JPS6239510A - External preparation for skin - Google Patents
External preparation for skinInfo
- Publication number
- JPS6239510A JPS6239510A JP60178068A JP17806885A JPS6239510A JP S6239510 A JPS6239510 A JP S6239510A JP 60178068 A JP60178068 A JP 60178068A JP 17806885 A JP17806885 A JP 17806885A JP S6239510 A JPS6239510 A JP S6239510A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- vitamin
- extract
- spleen
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は皮膚外用剤、ざらに詳しくは肌荒れ防止、肌荒
れ改善のほか、皮膚のたるみ、つやの消失などを防いで
老化を防止する効果の高い皮膚外用剤に関する。[Detailed Description of the Invention] [Field of Industrial Application] The present invention is a skin external preparation, more specifically, it is highly effective in preventing skin roughness, improving skin roughness, and preventing aging by preventing skin sagging and loss of luster. Regarding skin external preparations.
［従来の技術１
皮膚外用剤には種々の薬効剤が配合され、肌荒れ防止効
果は薬効の１つであり、肌荒れ防止、肌荒れ改善効果の
ある薬効剤は待望されている。従来、ビタミンＥ又はビ
タミンＥ誘導体が肌荒れ改善に用いられてきたが、その
効果はいまだ十分でなく効果を期待するには、およばな
かった。[Prior Art 1] External skin preparations contain various medicinal agents, and the effect of preventing rough skin is one of the medicinal effects, and a medicinal agent that has the effect of preventing and improving skin roughness is long-awaited. Conventionally, vitamin E or vitamin E derivatives have been used to improve rough skin, but their effects have not yet been sufficient to meet expectations.
［発明が解決しようとする問題点］
本発明者らはビタミンＥ又はその誘導体の肌荒れ防止、
肌荒れ改善のほか、皮膚のたるみ、つやの消失などを防
いで老化を防止する効果を高める方法はないものかと鋭
意研究した結果、ビタミンＥ又はその誘導体と、哺乳類
の肝臓又は脾臓からの水抽出物とを組合せることによっ
て、この目的が達成できることを見出して本発明を完成
するに至った。[Problems to be Solved by the Invention] The present inventors have used vitamin E or its derivatives to prevent rough skin,
In addition to improving rough skin, we conducted extensive research to find a way to prevent skin sagging and loss of luster, thereby increasing the effect of preventing aging. The present invention was completed by discovering that this object can be achieved by combining the following.
［問題点を解決するための手段］
すなわち、本発明はビタミンＥおよびビタミンＥ誘導体
の１種又は２種以上と、哺乳類の肝臓又は脾臓からの水
抽出物とを配合することを特徴とする皮膚外用剤を提供
するものである。[Means for Solving the Problems] That is, the present invention provides a skin care product which is characterized by blending one or more of vitamin E and vitamin E derivatives with an aqueous extract from the liver or spleen of a mammal. It provides external preparations.
以下、本発明の構成について詳述する。Hereinafter, the configuration of the present invention will be explained in detail.
本発明に使用されるビタミンＥは、下記に示す構造を有
する。Vitamin E used in the present invention has the structure shown below.
また、ビタミンＥ誘導体としては、ビタミンＥアセテー
ト、ビタミンＥニコチネート、ビタミンＥコハク酸塩、
ビタミンＥリルイン酸塩等が挙げられる。In addition, vitamin E derivatives include vitamin E acetate, vitamin E nicotinate, vitamin E succinate,
Examples include vitamin E riruphosphate.
本発明におけるビタミンＥ又はその誘導体の配合量は皮
膚外用剤全量中、０．００５〜２重量％、好ましくは０
．０１〜１重量％で、ざらに好ましくは、０．０５〜０
．５重量％である。ｏ、ｏｏｓ重量％未満では、効果を
十分に発揮できない。The amount of vitamin E or its derivative in the present invention is 0.005 to 2% by weight, preferably 0.005 to 2% by weight, based on the total amount of the skin external preparation.
．． 01 to 1% by weight, preferably 0.05 to 0
．． It is 5% by weight. If the amount is less than o, oos weight percent, the effect cannot be sufficiently exhibited.
