には第
１試薬分注用ノズル５によって第１試薬が分注され、Ｃ
位置に対向している反応管には第２試薬分注用ノズル６
によって第２試薬が分注される。またり位置に対向して
いる反応管には撹拌子７によってサンプル及び試薬の撹
拌が行われる。(Prior art) By using human serum, etc. as a sample, mixing it with a desired reagent, and optically detecting the reaction state between the two, items such as protein and cholesterol in the serum can be measured. Automated chemical analyzers that are used for diagnosis are known. FIG. 4 is a schematic plan view showing a conventional example of such an automatic chemical analyzer, in which a plurality of reaction tubes 3a, 3b, 3c, . It is arranged so that it moves in the direction of the arrow together with the constant temperature bath 1. A sample dispensing nozzle 4 is arranged at position A around the thermostatic chamber 1, a first reagent dispensing nozzle 5 is disposed at position B, and a second reagent dispensing nozzle 6 is disposed at position C. The stirrer 7 is placed at the D position. When the constant temperature chamber 1, that is, the reaction tube 3 is stopped, the sample is dispensed by the sample dispensing nozzle 4 to the reaction tube facing the A position, and the sample is dispensed to the reaction tube facing the B position. The first reagent is dispensed by the first reagent dispensing nozzle 5, and the C
A second reagent dispensing nozzle 6 is installed in the reaction tube facing the position.
The second reagent is dispensed. The sample and reagent are stirred by a stirring bar 7 in the reaction tube facing the straddle position.
恒温槽１の内側に設けられた光源８から外側に向けて光
を照射し、反応管３内のサンプルと試薬との混合液を透
過させることにより回折格子９及び検出器１０を含む検
出系によって、その混合液の反応状態即ち吸光度の検出
が行われる。このように混合液の反応状態を光学的に検
出するにあたり、サンプルと試薬とが良く混り合ってい
ることは正確な検出を行う上での重要な要件となる。こ
のために撹拌子７を設けて両者を強制的に撹拌すること
が行われている。A detection system including a diffraction grating 9 and a detector 10 irradiates light outward from a light source 8 provided inside the thermostatic chamber 1 and transmits the sample and reagent mixture in the reaction tube 3. , the reaction state of the mixed solution, that is, the absorbance is detected. In optically detecting the reaction state of a liquid mixture as described above, it is an important requirement for accurate detection that the sample and reagent are well mixed. For this purpose, a stirring bar 7 is provided to forcibly stir both.
（発明が解決しようとする問題点）
ところでこのような従来の自動化学分析装置では、撹拌
を行うための撹拌子７を設けているため装置の駆動機構
が複雑になっている。またこの撹拌子７による撹拌は順
次り位置に到達してぎた反応管内の混合液に対して行う
ため、前回の撹拌による混合液が撹拌子７に付着してい
る状態で次の混合液の撹拌を行うことになるので、コン
タミネーションの発生が増加し、誤検出の原因となる。(Problems to be Solved by the Invention) By the way, in such a conventional automatic chemical analyzer, the drive mechanism of the apparatus is complicated because it is provided with a stirring bar 7 for stirring. In addition, since this stirring by the stirring bar 7 is performed on the mixed liquid in the reaction tube that has reached the next position one after another, the next mixed liquid is stirred while the mixed liquid from the previous stirring is attached to the stirring bar 7. This increases the occurrence of contamination and causes false detection.
さらに撹拌工程が独立して必要になっているため処理速
度が上げられない。Furthermore, since an independent stirring step is required, the processing speed cannot be increased.
本発明は以上のような問題に対処してなされたもので、
撹拌工程を省略した自動化学分析装置を提供することを
目的とするものである。The present invention has been made in response to the above-mentioned problems.
The object of the present invention is to provide an automatic chemical analyzer that does not require a stirring step.
［発明の構成］
（問題点を解決するための手段）
上記目的を達成するために本発明は、サンプル分注用ノ
ズル又は試薬分注用ノズルのいずれか一方に撹拌翼を設
けたことを特徴としている。[Structure of the Invention] (Means for Solving the Problems) In order to achieve the above object, the present invention is characterized in that a stirring blade is provided on either the sample dispensing nozzle or the reagent dispensing nozzle. It is said that
（作 用）
反応管に対してサンプル分注及び試薬分注を行う場合、
後の工程で行われる分注用ノズル例えばサンプル分注用
ノズルに撹拌翼を設けておくことにより、サンプル分注
のときその撹拌翼によって同時に試薬（前の工程で予め
反応管内に分注されている）との撹拌を行うことができ
る。(Function) When dispensing samples and reagents into reaction tubes,
By providing a stirring blade on a dispensing nozzle that will be used in a later process, such as a sample dispensing nozzle, the stirring blade will simultaneously remove reagents (previously dispensed into the reaction tube in the previous process) during sample dispensing. Stirring can be performed with
（実施例）
第１図は本発明の自動化学分析装置の実施例を示す概略
斜視図で、矢印方向に回転する恒温槽１１内の゛耐温水
１２には複数の反応管１３ａ。(Embodiment) FIG. 1 is a schematic perspective view showing an embodiment of the automatic chemical analyzer of the present invention, in which a plurality of reaction tubes 13a are disposed in the hot water 12 in a constant temperature bath 11 that rotates in the direction of the arrow.
