JPS62153739A - High-frequency irradiation apparatus in nuclear magnetic resonance apparatus - Google Patents
High-frequency irradiation apparatus in nuclear magnetic resonance apparatusInfo
- Publication number
- JPS62153739A JPS62153739A JP60295769A JP29576985A JPS62153739A JP S62153739 A JPS62153739 A JP S62153739A JP 60295769 A JP60295769 A JP 60295769A JP 29576985 A JP29576985 A JP 29576985A JP S62153739 A JPS62153739 A JP S62153739A
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- time series
- signal
- inverse fourier
- data
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Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は核磁気共鳴装置（ＮＭＲ装置）に関し、特にデ
カップリングのために高周波磁場を照射する高周波照射
装置に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a nuclear magnetic resonance apparatus (NMR apparatus), and particularly to a high-frequency irradiation apparatus that irradiates a high-frequency magnetic field for decoupling.
［従来技術］
ＮＭＲ装置を用いた測定においては、互いに結合関係に
ある複数のスピン系の結合を切ったり、ＮＯＥ （核オ
ーバーハウザー効果）を測定する場合、２台の高周波発
振器を用い、夫々の発振周波数を例えば第５図に示すよ
うなＮＭＲスペクトルにおけるピークＰ＋ 、Ｐ２に対
応する周波数ｆｌ。[Prior art] In measurements using an NMR device, when disconnecting multiple spin systems that are in a coupling relationship with each other or measuring NOE (nuclear Overhauser effect), two high-frequency oscillators are used and each The oscillation frequency is, for example, the frequency fl corresponding to the peak P+, P2 in the NMR spectrum as shown in FIG.
ｆｚに設定し、このｆ＋、ｆｚの高周波を試料の周囲に
巻回される照射コイルへ供給し、高周波磁場として照射
することが行なわれている。fz, and the high frequency waves of f+ and fz are supplied to an irradiation coil wound around the sample to irradiate it as a high frequency magnetic field.
［発明が解決しようとする問題点］
結合を切るべきピークの数が更に多く、しかもノイズ変
調などで広い周波数帯域を与えた高周波によりすべての
ピークの結合を一度に切ることができない場合、高周波
発振器の数もそれに対応して増さねばならず、コスト的
に不利となるし、その複数の発振器の周波数を夫々設定
しなければならないので調整に時間がかかつてしまう。[Problems to be solved by the invention] When there are many more peaks to be disconnected, and it is not possible to disconnect all the peaks at once using a high frequency wave that has a wide frequency band due to noise modulation, etc., a high frequency oscillator is used. The number of oscillators must be correspondingly increased, which is disadvantageous in terms of cost, and since the frequencies of the plurality of oscillators must be set individually, adjustment takes time.
又、低周波発振器を複数設け、その出力を合成した信号
を１つの高周波信号と混合して複数の８周波成分を得る
ことも考えられ、そうすれば高周波回路が１つでづむの
でコスト的に右利であるが、複数の発掘器を用意しなけ
ればならない問題は依然として残る。It is also possible to obtain multiple 8-frequency components by providing multiple low-frequency oscillators and mixing their combined outputs with a single high-frequency signal, which would reduce the cost since only one high-frequency circuit would be required. However, the problem of having to prepare multiple excavators still remains.
本発明はこの点に鑑みてなされたものであり、高周彼琵
系器の数を増−すことなくしかも簡単に数多くの周波数
成分を持つ高周波を照射することのできる高周波照射装
置を提供することを目的としている。The present invention has been made in view of this point, and provides a high-frequency irradiation device that can easily irradiate high-frequency waves having a large number of frequency components without increasing the number of high-frequency helical devices. The purpose is to
［問題点を解決するための手段］
この目的を達成するため、本発明は、複数の周波数成分
を持つ高周波を試料の回りに巻回した照射コイルへ供給
し、高周波磁場として試料に照射する核磁気共鳴装置に
おける高周波照射装置において、複数の周波数値と夫々
の強度に関する情報を指定する入力手段と、該入力手段
からの周波数情報及び強度情報に基づき時系列情報を得
る逆フーリエ変換手段と、該逆フーリエ変換手段から得
られた時系列情報に基づき基準周波数信号を変調する変
調手段とを設け、該変調手段の出力信号を前記照射コイ
ルへ供給するようにしたことを特徴としている。[Means for Solving the Problems] In order to achieve this object, the present invention supplies a high frequency wave having a plurality of frequency components to an irradiation coil wound around a sample, and irradiates the sample as a high frequency magnetic field. A high-frequency irradiation device in a magnetic resonance apparatus includes an input means for specifying information regarding a plurality of frequency values and respective intensities, an inverse Fourier transform means for obtaining time series information based on the frequency information and intensity information from the input means, and A modulation means for modulating the reference frequency signal based on time series information obtained from the inverse Fourier transform means is provided, and an output signal of the modulation means is supplied to the irradiation coil.
