JPS62298528A - Troche for remedy of pharyngeal pain - Google Patents
Troche for remedy of pharyngeal painInfo
- Publication number
- JPS62298528A JPS62298528A JP13993586A JP13993586A JPS62298528A JP S62298528 A JPS62298528 A JP S62298528A JP 13993586 A JP13993586 A JP 13993586A JP 13993586 A JP13993586 A JP 13993586A JP S62298528 A JPS62298528 A JP S62298528A
- Authority
- JP
- Japan
- Prior art keywords
- indomethacin
- tablet
- troche
- effect
- remedy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229960000905 indomethacin Drugs 0.000 claims abstract description 19
- 206010068319 Oropharyngeal pain Diseases 0.000 claims description 7
- 201000007100 Pharyngitis Diseases 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 11
- 239000003826 tablet Substances 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 4
- 235000019658 bitter taste Nutrition 0.000 abstract description 3
- 239000002775 capsule Substances 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000000654 additive Substances 0.000 abstract description 2
- 239000011230 binding agent Substances 0.000 abstract description 2
- 239000000796 flavoring agent Substances 0.000 abstract description 2
- 235000003599 food sweetener Nutrition 0.000 abstract description 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 2
- 210000003800 pharynx Anatomy 0.000 abstract description 2
- 239000000843 powder Substances 0.000 abstract description 2
- 239000003765 sweetening agent Substances 0.000 abstract description 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000007937 lozenge Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 244000239659 Eucalyptus pulverulenta Species 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229960001378 dequalinium chloride Drugs 0.000 description 1
- LTNZEXKYNRNOGT-UHFFFAOYSA-N dequalinium chloride Chemical compound [Cl-].[Cl-].C1=CC=C2[N+](CCCCCCCCCC[N+]3=C4C=CC=CC4=C(N)C=C3C)=C(C)C=C(N)C2=C1 LTNZEXKYNRNOGT-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Abstract
Description
【発明の詳細な説明】
3、発明の詳細な説明
(産業上の利用分野)
本発明は咽頭痛治療トローチに関し、更に詳しくはイン
ドメタシンを含有する咽頭痛治療トローチに関する。Detailed Description of the Invention 3. Detailed Description of the Invention (Field of Industrial Application) The present invention relates to a sore throat treatment troche, and more particularly to a sore throat treatment troche containing indomethacin.
(従来の技術)
従来、咽頭痛を治療するトローチには塩化リゾチーム、
塩化デカリニウムなどの薬物が用いられているが、イン
ドメタシンが用いられたことはなかった。(Prior art) Conventionally, lozenges used to treat sore throat include lysozyme chloride,
Drugs such as dequalinium chloride have been used, but indomethacin has never been used.
(発明が解決しようとする問題点)
インドメタシンは有効な抗炎症、鎮痛剤であり、通常は
錠剤、カプセル剤(インドメタシン25+Tg/錠)な
どとして経口投与するか、平割(インドメタシン50■
/個)、軟膏などとして非経口で投与する。(Problem to be Solved by the Invention) Indomethacin is an effective anti-inflammatory and analgesic, and is usually administered orally as tablets, capsules (indomethacin 25+Tg/tablet), or in flat portions (indomethacin 50g/tablet).
/piece), administered parenterally as an ointment, etc.
しかしながら、これは副作用が多く、ことに長期連用す
ると種々の副作用がかなりの頻度で発生するという欠点
がある。However, this has the disadvantage that it has many side effects, and especially when used for a long period of time, various side effects occur quite frequently.
本発明の目的は、効果的で副作用の少ない咽頭痛治療ト
ローチを提供することにある。An object of the present invention is to provide a sore throat treatment troche that is effective and has fewer side effects.
(問題を解決するための手段)
本発明の治療薬は、有効成分として1錠当り3〜10+
ygのインドメタシンを含有する咽頭痛治療トローチで
ある。(Means for Solving the Problem) The therapeutic agent of the present invention contains 3 to 10+ active ingredients per tablet.
This is a sore throat treatment lozenge containing yg of indomethacin.
