JPS62280297A - Low irritant detergent composition - Google Patents
Low irritant detergent compositionInfo
- Publication number
- JPS62280297A JPS62280297A JP12398886A JP12398886A JPS62280297A JP S62280297 A JPS62280297 A JP S62280297A JP 12398886 A JP12398886 A JP 12398886A JP 12398886 A JP12398886 A JP 12398886A JP S62280297 A JPS62280297 A JP S62280297A
- Authority
- JP
- Japan
- Prior art keywords
- ion
- group
- hydroxyethyl
- salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims description 20
- 239000003599 detergent Substances 0.000 title description 12
- 239000002085 irritant Substances 0.000 title 1
- 231100000021 irritant Toxicity 0.000 title 1
- -1 aliphatic amine ion Chemical class 0.000 claims description 29
- 238000004140 cleaning Methods 0.000 claims description 13
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 10
- 229930195729 fatty acid Natural products 0.000 claims description 10
- 239000000194 fatty acid Substances 0.000 claims description 10
- 229910019142 PO4 Inorganic materials 0.000 claims description 6
- 239000010452 phosphate Substances 0.000 claims description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 230000000774 hypoallergenic effect Effects 0.000 claims description 3
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 2
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 claims description 2
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 229910001413 alkali metal ion Inorganic materials 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 2
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical group CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 2
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229910001414 potassium ion Inorganic materials 0.000 claims description 2
- 229910001415 sodium ion Inorganic materials 0.000 claims description 2
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 description 14
- 102000004169 proteins and genes Human genes 0.000 description 14
- 238000005187 foaming Methods 0.000 description 13
- 238000004925 denaturation Methods 0.000 description 12
- 230000036425 denaturation Effects 0.000 description 12
- 239000002453 shampoo Substances 0.000 description 11
- 108010058846 Ovalbumin Proteins 0.000 description 8
- 229940092253 ovalbumin Drugs 0.000 description 8
- 239000004094 surface-active agent Substances 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 7
- 150000004665 fatty acids Chemical class 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 150000003863 ammonium salts Chemical class 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- 230000007794 irritation Effects 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 235000019864 coconut oil Nutrition 0.000 description 3
- 239000003240 coconut oil Substances 0.000 description 3
- 229940126142 compound 16 Drugs 0.000 description 3
- ZJXZSIYSNXKHEA-UHFFFAOYSA-N ethyl dihydrogen phosphate Chemical compound CCOP(O)(O)=O ZJXZSIYSNXKHEA-UHFFFAOYSA-N 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 3
- 208000017520 skin disease Diseases 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- YJLIKUSWRSEPSM-WGQQHEPDSA-N (2r,3r,4s,5r)-2-[6-amino-8-[(4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1CNC1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O YJLIKUSWRSEPSM-WGQQHEPDSA-N 0.000 description 2
- XASOHFCUIQARJT-UHFFFAOYSA-N 8-methoxy-6-[7-(2-morpholin-4-ylethoxy)imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1-one Chemical compound C(N1C(=O)C2=C(OC)C=C(C=3N4C(=NC=3)C=C(C=C4)OCCN3CCOCC3)C=C2CC1)C(F)(F)F XASOHFCUIQARJT-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- 244000060011 Cocos nucifera Species 0.000 description 2
- 239000004166 Lanolin Chemical class 0.000 description 2
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 229940125904 compound 1 Drugs 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 159000000003 magnesium salts Chemical class 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- UAOUIVVJBYDFKD-XKCDOFEDSA-N (1R,9R,10S,11R,12R,15S,18S,21R)-10,11,21-trihydroxy-8,8-dimethyl-14-methylidene-4-(prop-2-enylamino)-20-oxa-5-thia-3-azahexacyclo[9.7.2.112,15.01,9.02,6.012,18]henicosa-2(6),3-dien-13-one Chemical compound C([C@@H]1[C@@H](O)[C@@]23C(C1=C)=O)C[C@H]2[C@]12C(N=C(NCC=C)S4)=C4CC(C)(C)[C@H]1[C@H](O)[C@]3(O)OC2 UAOUIVVJBYDFKD-XKCDOFEDSA-N 0.000 description 1
- AOSZTAHDEDLTLQ-AZKQZHLXSA-N (1S,2S,4R,8S,9S,11S,12R,13S,19S)-6-[(3-chlorophenyl)methyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound C([C@@H]1C[C@H]2[C@H]3[C@]([C@]4(C=CC(=O)C=C4[C@@H](F)C3)C)(F)[C@@H](O)C[C@@]2([C@@]1(C1)C(=O)CO)C)N1CC1=CC=CC(Cl)=C1 AOSZTAHDEDLTLQ-AZKQZHLXSA-N 0.000 description 1
- GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 description 1
- SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 description 1
