JPS62185019A - Antiseptic disinfectant for animal and method therefor - Google Patents
Antiseptic disinfectant for animal and method thereforInfo
- Publication number
- JPS62185019A JPS62185019A JP2577986A JP2577986A JPS62185019A JP S62185019 A JPS62185019 A JP S62185019A JP 2577986 A JP2577986 A JP 2577986A JP 2577986 A JP2577986 A JP 2577986A JP S62185019 A JPS62185019 A JP S62185019A
- Authority
- JP
- Japan
- Prior art keywords
- iodine
- disinfectant
- water
- aqueous solution
- glycine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000645 desinfectant Substances 0.000 title claims abstract description 35
- 241001465754 Metazoa Species 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title claims description 11
- 230000002421 anti-septic effect Effects 0.000 title abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 26
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 26
- 239000011630 iodine Substances 0.000 claims abstract description 26
- 239000004471 Glycine Substances 0.000 claims abstract description 13
- 239000007864 aqueous solution Substances 0.000 claims abstract description 13
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims abstract description 13
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims abstract description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002904 solvent Substances 0.000 claims abstract description 8
- 239000000243 solution Substances 0.000 claims abstract description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims abstract description 4
- 235000006408 oxalic acid Nutrition 0.000 claims abstract description 4
- 230000003139 buffering effect Effects 0.000 claims abstract description 3
- 150000007519 polyprotic acids Polymers 0.000 claims abstract 2
- 230000001954 sterilising effect Effects 0.000 claims description 11
- 238000005507 spraying Methods 0.000 claims description 9
- 230000000249 desinfective effect Effects 0.000 claims description 6
- DKNPRRRKHAEUMW-UHFFFAOYSA-N Iodine aqueous Chemical compound [K+].I[I-]I DKNPRRRKHAEUMW-UHFFFAOYSA-N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 9
- 241000894006 Bacteria Species 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract description 2
- 241000700605 Viruses Species 0.000 abstract description 2
- 230000007794 irritation Effects 0.000 abstract description 2
- 231100000419 toxicity Toxicity 0.000 abstract description 2
- 230000001988 toxicity Effects 0.000 abstract description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000003641 microbiacidal effect Effects 0.000 abstract 1
- 229940124561 microbicide Drugs 0.000 abstract 1
- 239000002855 microbicide agent Substances 0.000 abstract 1
- 241000282887 Suidae Species 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 235000021050 feed intake Nutrition 0.000 description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 3
- 241000287828 Gallus gallus Species 0.000 description 2
- 206010060891 General symptom Diseases 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 229940035535 iodophors Drugs 0.000 description 2
- 238000011076 safety test Methods 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000004584 weight gain Effects 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- DIWRORZWFLOCLC-UHFFFAOYSA-N Lorazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-UHFFFAOYSA-N 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000459 effect on growth Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【発明の詳細な説明】
（イ）発明の目的
［産業上の利用分野］
本発明は動物用殺菌消毒剤並びに動物の殺菌消毒法に関
するものである。DETAILED DESCRIPTION OF THE INVENTION (a) Purpose of the invention [Field of industrial application] The present invention relates to an animal disinfectant and a method for disinfecting animals.
［従来の技術］ 動物用殺菌消毒剤は次の緒特性を兼備する必要がある。[Conventional technology] Animal disinfectants must have the following characteristics:
（ａ）有効成分を高濃度で含有し、使用時には任意の濃
度に稀釈できること。(a) Contains active ingredients at high concentrations and can be diluted to any desired concentration during use.
（ｂ）長時間保存しても変質しないこと。(b) It should not change in quality even if stored for a long time.
（Ｃ）安全性が高いこと。(C) High safety.
（ｄ）刺激性、毒性が弱く、動物に所定濃度の薬剤を投
与しても害のないこと。(d) The drug has low irritation and toxicity, and there is no harm in administering the drug to animals at a specified concentration.
（ｅ）腐食性の小さいこと。(e) Less corrosive.
（ｆ）広い抗菌スペクトルを持つこと。(f) Having a broad antibacterial spectrum.
（ｇ）動物の忌避性のないこと。(g) Not repellent to animals.
