JPS6158190B2 - - Google Patents
Info
- Publication number
- JPS6158190B2 JPS6158190B2 JP58185170A JP18517083A JPS6158190B2 JP S6158190 B2 JPS6158190 B2 JP S6158190B2 JP 58185170 A JP58185170 A JP 58185170A JP 18517083 A JP18517083 A JP 18517083A JP S6158190 B2 JPS6158190 B2 JP S6158190B2
- Authority
- JP
- Japan
- Prior art keywords
- fibers
- blood vessel
- artificial blood
- wall
- yarn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004204 blood vessel Anatomy 0.000 claims description 45
- 239000000835 fiber Substances 0.000 claims description 36
- 239000002473 artificial blood Substances 0.000 claims description 31
- 229920001410 Microfiber Polymers 0.000 claims description 26
- 239000004744 fabric Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 230000035699 permeability Effects 0.000 claims description 10
- 229920000728 polyester Polymers 0.000 claims description 8
- -1 polytetrafluoroethylene Polymers 0.000 claims description 6
- 239000004952 Polyamide Substances 0.000 claims description 4
- 229920002647 polyamide Polymers 0.000 claims description 4
- 229920000098 polyolefin Polymers 0.000 claims description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 3
- 239000008280 blood Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 230000014759 maintenance of location Effects 0.000 description 8
- 210000003556 vascular endothelial cell Anatomy 0.000 description 8
- 238000009941 weaving Methods 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 6
- 238000009940 knitting Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 210000002889 endothelial cell Anatomy 0.000 description 5
- 230000003872 anastomosis Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 102000009123 Fibrin Human genes 0.000 description 3
- 108010073385 Fibrin Proteins 0.000 description 3
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 3
- 230000002785 anti-thrombosis Effects 0.000 description 3
- 238000002788 crimping Methods 0.000 description 3
- 229950003499 fibrin Drugs 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 238000009987 spinning Methods 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- 208000034827 Neointima Diseases 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 239000002759 woven fabric Substances 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- CYTYCFOTNPOANT-UHFFFAOYSA-N Perchloroethylene Chemical group ClC(Cl)=C(Cl)Cl CYTYCFOTNPOANT-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 210000002376 aorta thoracic Anatomy 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000008692 neointimal formation Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229950011008 tetrachloroethylene Drugs 0.000 description 1
- 230000007998 vessel formation Effects 0.000 description 1
Landscapes
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Description
【発明の詳細な説明】
(技術分野)
本発明は、吻合性、抗血栓性、形態保持性に優
れた人工血管に関するものである。DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to an artificial blood vessel with excellent anastomotic properties, antithrombotic properties, and shape retention properties.
(従来技術)
人工血管として要求される主たる特性は、生体
に対して毒性のないこと、強度疲労による生体内
での劣化がないことなどは言うまでもなく、更に
その上
(1) 抗血栓性に優れていること。(Prior art) The main properties required for an artificial blood vessel are, needless to say, non-toxicity to the living body and no deterioration in the living body due to intense fatigue; That's what I'm doing.
(2) 生体血管との吻合性に優れていること。(2) Excellent anastomosis with biological blood vessels.
(3) 形態保持性に優れていること。(3) Excellent shape retention.
などが挙げられる。本発明で言う、抗血栓性とは
移植後すみやかに血管内皮細胞(新生血管壁)を
形成することを意味する。Examples include. In the present invention, antithrombotic properties mean that vascular endothelial cells (new blood vessel walls) are formed immediately after transplantation.
従来の人工血管は、単糸繊度が通常の太さのポ
リエステル繊維で形成された織物または編物であ
り、しかも人工血管壁からの漏血防止や形態保持
の必要から非常に高密度なすなわち目の詰まつた
織編物によつて成つている。その為、クリンプ加
工等の柔軟化手段が講じられているにもかかわら
ず非常に硬いものとなり、術時の縫合における針
通過性が非常に悪く、また生体血管が動脈硬化症
などにより硬化している場合などには生体血管と
人工血管との吻合不全の大きな原因となり、大量
出血などの危険が生じる。しかも吻合性を高める
ため織編物の目を粗くすると漏血を防止できず、
特に抗凝固剤を投与した場合にはより一層重要な
問題であつた。 Conventional artificial blood vessels are woven or knitted fabrics made of polyester fibers with a single yarn fineness of normal thickness.In addition, they are made of extremely high-density polyester fibers to prevent blood leakage from the artificial blood vessel walls and to maintain their shape. It is made of tightly woven and knitted fabric. For this reason, even though softening measures such as crimping have been taken, the material is extremely hard, making it difficult to pass through the needle during surgical sutures, and the blood vessels of the living body are hardened due to arteriosclerosis. If there is a problem, it can be a major cause of anastomosis failure between the biological blood vessel and the artificial blood vessel, leading to risks such as massive bleeding. Moreover, if the texture of the woven or knitted fabric is made coarse to improve anastomotic properties, blood leakage cannot be prevented.
