JPS61225134A - Production of cream and lotion from fomes japonicus - Google Patents
Production of cream and lotion from fomes japonicusInfo
- Publication number
- JPS61225134A JPS61225134A JP60068171A JP6817185A JPS61225134A JP S61225134 A JPS61225134 A JP S61225134A JP 60068171 A JP60068171 A JP 60068171A JP 6817185 A JP6817185 A JP 6817185A JP S61225134 A JPS61225134 A JP S61225134A
- Authority
- JP
- Japan
- Prior art keywords
- reishi
- lotion
- cream
- organic solvent
- bitter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、無味霊芝の製造によって副産される苦味成分
を用いた霊芝クリーム及び霊芝ローションの製造法に関
するものである。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a method for producing a Ganoderma cream and a Ganoderma lotion using a bitter component produced as a by-product of the production of tasteless Ganoderma.
霊芝はザルのコシカケ科マンネンタケに属する菌苔頽で
あって、霊芝の水仙１１后夜には肺炎菌、Ａ型しンザ球
菌、白色ブドウ球菌及び流感菌に対する一定の抑制作用
がある。また霊芝のエタノール或いはケトン抽出液は、
大腸菌、変性菌、赤痢菌および緑膿菌に対して一定の抑
制作用を有し、外用殺菌剤として使用されるものである
ことが知られている。上述した霊芝の抑制作用により、
霊芝のアルコール抽出液及び恒温水油１１脅夜或いはこ
れらの抽出液を乾燥して得た霊芝のエキス散在は、慢性
気管支炎、白血球減少症、冠状動脈硬化性心臓病や不整
脈等の治療に利用されている。Reishi is a fungal moss that belongs to the Physcomitraceae family, and Reishi daffodil has a certain inhibitory effect on Streptococcus pneumoniae, Streptococcus type A, Staphylococcus alba, and influenza fungus. In addition, ethanol or ketone extract of Ganoderma
It is known to have a certain inhibitory effect on Escherichia coli, dystrophic bacteria, Shigella bacteria, and Pseudomonas aeruginosa, and is used as an external disinfectant. Due to the above-mentioned suppressive action of Reishi,
Reishi alcohol extract and constant-temperature water oil 11-shoya or Ganoderma extract obtained by drying these extracts can be used to treat chronic bronchitis, leukopenia, coronary atherosclerotic heart disease, arrhythmia, etc. It is used for.
ところが、霊芝には特有の苦味成分があり、経口投与に
あたっては必ずしも容易ではなく、これを大量投与する
ことは患者に苦痛を強いることとなるものであって、そ
の使用が甚だ困テ「であるという欠点を有していた。こ
のため、服用を困難にする上記苦味成分を取り除いて容
易に服用できるという霊芝について、本願発明者等は先
に、苦味成分を効率よく抽出分離することのできる［無
味霊芝の製造方法−１（特願昭５９−１５１５５３号）
を提案した。However, Reishi mushrooms have a unique bitter component, and oral administration is not always easy, and administering large amounts of them causes pain to patients, making their use extremely difficult. For this reason, the inventors of the present application first developed a method for efficiently extracting and separating the bitter components of Reishi mushroom, which can be easily taken by removing the bitter components that make it difficult to take. [Production method of tasteless Reishi mushroom-1 (Patent application No. 151553/1989)]
proposed.
霊芝の成分に関する近年の研究〔第１０３回薬学会（２
８Ｃ４−１）昭和５９年仙台市〕によれば、霊芝より得
られた粗結晶はガスクロマ］・グラフィー法によって１
０種類の成分に分離・分画され、このうち３種類は苦味
を有するトリテルペン類であることが確認されている。Recent research on the ingredients of Reishi [103rd Pharmaceutical Society of Japan (2019)]
8C4-1) According to Sendai City in 1981, crude crystals obtained from Reishi mushrooms were 1.
It has been separated and fractionated into zero types of components, three of which have been confirmed to be triterpenes with a bitter taste.
本発明は、上記従来の問題点を考慮し、前記霊芝に関す
る公知の知見及び特願昭５９−１５１５５３号に記載の
研究に栽づきなされたものであって、苦味成分の取り除
かれた服用が容易な無味霊芝を製造するに際し、溶出分
１Ｆｉｉによって得られた苦味成分・胞子を利用して、
挫創、化膿側、非結核性潰瘍等の治療に有効な霊芝クリ
ーム及び霊芝ローションの製造法の提供を目的とするも
のである。The present invention has been developed in consideration of the above-mentioned conventional problems and based on the known knowledge regarding the reishi mushroom and the research described in Japanese Patent Application No. 59-151553. To easily produce tasteless Reishi mushrooms, use the bitter components and spores obtained from the elution fraction 1Fii.