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 description 1
- QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 description 1
- IWZSHWBGHQBIML-ZGGLMWTQSA-N (3S,8S,10R,13S,14S,17S)-17-isoquinolin-7-yl-N,N,10,13-tetramethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-amine Chemical compound CN(C)[C@H]1CC[C@]2(C)C3CC[C@@]4(C)[C@@H](CC[C@@H]4c4ccc5ccncc5c4)[C@@H]3CC=C2C1 IWZSHWBGHQBIML-ZGGLMWTQSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- ONBQEOIKXPHGMB-VBSBHUPXSA-N 1-[2-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 ONBQEOIKXPHGMB-VBSBHUPXSA-N 0.000 description 1
- RZRILSWMGXWSJY-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;sulfuric acid Chemical compound OS(O)(=O)=O.OCCN(CCO)CCO RZRILSWMGXWSJY-UHFFFAOYSA-N 0.000 description 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
- LKUNXBRZDFMZOK-GFCCVEGCSA-N Capric acid monoglyceride Natural products CCCCCCCCCC(=O)OC[C@H](O)CO LKUNXBRZDFMZOK-GFCCVEGCSA-N 0.000 description 1
- 229940126657 Compound 17 Drugs 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- CTPQLHGJNTXKID-UHFFFAOYSA-N N(CCO)(CCO)CCO.S(=O)(=O)(O)CCO Chemical compound N(CCO)(CCO)CCO.S(=O)(=O)(O)CCO CTPQLHGJNTXKID-UHFFFAOYSA-N 0.000 description 1
- OPFJDXRVMFKJJO-ZHHKINOHSA-N N-{[3-(2-benzamido-4-methyl-1,3-thiazol-5-yl)-pyrazol-5-yl]carbonyl}-G-dR-G-dD-dD-dD-NH2 Chemical compound S1C(C=2NN=C(C=2)C(=O)NCC(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(O)=O)C(N)=O)=C(C)N=C1NC(=O)C1=CC=CC=C1 OPFJDXRVMFKJJO-ZHHKINOHSA-N 0.000 description 1
- QHZLMUACJMDIAE-UHFFFAOYSA-N Palmitic acid monoglyceride Natural products CCCCCCCCCCCCCCCC(=O)OCC(O)CO QHZLMUACJMDIAE-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- LNUFLCYMSVYYNW-ZPJMAFJPSA-N [(2r,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[[(3s,5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-4,5-disulfo Chemical compound O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)[C@H]1O[C@H](COS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O LNUFLCYMSVYYNW-ZPJMAFJPSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- DCBSHORRWZKAKO-UHFFFAOYSA-N alpha-glycerol monomyristate Natural products CCCCCCCCCCCCCC(=O)OCC(O)CO DCBSHORRWZKAKO-UHFFFAOYSA-N 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- XRWSZZJLZRKHHD-WVWIJVSJSA-N asunaprevir Chemical compound O=C([C@@H]1C[C@H](CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)OC1=NC=C(C2=CC=C(Cl)C=C21)OC)N[C@]1(C(=O)NS(=O)(=O)C2CC2)C[C@H]1C=C XRWSZZJLZRKHHD-WVWIJVSJSA-N 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N beta-monoglyceryl stearate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229940125797 compound 12 Drugs 0.000 description 1
- 229940126543 compound 14 Drugs 0.000 description 1
- 229940125758 compound 15 Drugs 0.000 description 1
- 229940125782 compound 2 Drugs 0.000 description 1
- 229940125810 compound 20 Drugs 0.000 description 1
- 229940126086 compound 21 Drugs 0.000 description 1
- 229940126208 compound 22 Drugs 0.000 description 1
- 229940125961 compound 24 Drugs 0.000 description 1
- 229940125898 compound 5 Drugs 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- JAXFJECJQZDFJS-XHEPKHHKSA-N gtpl8555 Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](B1O[C@@]2(C)[C@H]3C[C@H](C3(C)C)C[C@H]2O1)CCC1=CC=C(F)C=C1 JAXFJECJQZDFJS-XHEPKHHKSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- VQSRKMNBWMHJKY-YTEVENLXSA-N n-[3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide Chemical compound C1=NC(OC)=CN=C1C(=O)NC1=CC=C(F)C([C@@]23[C@@H](CN(C2)C=2N=CC(F)=CN=2)CSC(N)=N3)=C1 VQSRKMNBWMHJKY-YTEVENLXSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- LADXKQRVAFSPTR-UHFFFAOYSA-M sodium;2-hydroxyethanesulfonate Chemical compound [Na+].OCCS([O-])(=O)=O LADXKQRVAFSPTR-UHFFFAOYSA-M 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、起泡性、洗浄性等の洗浄剤としての必須要件
を満足しながら、皮膚に対する刺激性が著しく低い洗浄
剤組成物に関するものである。Detailed Description of the Invention (Field of Industrial Application) The present invention relates to a detergent composition that satisfies essential requirements for a detergent such as foaming properties and cleansing properties, and has extremely low irritation to the skin. It is.
（従来の技術）
従来、蛋白質変性力の強い界面活性剤や界面活性剤組成
物では、これらを連用することにより強度の手荒れ現象
が認められるのに対し、蛋白質変性力の小さい界面活性
剤やその組成物（例えばシャンプー）は、長期間連用し
ても手荒れ等の皮膚障害が起こり難く、皮膚に対する刺
激性が著しく低いことがよく知られている。(Prior art) Conventionally, with surfactants and surfactant compositions that have a strong protein denaturing power, severe roughness has been observed when used repeatedly, whereas surfactants and surfactant compositions that have a low protein denaturing power have been used for a long time. It is well known that compositions (for example, shampoos) are unlikely to cause skin disorders such as rough hands even when used for a long period of time, and have extremely low irritation to the skin.
