JPS6230018B2 - - Google Patents
Info
- Publication number
- JPS6230018B2 JPS6230018B2 JP1826478A JP1826478A JPS6230018B2 JP S6230018 B2 JPS6230018 B2 JP S6230018B2 JP 1826478 A JP1826478 A JP 1826478A JP 1826478 A JP1826478 A JP 1826478A JP S6230018 B2 JPS6230018 B2 JP S6230018B2
- Authority
- JP
- Japan
- Prior art keywords
- belt conveyor
- container
- cooling
- conveyor
- cylindrical container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000007710 freezing Methods 0.000 claims description 37
- 230000008014 freezing Effects 0.000 claims description 37
- 239000007788 liquid Substances 0.000 claims description 33
- 238000001816 cooling Methods 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 15
- 238000005192 partition Methods 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 15
- 239000000126 substance Substances 0.000 description 13
- 239000003708 ampul Substances 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 230000007246 mechanism Effects 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 239000007921 spray Substances 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 239000011344 liquid material Substances 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000005096 rolling process Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000008155 medical solution Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Drying Of Solid Materials (AREA)
Description
【発明の詳細な説明】
本発明は薬液等の液状物を凍結するにあたり、
液状物を瓶、アンプル如き円筒状容器に収容した
後、これを回転して、液状物を容器内で薄層とし
て凍結する方法とその装置に関するものである。[Detailed Description of the Invention] The present invention provides the following steps for freezing liquid substances such as medicinal solutions.
The present invention relates to a method and an apparatus for storing a liquid substance in a cylindrical container such as a bottle or an ampoule, and then rotating the container to freeze the liquid substance as a thin layer within the container.
薬液等の液状物はその保存のため、凍結乾燥処
理によつて粉末化が行われている。即ち該処理は
通常、被処理液状物を急速に冷却凍結固化した
後、真空下で品質を害さない程度の温度で加熱し
て昇華現象に近い状態で水分を除き乾燥している
のが一般的である。そして薬液等はその品質の管
理の必要性からアンプル、薬瓶に収容した後これ
を急速に凍結固化し、ついで乾燥工程を経て直ち
に密封する方法が行われているが、前記凍結工程
における凍結効率の向上及び後工程の乾燥工程に
おける効率の向上のため、あるいは各工程処理時
間の短縮のためアンプルや薬瓶に収容した薬液を
瓶内で薄層として凍結することが有利であること
から薄層凍結方法が採用されている。そして従来
のこの種凍結方法は薬液を収容したアンプルや瓶
を、冷却機構を備えた凍結室内で、高速回転する
ターンテーブルに所定数量直立あるいは傾斜せし
めて載置し、ターンテーブルの高速回転によつて
生じる遠心力でアンプルや瓶内の薬液に回転（ス
ピン）を与え、この結果薬液がアンプルや瓶内の
内壁に沿つて上昇分散して薄層となり、その間に
冷却機構により薬液を冷却凍結するものである。
しかるにこのような従来の方法では均一な薄層状
態とするには高速回転を必要とし、このため、薬
液の流動が激しく凍結効率の向上のためには好ま
しくなく、又構造上、処理がバツチ方式となり、
一回の処理が装置規模により限られた数量にとど
まつていた。 In order to preserve liquid substances such as medicinal solutions, they are pulverized by freeze-drying. In other words, the process usually involves rapidly cooling, freezing, and solidifying the liquid material to be treated, then heating it under vacuum at a temperature that does not impair quality, removing moisture in a state similar to sublimation, and drying it. It is. Due to the need for quality control, medical solutions are placed in ampoules or medicine bottles, then rapidly frozen and solidified, followed by a drying process and immediately sealed. However, the freezing efficiency of the freezing process is It is advantageous to freeze a medicinal solution contained in an ampoule or vial as a thin layer in the bottle in order to improve the efficiency of the drying process in the subsequent process, or to shorten the processing time of each process. Freezing method is used. In the conventional freezing method of this type, a predetermined number of ampoules or bottles containing drug solutions are placed upright or tilted on a high-speed rotating turntable in a freezing chamber equipped with a cooling mechanism. The resulting centrifugal force gives rotation (spin) to the medicinal solution in the ampoule or bottle, and as a result, the medicinal solution rises and disperses along the inner wall of the ampoule or bottle, forming a thin layer, during which time the cooling mechanism cools and freezes the medicinal solution. It is something.
