JPS62175417A - Hair tonic cosmetic - Google Patents
Hair tonic cosmeticInfo
- Publication number
- JPS62175417A JPS62175417A JP61016573A JP1657386A JPS62175417A JP S62175417 A JPS62175417 A JP S62175417A JP 61016573 A JP61016573 A JP 61016573A JP 1657386 A JP1657386 A JP 1657386A JP S62175417 A JPS62175417 A JP S62175417A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- extract
- group
- tonic
- cosmetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004209 hair Anatomy 0.000 title claims abstract description 55
- 239000002537 cosmetic Substances 0.000 title claims abstract description 25
- 230000001256 tonic effect Effects 0.000 title abstract description 10
- 239000000284 extract Substances 0.000 claims abstract description 26
- 230000001737 promoting effect Effects 0.000 claims abstract description 14
- 230000017531 blood circulation Effects 0.000 claims abstract description 11
- 150000001875 compounds Chemical class 0.000 claims abstract description 7
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 claims abstract description 4
- 229950009883 tocopheryl nicotinate Drugs 0.000 claims abstract description 4
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 3
- 150000001340 alkali metals Chemical class 0.000 claims abstract description 3
- 150000001413 amino acids Chemical class 0.000 claims abstract description 3
- 150000001768 cations Chemical group 0.000 claims abstract description 3
- 240000008397 Ganoderma lucidum Species 0.000 claims description 5
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims description 5
- 229940008396 carrot extract Drugs 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 244000184734 Pyrus japonica Species 0.000 claims description 4
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 claims description 4
- 229950004580 benzyl nicotinate Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 35
- 230000003779 hair growth Effects 0.000 abstract description 28
- AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 abstract description 15
- 235000019136 lipoic acid Nutrition 0.000 abstract description 15
- 229960002663 thioctic acid Drugs 0.000 abstract description 15
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 abstract description 11
- 208000001840 Dandruff Diseases 0.000 abstract description 8
- 239000006071 cream Substances 0.000 abstract description 7
- 239000011159 matrix material Substances 0.000 abstract description 7
- -1 thioctic acid compound Chemical class 0.000 abstract description 7
- 201000004384 Alopecia Diseases 0.000 abstract description 5
- 240000004371 Panax ginseng Species 0.000 abstract description 4
- 235000002789 Panax ginseng Nutrition 0.000 abstract description 4
- 235000008434 ginseng Nutrition 0.000 abstract description 4
- 230000003213 activating effect Effects 0.000 abstract description 3
- 241000967294 Swertia japonica Species 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- FCCDDURTIIUXBY-UHFFFAOYSA-N lipoamide Chemical compound NC(=O)CCCCC1CCSS1 FCCDDURTIIUXBY-UHFFFAOYSA-N 0.000 abstract description 2
- 238000013329 compounding Methods 0.000 abstract 2
- 241000123326 Fomes Species 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 239000006210 lotion Substances 0.000 abstract 1
- UUDFBRWLHZIIQX-UHFFFAOYSA-M sodium;5-(dithiolan-3-yl)pentanoate Chemical compound [Na+].[O-]C(=O)CCCCC1CCSS1 UUDFBRWLHZIIQX-UHFFFAOYSA-M 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 53
- 238000012360 testing method Methods 0.000 description 19
- 235000019441 ethanol Nutrition 0.000 description 18
- 239000004615 ingredient Substances 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 10
- 238000002156 mixing Methods 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000003658 preventing hair loss Effects 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 235000015961 tonic Nutrition 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 3
- 206010068168 androgenetic alopecia Diseases 0.000 description 3
- 201000002996 androgenic alopecia Diseases 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 210000004761 scalp Anatomy 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 241000228212 Aspergillus Species 0.000 description 2
- 206010039792 Seborrhoea Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000003694 hair properties Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- 208000019300 CLIPPERS Diseases 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 241000222336 Ganoderma Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000218922 Magnoliophyta Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 235000002791 Panax Nutrition 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000981595 Zoysia japonica Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 239000000051 antiandrogen Substances 0.000 description 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
Abstract
Description
【発明の詳細な説明】
（技術分野）
本発明は、後記特定のチオクト酸系化合物を配合してな
る養毛化粧料に関する。更に詳しくは、毛母細胞を賦活
し、育毛効果及び養毛効果、脱毛予防、ふけ防止等の効
果の優れた養毛化粧料に関する。DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to a hair nourishing cosmetic containing a specific thioctic acid compound described below. More specifically, the present invention relates to a hair nourishing cosmetic that activates hair matrix cells and has excellent effects such as hair growth, hair nourishment, hair loss prevention, and dandruff prevention.