従来これらの特性を兼備する動物用殺菌消毒剤ｉ剤は知
られていないかった。Conventionally, there has been no known animal disinfectant i agent that has both of these properties.
例えば、可溶化剤としてアミノ酸及び水溶性ヨウ化物を
用いたヨウ素水溶液を殺菌剤として用いることは知られ
ているが（特公昭５９−３９８２３号公報参照）、この
殺菌剤（ヨードホール殺菌剤）を動物の殺菌、消毒剤と
して用いる場合、動物に対する安全性、刺激性１ｍ性の
点において必らずしも充分でない欠点があった。For example, it is known that an aqueous iodine solution using an amino acid and water-soluble iodide as a solubilizing agent is used as a disinfectant (see Japanese Patent Publication No. 59-39823). When used as a sterilizing or disinfecting agent for animals, it has the disadvantage that it is not necessarily sufficient in terms of safety to animals and irritability of 1 m.
［発明が解決しようとする問題点］
本発明は、従来技術の有していた前述の問題点を解消す
ることを目的とするものである。[Problems to be Solved by the Invention] The present invention aims to solve the above-mentioned problems that the prior art had.
（ロ）発明の構成
［問題点を解決するための手段］
本発明は前述の問題点を解決すべくなされたものであり
、可溶化剤としてグリシン、及び水溶性ヨウ化物を用い
たヨウ素水溶液よりなることを特徴とする動物用殺菌消
毒剤並びに可溶化剤としてグリシン、及び水溶性ヨウ化
物を用いたヨウ素水溶液を動物に噴霧することを特徴と
する動物の殺菌消毒法を提供するものである。(B) Structure of the Invention [Means for Solving the Problems] The present invention was made to solve the above-mentioned problems, and is based on an iodine aqueous solution using glycine as a solubilizer and a water-soluble iodide. The present invention provides a sterilizing disinfectant for animals, and a method for sterilizing animals, which comprises spraying animals with an iodine aqueous solution using glycine as a solubilizer and water-soluble iodide.
水溶性ヨウ化物としてはＨＩ、ＫＩが好適に使用できる
。これらは単独で使用してもよく１両者を併用すること
もできる。特にＫｌを使用するのが望ましい、水溶性ヨ
ウ化物の使用ｈ１はヨウ素に対し５０ｗｔ％以上特に６
５〜１５０ｗｔ％、更に好ましくは８０〜１２０ｗｔ％
とするのが適当である。As the water-soluble iodide, HI and KI can be suitably used. These may be used alone or in combination. In particular, it is preferable to use Kl, and the use h1 of water-soluble iodide is 50 wt% or more relative to iodine, especially 6
5 to 150 wt%, more preferably 80 to 120 wt%
It is appropriate to
本発明においては可溶化剤として更にグリシンを併用す
る。グリシンの使用量はヨウ素に対し３０〜１２０ｗｔ
％とするのが適当である。これらの可溶化と望ましくは
粉末状のヨウ素水性媒体中で反応させることにより本発
明動物用殺菌消毒剤（以下単に消毒剤という）をうるこ
とができる。In the present invention, glycine is further used as a solubilizing agent. The amount of glycine used is 30 to 120wt relative to iodine.
% is appropriate. The animal sterilizing disinfectant of the present invention (hereinafter simply referred to as a disinfectant) can be obtained by reacting these solubilized compounds with preferably powdered iodine in an aqueous medium.
本発明の消毒剤は。The disinfectant of the present invention is.
（ＣＨ２Ｎ８２ Ｃ０ＱＨ）２ ＨＥ、ｎ ＋ ［２（
ＣＨ２ＮＨ２ＣＯＯＨ）４ ＨＩ・ｎ ２Ｉ２（ＣＨ２
Ｎ）１２ Ｃ０ＯＨ）２ Ｋｌ−ｎ ３１２又は。(CH2N82 C0QH)2 HE, n + [2(
CH2NH2COOH)4 HI・n 2I2(CH2
N)12 C0OH)2 Kl-n 312 or.