以下、図面を用いて本発明の一実施例を詳説する。Hereinafter, one embodiment of the present invention will be explained in detail using the drawings.
［実施例］
第１図は本発明の一実施例の構成を示すブロック図であ
り、図において１は静磁場を発生するための磁石である
。この静磁場内には試料管２が配置され、更にこの試料
＠２の周囲には、観測用の送受信コイル３及び照射コイ
ル４が巻回されている。[Embodiment] FIG. 1 is a block diagram showing the configuration of an embodiment of the present invention, and in the figure, 1 is a magnet for generating a static magnetic field. A sample tube 2 is disposed within this static magnetic field, and a transmitting/receiving coil 3 for observation and an irradiation coil 4 are further wound around the sample @2.
観測用高周波発振器５で生成された高周波は、増幅器６
．ゲート７を介して送受信コイル３へ送られ、観測用高
周波パルス磁場として試料に照（ト）される。この高周
波パルスｖ１１揚照！）１後送受信コイル３に誘起され
た自由誘導減衰信号（ＦＩＤ信号）は、ゲート８．増幅
器９．復調器１０を介して取出され、Ａ−Ｄ変換器１１
を介してコンピュータ１２へ取込まれ、付属するメモリ
１３に格納される。１４はＦＩＤ信号をフーリエ変換し
て得たＮＭＲスペク１−ルを表示するための表示装置、
１５はコンピュータに付属する入力装置である。The high frequency generated by the observation high frequency oscillator 5 is transmitted to the amplifier 6.
．． The signal is sent to the transmitter/receiver coil 3 via the gate 7, and is applied to the sample as a high-frequency pulsed magnetic field for observation. This high frequency pulse v11 light! )1, the free induction damped signal (FID signal) induced in the transmitting/receiving coil 3 is passed through the gate 8. Amplifier 9. taken out via the demodulator 10 and sent to the A-D converter 11
The data is taken into the computer 12 via the computer 12 and stored in the attached memory 13. 14 is a display device for displaying the NMR spectrum obtained by Fourier transforming the FID signal;
15 is an input device attached to the computer.
１６はコンピュータ１２から送られる周波数データを時
系列データに変換するための逆フーリエ変換回路で、得
られた時系列データはレジスタ１７に格納される。この
時系列データは、読出し回路１８により繰返し読出され
、読出された時系列信号はＤ−△変換器１つを介して変
調器２０へ送られる。発掘器２１からの高周波信号はこ
の時系列信号によって変調された後、増幅器２２を介し
て前記照射コイル４へ送られる。16 is an inverse Fourier transform circuit for converting the frequency data sent from the computer 12 into time series data, and the obtained time series data is stored in the register 17. This time series data is repeatedly read out by the readout circuit 18, and the read time series signal is sent to the modulator 20 via one D-Δ converter. The high frequency signal from the excavator 21 is modulated by this time series signal and then sent to the irradiation coil 4 via the amplifier 22.
上記構成において、最初にデカップリングなしで測定を
行う。測定は、ゲート７を所定期間ＯＮにすることによ
り観測パルスを作成し、この観測パルスを送受信コイル
３へ送って試料に照射し、その後ゲート８をＯＮにして
族１ｔｌｌパルスの照ｑ寸に（Ｖっで送受信コイル３に
誘起されるＦＥＤ信号をＩＢ出し、メモリ１３に格納す
るという手順で行われる。そして、このＦＩＤ信号をコ
ンピュータ１２でフーリエ変換すれば、例えば第２図（
ａ）に示すようなＮＭＲスペクトルが得られる。In the above configuration, measurement is first performed without decoupling. For measurement, an observation pulse is created by turning on the gate 7 for a predetermined period of time, and this observation pulse is sent to the transmitter/receiver coil 3 to irradiate the sample.Then, the gate 8 is turned on and the irradiation pulse is The procedure is to output the FED signal induced in the transmitter/receiver coil 3 by V and store it in the memory 13.Then, if this FID signal is Fourier-transformed by the computer 12, for example, as shown in Fig. 2 (
An NMR spectrum as shown in a) is obtained.