The object of the present invention is to provide a method for producing Reishi mushroom cream and Reishi lotion that are effective in treating contusions, suppurative ulcers, non-tuberculous ulcers, etc.
本第１発明に係る霊芝クリームの製造法は、有機溶媒に
霊芝の胞子を浸漬して、霊芝の子実体裏面の胞子層・胞
子より溶出分画して得られた苦味成分を、油脂性、乳剤
性及び水溶性を有する軟膏基剤に微細均等に分散して混
合することにより、挫創、化膿側、非結核性潰瘍等の治
療に有効な霊芝クリームを得るように構成したことを特
徴とするものである。The method for producing Ganoderma cream according to the first invention is to immerse Ganoderma spores in an organic solvent and elute and fractionate the bitter components from the spore layer/spores on the back side of Ganoderma fruiting bodies. By finely and evenly dispersing and mixing in an ointment base having oil-based, emulsion-like and water-soluble properties, a reishi mushroom cream effective for the treatment of bruises, suppurative lesions, non-tuberculous ulcers, etc. can be obtained. It is characterized by:
また本第２発明に係る霊芝ローションの製造法は、有機
溶媒に霊芝の胞子を浸漬して、霊芝の子実体裏面の胞子
層・胞子より溶出分画して得られた苦味成分を、水溶性
の液中に微細均等に分散して混合することにより、挫創
、化膿側、非結核性潰瘍等の治療に有効な霊芝ローショ
ンを得るように構成したことを特徴とするものである。In addition, the method for producing Ganoderma lotion according to the second invention involves immersing Ganoderma spores in an organic solvent and eluating and fractionating the bitterness components from the spore layer and spores on the back side of Ganoderma fruiting bodies. , is characterized by being configured to obtain a reishi lotion effective for treating contusions, suppurative ulcers, non-tuberculous ulcers, etc. by finely and evenly dispersing and mixing in a water-soluble liquid. .
〔第１発明の実施例〕
第１発明の一実施例について説明すれば、次のとおりで
ある。[Embodiment of the first invention] An embodiment of the first invention will be described as follows.
この霊芝クリームを製造する場合、まず霊芝を水洗して
乾燥する。次に、エチルエーテルなどの（，３）
有機溶媒に浸漬して、霊芝の子実体裏面の胞子層や胞子
に局在している苦味成分を有機溶媒中に溶出させて分画
する。即ち、霊芝に含有されている苦味成分は、無味の
霊芝基体から苦味成分の溶出した濃縮有機溶媒抽出液あ
るいは胞子有機溶媒抽出液となって分離される。この濃
縮有機溶媒抽出液あるいは胞子有機溶媒抽出液を採取し
てこれを加熱することにより、有機溶媒が取り除かれて
黄白色の粗結晶が得られ溶出・分画されるものである。When manufacturing this Reishi mushroom cream, the Reishi mushrooms are first washed with water and dried. Next, it is immersed in a (,3) organic solvent such as ethyl ether, and the bitter components localized in the spore layer and spores on the back side of the fruiting body of Reishi are eluted into the organic solvent and fractionated. That is, the bitter components contained in Reishi are separated from the tasteless Reishi base as a concentrated organic solvent extract or a spore organic solvent extract in which the bitter components are eluted. By collecting this concentrated organic solvent extract or spore organic solvent extract and heating it, the organic solvent is removed and yellow-white crude crystals are obtained, which are eluted and fractionated.
このようにして得られた黄白色の粗結晶を、油脂性、乳
剤性および水溶性を有する軟膏基剤に加え、微細均等に
分散して混合させることにより、挫創、化膿側、非結核
性潰瘍等の治療に有効な霊芝クリームが得られる。The yellowish-white crude crystals obtained in this way are added to an oily, emulsified, and water-soluble ointment base, and are finely and evenly dispersed and mixed to treat contusions, suppurative areas, and non-tuberculous ulcers. A reishi mushroom cream that is effective for the treatment of the following can be obtained.
〔第２発明の実施例〕
第２発明の一実施例について説明すれば、次のとおりで
ある。[Embodiment of the second invention] An embodiment of the second invention will be described as follows.