However, in such conventional methods, high-speed rotation is required to form a uniform thin layer, which causes the chemical solution to flow rapidly, which is not desirable for improving freezing efficiency, and due to the structure, processing is not possible in batches. Then,
The amount that can be processed at one time is limited due to the scale of the equipment.
本発明は上述の如き現状に鑑み発明されたもの
で、その特徴は薬液を収容する容器が円筒状であ
ることを巧みに利用し、液状物を収容した円筒容
器を入口、出口を有して冷却されている断熱材壁
よりなる冷却凍結室内に前記入口より搬送し、前
記容器の底部を口部より低く位置するように傾斜
して横倒した状態を維持しながら前記冷却された
冷却室内を転動せしめながら出口に向けて搬送
し、収容した液体を容器内壁に沿つて薄層としつ
つ冷却凍結せしめて出口より円筒容器を連続して
搬出せしめるようにした方法と、これを連続処理
し得るようにした装置とを提供し、これにより従
来の方法の欠点を解決し連続化処理を可能とした
ものである。 The present invention was invented in view of the above-mentioned current situation, and its feature is that it skillfully utilizes the fact that the container containing the liquid drug is cylindrical, and that the cylindrical container containing the liquid has an inlet and an outlet. The container is transported through the inlet into a cooled freezing chamber made of a heat insulating wall, and is rolled inside the cooled cooling chamber while keeping the container tilted and laid down so that the bottom of the container is located lower than the mouth. A method in which the cylindrical container is conveyed while moving toward the outlet, and the contained liquid is cooled and frozen while forming a thin layer along the inner wall of the container, and the cylindrical container is continuously carried out from the outlet, and a method that enables continuous processing. The present invention provides an apparatus that solves the drawbacks of conventional methods and enables continuous processing.
以下本発明の実施態様を図により詳細に説明す
る。 Embodiments of the present invention will be described in detail below with reference to the drawings.
図において、１は断熱材壁２に囲繞された冷却
凍結室、３，４は冷却凍結室１の長手方向の両端
部にそれぞれ開口している入口開口及び出口開口
である。５は冷却凍結室１内に設けた冷却機構
で、一般に使用されている機械式冷凍機の蒸発器
あるいは液体窒素の如き無害な極低温液化ガスを
冷媒として直接噴霧する冷却機構でも良く適宜選
択して設置することが可能である。説明の都合上
ここでは液体窒素の如き低温液化ガスを直接噴霧
する冷却機構として述べる。即ち６は多数の噴出
ノズル７を設けてなる噴霧管で、その上端部は断
熱材壁２を気密に貫通して外部にのび、温度によ
つて開閉作動する制御弁８を介して低温液化ガス
たとえば液体窒素貯槽（図示せず）に連結してい
る。又９は温度検知素子、１０は温度検知素子９
よりの信号を受けて冷却凍結室１内の温度をある
特定の低温度に冷却維持するため、制御弁８を開
閉作動せしめる信号を送る温度設定制御器であ
る。そして温度検知素子９、温度設定制御器１０
及び制御弁８は導線１１で連結されている。 In the figure, 1 is a cooling/freezing chamber surrounded by a heat insulating wall 2, and 3 and 4 are an inlet opening and an outlet opening at both ends of the cooling/freezing chamber 1 in the longitudinal direction. Reference numeral 5 denotes a cooling mechanism installed in the cooling/freezing chamber 1, which may be an evaporator of a commonly used mechanical refrigerator or a cooling mechanism that directly sprays harmless cryogenic liquefied gas such as liquid nitrogen as a refrigerant, and may be appropriately selected. It is possible to install the For convenience of explanation, a cooling mechanism that directly sprays low-temperature liquefied gas such as liquid nitrogen will be described here. In other words, 6 is a spray pipe provided with a large number of spray nozzles 7, the upper end of which passes through the insulation wall 2 in an airtight manner and extends to the outside, and the low-temperature liquefied gas is supplied through a control valve 8 that opens and closes depending on the temperature. For example, it is connected to a liquid nitrogen storage tank (not shown). Further, 9 is a temperature detection element, and 10 is a temperature detection element 9.