（ＣＨ２ＮＯ３Ｃｏｏ）Ｉ ）４ Ｋｌ−ｎ ４１２（
、ｆｌ＋ 、 、ｆ１２、 ｎ４． ！１４ ＝０．
２〜ｉ、 ｎ′Ｊは同一値であってもよく、又互いに異
なる値であってもよい）を主体とするものであって、ヨ
ウ素濃度を１８ｗｔ％程度の高濃度とすることができ（
又所望により２〜１８ｗｔ％の値とすることもできる。(CH2NO3Coo)I )4 Kl-n 412(
, fl+ , , f12, n4. ! 14 = 0.
2 to i, n'J may be the same value or may be different values), and the iodine concentration can be as high as about 18 wt% (
Moreover, the value can be set to 2 to 18 wt% if desired.
）、長期間変質することなく保存可能である０例えば２
年間、ヨウ素を１６％含有する消毒剤を室温において保
存した場合、有効ヨウ素ｔｉ１は９８％に低下するに過
ぎない。), can be stored for a long time without deterioration, e.g. 2
If a disinfectant containing 16% iodine is stored at room temperature for a year, the effective iodine ti1 will only decrease to 98%.
本発明消毒剤には更に緩衝作用を有する多ＩＭ基酸を添
加することが好ましい、酸としてはリン酸、シュウ酸、
クエン酸が特に好適である。このような酸を加えること
により、本発明消毒剤を使用時に稀釈する水として広い
ＰＨ範囲の水を使用することが可能となる。なお酸の使
用量は製品のＰＨが０．５〜３．０好ましくは１〜２ど
なるよう定めるのが適当である。It is preferable to further add a multi-IM base acid having a buffering effect to the disinfectant of the present invention. Examples of the acid include phosphoric acid, oxalic acid,
Citric acid is particularly preferred. By adding such an acid, it becomes possible to use water with a wide pH range as water for diluting the disinfectant of the present invention during use. The amount of acid to be used is appropriately determined so that the pH of the product is 0.5 to 3.0, preferably 1 to 2.
第１表は有効ヨウ素濃度の高い本発明消毒剤の組成−例
、第２表は有効ヨウ素濃度の低い本発明消毒薬の組成の
一例である。Table 1 shows an example of the composition of a disinfectant of the present invention having a high concentration of effective iodine, and Table 2 shows an example of a composition of a disinfectant of the present invention having a low concentration of effective iodine.
第１表（ｗｔ％）
第２表（ｗｔ％）
Ｅ述の本発明消毒剤（原液）を水で稀釈し、動物に噴霧
し、殺菌、消毒を行なう、稀釈塵は有効ヨウ素２０〜２
００ ｐｐｔｓ程度とするのが適当であるが１本発明消
毒剤は毒性が低く高濃度で使用することが可能である。Table 1 (wt%) Table 2 (wt%) The disinfectant of the present invention (undiluted solution) described in E is diluted with water and sprayed on animals for sterilization and disinfection.The diluted dust contains 20-20% effective iodine.
The disinfectant of the present invention has low toxicity and can be used at a high concentration.
例えば、一般のヨードホールがＬ Ｄ ｓｏ経ロラット
１９８ ｍｇ／ｋｇ有効ヨウ素換算であるのに対して、
本発明のヨードホールはＬ Ｄ ｓｏ経ロラット５０２
＋ｇ／ｋｇ有効ヨウ素換算と２．５倍以上の安全性が
確認されている。For example, while common iodophor has an effective iodine equivalent of 198 mg/kg,
The iodophor of the present invention is L Dso meridian Lorat 502
It has been confirmed that it is more than 2.5 times safer than +g/kg effective iodine equivalent.
又、本発明消毒剤は殺菌力も大きく、低濃度でも充分な
効果をあげることができる。第３表に殺菌力の比較を示
す。Furthermore, the disinfectant of the present invention has a high bactericidal power and can be sufficiently effective even at low concentrations. Table 3 shows a comparison of bactericidal power.
