JPS61234866A - Glass beads for living body - Google Patents

Glass beads for living body

Info

Publication number
JPS61234866A
JPS61234866A JP60061647A JP6164785A JPS61234866A JP S61234866 A JPS61234866 A JP S61234866A JP 60061647 A JP60061647 A JP 60061647A JP 6164785 A JP6164785 A JP 6164785A JP S61234866 A JPS61234866 A JP S61234866A
Authority
JP
Japan
Prior art keywords
glass
glass beads
beads
bone
crystallized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60061647A
Other languages
Japanese (ja)
Other versions
JPS6314991B2 (en
Inventor
武宏 渋谷
昌 松井
雅隆 高木
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Electric Glass Co Ltd
Original Assignee
Nippon Electric Glass Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Electric Glass Co Ltd filed Critical Nippon Electric Glass Co Ltd
Priority to JP60061647A priority Critical patent/JPS61234866A/en
Publication of JPS61234866A publication Critical patent/JPS61234866A/en
Publication of JPS6314991B2 publication Critical patent/JPS6314991B2/ja
Granted legal-status Critical Current

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  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)

Abstract

(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。
(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

【発明の詳細な説明】 産業上の利用分野 本発明は、骨や歯根、を髄等の充填材として有用なガラ
スおよび結晶化ガラスからなる生体用ガラスに関するも
のである。
DETAILED DESCRIPTION OF THE INVENTION Field of Industrial Application The present invention relates to a glass for biological use made of glass and crystallized glass useful as a filling material for bones, tooth roots, pulp, etc.

従来技術 従来より骨や歯根、を髄等の欠損部に対して充填する材
料としては、セラミックをパウダー(粉末)状あるいは
テトラポット状にしたもの、またポーラスな焼結体にし
、て適当な形状にしたもの等が用いられているが、生体
組織との親和性が悪いこと、骨の増殖作用がないこと、
骨と化学結合を作らないこと等の欠点があった。またカ
ルシウム化合物を充填することも試みられているが、大
部分が体内に吸収されてしまい骨の増殖作用が小さく効
果が少なかった。
Conventional technology Conventionally, the materials used to fill defects in bones, tooth roots, pulp, etc. have been ceramic powdered or tetrapod-shaped, or porous sintered bodies and shaped into appropriate shapes. However, they have poor compatibility with living tissues, have no bone growth effect,
It had drawbacks such as not forming chemical bonds with bones. Attempts have also been made to fill the bones with calcium compounds, but most of them are absorbed into the body and have little effect on bone growth.

発明の目的 本発明は、上記欠点を改良するもので、生体親和生に優
れ、新生骨を充分に増殖させるとともに骨と直接化学結
合をつくるP2O6−CaO系のガラスあるいは結晶化
ガラスをビーズにすることによって骨や歯根、を髄等の
充填材として、作用な生体用ガラスピーズを提供するこ
とを目的とするものである。
Purpose of the Invention The present invention aims to improve the above-mentioned drawbacks by making beads of P2O6-CaO glass or crystallized glass, which is excellent in biocompatibility, allows sufficient growth of new bone, and creates direct chemical bonds with bone. The purpose of this invention is to provide glass beads for biological use that are effective in using bones, tooth roots, and pulp as filling materials.

発明の構成 本発明の生体用ガラスピーズは、P2O5−CaO系の
ガラスまたは結晶化ガラスからなることを特徴とする。
Structure of the Invention The biological glass beads of the present invention are characterized by being made of P2O5-CaO glass or crystallized glass.

本発明の生体用ガラスピーズは、好ましくは少なくとも
P2O51〜30重量%、CaO20〜50重量%、P
2O5とCaOを合量で25〜80重量%含存するガラ
スまたは結晶化ガラスからなることを特徴とする。
The biological glass beads of the present invention preferably include at least 51 to 30% by weight of P2O, 20 to 50% by weight of CaO, and at least 51 to 30% by weight of P2O.
It is characterized by being made of glass or crystallized glass containing 25 to 80% by weight of 2O5 and CaO in total.

本発明において組成範囲を上記のように限定したものは
以下の理由による。
In the present invention, the composition range is limited as described above for the following reasons.

