JPS62175413A - Powder-containing water-based preparation - Google Patents
Powder-containing water-based preparationInfo
- Publication number
- JPS62175413A JPS62175413A JP1608386A JP1608386A JPS62175413A JP S62175413 A JPS62175413 A JP S62175413A JP 1608386 A JP1608386 A JP 1608386A JP 1608386 A JP1608386 A JP 1608386A JP S62175413 A JPS62175413 A JP S62175413A
- Authority
- JP
- Japan
- Prior art keywords
- powder
- sulfur
- based preparation
- pva
- hyaluronic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000843 powder Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract description 11
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 10
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 10
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 8
- 229940014041 hyaluronate Drugs 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract description 21
- 239000011593 sulfur Substances 0.000 abstract description 21
- 229910052717 sulfur Inorganic materials 0.000 abstract description 21
- 239000004677 Nylon Substances 0.000 abstract description 5
- 239000002734 clay mineral Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 229920001778 nylon Polymers 0.000 abstract description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 abstract description 3
- 239000000454 talc Substances 0.000 abstract description 3
- 229910052623 talc Inorganic materials 0.000 abstract description 3
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 abstract description 3
- 238000007127 saponification reaction Methods 0.000 abstract description 2
- 239000002270 dispersing agent Substances 0.000 abstract 1
- 229920002689 polyvinyl acetate Polymers 0.000 abstract 1
- 239000011118 polyvinyl acetate Substances 0.000 abstract 1
- 238000004062 sedimentation Methods 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 description 9
- 239000006210 lotion Substances 0.000 description 7
- 239000003381 stabilizer Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 239000013011 aqueous formulation Substances 0.000 description 3
- 239000000440 bentonite Substances 0.000 description 3
- 229910000278 bentonite Inorganic materials 0.000 description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000010445 mica Substances 0.000 description 3
- 229910052618 mica group Inorganic materials 0.000 description 3
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 241000978776 Senegalia senegal Species 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 125000003158 alcohol group Chemical group 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000011812 mixed powder Substances 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000011787 zinc oxide Substances 0.000 description 2
- 235000014692 zinc oxide Nutrition 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- KILYNHHCRKVDRU-UHFFFAOYSA-N [S].C1CC2(C)C(=O)CC1C2(C)C Chemical compound [S].C1CC2(C)C(=O)CC1C2(C)C KILYNHHCRKVDRU-UHFFFAOYSA-N 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 229940038596 anti-acne preparations for topical use preparations containing sulfur Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229910000423 chromium oxide Inorganic materials 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 229910000428 cobalt oxide Inorganic materials 0.000 description 1
- IVMYJDGYRUAWML-UHFFFAOYSA-N cobalt(ii) oxide Chemical compound [Co]=O IVMYJDGYRUAWML-UHFFFAOYSA-N 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011163 secondary particle Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/03—Liquid compositions with two or more distinct layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は粉末の分散安定剤としてポリビニルアルコール
及び／又はヒアルロン酸塩を含有してなる粉末の再分散
性に優れた水性製剤に関する。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to an aqueous preparation containing polyvinyl alcohol and/or hyaluronate as a powder dispersion stabilizer and having excellent powder redispersibility.
粉末を含有したローション、いわゆる２層タイプの水性
製剤は粉末の特性を利用して、使用性面ではさっばりし
た清涼感を与え、また有用性面では収斂効果、消炎効果
あるいは皮脂抑制効果を与える製剤として医薬品、医薬
部外品、化粧品などに一般的に使用されている。このタ
イプのものは外観的には静置した時に上澄が透明な水相
で下層が粉末が沈澱した２層を呈し、振とうした時に粉
末が均一に分散した懸濁液となるものが求めらる。Powder-containing lotions, so-called two-layer aqueous preparations, utilize the properties of powder to provide a light and refreshing feeling in terms of usability, and in terms of usefulness, they have an astringent effect, an anti-inflammatory effect, or a sebum-suppressing effect. It is commonly used as a formulation in pharmaceuticals, quasi-drugs, cosmetics, etc. This type of product is required to have two layers, the upper layer being a transparent aqueous phase and the lower layer being a precipitated powder when left to stand still, and a suspension in which the powder is evenly dispersed when shaken. Ruru.
