JPS6253655A - Steam sterilization of semipermeable membrane module - Google Patents
Steam sterilization of semipermeable membrane moduleInfo
- Publication number
- JPS6253655A JPS6253655A JP60194435A JP19443585A JPS6253655A JP S6253655 A JPS6253655 A JP S6253655A JP 60194435 A JP60194435 A JP 60194435A JP 19443585 A JP19443585 A JP 19443585A JP S6253655 A JPS6253655 A JP S6253655A
- Authority
- JP
- Japan
- Prior art keywords
- module
- steam
- semipermeable membrane
- membrane module
- sterilization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、半透膜モジュールを蒸気滅菌するとき、モジ
エールをセットした装置系内を予め、加湿気体で加圧し
、系内の水分を追い出した後、滅菌温度の蒸気を系内に
導入することよりなるモジュールの蒸気滅菌方法に関す
るものである。[Detailed Description of the Invention] [Field of Industrial Application] The present invention, when steam sterilizing a semipermeable membrane module, pressurizes the equipment system in which the module is set with humidified gas in advance to drive out moisture in the system. The present invention relates to a method for steam sterilizing a module, which comprises introducing steam at a sterilization temperature into the system after the sterilization process has been completed.
半透膜を用いた分離方法は、熱を加えることなく、分離
、濃縮を実施することができ、かつ、閉回路で酸素の影
響を防ぎながら操作ができる。そのため、この方法は、
熱や酸素による影響の大きい食品工業分野等に近年多く
用いられるようになった。すなわち、茶汁・野菜ジュー
スの濃縮、大豆ホエー処理、乳業、製糖、卵白濃縮、澱
粉製造、製あん、味噌ｅ醤油製造、食用油精製等広くオ
ＩＪ用されている。Separation methods using semipermeable membranes can perform separation and concentration without applying heat, and can be operated in a closed circuit while preventing the influence of oxygen. Therefore, this method
In recent years, it has come to be widely used in the food industry, which is heavily influenced by heat and oxygen. That is, it is widely used for tea juice/vegetable juice concentration, soybean whey processing, dairy industry, sugar production, egg white concentration, starch production, bean paste production, miso/soy sauce production, edible oil refining, etc.
食品工業においては、衛生的で安全な製品を供給するこ
とは絶対的使命であり、従って、この分野で半透膜およ
びそのモジー−ルを使用する場合、菌の発生、繁殖を防
止するため、定期的に滅菌作業を行なわなければならな
い。それも、装置、配管類を分解移動することなく、そ
の場で洗浄、すなわち、定置洗浄（ｃｌｅａｎ ｉｎ
ｐｌａｃｅ、 ＣＩＰ ）ができる方法を考える必要が
ある。In the food industry, it is an absolute mission to supply hygienic and safe products. Therefore, when semipermeable membranes and their modules are used in this field, it is necessary to prevent the generation and proliferation of bacteria. Sterilization must be carried out regularly. It is also possible to clean the equipment and piping on the spot without disassembling and moving them, that is, cleaning in place.
place, CIP).
半透膜モジュールのＣＩＰにおける滅菌方法としては、
薬剤滅菌 、蒸気滅菌等がある。The CIP sterilization method for semipermeable membrane modules is as follows:
There are chemical sterilization, steam sterilization, etc.
薬剤滅菌方法としては、塩素、二酸化塩素、次亜塩素酸
ナトリウム、次亜塩素酸カルシウム、ソルビン酸、ソル
ビン酸カリウム、過酸化水素、ヨードホルム、ホルマリ
ン等の薬品の水溶液を用いるもので、滅菌効果はすぐれ
ているが、半透膜材料の耐薬品性、滅菌作業終了後の水
洗不充分による薬品残留、薬品取扱い時の安全、薬品廃
液の処理、薬品のコスト等いろいろな問題がある。Chemical sterilization methods use aqueous solutions of chemicals such as chlorine, chlorine dioxide, sodium hypochlorite, calcium hypochlorite, sorbic acid, potassium sorbate, hydrogen peroxide, iodoform, and formalin, but the sterilization effect is However, there are various problems such as the chemical resistance of the semipermeable membrane material, chemical residue due to insufficient water washing after sterilization, safety when handling chemicals, treatment of chemical waste, and cost of chemicals.