又本発明消毒剤は広い抗菌スペクトルを有する。殺菌力
に関しては、ダラム陰性、陽性菌はもちろん、ウィルス
、芽胞細菌に対して強い殺菌力を示した、特にヨウ素系
の殺菌剤がすぐれているカビ、酵母、芽胞に対して速効
性を示しており、特に芽胞に関しては一般のヨードホー
ルと比べて本発明のヨードホールに速効性が認められた
。Furthermore, the disinfectant of the present invention has a broad antibacterial spectrum. In terms of bactericidal power, it has shown strong bactericidal power not only against Durham negative and positive bacteria, but also against viruses and spore bacteria.In particular, it has shown fast efficacy against mold, yeast, and spores, where iodine-based fungicides are superior. In particular, the iodophors of the present invention were found to be more effective against spores than general iodophors.
例えば、Ｃａｎｄｉｄａ ａｌｂｉｃａｎｓ、Ｅｇｃｈ
ｅｒｉｃｈｉａｃｏｌｉ。For example, Candida albicans, Egch.
erichiacoli.
Ｐｓｅｕｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｇａ及び５
ｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓに対しては、
有効ヨウ素濃度１０ ＰＰ１１ 、接触時間１５秒で殺
菌効果があり、Ａｇｐｅｒｇｉｌｌｕｓｎｉｇｅｒに対
しては５０ｐｐｍ５分又は２００ｐｐｓ１分の接触時間
で殺菌効果がある。Pseudomonas aeruginoga and 5
For taphylococcusaureus,
It has a bactericidal effect with an effective iodine concentration of 10 PP11 and a contact time of 15 seconds, and a bactericidal effect against Agpergillus niger with a contact time of 5 minutes at 50 ppm or 1 minute at 200 pps.
更に又本発明消毒剤は腐食性も小さく、刺激性も弱い、
そして動物の忌避性もない、却って豚を消毒した場合豚
体に耐着した消毒剤を、互いになめ合うという嗜好性が
認められた。Furthermore, the disinfectant of the present invention is less corrosive and less irritating.
In addition, it was found that animals did not have repellency to animals, and on the contrary, when pigs were disinfected, they licked off the disinfectant that adhered to the pigs' bodies.
［実施例］ 次に本発明の消毒剤の一例であるＩ ＳＥ。[Example] Next, ISE is an example of the disinfectant of the present invention.
−１６を豚の殺菌、消毒に使用した実施例を示す。An example is shown in which 16-16 was used for sterilization and disinfection of pigs.
なおＩＳＥ、−１６の組成は次の通りである。The composition of ISE-16 is as follows.
ヨウ素 １６％
ＫＩ １１％
グリシン １９％
ｍ ８％
精製水 残
新ヨウ素系消毒剤ＩＳＥ、−１６の安全性試験（子豚に
対する噴霧による試験）
ｌ、要旨
新ヨウ素系の消ｉＪｆ剤であるＩＳＥ、−１，６を動物
用消毒薬として開発するにわたり実際の使用条件下にお
ける子豚に対する安全性の検討を行なった。Iodine 16% KI 11% Glycine 19% m 8% Purified water Safety test of the new iodine-based disinfectant ISE, -16 (test by spraying on piglets) l.Summary ISE, a new iodine-based disinfectant, -1,6 was developed as an animal disinfectant, and its safety for piglets under actual conditions of use was investigated.
試験は離乳直後の子豚に対し、１週間に２回の割合で合
計１２回（６週間）にわたり、底体及び豚房に直接ＩＳ
Ｅ、−１６の最高３２０ｐｐｍ（有効成分として）溶液
を噴霧した。The test was conducted on piglets immediately after weaning, twice a week for a total of 12 times (6 weeks), with IS applied directly to the bottom body and pig stall.
A solution of up to 320 ppm (as active ingredient) of E, -16 was sprayed.
その結果、ＩＳＥ、−１６を噴霧した各区の子豚には一
般症状及び皮膚刺激等で何ら副作用は認められず、鋳養
試験成績においても１発育及び飼料要求率の点で対照区
に比較してすぐれた成績を示し、安全性が確認された。As a result, piglets in each group sprayed with ISE, -16 did not exhibit any side effects such as general symptoms or skin irritation, and the results of casting tests showed that piglets in each group sprayed with ISE, -16 showed no side effects compared to the control group in terms of growth and feed conversion rate. It showed excellent results and its safety was confirmed.