This was an even more important problem especially when anticoagulants were administered.
更に、従来の人工血管の重大な問題点として血
管内皮細胞の形成が遅く且つ不均一なことが上げ
られる。すなわち、太い繊維でしかも目を詰めた
織編物であるため血管内皮細胞を形成する足場が
なくまた細胞が一度付着したとしても容易に血流
によつて洗い流されてしまう点であり、そのため
均一な内皮細胞が形成されないばかりでなく流れ
た血栓が末梢側の細くなつた血管を閉塞させるな
どの重要な問題を生じる点である。 Furthermore, a serious problem with conventional artificial blood vessels is that the formation of vascular endothelial cells is slow and non-uniform. In other words, because it is a woven fabric made of thick fibers and tightly packed, there is no scaffold for vascular endothelial cells to form, and even if cells once adhere to them, they are easily washed away by blood flow. This causes serious problems such as not only endothelial cells not being formed but also the blood clots that flow out occluding the narrow blood vessels on the peripheral side.
血管内皮細胞形成の足場を付与するだけの手段
としては、公開特許公報昭50−117287や同52−
94699や同52−113094や同53−137599に示されて
いるような編地の表面にループを形成させる方法
などが示されている。しかし、これらのいずれも
が通常の太さの繊維で形成されているため足場形
成に対する効果が不充分であり、しかも人工血管
として要求される他の特性例えば針通過性や吻合
性などの手術をより容易に行ないうるために必要
な特性や形態保持性や適度な漏血性や生体へのな
じみなどの点で充分満足出来る人工血管を得るこ
とが出来なかつた。 As a means to simply provide a scaffold for vascular endothelial cell formation, published patent publications 117287-1987 and 52-
94699, 52-113094, and 53-137599, methods of forming loops on the surface of knitted fabrics are disclosed. However, since all of these are made of fibers of normal thickness, they are insufficiently effective in forming scaffolds, and they also lack other properties required for artificial blood vessels, such as needle-passability and anastomotic properties. It has not been possible to obtain an artificial blood vessel that fully satisfies the characteristics necessary for easier operation, shape retention, appropriate blood leakage, and compatibility with living organisms.
特に漏血防止や形態保持性に重点をおけば吻合
性や針通過性に問題が生じ、吻合性や針通過性を
重要視すれば漏血や形態保持性に問題が生じるな
どの相入れない要因を合わせ満足させることが不
可能であつた。 In particular, if emphasis is placed on preventing blood leakage and shape retention, problems will arise with anastomotic properties and needle passability, and if emphasis is placed on anastomotic properties and needle passability, problems with blood leakage and shape preservation will occur. It was impossible to satisfy all the factors.
(本発明の目的)
本発明は、かかる従来の人工血管の欠点を改善
することを目的としたもので、血管内皮細胞(新
生血管壁)の形成が極めて早期且つ均一に行われ
漏血性が低く、術中術後の扁平化や折れ曲がりを
実質的に生じないなどのいわゆる形態保持性に優
れ且つ柔軟でしかも生体血管との吻合性に優れた
従来にない高性能人工血管に関するものである。(Objective of the present invention) The present invention aims to improve the drawbacks of the conventional artificial blood vessels, and the purpose is to form vascular endothelial cells (new blood vessel walls) extremely early and uniformly, resulting in low blood leakage. The present invention relates to an unprecedented high-performance artificial blood vessel that has excellent shape retention, such as virtually no flattening or bending during or after surgery, is flexible, and has excellent anastomotic properties with living blood vessels.
(本発明の構成)
すなわち本発明は、
(1) 多重組織から成る織編物で、且つ内壁およ
び/または外壁に0.5デニール以下の超極細繊
維(A)を少なくとも一部有し、且つ地組織を構成
する地糸は主として1.0デニール以上の繊維(B)
から成ることを特徴とする人工血管。(Structure of the present invention) That is, the present invention provides: (1) A woven or knitted fabric consisting of multiple structures, having at least a portion of ultrafine fibers (A) of 0.5 denier or less on the inner wall and/or outer wall, and having a base structure. The constituent threads are mainly fibers of 1.0 denier or more (B)
An artificial blood vessel characterized by comprising:
(2) 更に人工血管の内壁および/または外壁に立
毛が形成されて成ることを特徴とする人工血
管。(2) An artificial blood vessel characterized by further comprising piloere formed on the inner and/or outer walls of the artificial blood vessel.