一方、後記の一般式（８）及び（Ｂ）で表わされる高級
ら洗顔料やシャンプー等の洗浄剤に配合使用されている
が、蛋白質変性力や皮膚刺激性が強く手荒れ等の皮膚障
害を起こしやすい欠点がある。このような背景と生活水
準の高度化に伴い、人体に対して高度な安全性を有する
は皮膚刺激性の界面活性剤や洗浄剤組成物の開発が強く
要望されるようになって来ているのが現状である。On the other hand, high-grade products represented by general formulas (8) and (B) below are used in cleansers such as facial cleansers and shampoos, but they have strong protein denaturing power and skin irritation, causing skin disorders such as rough hands. There are some easy drawbacks. Against this background and with the advancement of living standards, there is a strong demand for the development of skin-irritating surfactants and detergent compositions that are highly safe for the human body. is the current situation.
（発明が解決しようとする問題点）
本発明者等は、前記従来技術の難点を改良せんとして鋭
意研究した結果、先に出願した（特願昭５９−２６８４
８７号、特願昭６０−１５４４７８号）界面活性剤の後
記一般式（Ｃ）で表わされるＮ−（２−アルキル−２−
ヒドロキシエチル）−Ｎ−メチルアミノエタノールリン
酸エステル塩の適当量を、後記一般式穴で表わされる高
級脂肪酸モノ合は、起泡性、洗浄性等の洗浄剤としての
必須要件を満足しながら、蛋白質変性力が小さく、手荒
れ等の皮膚障害を起し難く皮膚刺激性の著しく低い洗浄
剤組成物が得られることを見出し、本発明を完成するに
至った。(Problems to be Solved by the Invention) As a result of intensive research aimed at improving the drawbacks of the above-mentioned prior art, the present inventors have previously filed an application (Japanese Patent Application No. 59-2684).
No. 87, Japanese Patent Application No. 60-154478) N-(2-alkyl-2-
A suitable amount of (hydroxyethyl)-N-methylaminoethanol phosphate ester salt is added to a higher fatty acid monomer represented by the general formula below, while satisfying the essential requirements as a detergent such as foaming properties and detergency. The present inventors have discovered that a detergent composition that has low protein denaturing power, is less likely to cause skin disorders such as rough hands, and has extremely low skin irritation has been completed, and the present invention has been completed.
本発明の目的は、起泡性、洗浄性等の洗浄剤としての必
須要件を満足しながら、皮膚に対する刺激性が著しく低
い洗浄剤組成物を提供することにある。An object of the present invention is to provide a detergent composition that satisfies essential requirements for a detergent such as foaming properties and cleansing properties, and has extremely low irritation to the skin.
（問題点を解決するための手段）
上述の目的は、下記の成分（Ｉ）及び（ＩＩ）とを有効
成分として含有している低刺激性洗浄剤組成物によって
達成される。(Means for Solving the Problems) The above object is achieved by a mild detergent composition containing the following components (I) and (II) as active ingredients.
（Ｉ）一般式穴又は■） ＣＨ２０ＣＯＲ１ ＣＨＯＨ・・・・・・・・・ 囚 ＣＨ２Ｏ３０８Ｍ。(I) General type hole or ■) CH20COR1 CHOH・・・・・・・Prisoner CH2O308M.
Ｒ，Ｃ０Ｃ００ＣＨ２ＣＨ２５０８・・−・・−（Ｂｌ
（上記式中、Ｒ１は炭素数８〜２０の直鎖又は分岐鎖の
アルキル基、Ｍｌはナトリウムイオン、カリウムイオン
、マグネシウムイオン、アンモニウムイオン、アルカノ
ールアミンイオン、又は低級脂肪族アミンイオン）
（ＩＩ）一般式（Ｃ）
０ＨＣＨｓ
（上記式中で、Ｒ２はカプリル基、ラウリル基、ミリス
チル基、パルミチル基、ステアリル基またはオレイル基
、Ｍ２はアルカリ金属イオン、アンモニウムイオン、又
はアルカノールアミンイオンである。）
で表わされるＮ−（２−アルキル−２−ヒドロキシエチ
ル）−Ｎ−メチルアミノエタノールリン酸エステル塩。R, C0C00CH2CH2508・・・・・−(Bl
(In the above formula, R1 is a linear or branched alkyl group having 8 to 20 carbon atoms, Ml is a sodium ion, potassium ion, magnesium ion, ammonium ion, alkanolamine ion, or lower aliphatic amine ion) (II) General formula (C) 0HCHs (In the above formula, R2 is a caprylic group, a lauryl group, a myristyl group, a palmityl group, a stearyl group, or an oleyl group, and M2 is an alkali metal ion, an ammonium ion, or an alkanolamine ion.) N-(2-alkyl-2-hydroxyethyl)-N-methylaminoethanol phosphate ester salt.
本発明における前記一般式穴で表わされる高級脂肪酸モ
ノグリセリド硫酸エステル塩としては、例えばカプリン
酸モノグリセリド硫０！エステル、ラウリン酸モノグリ
セリド硫酸エステル、ミリスチン酸モノグリセリド硫酸
エステル、パルミチン酸モノグリセリド硫酸エステル、
ステアリン酸モノグリセリド硫酸エステル及びオレイン
酸モノグリセリド硫酸エステルのナトリウム塩、カリウ
ム塩、マグネシウム塩、アンモニウム塩、トリエタリウ
ム塩、マグネシウム塩、アンモニウム塩、トリエタノー
ルアミン塩等が挙げられる。In the present invention, the higher fatty acid monoglyceride sulfate ester salt represented by the above general formula is, for example, capric acid monoglyceride sulfur 0! ester, lauric acid monoglyceride sulfate, myristic acid monoglyceride sulfate, palmitic acid monoglyceride sulfate,
Examples include sodium salt, potassium salt, magnesium salt, ammonium salt, triethalium salt, magnesium salt, ammonium salt, triethanolamine salt, etc. of stearic acid monoglyceride sulfate ester and oleic acid monoglyceride sulfate ester.