PAが1%より少ない場合は、新生骨の増殖効果み小さ
くまた骨との結合強度が低くなる。30%より多い場合
は、化学耐久性が悪くなるとともにビーズが破損しやす
くなる。
If the PA content is less than 1%, the effect of new bone growth will be small and the bonding strength with the bone will be low. When the amount is more than 30%, chemical durability deteriorates and the beads become easily damaged.

ChOが20%より少ない場合は、生体親和性が悪く骨
の再生、増殖効果が低く、55%より多い場合は、失透
性が高くなり、ビーズ化が困難となる。
When ChO is less than 20%, the biocompatibility is poor and bone regeneration and proliferation effects are low, and when it is more than 55%, devitrification becomes high and it becomes difficult to form beads.

PAとCaOの合量が25重量%より少ない場合は、骨
を再生増殖する効果が弱く、欠損部に充填した後の骨再
生が遅くなり、またビーズ表面と骨とのズが困難となる
If the total amount of PA and CaO is less than 25% by weight, the effect of regenerating and proliferating bone will be weak, bone regeneration after filling a defect will be slow, and it will be difficult to bond the bead surface to bone.

以下本発明について具体的に説明する。The present invention will be specifically explained below.

本発明の生体用ガラスピーズは、球形体でありパウダー
(粉末)やテトラポット等の非球形体と異なり、例えば
充填しにくい部位に対し注射器等で注入する際、管が詰
まることがなく充填作業が容易である。更に非球形体が
生体組織内でそのシャープエッヂ部分に於て過敏反応を
生ぜしめ昌いのに対して、本発明のガラスは、生体組織
に対する影響が緩やかである。
The biological glass beads of the present invention are spherical, and unlike non-spherical bodies such as powder and tetrapods, they do not clog the tube when injected with a syringe into areas that are difficult to fill, for example. is easy. Furthermore, whereas non-spherical bodies cause hypersensitivity reactions at their sharp edges within living tissues, the glass of the present invention has a gentle effect on living tissues.

また本発明のガラスピーズは、機械的強度が高いことが
必要である用途に用いられる場合、結晶化ガラスである
ことが好ましい。すなわち結晶化ガラスからなるガラス
ピーズは、多数のアパタイトやその他の種類の微結晶が
ガラス媒体中に析出した緻密な構造を存する。アパタイ
ト結晶は、結晶化ガラスと骨との間に化学結合を生じさ
せると共に生体親和性を良好にし、その他の種rの結晶
は、結晶化ガラスの機械的強度を高める作用をもたらす
。特に医用高分子材や歯科用補修材と混合して用いる時
は、結晶化ガラスピーズのほうが骨の再生増殖作用が高
(骨や歯の欠損部の再生、治療に有効である。
Moreover, when the glass beads of the present invention are used for applications requiring high mechanical strength, it is preferable that the glass beads are crystallized glass. That is, glass beads made of crystallized glass have a dense structure in which a large number of apatite and other types of microcrystals are precipitated in a glass medium. Apatite crystals create a chemical bond between crystallized glass and bone and improve biocompatibility, and other seed crystals have the effect of increasing the mechanical strength of crystallized glass. Especially when mixed with medical polymer materials or dental repair materials, crystallized glass beads have a higher bone regeneration and proliferation effect (effective for regeneration and treatment of bone and tooth defects).

本発明によるガラスピーズは例えば次ノヨウニして製造
することができる。常法により所望のガラス組成になる
ように原料を秤量し、それを混合して溶融する。溶融後
、薄いリボン状に成形し、次いでボールミルにて粉砕し
280メツシュ程度のフルイで分級してガラス粉末を製
造する。こうしてできたガラス粉末を例えばスプレード
ライヤーで造粒あるいは再造粒した後、焼成するとガラ
スピーズあるいは結晶化ガラスピーズとなる。
The glass beads according to the invention can be produced, for example, by the following process. Raw materials are weighed, mixed and melted using a conventional method to obtain a desired glass composition. After melting, it is formed into a thin ribbon shape, then ground in a ball mill and classified with a sieve of about 280 mesh to produce glass powder. The glass powder thus produced is granulated or re-granulated using, for example, a spray dryer, and then fired to form glass beads or crystallized glass beads.