しかしながら、粉末の種類によってはその性質上、きれ
いに面沈降（沈澱過程の粉末層の上部界面が明確な面を
形成してきれいに沈澱していくこと）しなかったり凝集
を起こしたりして美しい外観が得られない事がある。特
にイオウを配合した水性製剤では均一な系を得るのが難
しい。However, depending on the type of powder, due to its nature, it may not settle neatly (the upper interface of the powder layer during the settling process forms a clear surface and settles neatly) or it may aggregate, resulting in a beautiful appearance. There are things you can't get. In particular, it is difficult to obtain a uniform system with aqueous preparations containing sulfur.
従来から、イオウを主剤として配合したローション、軟
膏などの外用剤はアクネ患者及びアクネになり易い脂性
肌の人に医薬品や化粧品として使用されている。BACKGROUND ART Conventionally, external preparations such as lotions and ointments containing sulfur as a main ingredient have been used as medicines and cosmetics by acne patients and people with oily skin who are prone to acne.
しかしながら、イオウは親水性の弱い粉末なので水への
分散性が悪く、安定な水性製剤を得るのは困難であった
。However, since sulfur is a weakly hydrophilic powder, it has poor dispersibility in water, making it difficult to obtain stable aqueous preparations.
基剤として水相が油相と乳化されて全体の粘度が上昇し
ているクリーム製剤を選んだ場合には、まず基剤中のグ
リセリンやソルビトールなどの湿潤剤とイオウを混和す
ることによってイオウを−次粒子化し、さらにベントナ
イトなどの分散安定剤を組み合わせて安定化する方法が
知られている。If you choose a cream formulation in which the aqueous phase is emulsified with an oil phase to increase the overall viscosity as a base, first remove the sulfur by mixing the sulfur with a humectant such as glycerin or sorbitol in the base. A method is known in which the particles are made into secondary particles and further stabilized by combining a dispersion stabilizer such as bentonite.
またローション基剤としては、イオウの分散安定化剤と
してアラビアゴム、トラガントガム、カルボキシメチル
セルロースナトリウムあるいはメチルセルロースなどを
配合した、例えばクンメルフエルド液やイオウカンフル
ロ−ジョンなどが知られている。Known lotion bases include, for example, Kummelfeld's solution and sulfur camphor lotion, which contain gum arabic, gum tragacanth, sodium carboxymethylcellulose, or methylcellulose as a sulfur dispersion stabilizer.
しかしながら、上記ローションタイプのものは未だイオ
ウの分散安定性が充分でなく、特に一度沈澱したイオウ
を再度振とうして分散（以下、再分散という）させると
きに固まりになってしまって均一に分散しない。また特
に大Ｎ製造時にはイオウが製剤表面に浮いてきてしまい
、製造の邪魔になったりボトルに充填しようとしても全
ボトルを均質の配合組成にできないなどの問題点ををし
ていた。However, the above-mentioned lotion type products still do not have sufficient dispersion stability of sulfur, and in particular, when the sulfur that has precipitated is shaken again and dispersed (hereinafter referred to as redispersion), it becomes agglomerated and cannot be uniformly dispersed. do not. In addition, sulfur floats to the surface of the preparation, especially during the manufacture of large N, which hinders the manufacture and makes it impossible to fill all bottles with a homogeneous composition.
〔問題点を解決するための手段〕
本発明者らは前記の問題点を解決すべく鋭意研究を重ね
た結果、粉末の分散安定剤として、通常は皮膜剤として
汎用されているポリビニルアルコールあるいは保湿剤と
して用いられているヒアルロン酸塩を用いることにより
、イオウの分散性、再分散性に擾れ静置時には粉末層が
面沈降をして美しい外観を呈し使用感触も優れている水
性製剤が得られる事を見い出し、本発明をなすに至った
。[Means for Solving the Problems] As a result of intensive research in order to solve the above-mentioned problems, the present inventors have found that polyvinyl alcohol or a moisturizing agent, which is commonly used as a coating agent, is used as a powder dispersion stabilizer. By using hyaluronate as an agent, the dispersibility and redispersibility of sulfur are affected, and when left standing, the powder layer settles on the surface, giving an aqueous formulation that has a beautiful appearance and an excellent feel when used. The present inventors have discovered that this can be done, and have come up with the present invention.
すなわち、本発明は粉末と、ポリビニリアルコール及び
／又はヒアルロン酸塩を配合したことを特徴とする粉末
含有水性製剤を提供するものである。That is, the present invention provides a powder-containing aqueous preparation characterized by blending powder with polyvinylic alcohol and/or hyaluronate.
本発明の方法はイオウのみならず、広く一般の他の粉末
に対しても有効である。The method of the present invention is effective not only for sulfur but also for a wide range of other common powders.