また曲記一般式（Ｃ１で表わされるＮ−（２−アルキル
−２−ヒドロキシエチル）−Ｎ−メチルアミノエタノー
ルリン酸エステル塩としては、例えば、Ｎ−（２−ラウ
リル−２−ヒドロキシエチル）−Ｎ−メチルアミンエタ
ノールリン酸二゛ステル１ナトリウム塩Ｃ以下、化合物
１という）、Ｎ−（２−ラウリル−２−ヒドロキシエチ
ル）−Ｎ−メチルアミノエタノールリン酸エステル１カ
リウム塩（化合物２）、Ｎ−（２−ラウリル−２−ヒド
ロキシエチル）−Ｎ−メチルアミンエタノールリン酸エ
ステル１アンモニウム塩（化合物ｓ ）、Ｎ−（２−ラ
ウリル−２−ヒドロキシエチル） −Ｎ −メチルアミ
ノエタノールリン酸エステルｌトリエタノールアミン塩
（化合物４）、Ｎ−（２−カプリル−２−ヒドロキシエ
チル）−Ｎ−メチルアミンエタノールリン酸エステルｌ
ナトリウム塩（化合物５）、Ｎ−（２−カプリル−２−
ヒドロキシエチル）−Ｎ−メチルアミノエタノールリン
酸エステル１カリウム塩（化合物６）、Ｎ−（２−１’
Ｊプリル−２−ヒドロキシエチル）−Ｎ−メチルアミン
エタノールリン酸エステル１アンモニウム塩（化合物７
）、Ｎ−（２−カプリルー２−ヒドロキシエチル）−Ｎ
−メチルアミノエタノールリン酸エステル１トリエタノ
ールアミン塩（化合物８）、Ｎ−（２−ミリスチル−２
−ヒドロキシエチル）−Ｎ−メチルアミノエタノールリ
ン酸エステル１ナトリウム塩（化合物９）、Ｎ−（２−
４１Ｊスチル−２−ヒドロキシエチル）−Ｎ−メチルア
ミノエタノールリン酸エステル１カリウム塩（化合物１
０）、Ｎ−（２−ミリスチル−２−ヒドロキシエチル）
−Ｎ−メチルアミノエタノールリン酸エステルｌアンモ
ニウム塩Ｃ化合物１１）、Ｎ−（２−ミリスチル−２−
ヒドロキシエチル）−Ｎ−メチルアミノエタノールリン
酸エステル１トリエタノールアミン塩（化合物１２）、
Ｎ−（２−パルミチルー２−ヒドロキシエチル） −Ｎ
−メチルアミノエタノールリン酸エステル１ナトリウム
塩（化合物１Ｂ）、Ｎ−（２−バルミチルー２−ヒドロ
キシエチル） −Ｎ−メチルアミノエタノールリン酸エ
ステル１カリウム塩（化合物１４）、Ｎ−（２−パルミ
チルー２−ヒドロキシエチル）−Ｎ−メチルアミンエタ
ノールリン酸エステル１アンモニウム塩（化合物１５）
、Ｎ−（２−パルミチルー２−ヒドロキシエチル）−Ｎ
−メチルアミノエタノールリン酸エステル１トリエタノ
ールアミン塩（化合物１６）、Ｎ−（２−ステアリル−
２−ヒドロキシエチル）−Ｎ−メチルアミノエタノール
リン酸エステルｌナトリウム塩（化合物１７）、Ｎ−（
２−ステアリル−２−ヒドロキシエチル）−Ｎ−メチル
アミノエタノールリン酸エステル１カリウム塩（化合物
１８）、Ｎ−（２−ステアリル−２−ヒドロキシエチル
）−Ｎ−メチルアミノエタノールリン酸エステル１アン
モニウム塩（化合物１９）、（２−ステアリル−２−ヒ
ドロキシエチル）−Ｎ−メチルアミノエタノールリン酸
エステル１トリエタノールアミン塩（化合物２０）、Ｎ
−（２−オレイル−２−ヒドロキシエチル） −Ｎ−メ
チルアミノエタノールリン酸エステル１ナトリウム塩（
化合物２１）、Ｎ−（２−オレイル−２−ヒドロキシエ
チル）−Ｎ−メチルアミノエタノールリン酸エステル１
カリウム塩（化合物２２）、Ｎ−（２−オレイル−２−
ヒドロキシエチル）−Ｎ−メチルアミノエタノールリン
酸エステルｌアンモニウム塩、（化合物２８）及ヒＮ−
（２−オレイル−２−ヒドロキシエチル）−Ｎ−メチル
アミノエタノールリン酸エステルトリエタノールアミン
塩（化合物２４）等である。Further, as the N-(2-alkyl-2-hydroxyethyl)-N-methylaminoethanol phosphate salt represented by the general formula (C1), for example, N-(2-lauryl-2-hydroxyethyl)- N-methylamine ethanol phosphate monosodium salt (hereinafter referred to as compound 1), N-(2-lauryl-2-hydroxyethyl)-N-methylaminoethanol phosphate monopotassium salt (compound 2), N-(2-lauryl-2-hydroxyethyl)-N-methylamine ethanol phosphate monoammonium salt (compound s), N-(2-lauryl-2-hydroxyethyl)-N-methylaminoethanol phosphate ester l Triethanolamine salt (compound 4), N-(2-capryl-2-hydroxyethyl)-N-methylamine ethanol phosphate l
Sodium salt (compound 5), N-(2-capryl-2-
hydroxyethyl)-N-methylaminoethanol phosphate monopotassium salt (compound 6), N-(2-1'
J pryl-2-hydroxyethyl)-N-methylamine ethanol phosphate 1 ammonium salt (compound 7
), N-(2-capryl-2-hydroxyethyl)-N
-Methylaminoethanol phosphate 1 triethanolamine salt (compound 8), N-(2-myristyl-2
-Hydroxyethyl)-N-methylaminoethanol phosphate monosodium salt (Compound 9), N-(2-
41J Styl-2-hydroxyethyl)-N-methylaminoethanol phosphate monopotassium salt (compound 1
0), N-(2-myristyl-2-hydroxyethyl)
-N-methylaminoethanol phosphate ester ammonium salt C compound 11), N-(2-myristyl-2-
hydroxyethyl)-N-methylaminoethanol phosphate ester 1 triethanolamine salt (compound 12),
N-(2-palmityl-2-hydroxyethyl) -N