１３ｂ、１３ｃが配置され、恒温槽１１と共に移動する
。Ａ位置にはサンプリングアーム１４ａの先端に取付け
られたサンプル分注用ノズル１４が配置され、支軸１４
ｂを支点として回動可能となっている。Ｂ位置には第１
試薬アーム１５ａの先端に取付けられた第１試薬分注用
ノズル１５が配置され、支軸１５ｂを支点として回動可
能となっている。Ｃ位置には第２試薬アーム１６ａの先
端に取付けられた第２試薬分注用ノズル１６が配置され
、支軸１６ｂを支点として回動可能となっている。なお
、この場合第２試薬分注用ノズル１６には第２図のよう
に撹拌翼１７が設けられている。13b and 13c are arranged and move together with the constant temperature bath 11. At position A, the sample dispensing nozzle 14 attached to the tip of the sampling arm 14a is arranged, and the support shaft 14
It is rotatable around b as a fulcrum. The first one is in the B position.
A first reagent dispensing nozzle 15 attached to the tip of the reagent arm 15a is arranged and is rotatable about a support shaft 15b. At position C, the second reagent dispensing nozzle 16 attached to the tip of the second reagent arm 16a is arranged and is rotatable about the support shaft 16b. In this case, the second reagent dispensing nozzle 16 is provided with a stirring blade 17 as shown in FIG.
次に本実施例の作用を説明する。Next, the operation of this embodiment will be explained.
反応管が停止している状態でＡ位置に対向している反応
管１３には、第３図（ａ＞のようにサンプル分注用ノズ
ル１５によって第１試薬が矢印のように分注される。ま
たＣ位置に対向している反応管１３には、第３図（Ｃ）
のように第２試薬分注用ノズル１６によって第２試薬が
矢印のように分注されると共に、ノズル１６先端及び撹
拌翼１７が混合液に浸される。次に第３図（Ｃｆ）のよ
うにノズル１６先端及び撹拌翼１７が混合液から引上げ
られるとき、撹拌翼１７によって混合液が撹拌される。When the reaction tube is stopped, the first reagent is dispensed in the direction of the arrow by the sample dispensing nozzle 15 as shown in FIG. 3 (a>) into the reaction tube 13 facing position A. .In addition, the reaction tube 13 facing the C position is shown in Fig. 3(C).
The second reagent is dispensed by the second reagent dispensing nozzle 16 as shown by the arrow, and the tip of the nozzle 16 and the stirring blade 17 are immersed in the mixed liquid. Next, as shown in FIG. 3 (Cf), when the tip of the nozzle 16 and the stirring blade 17 are pulled up from the mixed liquid, the mixed liquid is stirred by the stirring blade 17.
従って第２試薬分注用ノズル１６によって第２試薬の分
注と共に撹拌作用を行わせることができることになる。Therefore, the second reagent dispensing nozzle 16 can perform a stirring action as well as dispensing the second reagent.
なお、撹拌ｎ１７によって撹拌を行わせるには第３図（
ｅ）のように、混合液内で撹拌翼１７を上下に振とうさ
せるようにしても良い。In addition, in order to perform stirring by stirring n17, please refer to Fig. 3 (
As in e), the stirring blade 17 may be shaken up and down within the mixed liquid.
このような本実施例によれば第２試薬の分注工程で撹拌
工程を賄ねることができるため、撹拌工程を独立して設
ける必要はないので処理速度を上げることができる。ま
たこれに伴いそのための駆動機構が不要となるので構造
を簡単にすることができる。ざらにコンタミネーション
の発生を最小に抑えることができるので誤検出を防止す
ることができる。According to this embodiment, since the stirring step can be covered by the dispensing step of the second reagent, there is no need to provide an independent stirring step, so that the processing speed can be increased. Additionally, since a drive mechanism for this purpose is not required, the structure can be simplified. Since the occurrence of contamination can be kept to a minimum, false detection can be prevented.
以上の実施例では第２試薬分注用ノズル１６に撹拌翼１
７を設けた例で説明したが、試薬分注用ノズルは１個の
み用いる場合でも同様に適用することができる。−また
サンプル分注を先の工程で行った例で説明したが、試薬
の分注を先の工程で行うこともでき、この場合は後の工
程となるサンプル分注用ノズル１４に対して撹拌翼１７
を設けるようにする。要するに撹拌の目的からして、後
の工程で用いられる分注用ノズルに対して屑拌翼を設け
れば良い。In the above embodiment, the stirring blade 1 is attached to the second reagent dispensing nozzle 16.