オペレータがこのスペクトルを詳細に検討し、この内の
ビークｐＨ，ＰＩ３． ＰＩ３の核についてデカップリ
ングを行うと判断した場合、オペレータはキーボード１
５を用いて各ピークに相当する周波数ｆ１１． ｆ１２
． ｆ１３の値と、各周波数の強度比を例えば１ ：２
：１のようにコンピュータ１２に入力する。この入力デ
ータは、即ち、第２図（ｂ＞に示すように周波数ｆ１１
． ｆ１２． ｆ１３の各周波数成分を持ち、その
強度比が１＝２：１の高周波を試料に照射することを意
味しており、この入力データは逆フーリエ変換回路１６
へ送られる。逆フーリエ変換回路１６はこの入力データ
に基づいて逆フーリエ変換を行うことにより、第２図（
ｂ）のスペクトルを発生するための例えば第２図（Ｃ）
に示すような時系列データを得、得られた時系列データ
はレジスタ１７に格納される。The operator examines this spectrum in detail and determines the peak pH, PI3. If it is determined that the core of PI3 is to be decoupled, the operator
5 is used to calculate the frequency f11.5 corresponding to each peak. f12
．． For example, set the value of f13 and the intensity ratio of each frequency to 1:2.
:1 into the computer 12. This input data has a frequency f11 as shown in FIG.
．． f12. This means that the sample is irradiated with high frequency waves that have each frequency component of f13 and whose intensity ratio is 1=2:1, and this input data is sent to the inverse Fourier transform circuit 16.
sent to. The inverse Fourier transform circuit 16 performs an inverse Fourier transform based on this input data, thereby converting the data into the form shown in FIG.
For example, FIG. 2(C) for generating the spectrum of b)
Time series data as shown in is obtained, and the obtained time series data is stored in the register 17.
読出し回路１８は、この時系列データを高速度で繰返し
読出し、Ｄ−Ａ変換器１９へ送るため、Ｄ−Ａ変換器１
９の出力としては、第２図（ｄ）に示すような時系列信
号が得られる。そして、変調器２０においてこの時系列
信号で発振器２１からの高周波信号を変調ずれば、その
出力として得られる変調後の高周波信号は、第２図（ｂ
）に示すような周波数成分を持つことになり、この変調
後の高周波信号を照射コイル４へ供給すれば、所望のビ
ークＰ１１． ＰＩ３． ＰＩ３をデカップリングする
ためのｆｌｌ、 ｆ１２． ｆ１３の周波数成分を持
つ高周波磁場を試料に照射することができる。The readout circuit 18 repeatedly reads this time series data at high speed and sends it to the DA converter 19.
As the output of 9, a time series signal as shown in FIG. 2(d) is obtained. If the modulator 20 modulates the high-frequency signal from the oscillator 21 with this time-series signal, the modulated high-frequency signal obtained as the output is as shown in FIG.
), and if this modulated high-frequency signal is supplied to the irradiation coil 4, the desired peak P11. PI3. fll for decoupling PI3, f12. A high frequency magnetic field having a frequency component of f13 can be irradiated onto the sample.
本実施例では時系列信号で高周波信号を直接変調したが
、時系列信号で比較的低い周波数の信号を変調し、変調
後の信号を高い周波数の信号と混合して周波数を共鳴周
波数まで上昇させるようにしても良い。In this example, the high-frequency signal was directly modulated with the time-series signal, but a relatively low-frequency signal is modulated with the time-series signal, and the modulated signal is mixed with a high-frequency signal to raise the frequency to the resonant frequency. You can do it like this.
変調器による変調の種類としては、振幅変調を始め周波
数変調１位相変調などが利用できる。As the types of modulation by the modulator, amplitude modulation, frequency modulation, single phase modulation, etc. can be used.