この霊芝ローションを製造する場合、まず霊芝を水洗し
て乾燥する。次いで、エチルエーテルなどの有機溶媒に
浸漬して、霊芝の子実体裏面の胞子層や胞子に局在して
いる苦味成分を有機溶媒中に溶出させる。これにより、
霊芝に含有されている苦味成分は、無味の霊芝基体から
苦味成分の溶出した濃縮有機溶媒抽出液あるいは胞子有
機溶媒抽出液となって分離される。この濃縮有機溶媒抽
出液あるいは胞子有機溶媒抽出液を採取してこれを加熱
することにより、有機溶媒が取り除かれて黄白色の粗結
晶が得られ溶出・分画されるものである。このようにし
て得られた黄白色の粗結晶を、水溶性の液中に加えて、
微細均等に分散し混合させることにより、挫創、化膿側
、非結核性潰瘍等の治療に有効な霊芝ローションが得ら
れる。When manufacturing this Reishi mushroom lotion, the Reishi mushroom is first washed with water and dried. Next, by immersing it in an organic solvent such as ethyl ether, the bitter components localized in the spore layer and spores on the back side of the fruiting body of Reishi are eluted into the organic solvent. This results in
The bitter components contained in Reishi are separated from the tasteless Reishi base as a concentrated organic solvent extract or a spore organic solvent extract in which the bitter components are eluted. By collecting this concentrated organic solvent extract or spore organic solvent extract and heating it, the organic solvent is removed and yellow-white crude crystals are obtained, which are eluted and fractionated. The yellowish white crude crystals thus obtained were added to an aqueous solution,
By finely and evenly dispersing and mixing, a reishi lotion that is effective for treating contusions, purulent ulcers, non-tuberculous ulcers, etc. can be obtained.
〔実験例１〕
本第１発明に係る霊芝クリームの製造法について、霊芝
１％亜鉛華軟膏の製造法の実験例を以下に説明する。[Experimental Example 1] Regarding the method for producing the Reishi cream according to the first invention, an experimental example of the method for producing a 1% Reishi mushroom ointment will be described below.
簡単に水洗した赤霊芝１ ｋｇを０．１％クエン酸含有
の酸性溶液１０Ｊ中に浸漬し、室温（２０°Ｃ）で１０
分間放置した。次いで、この霊芝を一旦熱風（６０℃）
で乾燥した。これにより得られた乾燥霊芝を、有機）容
媒としてエチルエーテルを選び大豆油抽出機を利用して
４時間還流処理し、霊芝の苦味成分を抽出した。このエ
ーテル抽Ｂｉ ？＆を加熱して有機溶媒を携り除き、黄
白色をなした苦味成分の霊芝粗結晶を得た。1 kg of Red Reishi, which had been briefly washed with water, was immersed in 10 J of an acidic solution containing 0.1% citric acid, and then heated at room temperature (20°C) for 10 kg.
Leave it for a minute. Next, this Reishi mushroom is heated with hot air (60℃).
It was dried. The dried Ganoderma lucidum thus obtained was refluxed for 4 hours using a soybean oil extractor using ethyl ether as an organic vehicle to extract the bitter components of the Ganoderma lucidum. This ether extraction Bi? The organic solvent was removed by heating to obtain crude crystals of Ganoderma lucidum, a bitter component, which was yellowish white in color.
」二記の方法で得られた黄白色の霊芝粗結晶細末の有す
る薬理作用について研究を進めたところ、外用剤として
の用法に特徴のあることが判明した。つまり上記霊芝粗
結晶は単に殺菌作用のめならず、創面治癒促進作用をも
有していることが明らかとなった。ウサギの背部皮膚に
設けた筋肉に達する２ｃ＋Ａの新鮮創傷の治癒は、アク
リノールを用いた場合と比較して、本発明における霊芝
粗結晶含有クリームの方が明らかに早く治癒効果に優れ
たものであった。As a result of research into the pharmacological effects of the yellow-white coarse crystal fine powder of Ganoderma lucidum obtained by the method described in Section 2, it was discovered that it has a unique use as an external preparation. In other words, it has been revealed that the crude Reishi crystals have not only a bactericidal effect but also a wound surface healing promoting effect. The healing of fresh 2c+A wounds on the rabbit's back skin that reached the muscles was clearly faster and more effective with the cream containing crude Ganoderma crystals of the present invention than with acrinol. there were.