一本発明で用いる抽出物は牛、豚等の哺乳類の肝臓又は
脾臓から水にて抽出された抽出物である。One extract used in the present invention is an extract extracted with water from the liver or spleen of mammals such as cows and pigs.
脾臓の水抽出物はリバイタリン又はリバイタリンーＰ（
ペンタファーム社製）として知られ、このものが最も好
ましい。Spleen water extract is Revitalin or Revitalin-P (
(manufactured by Pentafirm), and this is the most preferred.
抽出は常法に従って行えば良いが、−例を挙げると次の
通りである。Extraction may be carried out according to conventional methods, for example as follows.
新１群な牛の冷凍脾臓を粉砕し、６０℃以上の熱水で１
時間以上かげて抽出し、ざらに８０℃以上で１０分間以
上加熱した後、濾過し濃縮する。濃縮物にエチルアルコ
ールを加えて除蛋白を行いざらに濾過して清澄化する。The frozen spleen of a new group of cows is crushed and soaked in hot water of 60℃ or higher.
Extract for more than 1 hour, heat roughly at 80°C or more for 10 minutes or more, then filter and concentrate. Ethyl alcohol is added to the concentrate to remove protein, and the concentrate is coarsely filtered and clarified.
次に分離限界分子量２０００のキャピラリー・メンプラ
ン濾過系を用い限外濾過を行う。このようにして得られ
た水抽出物中に含まれている水溶性の低分子有効成分の
分子量は約１００〜１０ 、０００の範囲にある。Next, ultrafiltration is performed using a capillary membrane filtration system with a separation limit molecular weight of 2000. The water-soluble low-molecular active ingredients contained in the water extract thus obtained have a molecular weight in the range of about 100 to 10,000.
本発明における肝臓又は脾臓の水抽出物の配合量は、乾
燥残渣で皮膚外用剤全量中０．００１〜２重量％、好ま
しくは０．００５〜１重量％で、ざらに好ましくは、０
．０１〜０．５重量％である。０．００１重量％未満で
は、本発明の効果が発揮されない。The amount of the aqueous extract of liver or spleen in the present invention is 0.001 to 2% by weight, preferably 0.005 to 1% by weight, and more preferably 0.001 to 2% by weight, preferably 0.005 to 1% by weight, based on the total amount of the skin external preparation as a dry residue.
．． 01 to 0.5% by weight. If the amount is less than 0.001% by weight, the effects of the present invention will not be exhibited.
本発明の皮膚外用剤は前記の必須成分に加えて必要に応
じて、本発明の効果を損なわない範囲で、化粧品、医薬
品等に一般に用いられる各種成分、すなわち水性成分、
粉末成分、油分、界面活性剤、保湿剤、増粘剤、防腐剤
、酸化防止剤、香料、色材、紫外線吸収剤、薬剤等を配
合することがてきる。また本発明の皮膚外用剤の剤型は
任意であり、例えば化粧水等の可溶化系、乳液、クリー
ム等の乳化系あるいは軟膏、分散液粉末製品などの剤型
をとることができる。In addition to the above-mentioned essential ingredients, the external skin preparation of the present invention may optionally contain various ingredients commonly used in cosmetics, pharmaceuticals, etc., i.e., aqueous ingredients, to the extent that the effects of the present invention are not impaired.
Powder components, oils, surfactants, humectants, thickeners, preservatives, antioxidants, fragrances, coloring materials, ultraviolet absorbers, drugs, etc. can be blended. Further, the dosage form of the skin external preparation of the present invention is arbitrary, and can be, for example, a solubilized system such as a lotion, an emulsified system such as a milky lotion or a cream, or a dosage form such as an ointment or a dispersion powder product.
［実施例］
つぎに、実施例によって本発明をざらに詳細に説明する
。なお、本発明は、これによって限定されるものではな
い。配合量は重量％である。[Example] Next, the present invention will be roughly described in detail with reference to Examples. Note that the present invention is not limited to this. The blending amount is in weight%.