本発明の対象である蒸気滅菌方法は、１００〜１３０℃
の温度の蒸気を半透膜モジー−ルに通気するもので、薬
剤滅菌方法のような問題はないが、欠点としては蒸気通
気時に半透膜が破れたシ、モジュールが破損したすする
ことによジ、半透膜モジュールとしての機能を失うこと
である。熱履歴のみであれば、１３０℃前後の温度に耐
える半透膜は、最近では、いくつかの報告が見られるが
、膜モジーールまたは、それを用いた装置の場合は例を
見ない。The steam sterilization method that is the subject of the present invention
This method ventilates steam at a temperature of Otherwise, it loses its function as a semipermeable membrane module. Recently, there have been some reports of semipermeable membranes that can withstand temperatures of around 130° C. in terms of thermal history alone, but there are no examples of membrane modules or devices using them.
半透膜モジュールを蒸気滅菌する場合、半透膜を破損す
る原因としては、系内の水分及び蒸気の凝縮した水分の
突沸、さらＫは、それらの水分による蒸気流路の閉塞に
起因する半透膜モジュール内でのハンマリング等が考え
られる。When steam sterilizing a semipermeable membrane module, the causes of damage to the semipermeable membrane include bumping due to moisture in the system and condensed moisture from steam; Possible causes include hammering within the membrane module.
本発明の目的は、これらの問題を解決し、半透膜性能を
劣化させない半透膜モジー−ルの蒸気滅菌方法を提供す
ることＫある。An object of the present invention is to solve these problems and provide a method for steam sterilizing a semipermeable membrane module without degrading the performance of the semipermeable membrane.
本発明者らは、半透膜モジー−ルを破損することなく、
蒸気滅菌する方法について、裡々検討した結果、次の発
明に至った。The present inventors have discovered that without damaging the semipermeable membrane module,
As a result of careful consideration of methods for steam sterilization, the following invention was achieved.
すなわち、本発明は、半透膜モジエールをセットした装
置系内を予め、加湿気体で加圧し、系内の水分を追い出
した後、滅菌温度の蒸気を系内に導入する蒸気滅菌方法
である。That is, the present invention is a steam sterilization method in which the inside of an apparatus system in which a semipermeable membrane module is set is pressurized with humidified gas in advance to drive out moisture in the system, and then steam at sterilization temperature is introduced into the system.
この場合、系内の圧力は、滅菌温度の蒸気圧よシも高く
し、膜面での蒸気の凝満１水の再蒸発による突沸を防止
する。In this case, the pressure in the system is made higher than the vapor pressure at the sterilization temperature to prevent bumping due to vapor condensation and re-evaporation of water on the membrane surface.
また、用いる気体は乾燥していると、膜が乾燥し劣化し
てしまうので、加湿する必要がある。湿度は相対湿度で
５０％以上が望ましい。更に、気体の種類は空気、Ｎ３
、Ｈｅ、 Ａｒ 等膜への影響及び安全上から問題のな
いものを用いる。Furthermore, if the gas used is dry, the membrane will dry and deteriorate, so it is necessary to humidify it. The humidity is preferably 50% or more in terms of relative humidity. Furthermore, the types of gas are air, N3
, He, Ar, etc., which do not affect the membrane or cause any safety problems, are used.
以上のようにして、蒸気滅菌によるモジュールの破損を
よう少なく出来たので、以下に実施例を用いて説明する
。In the manner described above, damage to the module due to steam sterilization was minimized, and will be described below using examples.
モジュールの機能劣化の程度は、易開昭６０−２０１３
５に記載されているポリビニルアルコール（以下ＰＶＡ
と称する）と反応性染料（以下りと称する）との反応生
成物（以下ＰＶＡ−Ｄと称する）の５００ ｐｐｍ水溶
液を用いて除去率で測定した。The degree of functional deterioration of the module is from 1983 to 2013.
Polyvinyl alcohol (hereinafter referred to as PVA) described in 5.
The removal rate was measured using a 500 ppm aqueous solution of a reaction product (hereinafter referred to as PVA-D) of a reactive dye (hereinafter referred to as PVA-D) and a reactive dye (hereinafter referred to as PVA-D).
テストフローは第１図に示した。The test flow is shown in Figure 1.
実施例１゜
モジュールとして、ダイセル化学工業■製耐熱性管型限
外濾過モジュールＤＭＨ−２５０、膜グレードＤＵＳ−
４０（分画分子量４０，０００以上、ポリエーテルサル
ホン膜）を用いて蒸気滅菌テストを行なった。Example 1 As a module, a heat-resistant tubular ultrafiltration module DMH-250 manufactured by Daicel Chemical Industries, Ltd., membrane grade DUS-
A steam sterilization test was conducted using 40 (molecular weight cut-off of 40,000 or more, polyether sulfone membrane).