This is a temperature setting controller that sends a signal to open and close the control valve 8 in order to maintain the temperature inside the cooling/freezing chamber 1 at a certain low temperature in response to a signal from the freezing chamber 1. And temperature detection element 9, temperature setting controller 10
and the control valve 8 are connected by a conducting wire 11.
１２は回転用ベルトコンベヤで、その端部がそ
れぞれ入口開口３及び出口開口４に通じるよう
に、駆動手段（図示せず）に連結されているロー
ラ１３，１３′に懸架しかつ巾方向に傾斜した状
態を保つて冷却凍結室１内に設置されている。１
４は前記回転ベルトコンベヤ１２の低端に位置す
るベルトの巾端部に沿つて設けられた堰壁ストツ
パーである。 Reference numeral 12 designates a rotating belt conveyor, which is suspended from rollers 13 and 13' connected to a drive means (not shown) and inclined in the width direction so that its ends communicate with the inlet opening 3 and the outlet opening 4, respectively. It is installed in the cooling/freezing chamber 1 to maintain the same state. 1
4 is a weir wall stopper provided along the width end of the belt located at the lower end of the rotary belt conveyor 12.
１５は搬送用ベルトコンベヤ（あるいはチエー
ンコンベヤ）で、前記回転用ベルトコンベヤの上
方にこれと並行して駆動手段（図示せず）に連結
されているローラ（あるいはギヤ）１６，１６′
に懸架されている。そして搬送用ベルトコンベヤ
（あるいはチエーンコンベヤ）１５には、適宜な
間隔を保持して複数の搬送用バー１７が設けられ
ている。そして該複数の搬送用バー１７の先端は
搬送用ベルトコンベヤ１５の回転によつて、回転
用ベルトコンベヤ１２上に面した時、回転用ベル
トコンベヤ１２上を巾方向に仕切り壁を形成して
小室Ａ，A′，A″……を区劃して進行するよう壁
状板１８を形成している。１９は被処理薬液等の
液状物２０を収容したアンプルあるいは瓶の如き
円筒状容器である。 Reference numeral 15 denotes a conveying belt conveyor (or chain conveyor), and rollers (or gears) 16, 16' are connected above and parallel to the rotating belt conveyor to a driving means (not shown).
is suspended. The conveyor belt conveyor (or chain conveyor) 15 is provided with a plurality of conveyor bars 17 at appropriate intervals. When the tips of the plurality of conveyor bars 17 face the rotary belt conveyor 12 by the rotation of the conveyor belt conveyor 15, they form a partition wall in the width direction on the rotary belt conveyor 12 to form a small compartment. A wall-like plate 18 is formed so as to move forward while dividing A, A', A''... 19 is a cylindrical container such as an ampoule or a bottle containing a liquid material 20 such as a chemical solution to be treated. .
上述の如く構成された本発明の装置は以下の如
く運転操作される。 The apparatus of the present invention constructed as described above is operated as follows.