２、試験方法 １）供試薬 ＩＳＥ、−１６（有効ヨウＪ：１６％含有製剤）。2. Test method 1) Test drug ISE, -16 (formulation containing 16% effective iodine J).
２）供試豚
約３０日令のＬ及びＷ種離乳子豚２９頭（♂１７、♀１
２）を平均体重及び由来がなるべく均等になるように４
区分に割り当てた。2) Test pigs 29 L and W weaned piglets approximately 30 days old (♂17, ♀1
2) so that the average weight and origin are as equal as possible 4
Assigned to category.
１区分あたりの頭数は１．３．４区が７頭。The number of animals per category is 7 in the 1, 3, and 4 wards.
２区が８頭であった。There were eight in Ward 2.
３）飼 料
市販の哺乳期子豚用人工乳Ａ及びＢを給与したが、試験
期間中のＡからＢへの切換えは、試験開始後ｆｉｌｌか
ら２週にかけて常法により行なったｅ
４）区の設定及び試験方法
区の設定は表４に示したとおり、Ｉ ＳＥ。3) Feed Commercially available artificial milk for suckling piglets A and B were fed, but the switch from A to B during the test period was carried out in a conventional manner from fill to 2 weeks after the start of the test. As shown in Table 4, the settings of ISE and test method area are as shown in Table 4.
−１６を水道水で希釈し、有効ヨウ素含量として３２．
８０．３２０ＰＰ−の濃度とした水溶液を噴霧する区分
をそれぞれ１区、２区、３区とした。-16 was diluted with tap water and the effective iodine content was 32.
The sections in which the aqueous solution having a concentration of 80.320 PP- was sprayed were designated as Section 1, Section 2, and Section 3, respectively.
ＩＳＥ、−１６は通常８０ ｐｐｍを常用最高用ｈＸ゛
として使用するものであり、本試験の最高濃度である３
２０ ｐｐａ＋は常用最高用醍の４倍量に相当し、こ
の場合１２回の噴霧で直接底体に噴霧される有効ヨウ素
量は１頭あたり約１．９〜３．８ｇの量になる。For ISE, -16, 80 ppm is normally used as the highest hX, and 3 is the highest concentration in this test.
20 ppa+ corresponds to four times the amount of the most commonly used iodine, and in this case, the effective amount of iodine sprayed directly onto the bottom body in 12 sprays is about 1.9 to 3.8 g per head.
５）飼養管理
飼料は不断給餌、飲水は自由としたほか、ワクチネーシ
ョン等は出場の慣行に従い、各供試豚とも均一となるよ
うに配慮した。5) Feeding management In addition to ad libitum feeding and ad libitum drinking water, vaccinations were administered in accordance with the practices of participating pigs, and care was taken to ensure that all test pigs were uniform.
なお、供試薬の投与は噴霧という形をとったので、他区
への流出による影響を考慮し、試験各区の豚ｍは１つお
きに設置し、又、試験期間中においては、他の消ｙＢ剤
による噴霧消１１１はいっさい実施しなかった。In addition, since the test drug was administered in the form of a spray, taking into consideration the impact of spillage to other areas, pigs in each test area were placed every other time, and during the test period, other No spray eradication 111 with the yB agent was performed.
８） Ｊ！ｌ査項目
山飼養試験に関する項目
・固体別体用測定（２週おき）
・飼料摂取量（〃）
・飼料要求率（／ｌ ）
（鉋安全性に関する項［１（野外臨床的観察）壷一般症
状及び死亡別
・皮膚刺激作用
・その他の副作用
３、試験結果
１）飼養試験成績
■発 育
発育に関する試験成績は第５表にとりまとめて示した。8) J! Inspection items Items related to the mountain feeding test - Measurement for individual animals (every two weeks) - Feed intake (〃) - Feed conversion rate (/l) (Section related to plane safety [1 (Field clinical observation) Pots in general Symptoms and mortality, skin irritation, and other side effects 3. Test results 1) Feeding test results ■ Test results regarding growth and development are summarized in Table 5.