尚、核磁気共鳴現象における核スピンのふるまいを解析
するにあたっては、９０°位相の異なる２つの検出系か
ら親書することが好ましく、現在のＮＭＲ装置では、観
測系においてＦＩＤ信号を取出す際、９０”位相の責な
る２つの復調器によって２種類のＦＩＤ信号を得る直角
位相検波方式（所謂ＱＤ方式）が採用されている。When analyzing the behavior of nuclear spins in nuclear magnetic resonance phenomena, it is preferable to use two detection systems with a 90° phase difference, and in current NMR equipment, when extracting FID signals in the observation system, 90" A quadrature phase detection method (so-called QD method) is adopted in which two types of FID signals are obtained using two demodulators responsible for the phase.
照射系は、核スピンから高周波位相情報を取出す観測系
とは逆に、高周波磁場を核スピンに与えるものであるが
、その際にも９０’位相の異なる２つの系から高周波磁
場を照射することが好ましい。The irradiation system applies a high-frequency magnetic field to the nuclear spins, contrary to the observation system that extracts high-frequency phase information from the nuclear spins.In this case, high-frequency magnetic fields are also irradiated from two systems with different 90' phases. is preferred.
第３図の実施例はこの考え方に基づく構成となっている
。第３図において、観測系は復調器を１０ｓ、ｉｏｃと
２チャンネル持つ（当然、Ａ−Ｄ変換器も”＋ｉｓ、ｉ
ｉｃと２つ備えている＞ＱＤ方式を採用している。２３
は参照信号の位相を９０°ずらすための移相器である。The embodiment shown in FIG. 3 has a configuration based on this idea. In Figure 3, the observation system has two demodulator channels, 10s and ioc (of course, the A-D converter also has "+is, ioc").
It uses the QD system, which has two ICs. 23
is a phase shifter for shifting the phase of the reference signal by 90°.
逆フーリエ変換回路１６は、第１図の実施例と同様に、
コンピュータ１２から送られるオペレータからの入力デ
ータに基づき複素フーリエ変換を行い、得られた時系列
データのｓｉｎ成分（位相０°、第２図（Ｃ））とＣＯ
Ｓ成分（位相９０°。The inverse Fourier transform circuit 16 is similar to the embodiment shown in FIG.
A complex Fourier transform is performed based on the input data from the operator sent from the computer 12, and the sine component (phase 0°, Fig. 2 (C)) of the obtained time series data and CO
S component (phase 90°.
第４図）をレジスタ１７３，１７０に夫々格納する。格
納された各データは、読出し回路１８Ｓ。4) are stored in registers 173 and 170, respectively. Each stored data is read out by a readout circuit 18S.
１８ｃによって高速度で繰返し読出され、Ｄ−Ａ変換器
１９ｓ、１９ｃを介して時系列信号として変調器２０ｓ
、２０ｃへ送られる。変調器２０ｓ。18c, the signal is read out repeatedly at high speed, and sent to the modulator 20s as a time-series signal via the D-A converters 19s and 19c.
, 20c. Modulator 20s.
２０ｃには、発振器２１からの高周波信号が一方はその
まま、他方は９０”移相器２４を介して供給されており
、各高周波信号は上記時系列信号によって変調された後
、加算回路２５において加算され、増幅器２２を介して
照射コイル４に送られる。20c, one of the high frequency signals from the oscillator 21 is supplied as is, and the other is supplied via a 90'' phase shifter 24, and after each high frequency signal is modulated by the above time series signal, it is added in the adder circuit 25. and sent to the irradiation coil 4 via the amplifier 22.
尚、本実施例においても、発振器２１の発振周波数を比
較的低く設定し、時系列信号でこの比較的低い周波数の
第１の信号を変調し、変調後の信号を高い周波数の第２
の信号と混合して周波数を共鳴周波数まで上昇させるよ
うにしても良い。In this embodiment as well, the oscillation frequency of the oscillator 21 is set relatively low, the first signal with a relatively low frequency is modulated with a time-series signal, and the modulated signal is used as the second signal with a high frequency.