まず噴霧管６に、温度検知素子９により凍結室
１内の温度を検出し温度設定制御器１０を介して
制御弁８を開閉作動せしめて、貯槽（図示せず）
より液体窒素の如き低温液化ガスを供給し、噴霧
ノズル７より凍結室１内に液体窒素を噴霧して、
凍結室１内の温度を低い温度好ましくは−30℃以
下の温度に保持する。続いて回転用ベルトコンベ
ヤ１２及び搬送用ベルトコンベヤ１５をそれぞれ
駆動手段（図示せず）により駆動する。そしてこ
の回動進行方向は、回転ベルトコンベヤ１２はそ
のベルトの上面１２ａの移動が出口開口４より入
口開口３に向けて進むように、又搬送用ベルトコ
ンベヤ１５は前記回転ベルトコンベヤ１２の上面
ベルト１２ａと面して移動するいわゆる搬送用ベ
ルトコンベヤの下面１５ｂが入口開口３より出口
開口４に向けて進むように駆動する。即ち回転用
ベルトコンベヤ１２の上面ベルト１２ａと搬送用
ベルトコンベヤ１５の下面ベルト１５ｂとは相対
向する進行方向（実質的には回転ドラム１３，１
３′と１６，１６′とは同じ回転方向）に駆動す
る。この結果搬送用ベルトコンベヤ１５に固着し
て設けた複数の搬送用バー１７は回転用ベルトコ
ンベヤ１２の傾斜した上面１２ａ上を小室Ａ、
A′、A′………に区劃した状態を保つて回転ベル
トコンベヤ１２と逆方向に入口開口３より出口開
口４に向けて進行する。 First, the temperature inside the freezing chamber 1 is detected by the temperature detection element 9 and the control valve 8 is opened and closed via the temperature setting controller 10 in the spray pipe 6.
A low temperature liquefied gas such as liquid nitrogen is supplied, and the liquid nitrogen is sprayed into the freezing chamber 1 from the spray nozzle 7.
The temperature inside the freezing chamber 1 is maintained at a low temperature, preferably -30°C or lower. Subsequently, the rotating belt conveyor 12 and the conveying belt conveyor 15 are each driven by driving means (not shown). The rotating direction of the rotating belt conveyor 12 is such that the upper surface 12a of the belt moves from the outlet opening 4 toward the inlet opening 3, and the conveying belt conveyor 15 is arranged so that the upper surface 12a of the belt moves from the outlet opening 4 to the entrance opening 3. The lower surface 15b of a so-called transport belt conveyor, which moves facing the conveyor belt 12a, is driven so as to advance from the inlet opening 3 toward the outlet opening 4. That is, the upper belt 12a of the rotary belt conveyor 12 and the lower belt 15b of the conveyor belt conveyor 15 are arranged in opposing traveling directions (substantially the rotating drums 13, 1
3' and 16, 16' are driven in the same rotational direction). As a result, the plurality of conveyor bars 17 fixedly provided on the conveyor belt conveyor 15 move over the inclined upper surface 12a of the rotary belt conveyor 12 into the small chamber A,
A′, A′ .