1錠当りのインドメタシンの含有量が3rrg未満では
十分な治療効果が得られないし、Lomgを超えると副
作用が発現しやすくなるとともに苦みが強くなって実用
に供し難くなる。実用上は5■稈度が好ましい。If the content of indomethacin per tablet is less than 3rrg, a sufficient therapeutic effect cannot be obtained, and if it exceeds Lmg, side effects are likely to occur and the bitterness becomes strong, making it difficult to put it into practical use. Practically speaking, a culm degree of 5 ■ is preferable.
微粉状のインドメタシンを常用の賦形剤、結合剤、甘味
剤、香料その他適当な添加剤などと均一に混和した後、
常法に従い本発明のトローチを製造することができる。After uniformly mixing finely powdered indomethacin with conventional excipients, binders, sweeteners, flavoring agents, and other appropriate additives,
The trochees of the present invention can be manufactured according to conventional methods.
(発明の効果)
本発明のトローチは、インドメタシンが咽頭患部に直接
作用するので、錠剤、カプセル剤、平割などの従来の剤
型に比して著しく少ない量で治療効果を挙げることがで
きる。(Effects of the Invention) In the troche of the present invention, since indomethacin acts directly on the affected area of the pharynx, a therapeutic effect can be achieved with a significantly smaller amount than in conventional dosage forms such as tablets, capsules, and flat splits.
また、その適用による副作用発現のおそれは少なく、イ
ンドメタシン特有の苦味による適用のしにくさもない。Furthermore, there is little risk of side effects occurring when applied, and there is no difficulty in application due to the bitter taste characteristic of indomethacin.
(実施例)
以下、実施例と試験例を挙げて本発明を具体的に説明す
る。(Example) Hereinafter, the present invention will be specifically explained with reference to Examples and Test Examples.
実施例1
微粉末白糖970gを希エタノール110gで湿潤して
顆粒とし、35℃以下で乾燥した後、更に100〜10
5℃で乾燥した。冷却後、これにインドメタシン5gと
乾燥乳糖15gの混合物を加え、更にステアリン酸マグ
ネシウム10gを加えてよく混合した後、打錠機(杵の
直径15I)を用いて打錠し、直径15I1重量1gの
トローチ1000錠を得た。Example 1 970 g of finely powdered white sugar was moistened with 110 g of diluted ethanol to form granules, dried at 35°C or lower, and further granulated with 100 to 10
It was dried at 5°C. After cooling, add a mixture of 5 g of indomethacin and 15 g of dry lactose, and further add 10 g of magnesium stearate and mix well. Obtained 1000 lozenges.
実施例2
微粉末白糖99gを微粉末アラビアゴム0.7gに適当
量の水を加えて練合して均一な糊状の基剤を得た。これ
にインドメタシン0,3gを加えて良く混合した後板状
に延ばし、円盤板状に打抜き、デンプンと微粉末白糖の
混合物をを打粉としてふりかけ、熱風乾燥器(60°C
)で乾燥し、重量1gのトローチ100錠を得た。Example 2 99 g of finely powdered white sugar and 0.7 g of finely powdered gum arabic were mixed with an appropriate amount of water to obtain a uniform pasty base. After adding 0.3 g of indomethacin and mixing well, it was rolled out into a plate shape, punched out into a disc shape, sprinkled with a mixture of starch and finely powdered white sugar as a powder, and dried in a hot air dryer (60°C).
) to obtain 100 troches weighing 1 g.
実施例3
シロップを加熱濃縮して粘稠物とし、その100gをと
ってインドメタシン1gを加えてよく練合して飴状とし
た。これを直径1cmの円形パイプから押し出し、重量
が1gとなるように切断後冷却しトローチ飴(重量t
K ) too個を得た。Example 3 Syrup was heated and concentrated to make it viscous, 100 g of it was taken, 1 g of indomethacin was added, and the mixture was thoroughly kneaded to form a candy. This is extruded through a circular pipe with a diameter of 1 cm, cut into pieces weighing 1 g, and then cooled to make lozenges (weighing t
K) Too pieces were obtained.
試験例
実施例1で調製したトローチを咽頭痛に悩む患者(6〜
45才の男女)17名に投与して、その治療効果を調べ
た所、はとんどすべての患者に効果が認められた。Test Example The lozenge prepared in Example 1 was administered to patients suffering from sore throat (6 to
When the drug was administered to 17 patients (45-year-old men and women) to examine its therapeutic effects, it was found to be effective in almost all patients.