-Methylaminoethanol phosphate monosodium salt (Compound 1B), N-(2-balmityl-2-hydroxyethyl) -N-methylaminoethanol phosphate monopotassium salt (Compound 14), N-(2-palmityl-2-hydroxyethyl) -Hydroxyethyl)-N-methylamine ethanol phosphate 1 ammonium salt (Compound 15)
, N-(2-palmityl-2-hydroxyethyl)-N
-Methylaminoethanol phosphate ester 1 triethanolamine salt (compound 16), N-(2-stearyl-
2-hydroxyethyl)-N-methylaminoethanol phosphate ester l sodium salt (compound 17), N-(
2-stearyl-2-hydroxyethyl)-N-methylaminoethanol phosphate monopotassium salt (Compound 18), N-(2-stearyl-2-hydroxyethyl)-N-methylaminoethanol phosphate monoammonium salt (Compound 19), (2-stearyl-2-hydroxyethyl)-N-methylaminoethanol phosphate ester 1 triethanolamine salt (Compound 20), N
-(2-oleyl-2-hydroxyethyl) -N-methylaminoethanol phosphate monosodium salt (
Compound 21), N-(2-oleyl-2-hydroxyethyl)-N-methylaminoethanol phosphate 1
Potassium salt (compound 22), N-(2-oleyl-2-
Hydroxyethyl)-N-methylaminoethanol phosphate ester ammonium salt, (compound 28) and H-N-
(2-oleyl-2-hydroxyethyl)-N-methylaminoethanol phosphate triethanolamine salt (compound 24), and the like.
オン酸塩は、充分なる起泡性、洗浄性等の界面活性能は
有するものの、蛋白質変性力は強く、単独で用いた場合
には所望の低刺激性洗浄剤は得られない。Although onate salts have sufficient surfactant properties such as foaming properties and detergency properties, they have a strong protein denaturing power, and when used alone, the desired mild detergent cannot be obtained.
一方、前記一般式（ｑで表わされるＮ−（２−アルキル
−２−ヒドロキシエチル） −Ｎ−メチルアミノエタノ
ールリン酸エステル塩は蛋白質変性力は非常に低く、刺
激性は弱いものであり、かつ起潅注、洗浄性等の界面活
性能は良好である。On the other hand, the N-(2-alkyl-2-hydroxyethyl)-N-methylaminoethanol phosphate ester salt represented by the general formula (q) has very low protein denaturing power, weak irritation, and It has good surfactant properties such as irrigation and detergency.
本発明者等は、前記一般式囚で表わされる高級記一般式
（Ｃ）で表わされるＮ−（２−アルキル−２−ヒドロキ
シエチル）−Ｎ−メチルアミノエタノールリン酸エステ
ル塩とを、ある一定の比率で混合した場合、あの詔の単
独の場合より粘度上昇、臨界ミセル濃度の低下等の現象
がおこる事を発見−２−ヒドロキシエチル）−Ｎ−メチ
ルアミンエタノールリン酸エステル塩との複合体が形成
されたものと推定される。この一定比率の混合物では、
ン酸塩単独の場合に優るとも劣らず、同時に蛋白質変性
力はＮ−（２−アルキル−２−ヒドロキシエチル）−Ｎ
−メチルアミノエタノールリン酸エステル塩基独の場合
とほぼ同等の程度まで著しく低下することを発見したも
のである。The present inventors have determined that the N-(2-alkyl-2-hydroxyethyl)-N-methylaminoethanol phosphate ester salt represented by the general formula (C), It was discovered that when mixed in the ratio of 2-hydroxyethyl)-N-methylamine ethanol phosphate ester salt, phenomena such as increased viscosity and decreased critical micelle concentration occurred compared to when the edict was used alone. It is assumed that this was formed. In this constant ratio mixture,
N-(2-alkyl-2-hydroxyethyl)-N
-Methylaminoethanol phosphate ester base was found to be significantly reduced to almost the same extent as the base.
即ち、混合して複合体を形成することにより、明らかに
相乗効果が発揮され、優れた界面活性能を維持しつつ、
蛋白質変性能の低い低刺激性洗浄剤組成物を得ることに
成功したものである。That is, by mixing to form a complex, a synergistic effect is clearly exhibited, and while maintaining excellent surfactant ability,
We have succeeded in obtaining a hypoallergenic detergent composition with low protein denaturation ability.