上記製造方法以外にも溶融したガラスを繊維状に引き出
しながらエアーで吹き飛ばすことによってガラスピーズ
を製造することができる。
In addition to the manufacturing method described above, glass beads can be manufactured by blowing away molten glass with air while drawing it into fibers.

更に結晶化したガラスピーズを得るためには、上記方法
で製造されたガラスピーズあるいは部分的に結晶化した
ガラスピーズを例えばセラミック容器に入れてガラスピ
ーズが充分結晶化するまで焼成する。
In order to obtain further crystallized glass beads, the glass beads produced by the above method or partially crystallized glass beads are placed in, for example, a ceramic container and fired until the glass beads are sufficiently crystallized.

本発明のガラスピーズの組成としては例えば下記の表の
ものが適用される。
As the composition of the glass beads of the present invention, for example, those in the table below are applicable.

実施例 実施例1 前記表の試料2の組成になるように各原料を秤量、混合
し、これを白金ルツボに入れ電気炉中で1400〜15
00℃で4時間溶融する。次いでこれらをステンレス製
水冷ローラーの間に流してリボン状に成形した後、アル
ミナボールにて280メツシユ以下に粉砕する。次いで
粉砕ガラスに蒸留水を40重量%添加してスプレードラ
イヤーで50〜200μに造粒する。造粒されたガラス
粒子を1300°Cの管状炉を通加させるとガラスが再
度溶融して球形の25〜100μのガラスピーズができ
、該ガラスピーズをアルミナ製ルツボの中に入れ110
0℃で20〜120分焼成することによりアパタイト、
7オラストナイト結晶の析出した結晶化ガラスが得られ
る。
Examples Example 1 Each raw material was weighed and mixed to have the composition of Sample 2 in the table above, and this was placed in a platinum crucible and heated to 1,400 to 15
Melt at 00°C for 4 hours. Next, these are passed between water-cooled stainless steel rollers to form a ribbon, and then ground to 280 mesh or less using an alumina ball. Next, 40% by weight of distilled water is added to the crushed glass and granulated to a size of 50 to 200 μm using a spray dryer. When the granulated glass particles are passed through a tube furnace at 1300°C, the glass is melted again to form spherical glass beads of 25 to 100μ, and the glass beads are placed in an alumina crucible at 110°C.
Apatite is produced by firing at 0℃ for 20 to 120 minutes.
A crystallized glass in which 7 alastonite crystals are precipitated is obtained.

実例2 前記表の試料5の組成になるように各原料を秤量混合し
、これを底部に細い白金ノズルの付いた白金ルツボに入
れ、ノズルを冷却しながら電気炉中1300〜1400
℃で2時間溶融する。溶解後ノズルを加熱して溶融ガラ
スをノズルより糸状に流出させ80k(/cJのエアー
で吹き飛ばし、バッグフィルターで回収したところ0.
1μ〜100μのガラスが得られた。
Example 2 Each raw material was weighed and mixed to have the composition of sample 5 in the table above, placed in a platinum crucible with a thin platinum nozzle at the bottom, and heated in an electric furnace at 1300 to 1400 ml while cooling the nozzle.
Melt for 2 hours at °C. After melting, the nozzle was heated and the molten glass flowed out from the nozzle in the form of a thread, blown out with 80k/cJ of air, and collected with a bag filter.
A glass of 1μ to 100μ was obtained.

実施例1.2で製造されたガラスピーズあるいは結晶化
ガラスピーズを成犬の大腿骨並びにあご骨の欠損部に注
入したところ4週間後にビーズ内に新生骨の成長が見ら
゛れ、lO週間後には欠損部を新生骨が完全に被いつく
し骨とビーズが一体になっていることが確認された。
When the glass beads or crystallized glass beads produced in Example 1.2 were injected into the defective parts of the femur and jawbone of an adult dog, new bone growth was observed within the beads after 4 weeks, and after 10 weeks. Later, it was confirmed that the defect area was completely covered with new bone and that the bone and bead were integrated.

