JPS62223011A - Production of tribasic calcium phosphate - Google Patents
Production of tribasic calcium phosphateInfo
- Publication number
- JPS62223011A JPS62223011A JP6782386A JP6782386A JPS62223011A JP S62223011 A JPS62223011 A JP S62223011A JP 6782386 A JP6782386 A JP 6782386A JP 6782386 A JP6782386 A JP 6782386A JP S62223011 A JPS62223011 A JP S62223011A
- Authority
- JP
- Japan
- Prior art keywords
- water
- calcium phosphate
- insoluble
- suspension
- phosphate salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract description 36
- 235000019731 tricalcium phosphate Nutrition 0.000 title claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 239000000725 suspension Substances 0.000 claims abstract description 9
- 239000011575 calcium Substances 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 5
- 238000010438 heat treatment Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000001506 calcium phosphate Substances 0.000 abstract description 16
- 229910000391 tricalcium phosphate Inorganic materials 0.000 abstract description 15
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract description 11
- 229910019142 PO4 Inorganic materials 0.000 abstract description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract description 5
- 235000010216 calcium carbonate Nutrition 0.000 abstract description 5
- 238000001179 sorption measurement Methods 0.000 abstract description 3
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 abstract description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 abstract description 2
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 abstract description 2
- 239000000919 ceramic Substances 0.000 abstract description 2
- 229910000393 dicalcium diphosphate Inorganic materials 0.000 abstract description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 abstract description 2
- 235000011010 calcium phosphates Nutrition 0.000 abstract 2
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 14
- 239000000047 product Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 239000012778 molding material Substances 0.000 description 4
- 238000001308 synthesis method Methods 0.000 description 4
- 238000002441 X-ray diffraction Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000010304 firing Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229940043430 calcium compound Drugs 0.000 description 1
- 150000001674 calcium compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- -1 phosphoric acid compound Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 238000003746 solid phase reaction Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Water Treatment By Sorption (AREA)
Abstract
Description
【発明の詳細な説明】
産業上の利用分野
この発明は、示性式Ｃａ３ （ＰＯ４）２で示される第
三リン酸カルシウムの製造方法に関するものである。DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application This invention relates to a method for producing tricalcium phosphate having the formula Ca3 (PO4)2.
発明の背景
第三リン酸カルシウムは、人工骨、人工歯根などの生体
硬１１１織用成形材料として極めて有用な物質である。Background of the Invention Tricalcium phosphate is an extremely useful substance as a molding material for bio-hard 111 fabrics such as artificial bones and artificial tooth roots.
またこれはタンパク質や核酸などの有機高分子物質の分
離に用いられるクロマトグラフィー用充填材としても有
用な物質である。そのため、近年、第三リン酸カルシウ
ムを安価にかつ高収率でａ産することのできる製造方法
が望まれている。It is also a useful substance as a chromatography packing material used to separate organic polymer substances such as proteins and nucleic acids. Therefore, in recent years, there has been a desire for a manufacturing method that can produce tricalcium phosphate at low cost and in high yield.
従来技術およびその問題点
一般に、第三リン酸カルシウムは、リン酸化合物とカル
シウム化合物とを混合し８００〜１５００℃の温度範囲
でこれらを焼成して固相反応を行なわせる乾式合成法に
よって［造されていた。Prior Art and Its Problems In general, tricalcium phosphate is produced by a dry synthesis method in which a phosphoric acid compound and a calcium compound are mixed and baked in a temperature range of 800 to 1500°C to perform a solid phase reaction. Ta.
しかしながら、上記のような乾式合成法では原料の混合
磯や焼成炉などの装置を使用するために、実験室的規模
ではともかくも、工業的な大量生産では多大な設備費お
よび燃料費と複雑な操作とが必要となり、また収率も満
足いくものではなかった。したがって、この方法は第三
リン酸カルシウムの工業的大量生産方法としては実用的
なものではなかった。However, the dry synthesis method described above uses equipment such as a mixing rock and a firing furnace for raw materials, and therefore, although it may be performed on a laboratory scale, industrial mass production requires a large amount of equipment and fuel costs and is complicated. Further, the yield was not satisfactory. Therefore, this method was not practical as a method for industrial mass production of tricalcium phosphate.
さらに、乾式合成法で得られた製品は、焼成によってセ
ラミック化したものであるため、上述した生体硬組織用
成形材料としては使用できないうえに、焼成によって吸
着力を喪失しているため、上述したクロマトグラフィー
用充填材としても使用できないうらみがあった。Furthermore, products obtained by the dry synthesis method cannot be used as the above-mentioned molding materials for biological hard tissue because they are made into ceramics by firing, and they also lose their adsorption power due to firing, so There was also a problem that it could not be used as a packing material for chromatography.