（従来技術）
従来より、種々の毛母細胞賦活作用または血行促進作用
を有する成分を配合してなる養毛化粧料が提案されてい
る。また、近年では養毛化粧料の適用と共にブラシ（パ
ッティングブラシ）を併用して頭皮の血行をマツサージ
またはパッティングにより促進することが普及し、目的
とする養毛効果が得られることが知られている。(Prior Art) Hair nourishing cosmetics containing various ingredients having a hair matrix activation effect or a blood circulation promoting effect have been proposed. In addition, in recent years, it has become popular to use a brush (putting brush) in conjunction with the application of hair-growth cosmetics to promote blood circulation in the scalp through pine surge or patting, and it is known that the desired hair-growth effect can be achieved. .
しかし、積極的に育毛効果または養毛効果を期待する程
度に優れた養毛化粧料を得ることは困難であった。However, it has been difficult to obtain hair-growth cosmetics that are excellent enough to positively promote hair-growth or hair-growth effects.
（発明の開示）
そこで本発明者は、毛母細胞を賦活する成分に関して鋭
意研究した結果、後記特定のチオクト酸系化合物は、育
毛効果（マウス毛成長促進効果、ヒト頭髪毛成長促進効
果）、養毛、脱毛予防、ふけ防止等の効果に優れた特性
を示し、更に、血行促進作用を有する成分を添加配合す
ることによって、育毛効果、養毛効果等に著効を呈する
ことを見出して本発明を完成するに至った。(Disclosure of the Invention) Therefore, as a result of intensive research into ingredients that activate hair matrix cells, the present inventor found that the specific thioctic acid-based compounds mentioned below have a hair growth effect (mouse hair growth promoting effect, human hair growth promoting effect), This book was developed based on the discovery that it exhibits excellent properties for hair growth, hair loss prevention, and dandruff prevention, and that by adding and blending ingredients that promote blood circulation, it exhibits remarkable effects on hair growth and hair growth. The invention was completed.
（発明の目的）
即ち、本発明の目的は、育毛効果（マウス毛成長促進効
果、ヒト頭髪毛成長促進効果）、養毛、脱毛予防、ふけ
防止等の効果に優れた養毛化粧料を提供することである
。(Objective of the Invention) That is, the object of the present invention is to provide a hair-growth cosmetic that is excellent in hair-growth effects (mouse hair growth-promoting effect, human hair growth-promoting effect), hair growth, hair loss prevention, dandruff prevention, etc. It is to be.
（発明の構成）
本発明は、下記の一般式で表わされる化合物（以下、便
宜上、チオクト酸系化合物という）の少なくとも一つを
配合してなる養毛化粧料である。(Structure of the Invention) The present invention is a hair nourishing cosmetic containing at least one compound represented by the following general formula (hereinafter referred to as a thioctic acid compound for convenience).
