JPS63103048A - Temperature-sensitive magnetic material - Google Patents
Temperature-sensitive magnetic materialInfo
- Publication number
- JPS63103048A JPS63103048A JP61247853A JP24785386A JPS63103048A JP S63103048 A JPS63103048 A JP S63103048A JP 61247853 A JP61247853 A JP 61247853A JP 24785386 A JP24785386 A JP 24785386A JP S63103048 A JPS63103048 A JP S63103048A
- Authority
- JP
- Japan
- Prior art keywords
- magnetic material
- temperature
- sensitive magnetic
- heat
- calorific value
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000696 magnetic material Substances 0.000 title claims abstract description 18
- 239000007943 implant Substances 0.000 abstract description 10
- 238000010438 heat treatment Methods 0.000 abstract description 8
- 230000035699 permeability Effects 0.000 abstract description 8
- 230000006698 induction Effects 0.000 abstract description 4
- 230000005674 electromagnetic induction Effects 0.000 abstract description 2
- 238000000015 thermotherapy Methods 0.000 abstract description 2
- 229910045601 alloy Inorganic materials 0.000 description 9
- 239000000956 alloy Substances 0.000 description 9
- 206010028980 Neoplasm Diseases 0.000 description 5
- 229910001252 Pd alloy Inorganic materials 0.000 description 5
- 229910000676 Si alloy Inorganic materials 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- VLJQDHDVZJXNQL-UHFFFAOYSA-N 4-methyl-n-(oxomethylidene)benzenesulfonamide Chemical compound CC1=CC=C(S(=O)(=O)N=C=O)C=C1 VLJQDHDVZJXNQL-UHFFFAOYSA-N 0.000 description 1
- 241000766026 Coregonus nasus Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 229910018054 Ni-Cu Inorganic materials 0.000 description 1
- 229910018481 Ni—Cu Inorganic materials 0.000 description 1
- 229910001260 Pt alloy Inorganic materials 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229910021340 platinum monosilicide Inorganic materials 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
Landscapes
- Radiation-Therapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、物体内部の局所加熱に係り、高周波電磁誘導
により発熱する発熱量の大きい感温磁性材料に関する。DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to local heating inside an object, and relates to a temperature-sensitive magnetic material that generates a large amount of heat due to high-frequency electromagnetic induction.
（従来の技術及び発明が解決しようとする問題点）人体
にわける悪性腫瘍（以下！１１！瘍という）の治療手段
として、ａ熱蒸法がある。この療法において、生体組織
の温度を４１℃ないしは４５℃に上界きせると、治療効
果が現れることが知られている。Ｍｆｉｉ烏が体表面に
ある場合は、温湯なとでｆｆ接あたためる方ｌムがある
。しかしながら、腫瘍が生体深部にある場合は、高周波
誘導加温あるいは電波により加温する方法が考えられて
いる。高周波誘導加温の方法とは、腫瘍内部に感温磁性
材料で作製された針（以下インブラントという）を埋込
み、外部コイルに高周波磁場を印加し、インブラントに
誘導７ｒｉ流を発生ざせて、そのジュール熱であたため
る方法である。しかし、高周波誘導加温を利用して、人
体のｍ瘍を治療する臨床例はなく、現在のところ、動物
実験による研究の段階である。最近、インブラントとし
て、Ｎｉ−Ｐｄ合金を使用した小動物のＦＡ瘍の治療効
果に関する報告がなきれな（小林達也、木田義久、太田
昌幸、田中孝幸、景山ｉｆ街、小林弘明、雨宮好文 Ｎ
ｅｕｒｏｌ、 Ｗｅｄ。(Prior Art and Problems to be Solved by the Invention) As a means of treating malignant tumors (hereinafter referred to as !11! tumors) in the human body, there is a thermal vaporization method. In this therapy, it is known that a therapeutic effect appears when the temperature of living tissue is raised to 41°C or 45°C. If the Mfii crow is on the surface of the body, there is a way to warm it up with warm water. However, if the tumor is located deep within the body, methods of heating using high-frequency induction heating or radio waves have been considered. The high-frequency induction heating method involves implanting a needle made of a temperature-sensitive magnetic material (hereinafter referred to as an implant) inside the tumor, applying a high-frequency magnetic field to an external coil, and generating an induced 7ri current in the implant. This is a method of heating using Joule heat. However, there are no clinical examples of using high-frequency induction heating to treat m-cancer in humans, and this is currently at the stage of research based on animal experiments. Recently, there have been many reports on the therapeutic efficacy of FA tumors in small animals using Ni-Pd alloy as an implant (Tatsuya Kobayashi, Yoshihisa Kida, Masayuki Ota, Takayuki Tanaka, Kageyama Ifgai, Hiroaki Kobayashi, Yoshifumi Amemiya N.
eurol, Wed.