本発明において用いるポリビニルアルコールは部分ケン
化酢酸ビニルをも含むポリビニルアルコールであり、具
体的にはケン化度７０〜９５％が好ましい。The polyvinyl alcohol used in the present invention is polyvinyl alcohol that also contains partially saponified vinyl acetate, and specifically, the degree of saponification is preferably 70 to 95%.
本発明において用いるヒアルロン酸塩はムコ多糖の一種
であり、保湿成分として化粧品などに用いられている成
分である。The hyaluronate used in the present invention is a type of mucopolysaccharide, and is an ingredient used in cosmetics and the like as a moisturizing ingredient.
本発明においては上記ポリビニルアルコール及び／又は
ヒアルロン酸塩が粉末とともに水性製剤中に配合される
が、その配合量は総計で水性製剤全量中の０．００１〜
１％が適当である。０．００１％未満では粉末の分散安
定性が悪く、１％を越えると粘度が高くなりかえって再
分散性が悪くなる。In the present invention, the above-mentioned polyvinyl alcohol and/or hyaluronate is blended together with the powder into the aqueous formulation, and the total amount of the polyvinyl alcohol and/or hyaluronate is from 0.001 to 0.001% of the total amount of the aqueous formulation.
1% is appropriate. If it is less than 0.001%, the dispersion stability of the powder will be poor, and if it exceeds 1%, the viscosity will increase and the redispersibility will become worse.
本発明で用いる粉末は通常化粧料に用いられる粉末であ
り、例えば酸化チタン、シリカ、タルク、カオリン、亜
鉛華、雲母チタン、マイカ、酸化鉄、グンジョウ、酸化
クロム、酸化コバルト、イオウ、ナイロンパウダー、シ
ルクパウダー、さらにはベントナイトやモンモリロナイ
トなどを主成分とする粘土鉱物であり、これらの一種ま
たは二種以上が用いられる。The powder used in the present invention is a powder normally used in cosmetics, such as titanium oxide, silica, talc, kaolin, zinc white, titanium mica, mica, iron oxide, gunjo, chromium oxide, cobalt oxide, sulfur, nylon powder, It is a clay mineral mainly composed of silk powder, bentonite, montmorillonite, etc., and one or more of these are used.
配合量は水性製剤全量中の０．２重量％〜１０重量％が
好ましい。粉末量が０．２重量％未満では粉末層のかさ
が低くて見た目にアンバランスであり、１０重量％を越
えると使用感触が粉っぽくなり好ましくない。The blending amount is preferably 0.2% to 10% by weight based on the total amount of the aqueous preparation. If the amount of powder is less than 0.2% by weight, the bulk of the powder layer will be low and the appearance will be unbalanced, and if it exceeds 10% by weight, the texture will be powdery and undesirable.
粉末としてイオウを選んだ場合には、イオウに加えてさ
らに粘土鉱物、ナイロンパウダー及びシルクパウダーの
一種又は二種以上を併用すると、より効果的である。When sulfur is selected as the powder, it is more effective to use one or more of clay minerals, nylon powder, and silk powder in combination in addition to sulfur.
この場合、粘土鉱物、ナイロンパウダーあるいはシルク
パウダーは、イオウに対して１／１０〜１０倍量（正量
）で配合するのが好ましい。In this case, the clay mineral, nylon powder, or silk powder is preferably blended in an amount of 1/10 to 10 times the amount of sulfur (correct amount).
本発明にはその効果をさまたげない限りにおいて必要に
応じて医薬品、医薬部外品、化粧品に配合される他の成
分、例えば香料、防腐剤、その他一般に汎用されている
成分を配合できる。The present invention may contain other ingredients commonly used in pharmaceuticals, quasi-drugs, and cosmetics, such as perfumes, preservatives, and other commonly used ingredients, as necessary, as long as they do not impede the effects of the invention.
本発明の粉末含有水性製剤は、イオウの分散性及び再分
散性に優れ、静置時には粉末層が面沈降をして美しい外
観を呈し、振とうすると容易に均一に分散する優れた水
性製剤である。使用感触もよい。The powder-containing aqueous preparation of the present invention has excellent sulfur dispersibility and redispersibility, and when left still, the powder layer settles on the surface and presents a beautiful appearance, and when shaken, it is an excellent aqueous preparation that disperses easily and uniformly. be. It also feels good when used.
次に実施例によって本発明をさらに詳細に説明する。本
発明はこれにより限定されるものではない。配合量は重
量％である。Next, the present invention will be explained in more detail with reference to Examples. The present invention is not limited thereby. The blending amount is in weight%.