The frequency may be raised to the resonant frequency by mixing with the signal of
［効果１
以上の説明から明らかなように、本発明では、オペレー
タが指定した複数の周波数値と強度に関する情報に基づ
いて逆フーリエ変換を行い、時系列データを作成し、そ
の時系列データに基づいて高周波を変調するようにした
ため、基本となる発振器は単一で、しかも任意の数で任
意の強度の周波数成分を持つ高周波を作成し、試料に照
射することのできる照射装置が実現される。[Effect 1] As is clear from the above description, in the present invention, time series data is created by performing inverse Fourier transform based on multiple frequency values and intensity information specified by the operator, and based on the time series data, By modulating the high frequency, an irradiation device is realized that uses a single basic oscillator and can create high frequency waves with any number of frequency components of any intensity and irradiate the sample.
第１図と第３図は夫々本発明の一実施例の構成を示すブ
ロック図、第２図は第１図の実施例の動作を説明するた
めの図、第４図は時系列データのＣＯＳ成分を説明する
ための図、第５図は測定により得られたＮＭＲスペクト
ルを示ず図である。
１：磁石 ２：試料管
３：送受信コイル ４：照射コイル
５：１１測用高周波発振器
７．８：ゲート １０：復調器
１１：Ａ−Ｄ変換器 １２：コンピュータ１３：メモリ
１４：表示装置
１５：入力装置
１６：逆フーリエ変換回路
１７：レジスタ １８；続出し回路１９：Ｄ−Ａ変
換器 ２０：変調器
２１：発撮器1 and 3 are block diagrams showing the configuration of an embodiment of the present invention, FIG. 2 is a diagram for explaining the operation of the embodiment of FIG. 1, and FIG. 4 is a COS of time series data. FIG. 5, which is a diagram for explaining the components, does not show the NMR spectrum obtained by measurement. 1: Magnet 2: Sample tube 3: Transmission/reception coil 4: Irradiation coil 5: High frequency oscillator for measurement 7.8: Gate 10: Demodulator 11: A-D converter 12: Computer 13: Memory 14: Display device 15: Input device 16: Inverse Fourier transform circuit 17: Register 18; Continuation circuit 19: D-A converter 20: Modulator 21: Image generator
Claims (1)
照射コイルへ供給し、高周波磁場として試料に照射する
核磁気共鳴装置における高周波照射装置において、複数
の周波数値と夫々の強度を指定する入力手段と、該入力
手段からの周波数情報及び強度情報に基づき時系列情報
を得る逆フーリエ変換手段と、該逆フーリエ変換手段か
ら得られた時系列情報に基づき基準周波数信号を変調す
る変調手段とを設け、該変調手段の出力信号を前記照射
コイルへ供給するようにしたことを特徴とする核磁気共
鳴装置における高周波照射装置。An input that specifies multiple frequency values and their respective strengths in a high-frequency irradiation device in a nuclear magnetic resonance apparatus that supplies high-frequency waves with multiple frequency components to an irradiation coil wound around the sample and irradiates the sample as a high-frequency magnetic field. means, inverse Fourier transform means for obtaining time series information based on the frequency information and intensity information from the input means, and modulation means for modulating the reference frequency signal based on the time series information obtained from the inverse Fourier transform means. A high-frequency irradiation device for a nuclear magnetic resonance apparatus, characterized in that the output signal of the modulation means is supplied to the irradiation coil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60295769A JPS62153739A (en) | 1985-12-27 | 1985-12-27 | High-frequency irradiation apparatus in nuclear magnetic resonance apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60295769A JPS62153739A (en) | 1985-12-27 | 1985-12-27 | High-frequency irradiation apparatus in nuclear magnetic resonance apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62153739A true JPS62153739A (en) | 1987-07-08 |
| JPH0455269B2 JPH0455269B2 (en) | 1992-09-02 |
Family
ID=17824927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60295769A Granted JPS62153739A (en) | 1985-12-27 | 1985-12-27 | High-frequency irradiation apparatus in nuclear magnetic resonance apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62153739A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002031673A (en) * | 2000-05-25 | 2002-01-31 | Bruker Sa | Multi-frequency rf signal generator |
-
1985
- 1985-12-27 JP JP60295769A patent/JPS62153739A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002031673A (en) * | 2000-05-25 | 2002-01-31 | Bruker Sa | Multi-frequency rf signal generator |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0455269B2 (en) | 1992-09-02 |
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