各区の供試豚はバラツキも少なく、会頭とも順調に発育
したが、試験終了時においてＩＳＥ、−１６を噴霧した
１、２．３区は対照区に比較して全般に体重が大きかっ
た。増体瓜でＩＳＥ、−１６噴霧の各区は対照区より１
．２〜１．３ ｋｇすぐれた結果となり、これを増俸指
数で示すと、約５％程度の改善となった。The test pigs in each group had little variation and grew normally, but at the end of the test, the weights of the 1 and 2.3 groups sprayed with ISE, -16 were generally larger than the control group. For weight gain melons, each plot sprayed with ISE and -16 was 1 lower than the control plot.
．． The result was an improvement of 2 to 1.3 kg, and when expressed as a salary increase index, it was an improvement of about 5%.
このように、ＩＳＥ、−１６の噴霧は子豚の発育に何ら
障害をダえず、逆に発育を改善する結果となった。又１
発育におけるＩＳＥ。As described above, spraying of ISE, -16 did not cause any damage to the growth of piglets, but on the contrary, it resulted in improved growth. Again 1
ISE in development.
−１６の用量による差は認められず、３２０ｐｐｍとい
う高濃度の噴霧においても発育に好影響を与えることが
示された。No difference was observed depending on the dose of -16, and it was shown that spraying at a high concentration of 320 ppm had a positive effect on growth.
■飼料摂取量、飼料要求率
１頭あたりの飼料摂取量の合計は各区とも約５０ｋｇ程
度であり、ＩＳＥ、−１６の噴霧による摂取量の低下等
の悪影響は何らみられなかった。飼料要求率においても
、ＩＳＥ、−１６噴霧の１．２，３区は増俸がすぐれて
いたことに由来して、４区の対照区に比較して約５〜７
％程度すぐれた値を示した。■Feed intake and feed conversion ratio The total feed intake per head was approximately 50 kg in each group, and no adverse effects such as a decrease in intake due to the spraying of ISE and -16 were observed. In terms of feed conversion rate, the increase in pay in plots 1.2 and 3 using ISE and -16 spraying was excellent, and it was approximately 5-7% compared to the control plot in plot 4.
It showed an excellent value of about %.
２）安全性
安全性に関する臨床的な調査結果につｌ、％ては１表６
にまとめて示した。2) Safety Clinical survey results regarding safety, 1%, Table 6
are summarized in the following.
以上のように、ＩＳＥ、＝１８の子豚に対する噴霧試験
の結果、常用最高濃度の４倍量においても、まったく安
全性には問題がないことが認められた。As mentioned above, as a result of the spraying test on piglets with ISE = 18, it was recognized that there were no safety problems at all even at a dose four times the highest concentration commonly used.
ヨウ素系消毒剤ＩＳＥ、−１６のブロイラーに対する噴
霧による安全性試験
１、試験目的
ブロイラーに対し、ヨウ素系消毒剤ＩＳＥ。Safety test 1 by spraying iodine-based disinfectant ISE, -16 on broilers, test purpose iodine-based disinfectant ISE on broilers.
−１６を追討に直接噴霧して１発育に及ぼす影響と安全
性につき調査した。-16 was directly sprayed on the plant to investigate its effect on growth and safety.
飼養試験に関する成績は表７に示した。The results regarding the feeding test are shown in Table 7.
（１）飼養試験 雄・雌平均では対照区に比較してＩＳＥ。(1) Feeding test Average ISE for males and females compared to control group.
−１６噴霧の各区は１．４〜１．７％程度の増体重の改
善がみられ、トータルでは発育が促進される傾向が認め
られた。In each group sprayed with -16, an improvement in weight gain of about 1.4 to 1.7% was observed, and a tendency for overall growth to be promoted was observed.
飼料要求率においては、対照区に比較してＩＳＥ、−１
６の３２ ｐｐｍ及び８０ｐｐｍ噴霧区が約８％の飼料
節約効果がみられ、３２０ｐｐａｔ噴霧区でも約４％の
飼料節約効果がみられた。In terms of feed conversion rate, ISE, -1 compared to the control group.
A feed saving effect of approximately 8% was observed in the 32 ppm and 80 ppm spray areas of No. 6, and a feed saving effect of approximately 4% was observed in the 320 ppt spray area.