(3) 更に地糸に嵩高加工糸を用いることを特徴と
する人工血管。(3) An artificial blood vessel further characterized in that a bulky textured thread is used as the ground thread.
(4) 更に超極細繊維(A)および繊維(B)がポリエステ
ル、ポリアミド、ポリオレフインおよびポリテ
トラフルオロエチレンのいずれかによつて形成
されることを特徴とする人工血管。(4) An artificial blood vessel further characterized in that the ultrafine fibers (A) and the fibers (B) are formed from any one of polyester, polyamide, polyolefin, and polytetrafluoroethylene.
(5) また更に透水率が2000ml/min以下なること
を特徴とする人工血管。(5) Furthermore, an artificial blood vessel characterized by a water permeability of 2000 ml/min or less.
に関するものである。It is related to.
本発明の最も特徴的な点は、超極細繊維(A)を用
いている点であり、しかも多重織編組織により超
極細繊維をより有効に生かすべく織編組織を工夫
した点である。超極細繊維(A)を用いることによつ
て織密度を詰めてもチユーブが硬くならず柔軟
で、針通過性に優れ、しかも驚くべきことに血管
内皮細胞(新生血管壁)がすみやかに且つ均一に
形成される。後者の効果については充分説明出来
ないが血管内皮細胞の形成にはフイブリンの沈着
状態が非常に重要な意味を持つものと考えられて
いることから、超極細繊維(A)を用いることにより
繊維間隙が微細で且つ多数形成され、細胞や線維
が入り易くなるためフイブリン沈着が極めて薄く
且つ均一に且つ強固に行われるためと考えられな
いこともない。また、血管の内壁ばかりでなく外
壁にも超極細繊維(A)を用いることによつて該血管
の周囲組織との馴染みも良く周囲組織の付着を向
上する効果があるが、外壁には必ずしも必要でな
い場合がある。 The most characteristic feature of the present invention is that ultra-fine fibers (A) are used, and the weaving and knitting structure is devised to make more effective use of the ultra-fine fibers by using a multiple weaving and knitting structure. By using ultra-fine fibers (A), the tube does not become hard and flexible even when the weaving density is reduced, and it has excellent needle passability, and surprisingly, vascular endothelial cells (new blood vessel walls) form quickly and uniformly. is formed. Although the latter effect cannot be fully explained, the state of fibrin deposition is thought to have a very important meaning in the formation of vascular endothelial cells. It is not inconceivable that this is because fibrin is deposited extremely thinly, uniformly, and firmly because the fibrin is formed in large numbers and minutely, making it easier for cells and fibers to enter. In addition, by using ultrafine fibers (A) not only on the inner wall but also on the outer wall of the blood vessel, it blends well with the surrounding tissue of the blood vessel and has the effect of improving adhesion of the surrounding tissue, but it is not necessary for the outer wall. It may not be.
本発明の超極細繊維(A)とは、0.5デニール以下
より好ましくは0.2デニール以下の超極細繊維を
さし、血管形成にあたつてはすでにかかる超極細
繊維の形態となつている繊維をそのまま用いても
良いが、化学的もしくは物理的手段により極細化
可能な繊維を用いてチユーブを形成し、しかる後
超極細化することにより結果的に超極細繊維でチ
ユーブが形成されるようにしてもよい。超極細繊
維を得る方法としては通常の紡糸方法で十分の注
意を払つて得ることができるが、ポリエステルの
場合のように未延伸糸を特定の条件下で延伸し超
極細繊維となすことも可能である。 The ultrafine fibers (A) of the present invention refer to ultrafine fibers of 0.5 denier or less, preferably 0.2 denier or less, and for blood vessel formation, fibers that are already in the form of ultrafine fibers are used as they are. However, it is also possible to form tubes using fibers that can be made ultra-fine by chemical or physical means, and then ultra-fine the tubes so that the tubes are formed from ultra-fine fibers as a result. good. Ultra-fine fibers can be obtained by using normal spinning methods with due care, but it is also possible to make ultra-fine fibers by stretching undrawn yarn under specific conditions, as in the case of polyester. It is.