一般式
（式中で、Ｒは一〇Ｈ基、−０Ｍ基、−ＮＨ２基、−０
ＣＨＨ２１＋ｘ基、または−〇ＣｎＨ２ｎ−１基である
。但し、Ｍはアルカリ金属またはアルカノールアミン、
塩基性アミノ酸から誘導されるカチオンである。）（構
成の具体的な説明）
本発明における前記一般式で表わされるチオクト酸系化
合物としては、例えばチオクト酸、チオクト酸アミド、
チオクト酸ナトリウム、チオクト酸カリウム、チオクト
酸メチル、チオクト酸エチル、チオクト酸オクチル、チ
オクト酸イソオクチル、チオクト酸ヘキサデシル、チオ
クト酸ステアリル、チオクト酸イソステアリル、チオク
ト酸オレイル、チオクト酸モノエタノールアミン、チオ
クト酸トリエタノールアミン、チオクト酸し一アルギニ
ン、チオクト酸し一リジン等が挙げられる。General formula (in the formula, R is 10H group, -0M group, -NH2 group, -0
CHH21+x group or -0CnH2n-1 group. However, M is an alkali metal or alkanolamine,
It is a cation derived from basic amino acids. ) (Specific description of structure) Examples of the thioctic acid-based compound represented by the above general formula in the present invention include thioctic acid, thioctic acid amide,
Sodium Thioctoate, Potassium Thioctoate, Methyl Thioctoate, Ethyl Thioctoate, Octyl Thioctoate, Isooctyl Thioctoate, Hexadecyl Thioctoate, Stearyl Thioctoate, Isostearyl Thioctoate, Oleyl Thioctoate, Monoethanolamine Thioctoate, Trioctoate Examples include ethanolamine, thioctic acid monoarginine, thioctic acid monolysine, and the like.
本発明の養毛化粧料中に配合せる上記チオクト酸系化合
物は、頭皮の毛母細胞を賦活して優れた養毛効果、脱毛
予防効果を発現し、更には、頭皮代謝機能を正常化して
ふけ防止効果を高め得る。The above-mentioned thioctic acid compound incorporated into the hair-growth cosmetic of the present invention activates the hair matrix cells of the scalp, exhibits excellent hair-growth effects and hair loss prevention effects, and further normalizes the scalp metabolic function. It can enhance the anti-dandruff effect.
特に男性型脱毛症に適用して著効を呈することができる
。It can be particularly effective when applied to androgenetic alopecia.
前記チオクト酸系化合物の配合量は、養毛化粧料の総量
を基準として０．０５〜２．０重量％（以下、ｗｔ％と
略記する）である。０．０５ｗｔ％未満では本発明の目
的とする効果が充分でなく、一方、２．０ｗｔ％を超え
てもその増加分に見合った効果の向上は望めないもので
ある。The amount of the thioctic acid compound is 0.05 to 2.0% by weight (hereinafter abbreviated as wt%) based on the total amount of the hair nourishing cosmetic. If it is less than 0.05 wt%, the effect aimed at by the present invention is not sufficient, and on the other hand, if it exceeds 2.0 wt%, it cannot be expected to improve the effect commensurate with the increase.
また、本発明の養毛化粧料には、前述のごとく血行促進
作用を有する成分を上記必須成分と添加配合することが
より好ましい。血行促進物質としては、例えば、センブ
リエキス、ニンジンエキス、霊芝エキス、ビタミンＥニ
コチネート、ニコチン酸ベンジル等が適用される。Further, it is more preferable that the hair nourishing cosmetic of the present invention contains a component having a blood circulation promoting effect as described above with the above-mentioned essential component. As the blood circulation promoting substance, for example, Japanese cabbage extract, carrot extract, reishi extract, vitamin E nicotinate, benzyl nicotinate, etc. are applied.
上記の成分のうち、天然物の抽出物であるセンブリエキ
ス、ニンジンエキス、霊芝エキスの製造法に関しては特
定されるものではないが、各々の製造方法の概要を以下
に記載する。Among the above ingredients, the methods for producing the natural product extracts, such as Jasperia japonica extract, carrot extract, and Reishi extract, are not specified, but the outline of each production method is described below.
センブリ（Ｓｗｅｒｔｉａ Ｊａｐｏｎｉｃａ Ｍａｋ
ｉｎｏ ）の開花期全草の乾燥粉砕物をエタノール或い
は含水エタノール中で温浸し、ろ別して得られた抽出液
である。実施例には、下記の方法で得られた抽出液を利
用した。Swertia Japonica Mak
This is an extract obtained by digesting a dried and pulverized product of the whole flowering plant of Ino ) in ethanol or aqueous ethanol and filtering it. In the Examples, an extract obtained by the following method was used.