この囚又は（Ｂ） ： （Ｃ）の混合比（重量比）は、
８；１乃至１：１０の範囲が望ましい。この範囲以外の
混合比や、他のアニオン界面活性剤等を多量に加えて系
のバランスを崩した場合では、充分な蛋白質変性能の低
下効果が得られない。The mixing ratio (weight ratio) of (B) and (C) is
A range of 8:1 to 1:10 is desirable. If the mixing ratio is outside this range or if a large amount of other anionic surfactant is added to disrupt the balance of the system, a sufficient effect of lowering protein denaturation performance cannot be obtained.
また（５）又は（Ｂｌ ＋ （Ｃ）の含有量は、洗浄剤
組成物全量中の５乃至４０１！量％が好ましい。The content of (5) or (Bl + (C)) is preferably 5 to 401% by weight based on the total amount of the cleaning composition.
本発明の洗浄剤組成物は、所望により、洗浄剤に一般に
配合される成分、例えば、高級アルコール、ラノリン誘
導体、蛋白誌導体や、ポリエチレングリコールの脂肪酸
エステル類等の油性成分、プロピレングリコール、グリ
セリン、ポリエチレングリコール等の保湿剤成分、脂肪
酸アルカロールアマイド、ポリオキシエチレンアルキル
エーテル及びアルキルアミンオキシド等の非イオン界面
活性剤、水溶性高分子物質（アニオン性、非イオン性、
カチオン性のものを含む）、金属イオン封鎖剤、防腐剤
、殺菌剤、ｐＨ調整剤、紫外線吸収剤、酸化防止剤、色
素及び香料等を含むことができる。The cleaning composition of the present invention may optionally contain ingredients commonly added to cleaning agents, such as higher alcohols, lanolin derivatives, proteinaceous conductors, oily ingredients such as fatty acid esters of polyethylene glycol, propylene glycol, glycerin, Moisturizer ingredients such as polyethylene glycol, nonionic surfactants such as fatty acid alkalolamide, polyoxyethylene alkyl ether, and alkylamine oxide, water-soluble polymer substances (anionic, nonionic,
(including cationic ones), sequestering agents, preservatives, bactericidal agents, pH adjusters, ultraviolet absorbers, antioxidants, pigments, fragrances, and the like.
（実施例）
次に本発明を実施例をもって詳細に説明するが、本発明
はこれにより限定されるものではない。実施例に先立ち
、各実施例で採用した試験法、評価法を説明する。(Example) Next, the present invention will be explained in detail with reference to Examples, but the present invention is not limited thereto. Prior to the examples, the test methods and evaluation methods employed in each example will be explained.
起泡性試＃法
活性剤濃度が０．２％の水溶液を調製しロスマイルズ試
験法（ＡＳＴＭＤＬ Ｌ７３−５８ ）によって行った
。また、評価の基準を次のように設定した。Foaming test method An aqueous solution having an active agent concentration of 0.2% was prepared and tested according to the Ross Miles test method (ASTM DL L73-58). In addition, the evaluation criteria were set as follows.
◎・・・泡立ち優秀 泡１２８０ ｍ１以上Ｏ・・泡立
ち良好 泡量 ２００ｍｎ以上２８０ｍ１未満△・・泡
立ち普通 泡ｆｆｉ １５０ｍ１以上２００ｍＡ未満
×・・・泡立ち不良 泡ｆＪ １５０ｍＡ’未満洗浄
性試験法
５ｃｍＸ５ｃｍのウールモスリン布にラノリン７％及び
スダンＩ Ｏ，００５％のクロロホルム溶液０、４ ｍ
ｌ を均一に塗布し乾燥させ、この汚染布を８％の洗浄
剤溶液４０ｍ１が入った約１００ ｍｌのガラス製シリ
ンダー中に入れ、４０’Ｃの恒温槽中で１６分振とうし
、汚染布を流水中でよくすすぎ、乾燥させ、反射率を調
べ、次式により洗浄率を求めた。◎... Excellent foaming Foam 1280 m1 or more O... Good foaming Foam volume 200 m1 or more and less than 280 m1 △... Normal foaming Foam ffi 150 m1 or more and less than 200 mA 0.4 m of a chloroform solution of 7% lanolin and 5% Sudan I O on a muslin cloth.
The contaminated cloth was placed in a glass cylinder of approximately 100 ml containing 40 ml of 8% detergent solution, and shaken for 16 minutes in a thermostatic bath at 40'C. was thoroughly rinsed under running water, dried, and examined for reflectance, and the cleaning rate was determined using the following formula.
また、評価の基準を次のように設定した。In addition, the evaluation criteria were set as follows.
０：洗浄性優秀 洗浄効率 ８５％以上以上先：洗浄好
洗浄効率 ７０％以上８５％未満△：洗浄性普通 洗
浄効率 ５５％以上７０％未満×：洗浄性不良 洗浄効
率 ５５％未満蛋白質゛変性率測定法
水系高速液体クロマトグラフィーを利用し、卵白アルブ
ミンｐＨ７Ｍ衝溶液に、試料濃度１％になるように試料
を加えた場合の卵白アルブミン変性率を、２２ Ｇ ｎ
ｍの吸収ピークを用いて測定した。0: Excellent cleaning performance Cleaning efficiency 85% or more: Good cleaning Cleaning efficiency 70% or more and less than 85% △: Average cleaning performance Cleaning efficiency 55% or more and less than 70% ×: Poor cleaning performance Cleaning efficiency Less than 55% protein denaturation rate Measurement method Using aqueous high-performance liquid chromatography, the ovalbumin denaturation rate when a sample is added to an ovalbumin pH 7M buffer solution at a sample concentration of 1% is calculated using 22 G n
It was measured using the absorption peak of m.