また実施例!、の結晶化ガラスピーズ70重量%とポリ
メチルメタクリレート30重量%混合したものを成犬の
大腿骨欠損部に充填したところ10週間後には周辺組成
に対し何ら害を示さず周囲の骨と強く結合していること
が確認された。
Another example! When a mixture of 70% by weight of crystallized glass beads and 30% by weight of polymethyl methacrylate was filled into the femoral bone defect of an adult dog, it showed no harm to the surrounding composition after 10 weeks and was strongly bonded to the surrounding bone. It was confirmed that

発明の効果 以上のように本発明の生体用ガラスピーズは、生体視相
性に優れ、骨と直接化学結合をつく゛ると共にガラスピ
ーズの隙間に骨を増殖するため骨や歯根、を髄等の充填
材として育用である。また生体用高分子、陶歯材、歯科
補修材と混合して用いる生体の骨や歯の欠損部補修材と
しても同様の効果を期待できる。
Effects of the Invention As described above, the glass beads for biological use of the present invention have excellent biological compatibility, create direct chemical bonds with bones, and grow bone in the gaps between the glass beads, so they can be used to fill bones, tooth roots, and pulp with pulp, etc. It is cultivated as wood. Similar effects can also be expected when used as a repair material for damaged bones and teeth of living bodies when mixed with biological polymers, porcelain tooth materials, and dental repair materials.

更に本発明の生体用ガラスピーズiヨ、球形体であるた
め注射器等で注入する際、管が詰まることがなく充填作
業が容易であり、場合によっては手術することなく骨や
歯の欠損部に必要量のビーズを充填でき、生体組織内の
過敏反応もほとんどない。更にビーズの大きさも症状や
用途に応じて変えることができる。
Furthermore, since the biological glass beads of the present invention are spherical, they do not clog the tube when injected with a syringe, making filling work easy, and in some cases, they can be used to fill bone or tooth defects without surgery. The required amount of beads can be filled, and there is almost no hypersensitivity reaction within living tissues. Furthermore, the size of the beads can be changed depending on the symptoms and uses.

特許出願人  日本電気硝子株式会社 代表者 長崎率− 手続補正書 1、事件の表示   ・ 昭和60年特許願第61647号 2、発明の名称 生体用ガラスピーズ 3、補正をする者 事件との関係  特許出願人 シ 万  ミオ)  セイラン 住所 滋賀県大津市晴嵐二丁目7番1号ニフポンデンキ
ガラス 名称  日本電気硝子株式会社 ・・・」に訂正する。
Patent Applicant: Nippon Electric Glass Co., Ltd. Representative Nagasaki Ryo - Procedural Amendment 1, Indication of the Case - 1985 Patent Application No. 61647 2, Title of Invention: Biological Glass Peas 3, Relationship with the Amendment Person Case Patent Applicant: Seiran Address: 2-7-1 Seiran, Otsu City, Shiga Prefecture Nifpon Denki Glass Name: Nippon Electric Glass Co., Ltd."

■ 明細書第7頁3行目「ズが・・・」を「ズ化が・・
・」に訂正する。
■ On page 7, line 3 of the specification, change "Zuga..." to "Zuga..."
・Corrected to ``.

■ 第6頁の表を別紙のものと差し代える。■ Replace the table on page 6 with the one on the separate sheet.

■ 明細書第7頁下O行目「・・・フォラスト」を「・
・・ウオラスト」に訂正する。
■ On the bottom O line of page 7 of the specification, change “...Forest” to “・
...Corrected to "Wollast".

■ 明細書第7頁下から8行目「実例2Jを「実施例2
」に訂正する。
■ On page 7 of the specification, line 8 from the bottom, “Example 2J” is changed to “Example 2
” is corrected.

■ 明細書第7頁下から1行目「・・・ガラス ・・・
」を「・・・ガラスピーズ・・・」に訂正する。
■ 1st line from the bottom of page 7 of the specification “...Glass...
" is corrected to "...Glass Peas...".