一方、後手段により超極細化可能な繊維として
は例えば特公昭48−22126、特公昭53−22593等で
見られるごとく多成分系繊維の一成分を除去する
か、もしくは剥離させるか等の手段によりフイブ
リル化もしくは超極細化するタイプの繊維を意味
する。かかる繊維の場合、チユーブ加工時は通常
の繊維の太さであつても加工後超極細化出来るた
め加工上のトラブル例えば製織や製編時、製織や
製編前の各種の糸加工手段を講じる場合の糸切れ
や毛羽発生等を最小限に押さえることが出来て好
ましい。 On the other hand, fibers that can be made ultra-fine by post-processing include removing or exfoliating one component of multicomponent fibers, as seen in Japanese Patent Publication No. 48-22126, Japanese Patent Publication No. 53-22593, etc. It means a type of fiber that becomes fibrillated or ultra-fine. In the case of such fibers, during tube processing, even if the fiber is of normal thickness, it can be made ultra-fine after processing, resulting in processing problems such as when weaving or knitting, or by taking various yarn processing methods before weaving or knitting. This is preferable because it can minimize the occurrence of thread breakage and fuzz generation.
また、繊維として用いるポリマーはポリエステ
ル、ポリアミド、ポリテトラフルオロエチレン、
ポリオレフインなど特にその種類を問わないが、
特にポリエステルが好ましい。多成分系繊維を用
いる場合は最終的に残るポリマーは上記ポリマー
であるが他の組み合わせ成分としてはポリスチレ
ン、ポリエチレン、水溶性ポリアミド、アルカリ
水溶液可溶型ポリエステル、水溶性ポリビニルア
ルコール等を適宜組合わせることが可能である。
かかるポリマーの組合わせは製糸性、加工性、機
能性を見て場合場合に応じて決定されるものであ
る。 Polymers used as fibers include polyester, polyamide, polytetrafluoroethylene,
Although it does not matter what kind it is, such as polyolefin,
Particularly preferred is polyester. When using multi-component fibers, the final polymer remaining is the above-mentioned polymer, but other combined components include polystyrene, polyethylene, water-soluble polyamide, alkaline aqueous solution-soluble polyester, water-soluble polyvinyl alcohol, etc., as appropriate. is possible.
The combination of such polymers is determined depending on the case, taking into account spinning properties, processability, and functionality.
また超極細繊維(A)は、いわゆるフイラメントヤ
ーンでもステープルヤーンでも良いがケバ落ちな
どの点からフイラメントヤーンの方が好ましい場
合が多い。一方、繊維(B)は通常の紡糸方法によつ
て得られる1.0デニール以上より好ましくは1.3デ
ニール以上のマルチフイラメントヤーンやステー
プルヤーンが良く、場合によつてはモノフイラメ
ントヤーンが好ましい場合もあるがマルチフイラ
メントヤーンの方が好ましい場合が多く、より好
ましくは仮ヨリ加工などのような嵩高加工を施し
た加工糸を用いる方が針通過性が柔軟性をより向
上出来るので望ましい。 Further, the ultrafine fiber (A) may be a so-called filament yarn or a staple yarn, but filament yarn is often preferable from the viewpoint of fluff removal. On the other hand, the fiber (B) is preferably a multifilament yarn or staple yarn of 1.3 denier or more than 1.0 denier obtained by a normal spinning method. In some cases, monofilament yarn is preferable, but multifilament yarn is preferable. Filament yarn is preferred in many cases, and it is more preferable to use textured yarn that has been subjected to a bulking process such as a temporary twisting process, since needle passability and flexibility can be further improved.
本発明で言う多重組織から成る織編物としては
例えば緯2重組織や経2重組織や経緯2重組織ま
た片3重以上の組織や経緯3重以上の組織、また
緯パイル組織や経パイル組織やこれらの応用組織
やまたはこれらのカツトパイルおよびこれらの組
合せ組織による織物などがその具体的な一例であ
り、また編物の場合も織物と同様の構成を成し得
る編組織などによつて容易に成すことが出来る。 Woven and knitted fabrics having multiple textures as referred to in the present invention include, for example, double weft texture, double warp texture, double warp texture, texture with three or more layers in each side, texture with three or more layers in warp, weft pile texture, warp pile texture, etc. Specific examples include woven fabrics with applied structures, cut piles, and combinations of these structures; I can do it.