この発明は、以上の点に鑑み、化学量論的組成を有しか
つ焼成されていない第三リン酸カルシウムを簡単な操作
で大量生産することができる第三リン酸カルシウムの新
規製造方法を提供することを目的とする。゛
問題点の解決手段
この発明による第三リン酸カルシウムの製造方法は、水
に不溶性のリン酸カルシウム塩を水中に懸濁させ、懸濁
液に水に不溶性であるＣａＣＯ３を添加し、懸濁液を撹
拌下に加熱してリン酸カルシウム塩にＣａＣ０ａを反応
させることを特徴とする。In view of the above points, an object of the present invention is to provide a new method for producing tribasic calcium phosphate that has a stoichiometric composition and can mass-produce uncalcined tribasic calcium phosphate with simple operations. shall be.゛Means for solving problems The method for producing tricalcium phosphate according to the present invention involves suspending a water-insoluble calcium phosphate salt in water, adding water-insoluble CaCO3 to the suspension, and stirring the suspension. It is characterized by heating the calcium phosphate salt to react with CaC0a.
水に不溶性のリン酸カルシウム塩の代表例としては、Ｃ
ａ日ＰＯ４・２ＨｚＯ１ＣａＨＰＯ４、Ｃａ２ Ｐ２Ｏ
７およびＣａｎ Ｈ２（ＰＯ４）８ ・５日２Ｏよりな
る群から選ばれた１または２以上の化合物が挙げられる
。A typical example of a water-insoluble calcium phosphate salt is C
a day PO4・2HzO1CaHPO4, Ca2 P2O
7 and Can H2(PO4)8.5day2O.
リン酸カルシウム塩とＣａＣｏ３の割合は、これらの混
合物のＣａ／Ｐモル比が約１．５０になるように設定さ
れる。The proportions of calcium phosphate salt and CaCo3 are set such that the Ca/P molar ratio of the mixture is approximately 1.50.
懸濁液の加熱は、大気圧下に５０〜１００℃、好ましく
は８０〜１００℃の温度範囲で行なわれる。Heating of the suspension is carried out under atmospheric pressure in a temperature range of 50 to 100°C, preferably 80 to 100°C.
反応装置としては、通常の撹拌機付きステンレス鋼製反
応器を用いることができる。As the reaction device, a common stainless steel reactor equipped with a stirrer can be used.
発明の作用・効果
この発明の第三リン酸カルシウムの製造方法は以上のと
おり構成されているので、化学量論的組成を有する第三
リン酸カルシウムを簡単な操作で製造することができる
。Functions and Effects of the Invention Since the method for producing tribasic calcium phosphate of the present invention is configured as described above, tribasic calcium phosphate having a stoichiometric composition can be produced by simple operations.
またこの発明の方法によれば、水に不溶性のリン酸カル
シウム塩と水に不溶性のＣａＣＯ３とをともに水に懸濁
状態で反応させるので、原料の結晶系をそのまま保持す
ることができる。Furthermore, according to the method of the present invention, since the water-insoluble calcium phosphate salt and the water-insoluble CaCO3 are reacted together in a suspended state in water, the crystalline system of the raw materials can be maintained as is.
したがって得られた第三リン酸カルシウムはセラミック
化されていないうえに、大きな吸着容置を有しており、
生体硬組織用成形材料およびりＯマドグラフィー用充填
材としてそれぞれ浸れた性能を備えている。Therefore, the obtained tricalcium phosphate is not ceramicized and has a large adsorption capacity.
It has excellent performance as a molding material for biological hard tissues and as a filler for O-mography.
またこの発明の方法では通常の湿式合成法で用いる反応
装置をそのまま使用できるので、設備費の点でも有利で
ある。Furthermore, the method of the present invention is advantageous in terms of equipment costs, since the reaction equipment used in conventional wet synthesis methods can be used as is.
こうしてこの発明の方法によれば、生体硬組織用成形材
料およびクロマトグラフィー用充填材として有用であり
、かつ化学量論的組成を有する第三リン酸カルシウムを
、簡単な操作で大量生産することができる。Thus, according to the method of the present invention, tricalcium phosphate, which is useful as a molding material for biological hard tissue and a filler for chromatography and has a stoichiometric composition, can be mass-produced with simple operations.
実 施 例
つぎに、上記効果を実証するためにこの発明の実施例を
挙げる。Examples Next, examples of the present invention will be given to demonstrate the above effects.