■ 明細書第8頁4行目「・・・欠損部・・・」を「・
・・欠損部・・・」に訂正する。
■ On the 4th line of page 8 of the specification, change "...missing part..." to "・
...The missing part..." is corrected.

■ 明細書第8頁4行目「・・・内・・・」を「・・・
隙間・・・」に訂正する。
■ On the 4th line of page 8 of the specification, replace "...within..." with "...
Gap..." is corrected.

■ 明細書第7頁11行目「・・・組成・・・Jを「・
・・組織・・・」に訂正する。
■Page 7, line 11 of the specification “...composition...J”
...Organization..."

[株] 明細書第8頁下から3行目「・・・を髄等の」
の後に「各部位の欠損部の」を挿入する。
[Stocks] Page 8 of the specification, 3rd line from the bottom, “...is the marrow, etc.”
After that, insert "of the missing part of each part".

■ 明細書第7頁4行目「・・は手」を「・・・は切開
手」に訂正する。
■ On page 7, line 4 of the specification, "...is a hand" is corrected to "...is an incised hand."

(重量%)(weight%)

Claims (2)

【特許請求の範囲】[Claims] (1)P_2O_5−CaO系のガラスまたは結晶化ガ
ラスからなる生体用ガラスビーズ。
(1) Biological glass beads made of P_2O_5-CaO-based glass or crystallized glass.
(2)少なくともP_2O_51〜30重量%、CaO
20〜55重量%、P_2O_5とCaOを合量で25
〜80重量%含有するガラスまたは結晶化ガラスからな
る特許請求の範囲第1項記載の生体用ガラスビーズ。
(2) At least P_2O_51-30% by weight, CaO
20-55% by weight, total amount of P_2O_5 and CaO is 25
The biological glass beads according to claim 1, which are made of glass or crystallized glass containing ~80% by weight.
JP60061647A 1985-03-25 1985-03-25 Glass beads for living body Granted JPS61234866A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP60061647A JPS61234866A (en) 1985-03-25 1985-03-25 Glass beads for living body

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60061647A JPS61234866A (en) 1985-03-25 1985-03-25 Glass beads for living body

Publications (2)

Publication Number Publication Date
JPS61234866A true JPS61234866A (en) 1986-10-20
JPS6314991B2 JPS6314991B2 (en) 1988-04-02

Family

ID=13177220

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60061647A Granted JPS61234866A (en) 1985-03-25 1985-03-25 Glass beads for living body

Country Status (1)

Country Link
JP (1) JPS61234866A (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5198754A (en) * 1975-01-17 1976-08-31
JPS5391960A (en) * 1976-12-03 1978-08-12 Smith & Nephew Res Polycarboxylate cement composition and uses thereof
JPS5626743A (en) * 1979-08-10 1981-03-14 Fuji Photo Film Co Ltd Phosphate type glass, its crystallized glass and their manufacture
JPS5654841A (en) * 1979-10-08 1981-05-15 Mitsubishi Mining & Cement Co Bone broken portion and filler for void portion and method of treating bone of animal using said filler
JPS5657710A (en) * 1979-09-26 1981-05-20 Bayer Ag Dental substance based on pasty organic plastics
JPS57191252A (en) * 1981-05-22 1982-11-25 Univ Kyoto Crystallized glass for artificial bone and its preparation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5198754A (en) * 1975-01-17 1976-08-31
JPS5391960A (en) * 1976-12-03 1978-08-12 Smith & Nephew Res Polycarboxylate cement composition and uses thereof
JPS5626743A (en) * 1979-08-10 1981-03-14 Fuji Photo Film Co Ltd Phosphate type glass, its crystallized glass and their manufacture
JPS5657710A (en) * 1979-09-26 1981-05-20 Bayer Ag Dental substance based on pasty organic plastics
JPS5654841A (en) * 1979-10-08 1981-05-15 Mitsubishi Mining & Cement Co Bone broken portion and filler for void portion and method of treating bone of animal using said filler
JPS57191252A (en) * 1981-05-22 1982-11-25 Univ Kyoto Crystallized glass for artificial bone and its preparation

Also Published As

Publication number Publication date
JPS6314991B2 (en) 1988-04-02

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