センブリ細砕物５０ｆを含水エタノール（エタノール９
０ｗｔ％） ２５０ ｍｌに温度４０〜５０℃で温浸し
てろ別した後、再び残渣を同様に温浸することを数回く
り返し、抽出液１．５１を得た。これを減圧濃縮した残
留物に精製水をｌ ＯＯｍｌ加え、１週間熟成した後、
不溶部をろ別して得た抽出液を減圧濃縮し、次いでエタ
ノールを加えて抽出液のエタノール含有量が４０ ｗｔ
％になるように調整し、１００ ｍｌのセンブリエキス
を得たｂ［ニンジンエキスの製造ｍ ］
オタネニンジン（Ｐａｎａｘ ｇｉｎｓｅｎｇ Ｃ，Ａ
、 Ｍｅｙｅｒ ）の５〜６年根乾燥細砕物をエタノー
ル或いは含水エタノール中に冷浸し、ろ別して得られた
抽出液である。実施例には下記の方法でえられた抽出液
を利用した。50f of crushed Aspergillus was added to water-containing ethanol (Ethanol 9
0wt%) was digested at a temperature of 40 to 50°C and filtered, and the residue was digested in the same manner several times to obtain an extract of 1.51. This was concentrated under reduced pressure, 1 OOml of purified water was added to the residue, and after aging for one week,
The extract obtained by filtering off the insoluble portion was concentrated under reduced pressure, and then ethanol was added to reduce the ethanol content of the extract to 40 wt.
%, and 100 ml of Panax ginseng extract was obtained b [Manufacture of carrot extract m] Panax ginseng (Panax ginseng C, A
This is an extract obtained by cold-soaking a 5- to 6-year-old dried pulverized root of A., Meyer) in ethanol or water-containing ethanol and filtering it. In the Examples, an extract obtained by the following method was used.
オタネニンジン細砕物５０ｆを含水エタノール（エタノ
ール９ Ｑ ｗｔ％） ２００ ｍｌに１週間冷浸し、
ろ別して得られた抽出液のエタノールを留去し、精製水
を加えて抽出液のエタノール含有量が５０ ｗｔ％にな
るように調整し、更にこれを゛７〜１０週間冷所で熟成
した後、ろ別して１００ ｍｌのニンジンエキスを得た
。50 f of crushed Panax carrots were cold soaked in 200 ml of aqueous ethanol (ethanol 9 Q wt%) for one week.
Ethanol in the extract obtained by filtration was distilled off, purified water was added to adjust the ethanol content of the extract to 50 wt%, and this was further aged in a cold place for 7 to 10 weeks. , and filtered to obtain 100 ml of carrot extract.
［ＷＬ芝芝生キス製造法］
霊芝（Ｇａｎｏｄｅｒｍａ Ｌｕｃｉｄｕｍ ）の乾燥
細砕物ヲエタノール或いは含水エタノールに温浸し、ろ
別して得られた抽出液である。実施例には下記の方法で
得られた抽出液を使用した。[WL Shiba Lawn Kiss Production Method] This is an extract obtained by soaking dried crushed Ganoderma Lucidum in ethanol or hydrous ethanol and filtering it. In the examples, an extract obtained by the following method was used.
霊芝の乾燥粉末５０Ｆを２００ ｍｌｌの含水エタノー
ル（エタノール９０ ｗｔ％）に８日間５０°Ｃで温浸
し、ろ別して得られた抽出液を減圧濃縮し、得られた残
留物に精製水を加えてエタノール濃度を５０ ｗｔ％と
じ、ろ別して霊芝エキス１００ ｍｊ？を得た。これら
の血行促進作用を有する成分を本発明の養毛化粧料に配
合する量は、各々の成分の作用効果あるいは該養毛化粧
料の剤型等により適宜調征されるものであるが、−例を
示すと通常第１表に示す配合量が好適である。尚、配合
量は養毛化粧料の総量を基準とした。Dry powder of Ganoderma 50F was digested in 200 ml of aqueous ethanol (90 wt% ethanol) at 50°C for 8 days, filtered, the resulting extract was concentrated under reduced pressure, and purified water was added to the resulting residue. The ethanol concentration was adjusted to 50 wt%, filtered, and reishi extract was added to 100 mj? I got it. The amount of these ingredients having a blood circulation promoting effect to be blended into the hair nourishing cosmetic composition of the present invention is adjusted as appropriate depending on the effect of each ingredient or the dosage form of the hair nourishing cosmetic composition. For example, the amounts shown in Table 1 are usually suitable. Incidentally, the blending amount was based on the total amount of the hair nourishing cosmetic.