つぎに薬液の如き液状物２０を収容したアンプ
ルや瓶等の円筒状容器１９を、入口開口３より冷
却凍結室１内に、巾方向に傾斜する回転ベルトコ
ンベヤ１２にしたがつて口部を底部より高く位置
するように横倒して導入する。そして搬送用ベル
トコンベヤ１５の回動によつて搬送用バー１７の
壁状板１８が円筒状容器１９を引懸け、巾方向に
傾斜する回転用ベルトコンベヤ１２上に運び、ベ
ルトの巾方向に円筒状容器１９の口部を高く、底
部を低くして堰壁ストツパー１４に支持されて回
転用ベルトコンベヤ１２の上面１２ａ上に、複数
の搬送用バー１７の壁状板１８によつて仕切られ
た小室Ａ、A′、A″………に１個づつ区分されて
載置される。そして円筒状容器１９入口開口３よ
りは横倒した傾斜状態を維持されて、搬送用バー
１７によつて押動されて移動すると共にこれと対
向して駆動する回転用ベルトコンベヤ１２によつ
て転動回転が付与される。即ち横倒した円筒状容
器１９は第３図乃至第５図に示す如く搬送用バー
１７の壁状板１８で支持されているので回転ベル
トコンベヤ１２の進行により、該ベルトコンベヤ
１２によつて矢印の方向に転動し、この結果円筒
状容器１９中の薬液の如き液状物２０は重力によ
り円筒状容器１９の回転方向とは逆方向に流動す
る。そして更に回転を付与することにより液状物
２０は円筒状容器１９はその筒状内壁に沿つて均
一に分散して薄層を形成しながら出口開口４より
連続して搬出される。なお均一な薄層を形成する
ために付与すべき回転数は、被処理液状物の粘性
等の物性によつて異なるが、通常の薬液では10〜
80回／分の回転数でよい。そしてこのような回転
数を変化させるには、単に回転ベルトコンベヤ１
２の進行速度を変化調節することによつて容易に
実施することが出来る。又回転する円筒状容器１
９は口部より底部を低く位置して傾斜して横倒し
てあるので、回転移動を与えても収容した液状物
２０は口部より飛散することはない。そして回転
数を多くして回転することにより口部より飛散す
る虞がある場合には、回転用ベルトコンベヤ１２
の巾方向の傾斜角度を適宜調節すればよく、この
場合ドラム１３，１３′の角度を調整すればよ
い。 Next, a cylindrical container 19 such as an ampoule or a bottle containing a liquid substance 20 such as a medicinal solution is placed into the cooling/freezing chamber 1 through the inlet opening 3, and the opening is moved toward the bottom of the rotating belt conveyor 12 which is inclined in the width direction. Install it on its side so that it is positioned higher. Then, as the conveyor belt conveyor 15 rotates, the wall plate 18 of the conveyor bar 17 hooks the cylindrical container 19 and carries it onto the rotary belt conveyor 12 inclined in the width direction. A shaped container 19 has a high opening and a low bottom, is supported by a weir wall stopper 14, and is placed on the upper surface 12a of the rotary belt conveyor 12 and partitioned by a wall plate 18 of a plurality of conveyor bars 17. The containers are placed one by one in the small chambers A, A', A'', etc.Then, the cylindrical container 19 is maintained in a horizontally inclined state from the inlet opening 3, and is pushed by the transport bar 17. The cylindrical container 19 is moved and rotated by the rotating belt conveyor 12, which is driven opposite to the belt conveyor 12. That is, the cylindrical container 19, which is laid down on its side, is moved by the conveyor bar as shown in FIGS. 3 to 5. 17 is supported by a wall plate 18, and as the rotary belt conveyor 12 advances, the belt conveyor 12 rolls in the direction of the arrow, and as a result, the liquid 20, such as a medicinal solution, in the cylindrical container 19 is Due to gravity, the liquid 20 flows in the opposite direction to the direction of rotation of the cylindrical container 19. By further applying rotation, the liquid 20 is uniformly dispersed along the inner wall of the cylindrical container 19 to form a thin layer. The number of rotations that should be applied to form a uniform thin layer varies depending on the physical properties such as viscosity of the liquid to be treated, but for normal chemical liquids, it is continuously carried out from the outlet opening 4. ~
A rotation speed of 80 times/minute is sufficient. And to change the rotation speed like this, simply change the rotation belt conveyor 1.
This can be easily carried out by varying and adjusting the advancing speed of step 2. Also rotating cylindrical container 1
Since the container 9 is tilted and laid down with the bottom lower than the mouth, the contained liquid 20 will not scatter from the mouth even if rotated. If there is a risk of scattering from the mouth by rotating at a high rotation speed, the rotating belt conveyor 12
The inclination angle of the drums 13, 13' in the width direction may be adjusted as appropriate, and in this case, the angles of the drums 13, 13' may be adjusted.