実施例１ クリーム
Ａ、ステアリン酸 １０．０ステ
アリルアルコール ４．０ステアリン酸ブ
チル ８．０ステアリン酸モノ
グリセリンエステル ２．０
ビタミンＥアセテート ０．５香料
０．４防腐剤
適量Ｂ、プロピレングリコール
１０．０牛牌臓の水抽出物
２．０グリセリン ４．０水
酸化カリウム ０．４エデト酸三
ナトリウム ０．０５精製水
残余Ａの油相部とＢの水相部をそれ
ぞれ７０’Ｃに加熱し完全溶解する。Ａ相をＢ相に加え
て、乳化機で乳化する。乳化物を熱交換機を用いて冷却
してクリームを得た。Example 1 Cream A, stearic acid 10.0 Stearyl alcohol 4.0 Butyl stearate 8.0 Stearic acid monoglycerin ester 2.0 Vitamin E acetate 0.5 Fragrance
0.4 preservative
Adequate amount B, propylene glycol
10.0 Beef viscera water extract
2.0 Glycerin 4.0 Potassium hydroxide 0.4 Trisodium edetate 0.05 Purified water
The remaining oil phase part A and water phase part B are each heated to 70'C to completely dissolve them. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain cream.
比較例 １
実施例１から牛脾臓の水抽出物を除いた以外は全て実施
例１と同様にして比較例１を得た。Comparative Example 1 Comparative Example 1 was obtained in the same manner as in Example 1 except that the aqueous extract of bovine spleen was removed.
比較例 ２
実施例１からビタミンＥアセテートを除いた以外は全て
実施例１と同様にして比較例２を得た。Comparative Example 2 Comparative Example 2 was obtained in the same manner as in Example 1 except that vitamin E acetate was removed.
肌荒れ防止、肌荒れ改善効果試験
女性健康人（顔面）の皮膚表面形態をミリスチン樹脂に
よるレブリ男法を用いて肌のレプリカを採り顕微鏡（１
７倍）にて観察した。すなわち反収の状態および角層の
剥離状態から表−１に示す基準に基づいて肌荒れ評価１
．２と判断された者（肌荒れパネル）３０名を用い、顔
面左右半々に、実施例１、比較例１、比較例２で得たク
リームを１日２回塗布した。２週間後再びレプリカを採
り肌の状態を観察し、表−１の判断基準に従って評価し
た。Skin roughness prevention and skin improvement effect test The skin surface morphology of a healthy female person (face) was taken using the Revli method using myristic resin and a replica of the skin was taken using a microscope (1
Observation was made at 7x magnification. In other words, rough skin evaluation 1 based on the criteria shown in Table 1 from the state of recovery and the state of peeling of the stratum corneum.
．． The creams obtained in Example 1, Comparative Example 1, and Comparative Example 2 were applied twice a day to the left and right half of the face of 30 people who were judged to have skin irritation of 2 (rough skin panel). Two weeks later, a replica was taken again and the condition of the skin was observed and evaluated according to the criteria in Table 1.
（１丁余白） 表−１ （以下余 白） 結果を表−２に示す。(1 page margin) Table-1 (Left below) The results are shown in Table-2.
表−２
この結果よりビタミンＥアセテートと哺乳類の脾臓から
の水抽出物とを配合したクリームを使用した顔面部位は
、他のクリームを使用した顔面部位と比較し、顕著な肌
荒れ防止・肌荒れ改善効果が認められた。Table 2 The results show that facial areas treated with a cream containing vitamin E acetate and aqueous extract from mammalian spleen have a significant effect on preventing and improving skin roughness compared to facial areas using other creams. was recognized.
（以下余白）
実施例２ クリーム
Ａ、セタノール ４．０ワセ
リン ７．０イソプロピル
ミリステート８．０
スクワラン １５．０ステア
リン酸モノ
グリセリンエステル ２．２
ＰＯＥ （２０モル）ソルビタン
モノステアレート ２．８
ビタミンＥニコチネート２．０
パントテニルエチルエーテル ０．０５香料
０．３酸化防止剤
適量防門剤
適量Ｂ、グリセリン
１ｏ、０ジプロピレングリコール ５
．０牛牌臓の水抽出物 ０．０２エ
デト酸二ナトリウム ０．０１精製水
残余実施例１に４じてク
リームを得た。(Left below) Example 2 Cream A, Cetanol 4.0 Vaseline 7.0 Isopropyl myristate 8.0 Squalane 15.0 Stearic acid monoglycerol ester 2.2 POE (20 mol) Sorbitan monostearate 2.8 Vitamin E Nicotinate 2.0 Pantothenyl ethyl ether 0.05 Flavor
0.3 antioxidant
Appropriate amount of barrier agent
Appropriate amount B, glycerin
1o,0 dipropylene glycol 5
．． 0 Bovine spleen water extract 0.02 Edetate disodium 0.01 Purified water
The rest of Example 1 was repeated to obtain a cream.