表１に実施例に用いた基剤の処方、表２に該基剤に配合
した各種高分子及びその結果を示す。Table 1 shows the formulation of the base used in the examples, and Table 2 shows the various polymers blended into the base and the results.
実施例１はポリビニルアルコールを配合して極めて良好
な結果が得られた例であり、実施例２はヒアルロン酸を
配合して良好な結果が得られた例である。一方、比較例
１〜３は従来からイオウや他の粉末の分散安定剤として
使用されているアラビラゴム、カルボキシメチルセルロ
ースナトリウム、カルボキシビニルポリマーを配合した
例であるが、粉末の凝集や浮きが見られ好ましくない。Example 1 is an example in which extremely good results were obtained by blending polyvinyl alcohol, and Example 2 is an example in which good results were obtained by blending hyaluronic acid. On the other hand, Comparative Examples 1 to 3 are examples in which gum arabic, sodium carboxymethylcellulose, and carboxyvinyl polymer, which have been conventionally used as dispersion stabilizers for sulfur and other powders, were blended, but agglomeration and floating of the powder were observed, making it undesirable. do not have.
比較例４〜１０は他の高分子や分散安定剤を配合した例
であるが、やはり良い結果が得られなかった。Comparative Examples 4 to 10 are examples in which other polymers and dispersion stabilizers were blended, but good results were not obtained.
表１
成分名 配合量
イオン交換水 ９６．７
グリセリン １．０
食塩 ０．１
分散安定剤 ０．１
イオウ ０．３
亜鉛華 １．２
ベントナイト ０．６
表２ ｌ訪缶仔１１〜２、比に３列１〜１０◎；極めて
良好 ○；良好 △；やや悪い ×；悪い［テス
ト方法］
水性製剤を充填したガラス瓶を２０ｃｍ巾で６０回／分
撮とうする振とう試験器を用いてテストする方法、及び
手で軽く５回振とうする方法でもってテストして総合的
に評価した。Table 1 Ingredient name Compounding amount Ion-exchanged water 96.7 Glycerin 1.0 Salt 0.1 Dispersion stabilizer 0.1 Sulfur 0.3 Zinc white 1.2 Bentonite 0.6 Table 2 l Visitanzi 11-2, ratio 3 rows 1-10 ◎: Very good ○: Good △: Fairly bad ×: Poor [Test method] Test using a shaking tester that shakes a glass bottle filled with an aqueous preparation 60 times/min with a width of 20 cm. A comprehensive evaluation was made by testing using a method of gently shaking the sample 5 times by hand.
実施例３
（重量％）
（Ａ）精製水 ？３．２５９
１．３−ブチレングリコール ０．３塩化マグネシ
ウム ０．１（Ｂ）エタノール
１５ジグリセリンジイソステアレー
ト ０．０３ビタミンＥアセテート ０
．００１香料 ０．０１
メチルパラベン ０．１（Ｃ）
ネ青製水
１０．０ポリビニルアルコール １．０
（Ｄ）カオリン ０．１シリ
カ ０．１（製法）
（Ａ）の水都及び（Ｂ）のアルコール部をそれぞれ均一
に溶解した後、（Ａ）に（Ｂ）を加えて混合する。次に
均一に溶解した（Ｃ）に、均一に混合した（Ｄ）の粉末
部を添加し、均一に分散する。これを（Ａ）、（Ｂ）の
混合液に添加して２層型アストリンゼンドロージョンを
得た。Example 3 (wt%) (A) Purified water? 3.259
1.3-Butylene glycol 0.3 Magnesium chloride 0.1 (B) Ethanol
15 diglycerine diisostearate 0.03 vitamin E acetate 0
．． 001 Fragrance 0.01
Methylparaben 0.1(C)
ne blue water
10.0 Polyvinyl alcohol 1.0
(D) Kaolin 0.1 Silica 0.1 (Production method) After uniformly dissolving Suito (A) and alcohol part (B), (B) is added to (A) and mixed. Next, the uniformly mixed powder part of (D) is added to the uniformly dissolved (C) and uniformly dispersed. This was added to the mixed solution of (A) and (B) to obtain a two-layered astringent lotion.