かくして回転ベルトコンベヤ１２で回転を付与
された円筒状容器１９内では薬液等の液状物２０
が筒壁に沿つて薄層化し、その間搬送用ベルトコ
ンベヤ１５の駆動により、複数の搬送用バー１７
が前記円筒状容器１９を引懸けて入口開口３よ
り、出口開口４に向けて回転ベルトコンベヤ１２
上に沿つて冷却凍結室１内を搬送する。この結
果、液の薄層化の回転を、入口より出口へ向けて
搬送する転動移送に使用し得る。そして前記した
如く冷却凍結室１内は低温度（−30℃以下）に保
持されているので、円筒状容器１９が転動されつ
つ入口開口３より出口開口４に達する間に、円筒
状容器１９内の薬液等の液状物２０は均一な薄層
状態で凍結固化されて、出口開口４より搬出さ
れ、次の乾燥工程へと導びかれる。 In this way, inside the cylindrical container 19 rotated by the rotating belt conveyor 12, a liquid such as a medicinal solution 20
becomes a thin layer along the cylindrical wall, and in the meantime, by driving the conveyor belt conveyor 15, a plurality of conveyor bars 17
carries the cylindrical container 19 through the rotary belt conveyor 12 from the inlet opening 3 toward the outlet opening 4.
It is transported inside the cooling and freezing chamber 1 along the top. As a result, the rotation of the thin layer of liquid can be used for rolling transfer from the inlet to the outlet. As described above, since the inside of the cooling/freezing chamber 1 is maintained at a low temperature (-30°C or lower), while the cylindrical container 19 is being rolled and reaches the outlet opening 4 from the inlet opening 3, the cylindrical container 19 The liquid substance 20 such as a chemical solution inside is frozen and solidified in a uniform thin layer, and is carried out from the outlet opening 4 and led to the next drying process.
なお、冷却凍結室１内に円筒状容器１９を滞溜
させる時間即ち凍結時間は被処理液状物の物性あ
るいは冷却凍結室１内の保持温度等により異なる
が、その時間の調節は搬送用ベルトコンベヤ１５
の駆動速度を適宜調節することにより容易に達せ
られる。即ち搬送用ベルトコンベヤ１５を停止す
れば、液状物２０を収容した円筒状容器１９を回
転せしめて冷却凍結室１内に何時間でも滞溜せし
めることが出来るし、又急速に冷却凍結室１内を
通過せしめようとすれば、搬送用ベルトコンベヤ
１５の駆動速度を速めればよい。 Note that the time for which the cylindrical container 19 stays in the cooling/freezing chamber 1, that is, the freezing time, varies depending on the physical properties of the liquid to be treated or the temperature maintained within the cooling/freezing chamber 1, but the time can be adjusted by using the conveyor belt conveyor. 15
This can be easily achieved by adjusting the driving speed appropriately. That is, if the conveyor belt conveyor 15 is stopped, the cylindrical container 19 containing the liquid material 20 can be rotated and retained in the cooling/freezing chamber 1 for many hours, and the interior of the cooling/freezing chamber 1 can be rapidly If you want to make it pass through, you just need to increase the driving speed of the conveyor belt conveyor 15.