実施例３ 乳液
Ａ、スクワラン ５．０オレ
イルオレート ３．０ワセリン
２．０ソルビタンセスキ
オレイン酸エステル ０．８ポリオキシエチレン（２０
モん）
オレイルエーテル １．２
ビタミンＥコハク酸塩 ０．３香料
０．３防腐剤
適量Ｂ、１．３ブチレングリコー
ル ５．０牛牌臓の水抽出物
１．５エタノール
３．０力ルボキシビニルボルリマ−０，２
水酸化カリウム ０．１へキサメ
タリン酸ナトリウム ０．０５精製水
残余実施例１に準じて乳液を得た
。Example 3 Emulsion A, squalane 5.0 oleyl oleate 3.0 petrolatum
2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene (20
Mon) Oleyl ether 1.2 Vitamin E succinate 0.3 Fragrance
0.3 preservative
Appropriate amount B, 1.3 Butylene glycol 5.0 Bovine giblet water extract
1.5 ethanol
3.0 Ruboxyvinylborrimer 0.2 Potassium hydroxide 0.1 Sodium hexametaphosphate 0.05 Purified water
A milky lotion was obtained according to the rest of Example 1.
実施例４ ファンデーション
Ａ、セタノール ３．５脱臭
ラノリン ４．０ホホバ油
５．０ワセリン
２．０スクワラン
６．０ステアリン酸モノ
グリセリンエステル ２．５
ＰＯＥ （６０モル）硬化ヒマシ油 １．
５ＰＯＥ （２０モル）セチルエーテル
１．０ビタミンＥリノール酸塩 ０．１防
腐剤 適量香料
０．３Ｂ、プロピレングリコー
ル １０．０牛肝臓の水抽出物
２．０調合粉末
１２．０エデト酸三ナトリウム ０．
２精製水 残余実施例１に
準じてファンデーションを得た。Example 4 Foundation A, Setanol 3.5 Deodorized lanolin 4.0 Jojoba oil
5.0 Vaseline
2.0 squalane
6.0 Stearic acid monoglycerin ester 2.5 POE (60 mol) Hydrogenated castor oil 1.
5POE (20 mol) Cetyl ether
1.0 Vitamin E linoleate 0.1 Preservatives Appropriate amount of fragrance
0.3B, propylene glycol 10.0 Beef liver water extract
2.0 blended powder
12.0 Trisodium edetate 0.
2 Purified Water A foundation was obtained according to the remainder of Example 1.
実施例５ 化粧水
Ａ、エタノール ５．０ＰＯ
Ｅ （２０モル）オレイル
アルコールエーテル ２．０
２−エチルへキシル−Ｐ−ジメチル
アミノベンゾエート０．１８
ビタミンＥアセテ−）−０，００５
香料 ０．０５Ｂ、１
．３−ブチレングリコール １０．０牛牌臓
の水抽出物 ０．０２グリセリン
５．０アスコルビン酸
０．４精製水
残余Ａのアルコール相をＢの水相に添加し、可溶化し
て化粧水を得た。Example 5 Lotion A, ethanol 5.0PO
E (20 mol) Oleyl alcohol ether 2.0 2-ethylhexyl-P-dimethylaminobenzoate 0.18 Vitamin E acetate-0,005 Fragrance 0.05B, 1
．． 3-Butylene glycol 10.0 Bovine giblet water extract 0.02 Glycerin
5.0 ascorbic acid
0.4 Purified water
The remaining alcohol phase of A was added to the aqueous phase of B and solubilized to obtain a lotion.