実施例１
水に不溶性のリン酸カルシウム塩としてＣａＨＰＯ４・
２Ｈ２Ｏを用い、その１０−３３９を内容１２Ｏ／の撹
拌機付きステンレス鋼製反応器にとり、水１６１を加え
てＣａＨＰＯ４・２Ｈ２Ｏを懸濁させた。Example 1 CaHPO4 as a water-insoluble calcium phosphate salt
Using 2H2O, the 10-339 was placed in a stirred stainless steel reactor with a content of 12O/, and 161 of water was added to suspend CaHPO4.2H2O.
懸濁液にＣａＣＯ３３００ｇを少ｆｆｉずつ添加し、懸
濁液を撹拌下に加熱して温度を徐々に８５℃まで上昇せ
しめ、さらに温度８５〜９０℃で４時間撹拌を続けた。3300 g of CaCO3 was added little by little to the suspension, and the suspension was heated with stirring to gradually raise the temperature to 85°C, and stirring was continued for 4 hours at a temperature of 85-90°C.
冷却後、生成した沈澱物を濾取し、洗浄後乾燥し、９２
７ｇの製品を得た。After cooling, the generated precipitate was collected by filtration, washed, and dried.
7g of product was obtained.
こうして得られた製品は、化学分析の結果、Ｃａ含有１
３７．６０％およびＰ含有但１９゜３７％、したがって
Ｃａ／Ｐモル比１．５０の化学量論的組成を有する第三
リン酸カルシウムであることが確認された。またＸ線回
折解析の結果、この物質は第三リン酸カルシウムの結晶
構造の典型的な回折図形を有する物質であることが確認
された。As a result of chemical analysis, the product thus obtained contained 1
It was confirmed to be tricalcium phosphate having a stoichiometric composition of 37.60% and P content of 19.37%, thus a Ca/P molar ratio of 1.50. Further, as a result of X-ray diffraction analysis, it was confirmed that this substance had a diffraction pattern typical of the crystal structure of tricalcium phosphate.
実施例２
水に不溶性のリン酸カルシウム塩としてＣａＨＰＯ４２
Ｏ０ｇと
Ｃａｅ Ｈ２（ＰＯ４）８ ”５Ｈ２Ｏ４９１！Ｊの
組合わせを用い、かつＣａＣＯ３２Ｏ０ｇを用いた点を
除いて、実施例１と同じ操作を繰返し、製品９２５９を
得た。Example 2 CaHPO42 as a water-insoluble calcium phosphate salt
Product 9259 was obtained by repeating the same operation as in Example 1, except that a combination of O0g and Cae H2(PO4)8''5H2O491!J was used, and CaCO32O0g was used.
化学分析およびＸ線回折解析の結果、この製品も、Ｃａ
／Ｐモル比１．５０を有し、かつ第三リン酸カルシウム
の結晶構造の典型的な回折図形を有する化学量論的組成
の第三リン酸カルシウムであることが確認された。As a result of chemical analysis and X-ray diffraction analysis, this product also contains Ca.
/P molar ratio of 1.50 and a stoichiometric composition of tricalcium phosphate having a typical diffraction pattern of the crystal structure of tricalcium phosphate.
実施例３
水に不溶性のリン酸カルシウム塩としてＣａ２Ｐ２Ｏ７
７６２ＳＦを用い、かっＣａＣＯ３３０（ｌを用いた点
を除いて、実施例１と同じ操作を繰返し、製品９２７ｇ
を得た。Example 3 Ca2P2O7 as water-insoluble calcium phosphate salt
Using 762SF, the same operation as in Example 1 was repeated, except that CaCO330 (l) was used, and 927 g of product was obtained.
I got it.
化学分析およびＸ線回折解析の結果、この製品も、Ｃａ
／Ｐモル比１．５１を有し、かつ第三リン酸カルシウム
の結晶構造の典型的な回折図形を有する化学ｍ論的組成
の第三リン酸カルシウムであることが確認された。As a result of chemical analysis and X-ray diffraction analysis, this product also contains Ca.
/P molar ratio of 1.51 and a diffraction pattern typical of the crystal structure of tricalcium phosphate, which was confirmed to be a stoichiometric composition of tricalcium phosphate.
以 上that's all
Claims (4)
せ、懸濁液に水に不溶性であるＣａＣＯ＿３を添加し、
懸濁液を撹拌下に加熱してリン酸カルシウム塩にＣａＣ
Ｏ＿３を反応させることを特徴とする第三リン酸カルシ
ウムの製造方法。(1) Suspending a water-insoluble calcium phosphate salt in water, adding water-insoluble CaCO_3 to the suspension,
The suspension is heated under stirring to convert CaC into calcium phosphate salt.