本発明は上述した如く、薬液等の液状物をアン
プル、瓶、缶等の円筒状容器に収容して、これを
薄層状にして冷却凍結処理する方法と装置であつ
て、従来の技術の如く薬液等の液状物を収容した
アンプル瓶等を冷凍室内で回転するターンテーブ
ルに直立又は傾斜して載置して、これを高速回転
せしめて遠心作用を生起せしめる方法及び装置と
は異なり、アンプル、瓶、缶等が円筒体であるこ
とを巧みに利用した全く新規な方法及び装置であ
る。即ち回転付与すべきアンプル、瓶、缶等が円
筒体形状であるのでこれを収容した液状物が洩出
しないように傾斜してこれを単に転動することに
より、極めて容易に筒状容器の内壁に沿つて収容
した液状物は薄層化する。従つて従来の方法が遠
心作用を生起する必要上１分間数百回転の高速回
転を必要とするのに対して本発明は１分間数十回
転の回転のみで容易に均一な薄層化が可能とな
る。この結果動力費の節減のみならず、運転操作
が安全となる。そして更に凍結処理を二つのベル
トコンベヤを巧みに利用して、一方を回転用とし
て使用し、他方を搬送用として使用することによ
り、薄層化に必要な回転を搬送のための転動に利
用し得ることによつて従来不可能であつた連続処
理を可能とし、大量の連続処理を可能とするばか
りか、回転ベルトコンベヤの速度を適宜変化させ
ることにより極めて容易に回転数を変化させるこ
とが出来て、各種粘度の異なる液状物を薄層凍結
することにも利用し得るし、又各種液状物の凍結
時間の差異も搬送用ベルトコンベヤの速度を適宜
調整して冷却凍結室内の滞留時間を調節すること
によつて極めて容易に対応して処理し得る等極め
て多くの利点がある。 As described above, the present invention is a method and apparatus for storing a liquid substance such as a medicinal solution in a cylindrical container such as an ampoule, a bottle, or a can, and cooling and freezing it in a thin layer. Unlike the method and apparatus in which an ampoule bottle or the like containing a liquid substance such as a medicinal solution is placed upright or tilted on a rotating turntable in a freezing chamber and rotated at high speed to generate a centrifugal action, an ampoule, This is a completely new method and device that skillfully utilizes the fact that bottles, cans, etc. are cylindrical bodies. That is, since the ampoule, bottle, can, etc. to be rotated is cylindrical, the inner wall of the cylindrical container is very easily rotated by simply rolling the ampoule, bottle, can, etc. at an angle to prevent the liquid contained therein from leaking. The liquid material contained along the line becomes thin. Therefore, while the conventional method requires high-speed rotation of several hundred revolutions per minute to generate centrifugal action, the present invention can easily and uniformly thin the layer by rotating at only several tens of revolutions per minute. becomes. As a result, not only power costs are reduced, but operation becomes safer. Furthermore, by skillfully utilizing two belt conveyors for the freezing process, using one for rotation and the other for conveyance, the rotation necessary for thinning the layer can be used for rolling for conveyance. This makes it possible to perform continuous processing, which was previously impossible, and not only enables continuous processing of large quantities, but also allows the number of rotations to be changed extremely easily by appropriately changing the speed of the rotary belt conveyor. It can also be used to freeze thin layers of liquids with different viscosities, and the residence time in the cooling and freezing chamber can be adjusted to accommodate differences in the freezing times of various liquids by adjusting the speed of the conveyor belt as appropriate. There are numerous advantages, such as the fact that it can be handled very easily by adjustment.
第１図は本発明装置を説明する長手方向縦断面
概略図、第２図は第１図の−線の縦断面概略
図、第３図乃至第５図は本発明の方法による液状
物の薄層化を説明する説明図である。
１は冷却凍結室、３は入口開口、４は出口開
口、５は冷却機構、１２は回転用ベルトコンベ
ヤ、１２ａは回転用ベルトコンベヤの上面、１４
は堰壁ストツパー、１５は搬送用ベルトコンベ
ヤ、１５ｂは搬送用ベルトコンベヤの下面、１７
は搬送用バー、１８は搬送用バーの壁状板、１９
は円筒状容器、２０は液状物である。
Fig. 1 is a schematic longitudinal cross-sectional view for explaining the apparatus of the present invention, Fig. 2 is a schematic longitudinal cross-sectional view taken along the - line in Fig. 1, and Figs. It is an explanatory diagram explaining stratification. 1 is a cooling/freezing chamber, 3 is an inlet opening, 4 is an outlet opening, 5 is a cooling mechanism, 12 is a rotating belt conveyor, 12a is the upper surface of the rotating belt conveyor, 14
15 is the weir wall stopper, 15 is the conveyor belt, 15b is the lower surface of the belt conveyor, 17
is a conveyance bar, 18 is a wall plate of the conveyance bar, 19
is a cylindrical container, and 20 is a liquid substance.