また多重組織における糸使いは、表組織を構成
する繊維には超極細繊維(A)および/または超極細
繊維(A)と繊維(B)の引き揃えまたは混繊を用い、地
組織を構成する繊維には繊維(B)および/または超
極細繊維(A)と繊維(B)の引き揃えまたは混繊を用い
る。本発明では人工血管の内壁および/または外
壁は表組織で構成し、外壁および/または内壁と
外壁の間のいわゆる中間壁は地組織によつて構成
する。地組織を構成する糸は地糸とか心糸とか芯
糸などと称し、また地組織を裏組織などと称する
場合もある。これらの多重組織や糸使いを選択す
ることによつて内皮細胞形成性に優れた0.5デニ
ール以下の超極細繊維(A)を該血管の内壁および/
または外壁に積極的に形成し、また繊維(B)を外壁
および/または内壁と外壁の間のいわゆる中間壁
に積極的に形成することによつて形態保持性を同
時に高めることが可能となつた。また内壁およ
び/または外壁、および/または内壁と外壁の間
のいわゆる中間部分に超極細繊維(A)と繊維(B)が適
度に存在することによつて針通過性や柔軟性をも
同時に付与することが可能となつた。従つて織編
組織や糸使いを適宜選択することによつて人工血
管の内皮細胞形成性や生体への適合性を高めると
同時に針通過性や柔軟性や形態保持性を付与する
ことが出来、また用いる部位や目的に沿つた人工
血管と成すことが可能と成つた。 In addition, the yarn used in the multi-layer structure uses ultra-fine fibers (A) and/or aligned or mixed fibers of ultra-fine fibers (A) and fibers (B) to form the surface structure. The fibers used are fibers (B) and/or aligned or mixed fibers of ultrafine fibers (A) and fibers (B). In the present invention, the inner wall and/or outer wall of the artificial blood vessel is made of superficial tissue, and the outer wall and/or the so-called intermediate wall between the inner wall and the outer wall is made of ground tissue. The threads that make up the ground weave are called base threads, core threads, core threads, etc., and the ground weave is sometimes called back weave. By selecting these multiple tissues and threads, we can coat the inner wall of the blood vessel and/or the ultra-fine fiber (A) of 0.5 denier or less with excellent endothelial cell forming properties.
Alternatively, by actively forming fibers (B) on the outer wall and/or actively forming the fibers (B) on the so-called intermediate wall between the inner wall and the outer wall, it is possible to simultaneously enhance shape retention. . In addition, the presence of ultra-fine fibers (A) and fibers (B) in appropriate amounts in the inner wall and/or outer wall, and/or in the so-called intermediate portion between the inner and outer walls provides needle passability and flexibility at the same time. It became possible to do so. Therefore, by appropriately selecting the weaving/knitting structure and thread usage, it is possible to improve the endothelial cell forming property of the artificial blood vessel and its compatibility with the living body, while at the same time imparting needle passability, flexibility, and shape retention. In addition, it has become possible to create an artificial blood vessel that matches the site and purpose of use.
チユーブ化の手段としては、織編物と成した後
裁断し、縫製や接着や融着によつてチユーブ状物
と成すことも出来るが、織編物と成すに際しチユ
ーブ状に形成した方が継ぎ目がなくより好まし
い。 As a means of forming a tube, it is possible to make a woven or knitted fabric, then cut it, and then make it into a tube-like object by sewing, gluing, or fusing. More preferred.
本発明を更により一層効果的に成らしめるため
には、血管の内壁および/または外壁に超極細繊
維(A)の立毛を形成するのが良い。しかし立毛して
いる繊維は超極細繊維(A)のみに限らず繊維(B)が共
存していても良く、また繊維(B)が全て立毛してい
なくても良い。 In order to make the present invention even more effective, it is preferable to form raised pili of ultrafine fibers (A) on the inner and/or outer walls of blood vessels. However, the fibers that are napped are not limited to only the ultrafine fibers (A), but the fibers (B) may coexist, and all of the fibers (B) do not need to be napped.
また本発明で言う立毛とは、ループおよび/ま
たはケバが存するようなものを言い、立毛を作る
手段には、織または編成時にループを作る手段、
例えばパイル織編物やそのカツトパイル方法、ま
た織編物を形成した後の加工例えば起毛機による
起毛やシヤーリングマシーンによる方法、場合に
よつては、サンドペーパーによるバフ方式などが
その代表的な手段であるが、本発明はこれらの手
段のみとらわれるものではない。また立毛状態は
目的に応じ調節可能であるが、本発明の思わぬ効
果は超極細繊維を用いているため立毛状態が多少
ばらついても性能が比較的少なくて済み安定した
性能を示すことである。一方、人工血管を形成す
るにあたりどの程度の繊維密度とすべきかは非常
に重要な問題であり場合場合に応じ要求度が異な
り難しいが一つの参考として透水率をみるのが実
際に則し便利である。ここで言う透水率とは120
mmHg圧下で布帛1cm2当り1分間に通過する水量
(ml)を言う。本発明ではこの値が2000ml/min
以下好ましくは1000ml/min以下よりこのましく
は500ml/min以下の低透水率の人工血管の場合
においてより効果を発揮する。 Furthermore, the term "napped" as used in the present invention refers to something that has loops and/or fluff, and the means for creating the napped includes means for creating loops during weaving or knitting;
For example, typical methods include pile woven and knitted fabrics, their cut and pile methods, processing after forming woven and knitted fabrics, such as raising with a napping machine, methods using a shearing machine, and in some cases, buffing with sandpaper. However, the present invention is not limited to these means only. In addition, although the napping state can be adjusted depending on the purpose, an unexpected effect of the present invention is that since ultra-fine fibers are used, even if the napping state varies somewhat, the performance is relatively small and stable performance is exhibited. . On the other hand, determining the fiber density when forming an artificial blood vessel is a very important issue, and the requirements vary depending on the case, making it difficult, but it is practical and convenient to look at the water permeability as a reference. be. The water permeability referred to here is 120
It refers to the amount of water (ml) that passes per minute per cm2 of fabric under mmHg pressure. In the present invention, this value is 2000ml/min.