Ｈｏ：卵白アルブミンの２２０ ｎｍ吸収ピークの高さ
Ｈ５：卵白アルブミン緩衝溶液に試料を加えた時の２２
０ ｎｍ吸収ピークの高さ
評価の基準を次のように設定した。Ho: Height of the 220 nm absorption peak of ovalbumin H5: 22 when the sample is added to the ovalbumin buffer solution
The criteria for evaluating the height of the 0 nm absorption peak was set as follows.
◎：卵白アルブミン変性率 ８０％未満○；卵白アルブ
ミン変性率 ３０％以上６０％未満
△；卵白アルブミン皮性率 ６０％以上８０％未満
×：卵白アルブミン変性率 ８０％以上手荒れ試験法
各試料につき、男女各５名、合計１０名のパネルを用い
、左右どちらか一万の手を、試料濃度５％、温度８５°
Ｃの水溶液に、他方の手を同温度の水に１０分間浸漬す
る操作を１日当り２回、２日間続けて行ない、左右の手
の肌荒れ状態の差を肉眼で判定した。◎: Ovalbumin denaturation rate less than 80% ○; Ovalbumin denaturation rate 30% or more and less than 60% △; Ovalbumin peel rate 60% or more and less than 80% ×: Ovalbumin denaturation rate 80% or more Rough hands test method For each sample, Using a panel of 10 people (5 men and 5 men), 10,000 hands on either the left or right, sample concentration 5%, temperature 85°.
An operation of immersing the other hand in the aqueous solution of C and water at the same temperature for 10 minutes was performed twice a day for 2 consecutive days, and the difference in rough skin between the left and right hands was visually determined.
◎・・・手荒れ性著しく弱い １０人中θ〜１名試料側
に手荒れが認められた
Ｏ・・手荒れ性やや弱い １０人中２〜４名試料側に
手荒れが認められた
△・・・手荒れ性やや強い １０人中５〜７名試料側
に手荒れが認められた
×・・・手荒れ性著しく強い １０人中８〜１０名゛試
料側に手荒れが認められた
実施例１〜８、比較例１〜７
実施例１〜８及び比較例１〜７では、第１表及び第２表
に記載の配合組成よりなるシャンプーを調製し、その起
泡性、洗浄性、蛋白質変性率及び手荒れ性を調べた結果
を、第１表及び第２表に示す。◎... Extremely weak hand roughness θ ~ 1 person out of 10 had rough hands observed on the sample side 0... Slightly weak hand roughness 2-4 out of 10 people had rough hands observed on the sample side △... Hand roughness Slightly strong 5-7 out of 10 people Roughness of hands was observed on the sample side 1 to 7 In Examples 1 to 8 and Comparative Examples 1 to 7, shampoos having the compositions listed in Tables 1 and 2 were prepared, and their foaming properties, detergency, protein denaturation rate, and roughness on hands were evaluated. The results of the investigation are shown in Tables 1 and 2.
以下余白 ・・□′／ 実施例９ 次の配合組成よりなるボディシャンプーを調製した。Margin below ・・□′／ Example 9 A body shampoo having the following composition was prepared.
ラウリン酸モノグリセリド硫酸
エステルトリエタノールアミン塩 １２％（重ｆ
ｆ１）化 合 物１６
化合物５６
グリセリン ２
香 料 ０．８水
残余
このボディシャンプーの起泡性、洗浄性、蛋白質変性率
、手荒れ性を調べた結果、各々◎、◎、０、◎であった
。Lauric acid monoglyceride sulfate triethanolamine salt 12% (heavy F
f1) Compound 16 Compound 56 Glycerin 2 Fragrance 0.8 Water Residual The results of examining the foaming properties, cleansing properties, protein denaturation rate, and roughness on hands of this body shampoo were ◎, ◎, 0, and ◎, respectively. .
実施例１０ 次の配合組成よりなるシャンプーを調製した。Example 10 A shampoo consisting of the following formulation was prepared.
ヤシ油脂肪酸モノグリセリド硫
酸エステルアンモニウム塩５
化 合 物４８
化合物８８
ヤシ脂肪酸ジエタ／−ルアマイト ６香
料 Ｏ，ａ水
残余
このシャンプーの起泡性、洗浄性、蛋白質変性率、手荒
れ性を調べた結果、各々◎、◎、◎、◎であった。Coconut oil fatty acid monoglyceride sulfate ammonium salt 5 Compound 48 Compound 88 Coconut fatty acid dieta/-ruamite 6 Fragrance
Fee O,a Water
Residual The results of examining the foaming properties, detergency, protein denaturation rate, and roughness of hands of this shampoo were ◎, ◎, ◎, and ◎, respectively.
実施例１１ 次の配合組成よりなるボディシャンプーを：Ａ製した。Example 11 A body shampoo consisting of the following composition was prepared by A.
ヤシ油脂肪酸イセチオン酸
トリエタノールアミン塩 １２％（重量）化
合物１６
化 合 物５６
グリセリン ２
香 料 ０．３
水 残余
このボディシャンプーの起泡性、洗浄性、蛋白質変性率
、手荒れ性を調べた結果、各々Ｇ、◎、◎、◎であった
。Coconut oil fatty acid isethionic acid triethanolamine salt 12% (weight) Compound 16 Compound 56 Glycerin 2 Flavor 0.3
Water Residual The results of examining the foaming properties, cleansing properties, protein denaturation rate, and roughness on hands of this body shampoo were G, ◎, ◎, and ◎, respectively.