Ｃｈｉｒ、 （Ｔｏｋｙｏ） ２６（１９８６）１１６
）。この報告では、直径が約８ｃ＠の小型発振コイルと
１００ワツトの出力を持つ発振器を使用し、良好な治療
効果を得たことが記載されている。しかしながら、人体
内部の１［１ｉの治療では、少なくとも、直径３０ｃｍ
以上のコイルが必要となることと、人体内部の血流によ
る熱放散があることを、考慮すると、旧−Ｐｄ合金で
を使用した場合、インブラントの発熱量が小といために
、１００キロワット以上の出力を持つ発Ｍｕが必要とな
る。そのほかにも、Ｎｉ−Ｃｕあるいは旧−Ｓｉ合金を
インブラントとして使用した報告例もある。しかし、こ
れらの合金もＮｉ−Ｐｄ合金と同様に発ＰＡ量が小きい
。従って発熱量の大きい感温磁性材料が必要になってい
る。Chir, (Tokyo) 26 (1986) 116
). This report states that good therapeutic effects were obtained using a small oscillation coil with a diameter of about 8 cm and an oscillator with an output of 100 watts. However, for treatment of 1 [1i inside the human body, at least 30 cm in diameter
Taking into consideration the need for more coils and the heat dissipation due to the blood flow inside the human body, when using an old-Pd alloy, the heat output of the implant is small, so the power output is 100 kW or more. An emitter Mu with an output of is required. In addition, there are reports of Ni-Cu or old-Si alloys being used as implants. However, like the Ni-Pd alloy, these alloys also generate a small amount of PA. Therefore, there is a need for temperature-sensitive magnetic materials that generate a large amount of heat.
（問題点を解決するための手段）
インブラントの発熱量はコイルの磁場と周波数ならびに
材料の比透磁率と比抵抗の大きざによって変化する。材
料の比透磁率が大きいほど発熱量は大きくなる。しかし
、比抵抗の値は、義電流の浸透深ざがインブラントの直
径の４分の１程度になるような値を持つことが必要であ
る。試算によれば、直径１■のインブラントを使用して
、周波数が１００ｋｌｌｚで、比透磁率が４０である場
合、最も発ＭＪｉｔの大きくなる比抵抗の値は１２５ｕ
Ω−Ｃ■である。従って、この比抵抗の値に近いほど発
熱量は大きくなる。このように、発熱量の大きい感温磁
性材料は透磁率が大きいことと、比抵抗が適当な値であ
ることが必要である。(Means for solving the problem) The amount of heat generated by the implant changes depending on the magnetic field and frequency of the coil, as well as the relative magnetic permeability and specific resistance of the material. The greater the relative magnetic permeability of the material, the greater the amount of heat generated. However, the value of the resistivity must be such that the depth of penetration of the positive current is approximately one quarter of the diameter of the implant. According to trial calculations, when using an implant with a diameter of 1 mm, the frequency is 100 kllz, and the relative permeability is 40, the value of resistivity that produces the largest MJit is 125 u.
Ω-C■. Therefore, the closer the resistivity is to the value, the greater the amount of heat generated. As described above, a temperature-sensitive magnetic material that generates a large amount of heat needs to have high magnetic permeability and appropriate resistivity.
本発明のＦｅ−ＰｔとＦｅ−Ｐｔ−Ｓｉ合金は前述の条
件を具備した感温磁性材料である。すなわち透磁率が大
きく、適当な比抵抗の値をもち、発熱量の大きい感温磁
性材料として、ｐｔが２３．５〜３８．５原子χで、残
部が実質的にＦｅよりなり、発熱量の大きい感温磁性材
料およびＰｔが２３．５〜３８．５原子２で、Ｓｉが０
．１〜１５．５原子駕で、残部が実質的にＦｅよりなり
、発熱量の大きい感温磁性材料をえたものである。The Fe--Pt and Fe--Pt--Si alloys of the present invention are temperature-sensitive magnetic materials that meet the above-mentioned conditions. In other words, as a temperature-sensitive magnetic material with high magnetic permeability, appropriate resistivity value, and large calorific value, pt is 23.5 to 38.5 atoms χ, the remainder is substantially composed of Fe, and the calorific value is low. Large temperature-sensitive magnetic material and Pt 23.5-38.5 atoms 2 and Si 0
．． This is a temperature-sensitive magnetic material that has 1 to 15.5 atoms, the remainder being substantially Fe, and has a large calorific value.
（実施例） 以下に、本発明を実施例により具体的に説明する。(Example) The present invention will be specifically explained below using examples.
純度９９．９％以上のＦｅ、 Ｐｔ１Ｓｉを使用し、ア
ルゴンガス雰囲気中で溶解し、１１００℃で均一化焼鈍
して得られたインゴットより、直径１ｍ−１長ざ１０１
の円柱棒を切り出して、針を作製した。これらの針を８
００℃から１１００℃の範囲の温度より炉中にて、ある
いは水中に冷却して、比透磁率（μ）と比抵抗（ρ）の
測定を行った。そして、高周波磁場１７ガウス、周波数
１６７ｋｌｌｚで、直径１５０１のコイルを使用して、
上界温度を開穿し、単位体積当りの発熱量Ｑ（ワット／
ＣＣ）を算出した。Using Fe and PtSi with a purity of 99.9% or more, an ingot with a diameter of 1 m and a length of 101
A needle was made by cutting out a cylindrical rod. 8 these needles
The relative magnetic permeability (μ) and specific resistance (ρ) were measured by cooling in a furnace or in water from a temperature in the range of 00°C to 1100°C. Then, using a coil with a diameter of 1501 mm and a high frequency magnetic field of 17 gauss and a frequency of 167 kllz,
Open the upper limit temperature and calculate the calorific value Q per unit volume (Watts/
CC) was calculated.