It is more effective in the case of an artificial blood vessel with a low water permeability, preferably 1000 ml/min or less, more preferably 500 ml/min or less.
しかしかかる値はあくまでも一つの目安であつ
て必ずしもこれにとらわれるべきではなく実際
300ml/minや5000ml/min程度の透水率を有する
ものでも従来ものに比べ血管内皮細胞の形成性や
吻合性などに優れた性質を示す。しかし特に低透
水率下で総合的効果が発揮されるものである。通
常このような低透水率下では内皮細胞の形成が極
めて難しい本発明の如く超極細繊維を用いると繊
維と細胞とのなじみが良いためかこの形成も容易
になる。また、本発明の人工血管はクリンプ加工
を施さなくても十分目的を達し得るのでクリンプ
加工を敢えて必要としないがより柔軟性やより高
い形態保持性を必要とする場合には効果を発揮す
る場合もある。 However, this value is just a guideline and should not necessarily be used as a guideline.
Even products with a water permeability of around 300ml/min or 5000ml/min show superior properties in terms of vascular endothelial cell formation and anastomosis compared to conventional products. However, the overall effect is particularly exhibited under low water permeability. Normally, it is extremely difficult to form endothelial cells under such low water permeability, but when ultrafine fibers are used as in the present invention, this formation becomes easy, probably because the fibers and cells are well compatible. In addition, the artificial blood vessel of the present invention can sufficiently achieve its purpose without crimping, so crimping is not necessary, but it may be effective in cases where more flexibility and higher shape retention are required. There is also.
(本発明の効果)
以上本発明について詳細に述べたが、超極細繊
維を用いた本発明の人工血管はその漏血性が著し
く低いにもかかわらず柔軟性に富み、また吻合性
が著しく改善されるのみならず超極細繊維である
が故に生体細胞が付着するに適した足場の数が著
しく増大し、繊維とのなじみを増し、優れた抗血
栓性を発揮し、内皮細胞の形成が極めて早期に且
つ良好に行われ従来にない人工血管と成し得たの
である。(Effects of the present invention) The present invention has been described in detail above, and the artificial blood vessel of the present invention using ultrafine fibers is highly flexible despite its extremely low leakage, and has significantly improved anastomotic properties. Not only that, but because they are ultra-fine fibers, the number of scaffolds suitable for biological cell attachment increases significantly, increasing compatibility with the fibers, exhibiting excellent antithrombotic properties, and forming endothelial cells at an extremely early stage. This process was carried out successfully and successfully, resulting in an unprecedented artificial blood vessel.
つぎに、実施例により本発明をより具体的に説
明するが本発明はこれのみにとらわれるものでは
ない。 Next, the present invention will be explained in more detail with reference to examples, but the present invention is not limited to these examples.
実施例 1
タテ糸およびヨコ地糸(裏糸)にポリエチレン
テレフタレートの50デニール24フイラメントの仮
ヨリ加工糸を用い、ヨコ表糸に特公昭48−22126
で定義される複合繊維で島成分ポリエチレンテレ
フタレート78部、海成分ポリスチレン22部、島数
36島の繊維245デニール40フイラメントのものを
用い、いわゆる経2重緯4重織組織でチユーブ状
に織り、内径17mmφ、長さ100cmのチユーブを形
成し、湯洗いし、次いで乾燥後パークロルエチレ
ンでポリスチレンを除去した。次いでこのチユー
ブを起毛機で起毛した。このチユーブを湯洗いし
乾燥後裏返し、エチレンオキサイドガスで滅菌し
た後犬の胸部下降大動脈に移植した。この布帛の
透水率は295ml/minであつた。Example 1 A 50-denier 24-filament polyethylene terephthalate yarn with temporary twisted texture was used for the warp yarn and the weft yarn (back yarn), and the weft surface yarn was made of Japanese Patent Publication No. 48-22126.