蒸気滅菌方法は、次の通シである。The steam sterilization method is as follows.
■ モジニールに２．０ Ｋｇ／ｃｒｄの加湿空気を又
、■を開いて導入し、３０分間放置した後、モジュール
内の残留水を透過水として鳩を開いて排出するＯ
■ 透過水がほとんど出なくなったのを確認した後、Ｐ
ｉが２．０ Ｋｇ／ｃｍ”になるように■、Ｖ２、ｖ４
を閉じる。■ Introduce humidified air of 2.0 Kg/crd into the module by opening ■. After leaving it for 30 minutes, open the module to discharge the remaining water as permeated water. ■ Most of the permeated water comes out. After confirming that it is gone, press P.
■, V2, v4 so that i is 2.0 Kg/cm"
Close.
■ 蒸気の圧力を調圧弁で２．０ Ｋｇ／ａｍ” に
し、翼、鳩を開いてモジュールに蒸気を導入する。■ Set the steam pressure to 2.0 Kg/am" using the pressure regulating valve, open the wings and doves, and introduce steam into the module.
■ 隅、ηを調節し、下記のような圧力、温度とした。■ The corner and η were adjusted to obtain the pressure and temperature as shown below.
圧力（Ｋσｃｍ” ） 温 度（℃）モジュール入
口 ２．０ １３２モジユ一ル濃縮側出口
１．９ １２９モジユ一ル透過側出
口 １．７ １２８■ ■の条件で３
０分間滅菌する。Pressure (Kσcm”) Temperature (°C) Module inlet 2.0 132 module concentration side outlet 1.9 129 module permeation side outlet 1.7 128 ■ 3 under the conditions of ■
Sterilize for 0 minutes.
■ 滅菌後、透過側出口圧が、濃縮側出口圧よシ高くな
らないように、徐々に■、■のバルブを開き■、屁を閉
じる。■ After sterilization, gradually open the valves ■ and ■ and close the fart so that the outlet pressure on the permeate side does not become higher than the outlet pressure on the concentrate side.
■ ■でモジュール入口、出口の温度が１００℃以下に
なつたら、加湿空気を徐々にモジュール内に導入し、モ
ジュールを室温まで冷却する。② When the temperature at the module inlet and outlet becomes 100°C or less in ②, humidified air is gradually introduced into the module to cool the module to room temperature.
■〜■を１サイクルとして、５０回繰シ返した。The cycles ① to ① were repeated 50 times.
実験後ＰＶＡ−Ｄにより、モジュールの洩れチェックを
行なりたが、ＰＶＡ−Ｄ（原水５００ ｐｐｍ）の排除
率は９９．９％以上であった。After the experiment, the module was checked for leaks using PVA-D, and the rejection rate of PVA-D (raw water 500 ppm) was 99.9% or more.
比較例１゜
実施例１と同じ型式、グレードのモジュールを用いて、
モジュール内に極、■を開いて、調圧弁で１．７ Ｋｇ
／Ｃｍ” にした蒸気を導入した。この場合部、へを
徐々に開にし、モジュール内の水を追い出した後、隔、
■を調節し、下記のような圧力、温度とした。Comparative Example 1゜Using a module of the same type and grade as Example 1,
Open the pole in the module and use the pressure regulating valve to weigh 1.7 kg.
/Cm" steam was introduced. In this case, after the water in the module was expelled by gradually opening the
(2) was adjusted to obtain the pressure and temperature as shown below.
圧力（Ｋｇ／ｃｍ２） 温 度（℃）モジエール
入 口 １．７ １２８モジユ一ル濃
縮側出口 １．６ １２７モジユ一ル
透過側出口 １．５ １２５上記条件
で、３０分間滅菌し、実施例１のようにＰＶＡ−Ｄによ
り、チェックした結果、５回で排除率は９５％まで低下
した。Pressure (Kg/cm2) Temperature (℃) Mosier
Inlet 1.7 128 module concentration side outlet 1.6 127 module permeate side outlet 1.5 125 Sterilized under the above conditions for 30 minutes and checked with PVA-D as in Example 1. After 5 trials, the elimination rate decreased to 95%.