手続補正書 昭和６１年 ４月 ３日Procedural amendment April 3, 1986
Claims (12)
たヨウ素水溶液よりなることを特徴とする動物用殺菌消
毒剤。(1) A sterilizing disinfectant for animals comprising an aqueous iodine solution using glycine and water-soluble iodide as a solubilizing agent.
とする特許請求の範囲第１項記載の動物用殺菌消毒剤。(2) The animal disinfectant according to claim 1, wherein the water-soluble iodide is HI or KI.
；（ＣＨ＿２ＮＨ＿２ＣＯＯＨ）＿４ＨＩ・ｎ＿２Ｉ＿
２（ＣＨ＿２ＮＨ＿２ＣＯＯＨ）＿２ＫＩ・ｎ＿３Ｉ＿
２又は、（ＣＨ＿２ＮＨ＿２ＣＯＯＨ）＿４ＫＩ・ｎ＿
４Ｉ＿２（ｎ＿１、ｎ＿２、ｎ＿３、ｎ＿４＝０．２〜
１）を主体とする水溶液よりなることを特徴とする特許
請求の範囲第２項記載の動物用殺菌消毒剤。(3) Iodine aqueous solution is (CH_2NH_2COOH)_2HI・n_1I_2
;(CH_2NH_2COOH)_4HI・n_2I_
2(CH_2NH_2COOH)_2KI・n_3I_
2 or (CH_2NH_2COOH)_4KI・n_
4I_2 (n_1, n_2, n_3, n_4=0.2~
1) The disinfectant for animals according to claim 2, characterized in that it is an aqueous solution mainly consisting of the following.
徴とする特許請求の範囲第１、２、３、項記載の動物用
殺菌消毒剤。(4) The disinfectant for animals according to claims 1, 2, and 3, characterized in that the aqueous solution contains a polybasic acid having buffering capacity.
特徴とする特許請求の範囲第１〜４項記載の動物用殺菌
消毒剤。(5) The disinfectant for animals according to claims 1 to 4, wherein the acid is phosphoric acid, oxalic acid, or citric acid.
は夫々３０〜１２０ｗｔ％、６５〜１５０ｗｔ％である
ことを特徴とする特許請求の範囲第１〜５項記載の動物
用殺菌消毒剤。(6) The disinfectant for animals according to claims 1 to 5, characterized in that the ratios of glycine and water-soluble iodizing agent to iodine are 30 to 120 wt% and 65 to 150 wt%, respectively.
たヨウ素水溶液を動物に噴霧することを特徴とする動物
の殺菌消毒法。(7) A method for sterilizing and disinfecting animals, which comprises spraying animals with an iodine aqueous solution using glycine and water-soluble iodide as solubilizers.
徴とする特許請求の範囲第７項記載の動物の殺菌消毒法
。(8) The method for sterilizing and disinfecting animals according to claim 7, wherein the water-soluble iodide is HI or KI.
、（ＣＨ＿２ＮＨ＿２ＣＯＯＨ）＿４ＨＩ・ｎ＿２Ｉ＿
２、（ＣＨ＿２ＮＨ＿２ＣＯＯＨ）＿２ＫＩ・ｎ＿３Ｉ
＿２又は、（ＣＨ＿２ＮＨ＿２ＣＯＯＨ）＿４ＫＩ・ｎ
＿４Ｉ＿２（ｎ＿１、ｎ＿２、ｎ＿３、ｎ＿４＝０．２
〜１）を主体とする水溶液よりなることを特徴とする特
許請求の範囲第７、８項記載の動物の殺菌方法。(9) Iodine aqueous solution is (CH_2NH_2COOH)_2HI・n_1I_2
, (CH_2NH_2COOH)_4HI・n_2I_
2, (CH_2NH_2COOH)_2KI・n_3I
_2 or (CH_2NH_2COOH)_4KI・n
_4I_2(n_1, n_2, n_3, n_4=0.2
A method for sterilizing animals according to claims 7 and 8, characterized in that the method comprises an aqueous solution mainly consisting of -1).