実施例１２ 次の配合組成よりなるシャンプーを調製した。Example 12 A shampoo consisting of the following formulation was prepared.
ヤシ油脂肪酸イセチオン
酸ナトリウム塩 ４％（重量）化
合 物４８
化合物８８
ヤシ脂肪酸ジェタノールアマイド ５香
料 ０．３水
残余
このシャンプーの起泡性、洗浄性、蛋白質変性率、手荒
れ性を調べた結果、各々◎、◎、◎、０であった。Coconut oil fatty acid isethionate sodium salt 4% (weight) Compound 48 Compound 88 Coconut fatty acid jetanolamide 5 fragrances
Fee 0.3 water
Residual The results of examining the foaming properties, detergency, protein denaturation rate, and roughness of hands of this shampoo were ◎, ◎, ◎, and 0, respectively.
Claims (2)
て含有している低刺激性洗浄剤組成物。 （ I ）一般式（Ａ）又は（Ｂ） ▲数式、化学式、表等があります▼………（Ａ） ▲数式、化学式、表等があります▼………（Ｂ） （上記式中、Ｒ＿１は炭素数８〜２０の直鎖又は分岐鎖
のアルキル基、Ｍ＿１はナトリウムイオン、カリウムイ
オン、マグネシウム イオン、アンモニウムイオン、アルカノー ルアミンイオン、又は低級脂肪族アミンイ オン） で表わされる高級脂肪酸モノグリセリド硫酸エステル塩
又はＯ−アシルイセチオン酸塩。 （II）一般式（Ｃ） ▲数式、化学式、表等があります▼……（Ｃ） （上記式中で、Ｒ＿２はカプリル基、ラウリル基、ミリ
スチル基、パルミチル基、ステ アリル基またはオレイル基、Ｍ＿２はアルカリ金属イオ
ン、アンモニウムイオン、又は アルカノールアミンイオンである。） で表わされるＮ−（２−アルキル−２−ヒドロキシエチ
ル）−Ｎ−メチルアミノエタノールリン酸エステル塩。(1) A hypoallergenic cleaning composition containing the following components (I) and (II) as active ingredients. (I) General formula (A) or (B) ▲There are mathematical formulas, chemical formulas, tables, etc.▼......(A) ▲There are mathematical formulas, chemical formulas, tables, etc.▼......(B) (In the above formula, R_1 is a linear or branched alkyl group having 8 to 20 carbon atoms, and M_1 is a sodium ion, potassium ion, magnesium ion, ammonium ion, alkanolamine ion, or lower aliphatic amine ion) Higher fatty acid monoglyceride sulfate ester salt or O-acyl isethionate. (II) General formula (C) ▲There are mathematical formulas, chemical formulas, tables, etc.▼...(C) (In the above formula, R_2 is a caprylic group, lauryl group, myristyl group, palmityl group, stearyl group, or oleyl group, M_2 is an alkali metal ion, ammonium ion, or alkanolamine ion.) N-(2-alkyl-2-hydroxyethyl)-N-methylaminoethanol phosphate ester salt.
１：１０の範囲である特許請求の範囲第（１）項記載の
低刺激性洗浄剤組成物。(2) The hypoallergenic cleaning composition according to claim (1), wherein the weight ratio of (I) and (II) is in the range of 3:1 to 1:10.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12398886A JPS62280297A (en) | 1986-05-28 | 1986-05-28 | Low irritant detergent composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12398886A JPS62280297A (en) | 1986-05-28 | 1986-05-28 | Low irritant detergent composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62280297A true JPS62280297A (en) | 1987-12-05 |
| JPH0542998B2 JPH0542998B2 (en) | 1993-06-30 |
Family
ID=14874261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12398886A Granted JPS62280297A (en) | 1986-05-28 | 1986-05-28 | Low irritant detergent composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62280297A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03153796A (en) * | 1989-11-13 | 1991-07-01 | Tamanohada Setsuken Kk | Lowly irritant detergent composition |
| JPH04283509A (en) * | 1990-11-07 | 1992-10-08 | Unilever Nv | Detergent composition |
| JPH0769848A (en) * | 1993-09-02 | 1995-03-14 | Mandamu:Kk | Transparent gelatinous hair-treating agent composition |
| WO1999009935A3 (en) * | 1997-08-25 | 1999-06-10 | Henkel Kgaa | Cosmetic preparations containing fatty acid polyglycol ester sulphates and polymers |
-
1986
- 1986-05-28 JP JP12398886A patent/JPS62280297A/en active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03153796A (en) * | 1989-11-13 | 1991-07-01 | Tamanohada Setsuken Kk | Lowly irritant detergent composition |
| JPH04283509A (en) * | 1990-11-07 | 1992-10-08 | Unilever Nv | Detergent composition |
| JPH0769848A (en) * | 1993-09-02 | 1995-03-14 | Mandamu:Kk | Transparent gelatinous hair-treating agent composition |
| WO1999009935A3 (en) * | 1997-08-25 | 1999-06-10 | Henkel Kgaa | Cosmetic preparations containing fatty acid polyglycol ester sulphates and polymers |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0542998B2 (en) | 1993-06-30 |
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