実施例４
（重量％）
（Ａ）精製水 ４８．９４９
グリセリン １．０乳酸
４．５Ｌ−アルギニン
０．５（Ｂ）エタノール
５．０香料 ０．
０３ブチルパラベン ０．０２（Ｃ
）精製水 ３０．０ヒアルロ
ン酸カリウム ０．００１（Ｄ）タルク
５雲母
４
酸化チタン １（製法）
（Ａ）の水都及び（Ｂ）のアルコール部をそれぞれ均一
に溶解した後、（Ａ）に（Ｂ）を加えて混合する。次に
均一に溶解した（Ｃ）に、均一に混合した（Ｄ）の粉末
部を添加し、均一に分散する。これを（Ａ）、（Ｂ）の
混合液に添加して２層型のサンケアローションを得た。Example 4 (wt%) (A) Purified water 48.949
Glycerin 1.0 lactic acid
4.5L-Arginine
0.5(B) Ethanol
5.0 Fragrance 0.
03 Butylparaben 0.02 (C
) Purified water 30.0 Potassium hyaluronate 0.001 (D) Talc
5 mica
4 Titanium oxide 1 (Production method) After uniformly dissolving Suito (A) and alcohol part (B), add (B) to (A) and mix. Next, the uniformly mixed powder part of (D) is added to the uniformly dissolved (C) and uniformly dispersed. This was added to the mixed solution of (A) and (B) to obtain a two-layer sun care lotion.
実施例５
（重量％）
イオウ ０．６ｄ
ｌ−カンフル ０．０５ポ
リビニルアルコール ０．０６水酸
化カルシウム ０．０１香料
通量精製水
残余（製法）
日本薬剤例会ｉＪｉ！調剤指針記載の常法に従ってイオ
ウカンフルロ−ジョンを得た。Example 5 (wt%) Sulfur 0.6d
L-camphor 0.05 Polyvinyl alcohol 0.06 Calcium hydroxide 0.01 Fragrance
Purified water
Residue (manufacturing method) Japan Pharmaceutical Regular Meeting iJi! Sulfur campfluorosis was obtained according to the conventional method described in the Preparation Guidelines.
Claims (1)
塩とを配合したことを特徴とする粉末含有水性製剤。A powder-containing aqueous preparation characterized by blending powder with polyvinyl alcohol and/or hyaluronate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1608386A JPS62175413A (en) | 1986-01-28 | 1986-01-28 | Powder-containing water-based preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1608386A JPS62175413A (en) | 1986-01-28 | 1986-01-28 | Powder-containing water-based preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS62175413A true JPS62175413A (en) | 1987-08-01 |
Family
ID=11906650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1608386A Pending JPS62175413A (en) | 1986-01-28 | 1986-01-28 | Powder-containing water-based preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62175413A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0733635A (en) * | 1993-07-21 | 1995-02-03 | Kao Corp | Skin external preparation |
| JPH07316488A (en) * | 1994-05-25 | 1995-12-05 | Health Kk | Composition used for painting skin or container |
| JP2012500210A (en) * | 2008-08-15 | 2012-01-05 | セキスイ・スペシャルティ・ケミカルズ・アメリカ・エルエルシー | Personal care products |
| JP2012528789A (en) * | 2008-06-19 | 2012-11-15 | ユニバーシティ・オブ・ジ・ウィトウォーターズランド・ヨハネスブルク | Transmucosal delivery system |
| WO2012169518A1 (en) * | 2011-06-07 | 2012-12-13 | ホソカワミクロン株式会社 | Liquid composition, and cosmetic and hair growth agent each comprising same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5274585A (en) * | 1975-12-19 | 1977-06-22 | Lion Corp | Surfactant composition in which water insoluble fine powder has been s tably dispersed |
-
1986
- 1986-01-28 JP JP1608386A patent/JPS62175413A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5274585A (en) * | 1975-12-19 | 1977-06-22 | Lion Corp | Surfactant composition in which water insoluble fine powder has been s tably dispersed |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0733635A (en) * | 1993-07-21 | 1995-02-03 | Kao Corp | Skin external preparation |
| JPH07316488A (en) * | 1994-05-25 | 1995-12-05 | Health Kk | Composition used for painting skin or container |
| JP2012528789A (en) * | 2008-06-19 | 2012-11-15 | ユニバーシティ・オブ・ジ・ウィトウォーターズランド・ヨハネスブルク | Transmucosal delivery system |
| US9205049B2 (en) | 2008-06-19 | 2015-12-08 | University Of The Witwatersrand, Johannesburg | Transmucosal delivery system |
| JP2012500210A (en) * | 2008-08-15 | 2012-01-05 | セキスイ・スペシャルティ・ケミカルズ・アメリカ・エルエルシー | Personal care products |
| WO2012169518A1 (en) * | 2011-06-07 | 2012-12-13 | ホソカワミクロン株式会社 | Liquid composition, and cosmetic and hair growth agent each comprising same |
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