第１表
本発明の養毛化粧料は、常法に従って、ヘアートニック
、ヘアーローン１ン、へアーク！Ｊ −Ａ等の剤型にす
ることが可能である。Table 1: The hair nourishing cosmetics of the present invention can be prepared using conventional methods such as Hair Tonic, Hair Lawn 1, and Hair Ark! It can be made into a dosage form such as J-A.
本発明の養毛化粧料には、色素、香料、殺菌剤、防腐剤
、角質溶解剤、抗アンドロゲン剤、養毛剤、抗酸化剤等
を本発明の目的を達成する範囲内で適宜配合することが
できる。The hair nourishing cosmetic composition of the present invention may contain pigments, fragrances, bactericidal agents, preservatives, keratolytic agents, anti-androgens, hair nourishing agents, antioxidants, etc. as appropriate within the scope of achieving the purpose of the present invention. can.
（実施例） 以下、実施例及び比較例に基づいて本発明を詳説する。(Example) Hereinafter, the present invention will be explained in detail based on Examples and Comparative Examples.
尚、マウス毛成長促進効果試験、ヒト頭髪毛成長促進効
果試験及び実用試験を下記に示す。A mouse hair growth promoting effect test, a human hair growth promoting effect test, and a practical test are shown below.
（１）マウス毛成長促進効果試験
ｄｄＹ系白色マウス（雄・６週齢・平均体重８５ｆ）の
尾部よりの背部皮膚を電気バリカンで刈った後、脱毛ク
リームにより完全に除毛し、翌日より実施例及び比較例
の各試料を被験部皮膚に毎日朝夕２回、−匹当り０．１
ｍｌ塗布した。−試料に対して動物は一群１０匹使用
した。(1) Mouse hair growth promotion effect test After cutting the dorsal skin from the tail of ddY white mice (male, 6 weeks old, average weight 85f) with electric clippers, the hair was completely removed with hair removal cream, and the test was carried out from the next day. Apply each sample of Examples and Comparative Examples to the skin of the subject twice daily in the morning and evening, -0.1 per animal.
ml was applied. - A group of 10 animals were used for each sample.
育毛効果の判定は、下表に示す判定基準による肉眼判定
の評価点と、毛長、毛重量を対照群と比較することによ
り行った。The hair growth effect was determined by comparing the visual evaluation score, hair length, and hair weight with the control group according to the criteria shown in the table below.
実験開始後１５日目に動物を層殺し判定基準により肉眼
判定し、その評価点を合計し、−匹当りの平均評価点を
求めた。さらに、被験部の皮膚を切除し、直径１２ｍｍ
のパンチで一定面積の皮膚を打ち抜き乾燥した後、毛の
重量を測定し、その中の２０本の毛の長さについても測
定し、各々の平均値で示した。On the 15th day after the start of the experiment, the animals were visually evaluated according to the stratification criteria, and the evaluation scores were totaled to determine the average evaluation score per animal. Furthermore, the skin of the test area was excised, and a diameter of 12 mm was removed.
After punching out a certain area of the skin and drying it, the weight of the hair was measured, and the lengths of 20 of the hairs were also measured, and the average value of each hair was measured.
育毛効果の評価点の判定基準
（２）ヒト頭髪毛成長促進効果試験
男性型脱毛症患者である被試験者１０名の頭部の耳の上
５ ｃｍの位置の頭髪を左右２ケ所に於て直径１ ｃｍ
の円形状に剃毛した被験部位に、実施例または比較例の
試料を左側に毎日朝夕２回、約８ ｍｌ塗布し、無処置
の右側と比較した。効果の判定は、試験開始後２８日目
に、左右の被験部位の毛髪各々２０本ずつを剃毛し、左
側（実施例または比較例を塗布）の毛２０本の長さの平
均値ＣＢ）を右側（無処置）の毛２０本の長さの平均値
（８）で除した値を求めて評価した。Judgment criteria for hair growth effect evaluation score (2) Human hair growth promotion effect test The hair of 10 test subjects who were patients with androgenetic alopecia was placed at two locations on the left and right, 5 cm above the ears. Diameter 1 cm
Approximately 8 ml of the sample of Example or Comparative Example was applied to the left side of the test site, which had been shaved in a circular shape, twice a day in the morning and evening, and compared with the untreated right side. The effectiveness was determined by shaving 20 hairs each on the left and right test sites on the 28th day after the start of the test, and averaging the length of the 20 hairs on the left side (where Example or Comparative Example was applied) (CB). was divided by the average length (8) of 20 hairs on the right side (untreated) for evaluation.