その結果を次表に示す。The results are shown in the table below.
Claims (1)
シンを含有する咽頭痛治療トローチ1) Sore throat treatment troche containing 3 to 10 mg of indomethacin per tablet as an active ingredient
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13993586A JPS62298528A (en) | 1986-06-16 | 1986-06-16 | Troche for remedy of pharyngeal pain |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13993586A JPS62298528A (en) | 1986-06-16 | 1986-06-16 | Troche for remedy of pharyngeal pain |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS62298528A true JPS62298528A (en) | 1987-12-25 |
Family
ID=15257092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13993586A Pending JPS62298528A (en) | 1986-06-16 | 1986-06-16 | Troche for remedy of pharyngeal pain |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS62298528A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03123445A (en) * | 1989-10-07 | 1991-05-27 | Taiyo Kagaku Co Ltd | Food for sustained release of sialic acid |
WO1998052540A1 (en) * | 1997-05-22 | 1998-11-26 | The Boots Company Plc | Pharmaceutical compositions |
JP2009502984A (en) * | 2005-08-02 | 2009-01-29 | ドロサファーム アクチェンゲゼルシャフト | Pharmaceutical composition comprising indomethacin and / or acemetacin |
JP2013064005A (en) * | 2003-09-05 | 2013-04-11 | Arrow No 7 Ltd | Buccal drug delivery |
-
1986
- 1986-06-16 JP JP13993586A patent/JPS62298528A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03123445A (en) * | 1989-10-07 | 1991-05-27 | Taiyo Kagaku Co Ltd | Food for sustained release of sialic acid |
WO1998052540A1 (en) * | 1997-05-22 | 1998-11-26 | The Boots Company Plc | Pharmaceutical compositions |
JP2013064005A (en) * | 2003-09-05 | 2013-04-11 | Arrow No 7 Ltd | Buccal drug delivery |
US8858984B2 (en) | 2003-09-05 | 2014-10-14 | Gelmedic Holding Aps | Buccal drug delivery |
JP2009502984A (en) * | 2005-08-02 | 2009-01-29 | ドロサファーム アクチェンゲゼルシャフト | Pharmaceutical composition comprising indomethacin and / or acemetacin |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR950008769B1 (en) | Swallowable tablet containing polycarbophil | |
JP5074190B2 (en) | Orally rapidly disintegrating tablets | |
WO2005112881A1 (en) | The dispersible montmorillonite tablet and its preparation technology | |
JP2000086537A (en) | Inorganic compound saccharide composition, vehicle, rapidly disintegrating compression molded product, and their production | |
WO2007119792A1 (en) | Dry direct compression fast disintegrating tablet | |
JPS62298528A (en) | Troche for remedy of pharyngeal pain | |
JPH0426618A (en) | Troche | |
TWI343818B (en) | ||
JPH04193823A (en) | Pill readily crushable with teeth and easily administrable without water | |
US3485920A (en) | Analgesic compositions of aspirin and pectin | |
JPWO2005094812A1 (en) | Nateglinide-containing preparation | |
JP2004269513A (en) | Solid preparation | |
JP4519444B2 (en) | Orally disintegrating tablets | |
JPH0491029A (en) | Galenical drug blended chewable tablet | |
US20070092561A1 (en) | Water-Soluble Aspirin Composition | |
JPH1135486A (en) | Solid pharmaceutical preparation | |
RU2240784C1 (en) | Arbidol-base medicinal agent | |
CN101269055B (en) | Ambroxol hydrochloride oral cavity disintegrating tablet and method of producing the same | |
CN113365612B (en) | Method for producing easy-to-take tablet containing ginkgo leaf dry extract | |
UA79567C2 (en) | Orodispersible pharmaceutical composition of antithrombolic compound | |
JPH0276826A (en) | Oral solid preparation | |
JP3545512B2 (en) | Effervescent tablets containing crude drugs | |
JP2002138055A (en) | Intraoral quick disintegration type compression molding and its production method | |
RU2558091C2 (en) | Dispersible tablet of dioctahedral smectite and method for producing it | |
TWI831808B (en) | Pharmaceutical composition in the form of a chewable tablet of diosmin or a flavonoid fraction |