ことを特徴とする特許請求の範囲第８、９項記載の動物
の殺菌消毒法。(10) The method for sterilizing and disinfecting animals according to claims 8 and 9, wherein the aqueous solution contains phosphoric acid, oxalic acid, or citric acid.
〜２７ｗｔ％、グリシン０．５〜２０ｗｔ％を含むこと
を特徴とする特許請求の範囲第７〜１１項記載の動物の
殺菌消毒法。(11) The aqueous solution contains 2 to 8 wt% of iodine and 2 to 8 wt% of water-soluble iodide.
12. The method for sterilizing and disinfecting animals according to claims 7 to 11, characterized in that the method contains 27 wt% of glycine and 0.5 to 20 wt% of glycine.
囲第７〜１１項記載の動物殺菌消毒法。(12) The method for sterilizing and disinfecting animals according to claims 7 to 11, wherein the animal is a pig.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2577986A JPS62185019A (en) | 1986-02-10 | 1986-02-10 | Antiseptic disinfectant for animal and method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2577986A JPS62185019A (en) | 1986-02-10 | 1986-02-10 | Antiseptic disinfectant for animal and method therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS62185019A true JPS62185019A (en) | 1987-08-13 |
Family
ID=12175322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2577986A Pending JPS62185019A (en) | 1986-02-10 | 1986-02-10 | Antiseptic disinfectant for animal and method therefor |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62185019A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000054594A1 (en) * | 1999-03-15 | 2000-09-21 | SALTER, Roy | Sterilant composition |
| CN106135274A (en) * | 2015-04-22 | 2016-11-23 | 苏州泰利三佳纳米科技有限公司 | A kind of medicated clothing skin degerming agent composition containing iodine and preparation method thereof |
-
1986
- 1986-02-10 JP JP2577986A patent/JPS62185019A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000054594A1 (en) * | 1999-03-15 | 2000-09-21 | SALTER, Roy | Sterilant composition |
| CN106135274A (en) * | 2015-04-22 | 2016-11-23 | 苏州泰利三佳纳米科技有限公司 | A kind of medicated clothing skin degerming agent composition containing iodine and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2940428C (en) | Stable compositions of uncomplexed iodine and methods of use | |
| KR920001457B1 (en) | Natural preservative composition for wet wipes | |
| US4923899A (en) | Sterilant composition | |
| CA1228297A (en) | Composition with high bactericidal power containing a biguanide and a pyrimidine | |
| US7078062B2 (en) | Hop-based udder and teat dips and washes | |
| EP0528697B1 (en) | Sporicidal disinfectant compositions production and use thereof | |
| EP3160234B1 (en) | Compositions for use in preventing and treating opthalmic, hand or feet biofilm growth | |
| EP1317262B1 (en) | Topically applied hoof treatment composition concentrate | |
| US3950554A (en) | Treatment of mastitis in bovine udders | |
| US6525071B2 (en) | Compositions and methods for the treatment and prevention of bovine mastitis | |
| CA2535004C (en) | Topical veterinary compositions and methods for the treatment and prevention of infection | |
| US6284719B1 (en) | Two pack system for the preparation of peracid compositions for teat-dips | |
| US20240122970A1 (en) | Compositions of and methods for dairy animal teat dip | |
| RU2151614C1 (en) | Antibacterial composition and method of sterilization | |
| US4025628A (en) | Control of bovine mastitis | |
| US9918991B2 (en) | Topical antimicrobial compositions and methods of using same | |
| US9474729B2 (en) | Topical antimicrobial compositions and methods of using same | |
| US8932655B2 (en) | Antiseptic teat dip microemulsion | |
| JPS62185019A (en) | Antiseptic disinfectant for animal and method therefor | |
| US4067967A (en) | Composition for topical application to humans and animals | |
| CN113854294A (en) | Disinfectant composition for musk deer breeding houses as well as preparation method and application of disinfectant composition | |
| EP0799570A1 (en) | Preparation and uses of microbicidal formulations | |
| CN114515255A (en) | Medical and common disinfectant for sterilization and disinfection and disinfectant wet tissue solution | |
| JPS5827771B2 (en) | Agricultural and horticultural sterilization and fruit storage disease control composition | |
| CA2010193C (en) | Sterilant composition |