判定結果は、被試験者１０名の（Ｂ）／（５）の平均値
で示した。The judgment results were shown as the average value of (B)/(5) for 10 test subjects.
（３）実用試験
男性型脱毛症患者である被試験者２０名の頭部に毎日朝
夕２回、連続６ケ月間試料を塗布した後の効果を評価し
た。試験結果は、養毛効果、脱毛予防効果、ふけ防止効
果の各項に対して、「生毛が剛毛化した或いは生毛が増
加した」、「脱毛が少なくなった」、「ふけが少なくな
った」と回答した人数で示した。(3) Practical test The effect was evaluated after applying the sample to the heads of 20 test subjects who were patients with androgenetic alopecia twice a day in the morning and evening for six consecutive months. The test results showed that ``grown hair became bristly or increased in length'', ``less hair loss'', and ``less dandruff'' for hair growth effect, hair loss prevention effect, and dandruff prevention effect. It is shown by the number of people who answered "Yes."
実施例１〜１０、比較例１〜２
〔オイリーヘアートニック〕
下記の原料組成に於いて、第２表に記載のごとくチオク
ト酸系化合物、血行促進作用成分を配合して各々のへア
ートニックを調製し、前記の諸試験を実施した。Examples 1 to 10, Comparative Examples 1 to 2 [Oily hair tonic] Each hair tonic was prepared by blending a thioctic acid-based compound and a blood circulation promoting ingredient as shown in Table 2 in the following raw material composition. The samples were prepared and the various tests described above were conducted.
（１） 組成
（２）調製法
（Ｃ）成分の内、チオクト酸の塩類を（８）成分中に、
他を四成分中に配合して囚、（Ｂ）成分を各々均一に溶
解した後、四成分と（Ｂ）成分を混合撹拌分散し、次い
で容器に充填する。使用時には内容物を均一に振盪分散
して使用する。(1) Composition (2) Preparation method Among component (C), salts of thioctic acid are included in component (8),
After blending the other ingredients into the four components and uniformly dissolving each component (B), the four components and component (B) are mixed and dispersed, and then filled into a container. When using, shake and disperse the contents uniformly.
（３） 特性
各オイリーヘアートニックの諸試験を実施した結果を第
２表右欄に記載した。(3) Characteristics The results of various tests conducted on each oily hair tonic are listed in the right column of Table 2.
第２表に示すごとく、比較例１のへアートニックの基剤
及び比較例２のバントテニルエチルアルコール（毛母賦
活作用成分）とセンブリエキス（血行促進作用成分）と
を配合してなる従来技術のへアートニックと比較して、
本発明の養毛化粧料である実施例１〜１０は諸試験に於
いて優れた特性が明らかに認められた。特に１．実施例
６〜ｌＯのチオクト酸系化合物と血行促進作用成分を配
合してなるヘアートニックは緒特性に於いて著効を示し
た。As shown in Table 2, the prior art is a combination of the hair tonic base of Comparative Example 1 and the vantotenyl ethyl alcohol (hair follicle activating ingredient) and Oriental Japonica extract (blood circulation promoting ingredient) of Comparative Example 2. Compared to Nohe Artnic,
Examples 1 to 10, which are hair nourishing cosmetics of the present invention, were clearly recognized to have excellent properties in various tests. Especially 1. The hair tonics prepared by blending the thioctic acid compounds of Examples 6 to 1O and the blood circulation-promoting ingredient showed remarkable effects in terms of hair properties.
実施例１１〜２１．比較例８〜４
［ヘアークリーム］
実施例１と同様にして各々のへアークリームを調製して
諸試験を実施し、その結果を第８表右欄に記載した。Examples 11-21. Comparative Examples 8 to 4 [Hair Cream] Each hair cream was prepared in the same manner as in Example 1 and various tests were conducted, and the results are listed in the right column of Table 8.