A method for producing tribasic calcium phosphate, which comprises reacting O_3.
４・２Ｈ＿２Ｏ、ＣａＨＰＯ＿４、Ｃａ＿２Ｐ＿２Ｏ＿
７およびＣａ＿８Ｈ＿２（ＰＯ＿４）＿６・５Ｈ＿２Ｏ
よりなる群から選ばれた１または２以上の化合物である
特許請求の範囲第１項記載の方法。(2) Water-insoluble calcium phosphate salt is CaHPO_
4・2H_2O, CaHPO_4, Ca_2P_2O_
7 and Ca_8H_2(PO_4)_6・5H_2O
The method according to claim 1, wherein the compound is one or more compounds selected from the group consisting of:
らの混合物のＣａ／Ｐモル比が約１．５０になるように
設定する特許請求の範囲第１または２項記載の方法。(3) The method according to claim 1 or 2, wherein the ratio of calcium phosphate salt and CaCO_3 is set so that the Ca/P molar ratio of the mixture thereof is about 1.50.
０℃である特許請求の範囲第１、２または３項記載の方
法。(4) Heating temperature is 50-100℃, preferably 80-10℃
The method according to claim 1, 2 or 3, wherein the temperature is 0°C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6782386A JPS62223011A (en) | 1986-03-25 | 1986-03-25 | Production of tribasic calcium phosphate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6782386A JPS62223011A (en) | 1986-03-25 | 1986-03-25 | Production of tribasic calcium phosphate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62223011A true JPS62223011A (en) | 1987-10-01 |
| JPH0463805B2 JPH0463805B2 (en) | 1992-10-13 |
Family
ID=13356047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6782386A Granted JPS62223011A (en) | 1986-03-25 | 1986-03-25 | Production of tribasic calcium phosphate |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62223011A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008501643A (en) * | 2004-05-06 | 2008-01-24 | イノフォス インコーポレーテッド | Novel hydroxyapatite calcium phosphate, its preparation and use |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6287406A (en) * | 1985-10-11 | 1987-04-21 | Agency Of Ind Science & Technol | Production of beta-tricalcium phosphate |
-
1986
- 1986-03-25 JP JP6782386A patent/JPS62223011A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6287406A (en) * | 1985-10-11 | 1987-04-21 | Agency Of Ind Science & Technol | Production of beta-tricalcium phosphate |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008501643A (en) * | 2004-05-06 | 2008-01-24 | イノフォス インコーポレーテッド | Novel hydroxyapatite calcium phosphate, its preparation and use |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0463805B2 (en) | 1992-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH03500161A (en) | Production method of hydroxylapatite | |
| JP3028375B2 (en) | Apatite whisker and method for producing the same | |
| JPH0369844B2 (en) | ||
| JP2004026648A (en) | Method for manufacture alpha- and beta-tricalcium phosphate powder | |
| JPS62223011A (en) | Production of tribasic calcium phosphate | |
| JPS62223010A (en) | Production of hydroxyapatite | |
| JPS624324B2 (en) | ||
| JP3247896B2 (en) | Method for producing hydroxyapatite | |
| JPH0624963B2 (en) | Method for producing hydroxyapatite | |
| JPH05310410A (en) | Production of strontium hydroxyapatite powder | |
| JPH0665635B2 (en) | Molding material | |
| JP3262233B2 (en) | Method for producing calcium phosphate | |
| KOJIMA et al. | ADSORPTION OF GLYCINE ON AMORPHOUS CALCIUM PHOSPHATE AND ITS THERMAL STABILITY | |
| JPH02180708A (en) | Production of hydroxyapatite | |
| JP3247899B2 (en) | Method for producing hydroxyapatite | |
| JPS6344683B2 (en) | ||
| JP3371539B2 (en) | Method for mass production of quaternary calcium phosphate by wet method | |
| JPS63100008A (en) | Preparation of tricalcium phosphate | |
| JPS6146402B2 (en) | ||
| JP2004284890A (en) | Method for manufacturing hydroxyapatite | |
| JPH0297409A (en) | Production of natural hydroxyapatite | |
| GB2349877A (en) | Preparing carbonated hydroxyapatite | |
| JP6786227B2 (en) | Calcium phosphate synthesizer and synthesis method | |
| JPS61151011A (en) | Production of carbonic acid-containing hydroxy apatite | |
| JPH01167209A (en) | Production of fine particle of hydroxyapatite |