Composite fiber defined by 78 parts of island component polyethylene terephthalate, 22 parts of sea component polystyrene, number of islands
Using 36 island fibers of 245 denier and 40 filament, weave them into a tube with a so-called double warp, weft, and quadruple weave structure to form a tube with an inner diameter of 17 mmφ and a length of 100 cm, which was then washed with hot water, dried, and perchlorethylene. The polystyrene was removed. Next, this tube was brushed using a napping machine. The tube was washed with hot water, dried, turned over, sterilized with ethylene oxide gas, and then transplanted into the descending thoracic aorta of a dog. The water permeability of this fabric was 295 ml/min.
犬の大動脈への移植を行うにあたつては生体血
管との縫い合わせは、極めて容易にしかも良好に
行ない得た。特に針通過性が良く、柔らかいため
縫合性、吻合性に優れていた。移植直前のプリク
ロツテイングは透水率が低いので行わなかつた
が、血液の漏れは殆んど見られなかつた。しかし
布全体に血液が滲み出し、布全体は赤くなつた。
その後、人工血管部の切除した試料を観察した結
果では2日目には移植直後の赤色が薄れ淡赤色と
なり、20日目には血液の滲み込みが減少していて
新生内膜の形成が著しく起こつていることが認め
られ、2ケ月を経過すると新生内膜の形成が非常
に活発であることを裏付ける肉芽様の盛り上がり
が認められた。約3ケ月後になると血管内壁の新
生内膜はほぼ完成し光沢のある灰白色となつてい
た。この結果は従来の人工血管と比較して治瘉が
著しく短縮されていることを示している。 When transplanting into the aorta of a dog, suturing with the living blood vessel was extremely easy and successful. In particular, it had good needle passability and was soft, so it had excellent suturing and anastomosis properties. Pre-clotting immediately before transplantation was not performed due to low water permeability, but almost no blood leakage was observed. However, blood seeped all over the cloth, turning it red.
Afterwards, the results of observing the excised specimen of the artificial blood vessel showed that on the second day, the red color immediately after transplantation faded to pale red, and on the 20th day, blood seepage had decreased and neointimal formation was marked. It was observed that this was occurring, and after 2 months, granulation-like swelling was observed, which indicates that the formation of neointima is very active. After about 3 months, the neointima on the inner wall of the blood vessel was almost completed and had become a shiny grayish white color. This result shows that the healing time is significantly shortened compared to conventional artificial blood vessels.
Claims (1)
び/または外壁に0.5デニール以下の超極細繊維
(A)を少なくとも一部有し、且つ地組織を構成する
地糸は主として1.0デニール以上の繊維(B)から成
ることを特徴とする人工血管。 2 内壁および/または外壁に立毛が形成されて
成ることを特徴とする特許請求範囲第1項に記載
の人工血管。 3 地糸に嵩高加工糸を用いることを特徴とする
特許請求範囲第1項または第2項に記載の人工血
管。 4 超極細繊維(A)および/または繊維(B)がポリエ
ステル、ポリアミド、ポリオレフイン、ポリテト
ラフルオロエチレンのいずれかによつて形成され
て成ることを特徴とする特許請求範囲第1項〜第
3項に記載の人工血管。 5 透水率が2000ml/min以下であることを特徴
とする特許請求範囲第1項〜第4項に記載の人工
血管。[Scope of Claims] 1. A woven or knitted fabric consisting of multiple structures, and having ultrafine fibers of 0.5 denier or less on the inner and/or outer walls.