Although the explanation has been given using an example in which the number of reagent dispensing nozzles is provided, the same application is possible even when only one reagent dispensing nozzle is used. -Also, although the example was explained in which sample dispensing was performed in the previous process, reagent dispensing could also be performed in the previous process, and in this case, stirring was performed to the sample dispensing nozzle 14, which was the subsequent process. Wings 17
should be established. In short, for the purpose of stirring, it is sufficient to provide a waste stirring blade to the dispensing nozzle used in a later step.
［発明の効果］
以上説明したように本発明によれば、サンプル分注用ノ
ズル又は試薬分注用ノズルのいずれか一方に撹拌翼を設
けるようにしたので、撹拌工程を省略することができる
。[Effects of the Invention] As explained above, according to the present invention, since a stirring blade is provided in either the sample dispensing nozzle or the reagent dispensing nozzle, the stirring step can be omitted.
第１図は本発明実施例の自動化学分析装置を示す概略斜
視図、第２図は本発明装置の主要部の拡大図、第３図（
ａ）乃至（ｅ）は本発明実施例の作用を説明する概略図
、第４図は従来例を示す概略平面図である。
１１・・・恒温槽、１２・・・恒温水、１３．１３ａ、
１３ｂ、１３ｃ・・・反応管、１４・・・サンプル分注
用ノズル、
１５・・・第１試薬分注用ノズル、
１６・・・第２試薬分注用ノズル、１７・・・撹拌翼。
代理人 弁理士 則 近 憲 缶周 大
胡 典 失策２図
第３図
第４図FIG. 1 is a schematic perspective view showing an automatic chemical analyzer according to an embodiment of the present invention, FIG. 2 is an enlarged view of the main parts of the device of the present invention, and FIG.
a) to (e) are schematic diagrams illustrating the operation of the embodiment of the present invention, and FIG. 4 is a schematic plan view illustrating a conventional example. 11... Constant temperature bath, 12... Constant temperature water, 13.13a,
13b, 13c... Reaction tube, 14... Sample dispensing nozzle, 15... First reagent dispensing nozzle, 16... Second reagent dispensing nozzle, 17... Stirring blade. Agent Patent Attorney Nori Chika Ken Shu Canshu Daiko Norihiro Mistakes Figure 2 Figure 3 Figure 4
Claims (3)
ル分注用ノズル及び試薬を分注するための試薬分注用ノ
ズルを備えた自動化学分析装置において、前記サンプル
分注用ノズル又は試薬分注用ノズルの少なくとも一方に
撹拌翼を設けたことを特徴とする自動化学分析装置。(1) In an automatic chemical analyzer equipped with a sample dispensing nozzle for dispensing a sample into a common reaction tube and a reagent dispensing nozzle for dispensing a reagent, the sample dispensing nozzle or the reagent dispensing An automatic chemical analysis device characterized in that a stirring blade is provided on at least one of the dispensing nozzles.
請求の範囲第１項記載の自動化学分析装置。(2) The automatic chemical analysis device according to claim 1, wherein the sample dispensing nozzle is provided with a stirring blade.
の範囲第１項記載の自動化学分析装置。(3) The automatic chemical analyzer according to claim 1, wherein the reagent dispensing nozzle is provided with a stirring blade.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61294643A JPS63148166A (en) | 1986-12-12 | 1986-12-12 | Automatic chemical analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61294643A JPS63148166A (en) | 1986-12-12 | 1986-12-12 | Automatic chemical analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS63148166A true JPS63148166A (en) | 1988-06-21 |
Family
ID=17810420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61294643A Pending JPS63148166A (en) | 1986-12-12 | 1986-12-12 | Automatic chemical analyzer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63148166A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1335205A2 (en) * | 2002-02-06 | 2003-08-13 | Hitachi High-Technologies Corporation | Automatic analyzing apparatus |
| EP2045606A2 (en) | 2007-07-20 | 2009-04-08 | Hitachi High-Technologies Corporation | Automated analyzer |
| WO2018221001A1 (en) | 2017-06-02 | 2018-12-06 | 株式会社日立ハイテクノロジーズ | Automatic analyzer and analysis method |
-
1986
- 1986-12-12 JP JP61294643A patent/JPS63148166A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1335205A2 (en) * | 2002-02-06 | 2003-08-13 | Hitachi High-Technologies Corporation | Automatic analyzing apparatus |
| EP1335205A3 (en) * | 2002-02-06 | 2004-04-14 | Hitachi High-Technologies Corporation | Automatic analyzing apparatus |
| EP2045606A2 (en) | 2007-07-20 | 2009-04-08 | Hitachi High-Technologies Corporation | Automated analyzer |
| WO2018221001A1 (en) | 2017-06-02 | 2018-12-06 | 株式会社日立ハイテクノロジーズ | Automatic analyzer and analysis method |
| US11906406B2 (en) | 2017-06-02 | 2024-02-20 | Hitachi High-Tech Corporation | Automatic analyzer and analysis method |
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