前記の方法で得た霊芝エーテル粗結晶の細末１０ｇを、
脂肪、脂肪油、ラノリン、ワセリン、パラフィン、蝋、
樹脂、プラスチック、グリコール類、高級アルコール、
グリセリン、水、乳化剤及び懸濁化剤の混合物に酸化亜
鉛１ｉＴｈ粉末（２００号ふるいで篩過）を混和して得
た軟膏の基剤９９０ｇに加えてよく混和し、霊芝１％亜
鉛華軟膏１，０００ｇを得た。10 g of fine powder of Reishi ether crude crystals obtained by the above method,
fats, fatty oils, lanolin, petrolatum, paraffin, wax,
Resins, plastics, glycols, higher alcohols,
Add to 990 g of an ointment base obtained by mixing zinc oxide 1iTh powder (passed through a No. 200 sieve) to a mixture of glycerin, water, an emulsifier, and a suspending agent, and mix well to obtain 1% zinc oxide ointment. 1,000g was obtained.
〔実験例２〕
本第１発明に係る霊芝クリームの製造法の実験例として
、霊芝１％・硼酸・亜鉛華軟膏の製造法を以下に説明す
る。[Experimental Example 2] As an experimental example of the method for producing the Reishi mushroom cream according to the first invention, a method for producing a 1% Reishi mushroom/boric acid/zinc oxide ointment will be described below.
白色ワセリン６３０ｇを水浴上でＪ用熱して？容かし、
これに前記第１実施例に述べた方法によって得た霊芝エ
ーテル粗結晶細末１０ｇ（或いは胞子エーテル抽出物）
を力ｌえて溶解した。次いで精製ラノリン１００ｇ及び
サラシミツロウ５０ｇを加えて水浴上から取り出し、上
記の溶液が固まる直前に硼酸細末９０ｇ （１００号ふ
るいで篩過）及び酸化亜鉛微末８０ｇ（２００号ふるい
で篩過）を加え、同化するまで混和して霊芝１％・硼酸
・亜鉛華軟膏１，０００ｇを得た。Heat 630g of white petrolatum on a water bath. Please,
Add to this 10 g of Reishi ether crude crystal fine powder (or spore ether extract) obtained by the method described in the first example.
was dissolved by straining. Next, 100 g of purified lanolin and 50 g of white beeswax were added and taken out from the water bath, and just before the above solution solidified, 90 g of fine boric acid powder (passed through a No. 100 sieve) and 80 g of fine zinc oxide powder (sieved through a No. 200 sieve) were added. The mixture was mixed until assimilated to obtain 1,000 g of 1% Reishi mushroom/boric acid/zinc oxide ointment.
（以下余白）
〔実験例３〕
本第２発明に係る霊芝ローションの製造法につ（ｌＯ）
いての実験例として、霊芝１％・楔力ステアリン酸・グ
リセリン・ローションの製造法を以下に説明する。(The following is a blank space) [Experimental Example 3] As an experimental example of the method for manufacturing a reishi lotion according to the second invention (lO), the method for manufacturing a 1% reishi mushroom, stearic acid wedge, and glycerin lotion is as follows. Explain.
ステアリン酸１００ｇ、カカオ脂２０ｇ、精製ラノリン
２０ｇ、ｌ−リエタノールアミン４０ｇ及び塩酸ジプカ
イン３ｇを混和し、加熱してン容解する。これに前記実
験例１で述べた方法によって得た霊芝エーテル粗結晶細
末１０ｇ（或いは胞子）を加えてよく混和し溶解する。100 g of stearic acid, 20 g of cocoa butter, 20 g of purified lanolin, 40 g of l-liethanolamine and 3 g of zypcaine hydrochloride are mixed and heated to dissolve. To this was added 10 g of Reishi ether crude crystal fine powder (or spores) obtained by the method described in Experimental Example 1, and the mixture was thoroughly mixed and dissolved.
次いで別に用意した積製氷６４１ｍ７！にグリセリン１
６０ｇを加える。これに上記の霊芝エーテル相結晶細末
を含有した溶液を加えて混和しながら室温まで冷却し、
白色の霊芝１％複楔力テアリン酸・グリセリン・ローシ
ョン１，０００ｇを得た。このローションは遮光保存の
必要があるためラミネートチューブに充填した。Next, we prepared a separate stack of ice cubes, 641m7! glycerin 1
Add 60g. Add the solution containing the above-mentioned Reishi ether phase crystal fine powder to this and cool to room temperature while mixing.
1,000 g of white Reishi 1% double wedge tearic acid/glycerin lotion was obtained. This lotion needed to be stored protected from light, so it was packed in a laminated tube.