Claims (1)
を付与して円筒容器内壁に沿つて薄層状とし冷却
凍結する方法において、液状物を収容した円筒容
器を入口、出口を有して冷却されている断熱材壁
よりなる冷却凍結室内に前記入口より搬入し、前
記容器の底部を口部より低く位置するように傾斜
して横倒した状態を維持しながら前記冷却された
冷却室内を転動せしめながら出口に向けて搬送
し、収容した液体を容器内壁に沿つて薄層としつ
つ冷却凍結せしめて出口より円筒容器を連続して
搬出せしめるようにしたことを特徴とする薄層凍
結方法。 ２ 内部に冷却手段を備え、入口開口と出口開口
とを有する断熱された冷却凍結室内に、その端部
がそれぞれ前記入口開口と出口開口に通じるよう
配置し、且つ巾方向に傾斜してその低端部に沿つ
て堰壁ストツパーを具備してなる回転用ベルトコ
ンベヤと、該回転用ベルトコンベヤの上方に位置
しかつこれと並行して配置した搬送用ベルトコン
ベヤとを設けると共に、前記搬送用ベルトコンベ
ヤの回動によつて該ベルトコンベヤが回転用ベル
トコンベヤの上面と相対して位置したとき、回転
用ベルトコンベヤ上を小区劃室に仕切つて進行す
る板状仕切壁よりなる複数個の搬送用バーを搬送
用ベルトコンベヤに固着したことを特徴とする薄
層凍結装置。[Scope of Claims] 1. In a method of storing a liquid in a cylindrical container and applying rotation to the liquid to form a thin layer along the inner wall of the cylindrical container and cooling and freezing, the cylindrical container containing the liquid is connected to an inlet, The container is transported through the inlet into a cooling/freezing chamber made of a heat insulating wall that has an outlet and is cooled, and the container is kept tilted and laid down so that the bottom of the container is located lower than the mouth of the container. The cylindrical container is conveyed toward the outlet while being rolled in the cooling chamber, and the contained liquid is cooled and frozen while forming a thin layer along the inner wall of the container, and the cylindrical container is continuously carried out from the outlet. Thin layer freezing method. 2.Inside an insulated cooling/freezing chamber that is equipped with a cooling means and has an inlet opening and an outlet opening, it is arranged so that its ends communicate with the inlet opening and the outlet opening, respectively, and the lower end thereof is inclined in the width direction. A rotating belt conveyor including a weir wall stopper along an end thereof, and a conveying belt conveyor located above and in parallel with the rotating belt conveyor, and the conveying belt When the belt conveyor is positioned opposite to the upper surface of the rotary belt conveyor due to the rotation of the conveyor, a plurality of plate-like partition walls that partition the rotary belt conveyor into small compartments and proceed. A thin layer freezing device characterized by a bar fixed to a conveyor belt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1826478A JPS54110311A (en) | 1978-02-20 | 1978-02-20 | Thin layer freezing method and apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1826478A JPS54110311A (en) | 1978-02-20 | 1978-02-20 | Thin layer freezing method and apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS54110311A JPS54110311A (en) | 1979-08-29 |
| JPS6230018B2 true JPS6230018B2 (en) | 1987-06-30 |
Family
ID=11966804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1826478A Granted JPS54110311A (en) | 1978-02-20 | 1978-02-20 | Thin layer freezing method and apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS54110311A (en) |
-
1978
- 1978-02-20 JP JP1826478A patent/JPS54110311A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS54110311A (en) | 1979-08-29 |
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