（１） 、ｆｆｉ成
（２） 調製法
（Ｃ）成分の内、チオクト酸の塩類を（Ｂ）成分中に、
他を（８）成分中に配合し、（８）、（Ｂ）成分を各々
温度８０″Ｃに加熱溶解したものを混合した後、撹拌し
つつ冷却して温度５０°ＣになったところでＣＤ＋成分
を加え、更に温度を３０°Ｃまで撹拌を続けて各ヘアー
クリームを調製した。(1), ffi formation (2) Preparation method Among the components (C), salts of thioctic acid are added to the component (B),
After blending the other ingredients into component (8), heating and dissolving components (8) and (B) at a temperature of 80"C, the mixture is cooled while stirring, and when the temperature reaches 50"C, CD+ Each hair cream was prepared by adding the ingredients and continuing stirring until the temperature reached 30°C.
（３） 特性
第８表に示すごとく、本発明の養毛化粧料である実施例
１１〜２１のへアークリームは、比較例３〜４と比較し
て緒特性に於いて優れていることが認められた。特に、
従来技術である比較例４のビオチン（毛母細胞賦活作用
酸１分）とビタミンＥニコチネートを配合してなるヘア
ークリームより、実施例１８〜２１の「チオクト酸系化
合物」と「血行促進作用成分」の各々少くとも１つを配
合してなる本発明のへアークリームは明らかに著効を呈
する。 、４．１−８、以
下余白
（発明の効果）
以上記載のごとく、本発明は、毛母細胞を賦活して毛の
成長を促進しく育毛効果）、養毛効果と共に特に脱毛予
防効果、ふけ防止効果に優れた養毛化粧料を提供するこ
とは明らかである。(3) Properties As shown in Table 8, the hair creams of Examples 11 to 21, which are hair nourishing cosmetics of the present invention, are superior in hair properties compared to Comparative Examples 3 to 4. Admitted. especially,
From the conventional hair cream of Comparative Example 4, which is a combination of biotin (acid with hair matrix activation effect for 1 minute) and vitamin E nicotinate, "thioctic acid-based compound" and "blood circulation promoting ingredient" of Examples 18 to 21 were used. The hair cream of the present invention, which contains at least one of each of the following, clearly exhibits remarkable effects. , 4.1-8, Margin below (Effects of the Invention) As described above, the present invention has a hair growth effect by activating hair matrix cells to promote hair growth), a hair growth effect, a hair loss prevention effect, and a dandruff prevention effect. It is clear that a hair nourishing cosmetic with excellent preventive effects can be provided.
Claims (3)
つを配合してなる養毛化粧料。 一般式 ▲数式、化学式、表等があります▼ （式中で、Ｒは−ＯＨ基、−ＯＭ基、−ＮＨ＿２基、−
ＯＣ＿ｎＨ＿２＿ｎ＿＋＿１基、または−ＯＣ＿ｎＨ＿
２＿ｎ＿−＿１基である。 但し、Ｍはアルカリ金属またはアルカノールアミン、塩
基性アミノ酸から誘導されるカチオンである。）(1) A hair nourishing cosmetic containing at least one compound represented by the following general formula. General formula ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ (In the formula, R is -OH group, -OM group, -NH_2 group, -
OC_nH_2_n_+_1 group, or -OC_nH_
2_n_-_1 group. However, M is a cation derived from an alkali metal, an alkanolamine, or a basic amino acid. )
囲第（１）項記載の養毛化粧料。(2) The hair nourishing cosmetic according to claim (1), which further contains a blood circulation promoting substance.