What is claimed is: 1. An artificial blood vessel comprising (A) at least in part, and wherein the base threads constituting the base tissue mainly consist of fibers (B) of 1.0 denier or more. 2. The artificial blood vessel according to claim 1, characterized in that the inner wall and/or the outer wall are formed with standing piloere. 3. The artificial blood vessel according to claim 1 or 2, characterized in that a bulky textured yarn is used as the ground yarn. 4. Claims 1 to 3, characterized in that the ultrafine fibers (A) and/or the fibers (B) are made of polyester, polyamide, polyolefin, or polytetrafluoroethylene. Artificial blood vessel described in. 5. The artificial blood vessel according to claims 1 to 4, which has a water permeability of 2000 ml/min or less.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58185170A JPS6077764A (en) | 1983-10-05 | 1983-10-05 | Artificial blood vessel |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58185170A JPS6077764A (en) | 1983-10-05 | 1983-10-05 | Artificial blood vessel |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6077764A JPS6077764A (en) | 1985-05-02 |
JPS6158190B2 true JPS6158190B2 (en) | 1986-12-10 |
Family
ID=16166053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP58185170A Granted JPS6077764A (en) | 1983-10-05 | 1983-10-05 | Artificial blood vessel |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6077764A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015080143A1 (en) | 2013-11-29 | 2015-06-04 | 東レ株式会社 | Vascular prosthesis |
WO2015093480A1 (en) * | 2013-12-18 | 2015-06-25 | 東レ株式会社 | Artificial blood vessel |
US9987119B2 (en) | 2014-08-12 | 2018-06-05 | Toray Industries, Inc. | Vascular prosthesis |
US10251742B2 (en) | 2014-02-12 | 2019-04-09 | Toray Industries, Inc. | Artificial blood vessel |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6392347A (en) * | 1986-10-06 | 1988-04-22 | 東レ株式会社 | In vitro implant tool |
JPS63115554A (en) * | 1986-11-04 | 1988-05-20 | 東レ株式会社 | Artificial blood vessel excellent in pseudo-endothelium forming property |
JPS63115555A (en) * | 1986-11-04 | 1988-05-20 | 東レ株式会社 | Artificial blood vessel excellent in living body compatibility and preclotting property |
WO2001070292A1 (en) * | 2000-03-24 | 2001-09-27 | Yuichi Mori | Artificial hollow organ |
JP4627978B2 (en) * | 2003-10-27 | 2011-02-09 | 泰晴 野一色 | Low blood permeability medical material |
JP2008075539A (en) * | 2006-09-21 | 2008-04-03 | Yamaha Corp | Silencer |
US9243353B2 (en) | 2011-01-26 | 2016-01-26 | Asahi Kasei Fibers Corp. | Stent grafts |
RU2015148536A (en) * | 2013-04-12 | 2017-05-18 | Торэй Индастриз, Инк. | ANTITROMBOTIC ARTIFICIAL BLOOD VESSEL |
JPWO2022209633A1 (en) * | 2021-03-30 | 2022-10-06 |
-
1983
- 1983-10-05 JP JP58185170A patent/JPS6077764A/en active Granted
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015080143A1 (en) | 2013-11-29 | 2015-06-04 | 東レ株式会社 | Vascular prosthesis |
US10070949B2 (en) | 2013-11-29 | 2018-09-11 | Toray Industries, Inc. | Vascular prosthesis |
WO2015093480A1 (en) * | 2013-12-18 | 2015-06-25 | 東レ株式会社 | Artificial blood vessel |
US20160317272A1 (en) * | 2013-12-18 | 2016-11-03 | Toray Industries, Inc. | Vascular prosthesis |
JPWO2015093480A1 (en) * | 2013-12-18 | 2017-03-16 | 東レ株式会社 | Artificial blood vessel |
TWI632899B (en) * | 2013-12-18 | 2018-08-21 | 東麗股份有限公司 | Artificial blood vessel |
RU2675113C1 (en) * | 2013-12-18 | 2018-12-17 | Торэй Индастриз, Инк. | Artificial blood vessel |
US10251742B2 (en) | 2014-02-12 | 2019-04-09 | Toray Industries, Inc. | Artificial blood vessel |
US9987119B2 (en) | 2014-08-12 | 2018-06-05 | Toray Industries, Inc. | Vascular prosthesis |
Also Published As
Publication number | Publication date |
---|---|
JPS6077764A (en) | 1985-05-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4695280A (en) | Artificial vascular graft | |
US4743250A (en) | Artificial blood vessel and method of manufacture | |
JPS6158190B2 (en) | ||
JP2004526472A (en) | High profile cloth graft for arteriovenous access | |
JP3165166B2 (en) | Artificial blood vessel and method for producing the same | |
AU2014355478B2 (en) | Vascular prosthesis | |
US20090192597A1 (en) | Surgical implant, method for the production and use thereof | |
WO1998037813A1 (en) | Fabric prosthesis and process for preparing the same | |
CN105764446B (en) | Artificial blood vessel | |
JPH11164881A (en) | Medical material and manufacture thereof | |
JPH0369543B2 (en) | ||
JPS632620B2 (en) | ||
JPH01126962A (en) | Preparation of medical prosthesis | |
JPH0880342A (en) | Tubular body for artificial blood vessel | |
JPH0523362A (en) | Preparation of artificial blood vessel | |
JP2002017758A (en) | Branch artifical blood vessel | |
RU2670671C2 (en) | Vascular prosthesis | |
JPH0528143B2 (en) | ||
JPH0462740B2 (en) | ||
JPH01107756A (en) | Medical prosthesis | |
JPH0459899B2 (en) | ||
JPS5932448A (en) | Artificial blood vessel | |
JPH0636820B2 (en) | Mandrill graft insertion method | |
JPH05111505A (en) | Artificial blood vessel | |
JPH05208045A (en) | Artificial blood vessel and its preparation thereof |