実施例６ 軟膏
ビタミンＥアセテート０．５
牛脾臓の水抽出物 １．０ステアリ
ルアルコール １８．０モクロウ
２０．０ポリオキシエチレン（１０
モル）
モノオレイン酸エステル ０．２５
グリセリンモノ
ステアリン酸エステル ０．２５
ワセリン ４０．０精製水
残余製法
牛脾臓の水抽出物を精製水に加え（水相）、他の成分を
７０℃にて混合溶解する（油相）。水相に油相を加え、
ホモミキサーで均一に乳化後冷却して軟膏を得た。Example 6 Ointment Vitamin E acetate 0.5 Bovine spleen water extract 1.0 Stearyl alcohol 18.0 Mokuro
20.0 polyoxyethylene (10
Mol) Monooleic acid ester 0.25 Glycerin monostearic acid ester 0.25 Vaseline 40.0 Purified water
Residue production method Add the aqueous extract of bovine spleen to purified water (aqueous phase), and mix and dissolve the other ingredients at 70°C (oil phase). Add the oil phase to the water phase,
The mixture was uniformly emulsified using a homomixer and cooled to obtain an ointment.
［発明の効果］
本発明の皮膚外用剤は、「ｍ乳類の肝臓又は牌猾からの
水抽出物を配合することにより、ビタミンＥ又はその誘
導体の持つ肌荒れ防止、肌荒れ改善効果、皮膚のたるみ
、つやの消失などを防いで老化を防止する効果を副作用
なく著しく増加きせることかできる利点を持っている。[Effects of the Invention] The skin external preparation of the present invention has the effect of preventing rough skin, improving skin roughness, and sagging skin, which vitamin E or its derivatives have, by blending water extracts from the liver or chinensis of mammals. It has the advantage of significantly increasing the anti-aging effect by preventing loss of luster, etc., without any side effects.
Claims (1)
と、哺乳類の肝臓又は脾臓からの水抽出物とを配合する
ことを特徴とする皮膚外用剤。1. A skin preparation for external use, comprising one or more of vitamin E and vitamin E derivatives, and an aqueous extract from mammalian liver or spleen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60178068A JPS6239510A (en) | 1985-08-13 | 1985-08-13 | External preparation for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60178068A JPS6239510A (en) | 1985-08-13 | 1985-08-13 | External preparation for skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6239510A true JPS6239510A (en) | 1987-02-20 |
Family
ID=16042051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60178068A Pending JPS6239510A (en) | 1985-08-13 | 1985-08-13 | External preparation for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6239510A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5398391A (en) * | 1992-07-31 | 1995-03-21 | Yokochi; Tokio | Wire connection member for strung beads ornaments |
| JP2009235039A (en) * | 2008-03-28 | 2009-10-15 | Kobayashi Pharmaceut Co Ltd | Composition containing basidiomycete extract and pig liver extract |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4955676A (en) * | 1972-10-03 | 1974-05-30 | ||
| JPS56501403A (en) * | 1979-11-28 | 1981-10-01 | ||
| JPS5916816A (en) * | 1982-07-16 | 1984-01-28 | Lion Corp | Composition for external use |
| JPS6064909A (en) * | 1983-09-20 | 1985-04-13 | Shiseido Co Ltd | Cosmetic |
| JPS6064908A (en) * | 1983-09-20 | 1985-04-13 | Shiseido Co Ltd | Cosmetic |
-
1985
- 1985-08-13 JP JP60178068A patent/JPS6239510A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4955676A (en) * | 1972-10-03 | 1974-05-30 | ||
| JPS56501403A (en) * | 1979-11-28 | 1981-10-01 | ||
| JPS5916816A (en) * | 1982-07-16 | 1984-01-28 | Lion Corp | Composition for external use |
| JPS6064909A (en) * | 1983-09-20 | 1985-04-13 | Shiseido Co Ltd | Cosmetic |
| JPS6064908A (en) * | 1983-09-20 | 1985-04-13 | Shiseido Co Ltd | Cosmetic |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5398391A (en) * | 1992-07-31 | 1995-03-21 | Yokochi; Tokio | Wire connection member for strung beads ornaments |
| JP2009235039A (en) * | 2008-03-28 | 2009-10-15 | Kobayashi Pharmaceut Co Ltd | Composition containing basidiomycete extract and pig liver extract |
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