第１表にＦｅ−Ｐｔ合金の実施例を示す。比較のため、
Ｆｅ６ｏＰｔ４ｏおよび従来のＮｉ−Ｐｄ合金の例を示
す。Table 1 shows examples of Fe-Pt alloys. For comparison,
Examples of Fe6oPt4o and conventional Ni-Pd alloys are shown.
表かられかるように、本発明例の感温磁性材料は第
１ 表
従来のＮｉ−Ｐｄ合金よりも発熱量が大きい。２３．５
から２６．５原子Ｘの合金は炉冷によるのが好ましく、
２６．５から３８．５原子鬼の合金は水冷によるのが好
ましい。ｐｔが３９原子駕を越えると発熱量は減少し好
ましくない。As can be seen from the table, the temperature-sensitive magnetic material of the present invention example
1 Table: Larger calorific value than conventional Ni-Pd alloys. 23.5
It is preferable that alloys with 26.5 atoms
Alloys of 26.5 to 38.5 atoms are preferably water cooled. If pt exceeds 39 atoms, the calorific value decreases, which is not preferable.
第２表にＦｅ−Ｐｔ−Ｓｉ合金の実施例を示す。Ｓｉが
１５．５原子Ｘ以下の合金は発熱量が大きく感温磁性材
料として好ましい。この合金は発熱量の大きいＦｅ−Ｐ
ｔ合金を基として発明きれた合金であり、Ｓｉの添加に
よって、透磁率は変化が少なく、比抵抗が増加し、発熱
量が大きくなっている。従って、第２表に示す実施例以
外のｐｔの組成を持つ合金も、ＳＩを添加することによ
って、比抵抗が増加して発熱量は大きくなる。なおＦｅ
−Ｐｔ−５ｔ合金は主として水冷することが好ましい。Table 2 shows examples of Fe-Pt-Si alloys. An alloy containing 15.5 atoms of Si or less (X) has a large calorific value and is preferable as a temperature-sensitive magnetic material. This alloy is Fe-P, which has a large calorific value.
This is an alloy that was invented based on the t-alloy, and by adding Si, the magnetic permeability does not change much, the specific resistance increases, and the amount of heat generated increases. Therefore, when SI is added to alloys having PT compositions other than the examples shown in Table 2, the specific resistance increases and the calorific value increases. Furthermore, Fe
-Pt-5t alloy is preferably mainly water-cooled.
（発明の効果）
本発明の感温磁性材料は発熱量が従来の感温磁性材料の
２倍から３倍近く大きく、インブラントとして高周波請
導加温による温熱療法に利用でき、その効果は著しい。(Effect of the invention) The temperature-sensitive magnetic material of the present invention has a calorific value nearly two to three times greater than that of conventional temperature-sensitive magnetic materials, and can be used as an implant for thermotherapy using high-frequency conduction heating, and its effects are remarkable. .
特許出願人 松 井 正 顯 清 水 利 文 小林達也Patent applicant: Tadashi Matsui Written by Kiyomizu Ri Tatsuya Kobayashi
Claims (1)
にＦｅよりなり、発熱量の大きい感温磁性材料。 ２、Ｐｔが２３．５〜３８．５原子％で、Ｓｉが０．１
〜１５．５原子％で、残部が実質的にＦｅよりなり、発
熱量の大きい感温磁性材料。[Scope of Claims] 1. A temperature-sensitive magnetic material containing 23.5 to 38.5 atomic % of Pt, with the remainder substantially consisting of Fe, and having a large calorific value. 2. Pt is 23.5 to 38.5 at%, Si is 0.1
A temperature-sensitive magnetic material with a content of ~15.5 atomic %, the remainder being substantially Fe, and having a large calorific value.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61247853A JPS63103048A (en) | 1986-10-19 | 1986-10-19 | Temperature-sensitive magnetic material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61247853A JPS63103048A (en) | 1986-10-19 | 1986-10-19 | Temperature-sensitive magnetic material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63103048A true JPS63103048A (en) | 1988-05-07 |
| JPH0443971B2 JPH0443971B2 (en) | 1992-07-20 |
Family
ID=17169625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61247853A Granted JPS63103048A (en) | 1986-10-19 | 1986-10-19 | Temperature-sensitive magnetic material |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63103048A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990001939A1 (en) * | 1988-08-19 | 1990-03-08 | Meito Sangyo Kabushiki Kaisha | Agent for thermotherapy |
-
1986
- 1986-10-19 JP JP61247853A patent/JPS63103048A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990001939A1 (en) * | 1988-08-19 | 1990-03-08 | Meito Sangyo Kabushiki Kaisha | Agent for thermotherapy |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0443971B2 (en) | 1992-07-20 |
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