（以下余白）
〔発明の効果〕
本第１発明および第２発明は以上のように、殺菌作用と
、さらに止血及び創面冶癒促進作用を有する霊芝の苦味
成分あるいは胞子有機溶媒抽出物の粗結晶を、軟膏基剤
または水溶性の液中に含有させることにより、創傷、擦
傷、挫創、化膿創、湿疹、膿癲疹、火傷及び非結核性潰
瘍等に優れた治療効果を発揮する霊芝クリーム及び霊芝
ローションの製造法であり、苦味成分の取り除かれた服
用が安易な無味霊芝を製造するに際し、副産物として得
られた苦味成分を有効に利用して製造することが出来る
という優れた効果を奏するものである。(Left below) [Effects of the Invention] As described above, the first and second inventions provide a crude extract of the bitter component or spore organic solvent extract of Ganoderma lucidum, which has a bactericidal effect and also has hemostatic and wound healing promoting effects. Ganoderma lucidum exhibits excellent therapeutic effects on wounds, abrasions, contusions, suppurative wounds, eczema, impetigo, burns, non-tuberculous ulcers, etc. by containing crystals in an ointment base or water-soluble liquid. This is a method for producing creams and reishi lotions, and is an excellent method for producing tasteless reishi that is easy to take and has its bitter components removed, by effectively utilizing the bitter components obtained as by-products. It is effective.
特許出願人 萱 垣 昇 同」−広瀬 三雄Patent applicant: Noboru Kaya Gaki Same” - Mitsuo Hirose
Claims (1)
面の胞子層・胞子より溶出分画して得られた苦味成分を
、油脂性、乳剤性及び水溶性を有する軟膏基剤に微細均
等に分散して混合することを特徴とする霊芝クリームの
製造法。 ２、有機溶媒に霊芝の胞子を浸漬して、霊芝の子実体裏
面の胞子層・胞子より溶出分画して得られた苦味成分を
、水溶性の液中に微細均等に分散して混合することを特
徴とする霊芝ローションの製造法。[Claims] 1. The bitter components obtained by soaking Reishi spores in an organic solvent and eluating and fractionating from the spore layer/spores on the back side of the Reishi fruiting body are extracted from oil-based, emulsion-based and A method for producing reishi cream, which is characterized by finely and evenly dispersing and mixing in a water-soluble ointment base. 2. Dip ganoderma spores in an organic solvent, elute and fractionate from the spore layer/spores on the back side of the ganoderma fruiting body, and then finely and evenly disperse the bitter components in a water-soluble liquid. A method for producing reishi lotion, which is characterized by mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60068171A JPS61225134A (en) | 1985-03-29 | 1985-03-29 | Production of cream and lotion from fomes japonicus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60068171A JPS61225134A (en) | 1985-03-29 | 1985-03-29 | Production of cream and lotion from fomes japonicus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61225134A true JPS61225134A (en) | 1986-10-06 |
| JPH047728B2 JPH047728B2 (en) | 1992-02-12 |
Family
ID=13366055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60068171A Granted JPS61225134A (en) | 1985-03-29 | 1985-03-29 | Production of cream and lotion from fomes japonicus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61225134A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06116162A (en) * | 1992-10-06 | 1994-04-26 | Toyo Seiyaku Kk | Antibacterial agent against staphylococcus |
| JPH06116161A (en) * | 1992-10-06 | 1994-04-26 | Toyo Seiyaku Kk | Antibacterial agent against streptococcus |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5197662U (en) * | 1975-02-03 | 1976-08-05 | ||
| JPS55161906U (en) * | 1979-05-09 | 1980-11-20 | ||
| JPS5860016U (en) * | 1981-10-20 | 1983-04-22 | 株式会社ニフコ | Fastener |
| JPS6023307U (en) * | 1983-07-22 | 1985-02-18 | オンキヨー株式会社 | Painted metal product tightening structure |
-
1985
- 1985-03-29 JP JP60068171A patent/JPS61225134A/en active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5197662U (en) * | 1975-02-03 | 1976-08-05 | ||
| JPS55161906U (en) * | 1979-05-09 | 1980-11-20 | ||
| JPS5860016U (en) * | 1981-10-20 | 1983-04-22 | 株式会社ニフコ | Fastener |
| JPS6023307U (en) * | 1983-07-22 | 1985-02-18 | オンキヨー株式会社 | Painted metal product tightening structure |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06116162A (en) * | 1992-10-06 | 1994-04-26 | Toyo Seiyaku Kk | Antibacterial agent against staphylococcus |
| JPH06116161A (en) * | 1992-10-06 | 1994-04-26 | Toyo Seiyaku Kk | Antibacterial agent against streptococcus |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH047728B2 (en) | 1992-02-12 |
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