、第１し］は、本発明の実施例に用いたテストフローで
ある。
■、・・・加湿空気導入弁
■２・・・モジュール人口弁
ｖ３・・・モジュール濃縮側出口弁
Ｖ４・・・モジュール透過側山口弁
■、・・・蒸気導入弁
ｖ６・・・モジュール透過側圧板弁
ｖ７・・・蒸気元調圧弁
Ｐｉ・・・モジュール入口圧力計
Ｐｏ・・・モジュール濃縮側出口圧力計Ｐｆ・・・モジ
ュール透過側出口圧力計Ｔｉ・・・モジエール入口温度
計
Ｔｏ・・・モジュール濃縮側出口温度計Ｔｆ・・・モジ
ュール透過側出口温度計Ｍ・・・モジュール, No. 1] is a test flow used in an embodiment of the present invention. ■,...Humidified air introduction valve ■2...Module population valve v3...Module concentration side outlet valve V4...Module permeation side Yamaguchi valve■,...Steam introduction valve v6...Module permeation side pressure Plate valve v7...Steam source pressure regulating valve Pi...Module inlet pressure gauge Po...Module concentration side outlet pressure gauge Pf...Module permeation side outlet pressure gauge Ti...Mosier inlet thermometer To... Module concentration side outlet thermometer Tf...Module permeation side outlet thermometer M...Module
Claims (4)
加湿気体で加圧し、系内の水分を追い出した後、滅菌温
度の蒸気を系内に導入することよりなる半透膜モジュー
ルの蒸気滅菌方法。(1) In advance, check the inside of the device system in which the semipermeable membrane module is set.
A method for steam sterilizing a semipermeable membrane module, which comprises applying pressure with humidified gas to expel moisture from the system, and then introducing steam at a sterilization temperature into the system.
気が半透膜モジュール内を流れたときの圧力損失ΔＰの
和よりも大（Ｐ＞Ｐ＿ｖ＋ΔＰ）であることを特徴とす
る特許請求の範囲第１項記載の半透膜モジュールの蒸気
滅菌方法。(2) A patent claim characterized in that the pressure P of the humidified gas is greater than the sum of the steam pressure P_v at the sterilization temperature and the pressure loss ΔP when the steam flows through the semipermeable membrane module (P>P_v+ΔP) A method for steam sterilization of a semipermeable membrane module according to item 1.
を特徴とする特許請求の範囲第１項記載の半透膜モジュ
ールの蒸気滅菌方法。(3) The method for steam sterilizing a semipermeable membrane module according to claim 1, wherein the humidifying gas is air, N_2, He, or Ar.
徴とする特許請求の範囲第１項記載の半透膜モジュール
の蒸気滅菌方法。(4) The method for steam sterilizing a semipermeable membrane module according to claim 1, wherein the relative humidity of the humidifying gas is 50% or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60194435A JPS6253655A (en) | 1985-09-03 | 1985-09-03 | Steam sterilization of semipermeable membrane module |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60194435A JPS6253655A (en) | 1985-09-03 | 1985-09-03 | Steam sterilization of semipermeable membrane module |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6253655A true JPS6253655A (en) | 1987-03-09 |
Family
ID=16324550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60194435A Pending JPS6253655A (en) | 1985-09-03 | 1985-09-03 | Steam sterilization of semipermeable membrane module |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6253655A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013137027A1 (en) * | 2012-03-16 | 2013-09-19 | 東レ株式会社 | Method for sterilizing separation-membrane module, method for producing chemical using continuous fermentation, and membrane-separation-type continuous fermentation device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61242604A (en) * | 1985-04-18 | 1986-10-28 | Asahi Chem Ind Co Ltd | Steam sterilization method for filtration device |
-
1985
- 1985-09-03 JP JP60194435A patent/JPS6253655A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61242604A (en) * | 1985-04-18 | 1986-10-28 | Asahi Chem Ind Co Ltd | Steam sterilization method for filtration device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013137027A1 (en) * | 2012-03-16 | 2013-09-19 | 東レ株式会社 | Method for sterilizing separation-membrane module, method for producing chemical using continuous fermentation, and membrane-separation-type continuous fermentation device |
| JPWO2013137027A1 (en) * | 2012-03-16 | 2015-08-03 | 東レ株式会社 | Separation method for separation membrane module, method for producing chemicals by continuous fermentation, and membrane separation type continuous fermentation apparatus |
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