キス、霊芝エキス、ビタミンＥニコチネート、ニコチン
酸ベンジルからなる群から選択された物質の少なくとも
一つである特許請求の範囲第（２）項に記載の養毛化粧
料。(3) Claim (2), wherein the promoting substance is at least one substance selected from the group consisting of Japonica japonica extract, carrot extract, reishi extract, vitamin E nicotinate, and benzyl nicotinate. The hair nourishing cosmetics described.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61016573A JPS62175417A (en) | 1986-01-27 | 1986-01-27 | Hair tonic cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61016573A JPS62175417A (en) | 1986-01-27 | 1986-01-27 | Hair tonic cosmetic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62175417A true JPS62175417A (en) | 1987-08-01 |
| JPH0327524B2 JPH0327524B2 (en) | 1991-04-16 |
Family
ID=11920030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61016573A Granted JPS62175417A (en) | 1986-01-27 | 1986-01-27 | Hair tonic cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62175417A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09510430A (en) * | 1993-10-04 | 1997-10-21 | アンドルックス ファーマスーティカルズ、インコーポレーテッド | Controlled release potassium dosage form |
| EP0747035A3 (en) * | 1995-06-07 | 1998-03-04 | Beiersdorf Aktiengesellschaft | Composition for the treatment of dandruff and the treatment of hair |
| EP1129687A3 (en) * | 1999-12-06 | 2001-09-12 | Bristol-Myers Squibb Company | Low odor permanent waving compositions containing a disulfide |
| EP1172110A2 (en) * | 2000-07-07 | 2002-01-16 | Basf Aktiengesellschaft | Use of lipoic acid as a bioavailaty enhancer of mineral salts |
| JP2006083147A (en) * | 2004-09-14 | 2006-03-30 | Oriza Yuka Kk | Cosmetic composition |
| WO2006117995A1 (en) * | 2005-04-28 | 2006-11-09 | Iwaki & Co., Ltd. | Therapeutic agent for loss of scalp hair |
| JP2008050330A (en) * | 2006-08-24 | 2008-03-06 | Ito:Kk | Bioactive composition containing thioctic acid derivative |
| FR2939671A1 (en) * | 2008-12-11 | 2010-06-18 | Oreal | Use of heterocyclic disulfide compound as an agent for treating keratin fibers, such as hair, where the disulfide compound is associated with reducing agent |
| WO2012080223A1 (en) | 2010-12-15 | 2012-06-21 | Sigea S.R.L. | Use of glycosaminoglycan lipoate esters in the trichology field |
-
1986
- 1986-01-27 JP JP61016573A patent/JPS62175417A/en active Granted
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09510430A (en) * | 1993-10-04 | 1997-10-21 | アンドルックス ファーマスーティカルズ、インコーポレーテッド | Controlled release potassium dosage form |
| EP0747035A3 (en) * | 1995-06-07 | 1998-03-04 | Beiersdorf Aktiengesellschaft | Composition for the treatment of dandruff and the treatment of hair |
| EP1129687A3 (en) * | 1999-12-06 | 2001-09-12 | Bristol-Myers Squibb Company | Low odor permanent waving compositions containing a disulfide |
| EP1172110A2 (en) * | 2000-07-07 | 2002-01-16 | Basf Aktiengesellschaft | Use of lipoic acid as a bioavailaty enhancer of mineral salts |
| EP1172110A3 (en) * | 2000-07-07 | 2003-09-17 | Basf Aktiengesellschaft | Use of lipoic acid as a bioavailaty enhancer of mineral salts |
| JP2006083147A (en) * | 2004-09-14 | 2006-03-30 | Oriza Yuka Kk | Cosmetic composition |
| WO2006117995A1 (en) * | 2005-04-28 | 2006-11-09 | Iwaki & Co., Ltd. | Therapeutic agent for loss of scalp hair |
| JP2008050330A (en) * | 2006-08-24 | 2008-03-06 | Ito:Kk | Bioactive composition containing thioctic acid derivative |
| FR2939671A1 (en) * | 2008-12-11 | 2010-06-18 | Oreal | Use of heterocyclic disulfide compound as an agent for treating keratin fibers, such as hair, where the disulfide compound is associated with reducing agent |
| WO2012080223A1 (en) | 2010-12-15 | 2012-06-21 | Sigea S.R.L. | Use of glycosaminoglycan lipoate esters in the trichology field |
| JP2013545774A (en) * | 2010-12-15 | 2013-12-26 | シジェア ソシエタ ア レスポンサビリタ リミタータ | Use of glycosaminoglycan lipoic acid ester in dermatology |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0327524B2 (en) | 1991-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |